Development Level

Tbio 710 | 11,651
Tchem 136 | 1,388
Tclin 46 | 612
Tdark 40 | 6,593

Collection

Kinase: IDG Consortium (Comple... 3 | 37

IMPC Phenotype

preweaning lethality, complete... 74 | 979
preweaning lethality, incomple... 34 | 499
embryonic lethality prior to t... 31 | 278
decreased vertical activity 22 | 208
abnormal behavior 21 | 298
abnormal embryo size 20 | 220
enlarged heart 19 | 210
embryonic lethality prior to o... 18 | 239
abnormal bone structure 17 | 187
decreased body weight 16 | 161
decreased total body fat amoun... 15 | 207
abnormal heart morphology 14 | 162
decreased lean body mass 14 | 135
increased total body fat amoun... 14 | 134
decreased circulating glucose ... 13 | 126
abnormal seminal vesicle morph... 12 | 114
increased lean body mass 12 | 172
increased mean corpuscular vol... 12 | 92
increased startle reflex 12 | 112
decreased prepulse inhibition 10 | 82
prenatal lethality prior to he... 10 | 87
abnormal retina morphology 9 | 71
embryonic growth retardation 9 | 106
hyperactivity 9 | 148
increased bone mineral content 9 | 108
male infertility 9 | 123
decreased circulating triglyce... 8 | 79
decreased leukocyte cell numbe... 8 | 73
decreased lymphocyte cell numb... 8 | 83
increased mean corpuscular hem... 8 | 96
increased neutrophil cell numb... 8 | 46
abnormal eye morphology 7 | 68
decreased bone mineral content 7 | 151
decreased circulating serum al... 7 | 82
decreased erythrocyte cell num... 7 | 62
decreased hemoglobin content 7 | 68
increased monocyte cell number 7 | 63
increased or absent threshold ... 7 | 101
thrombocytopenia 7 | 56
abnormal cornea morphology 6 | 31
abnormal kidney morphology 6 | 65
abnormal lens morphology 6 | 81
abnormal neural tube closure 6 | 46
cataract 6 | 92
corneal opacity 6 | 32
decreased body length 6 | 101
decreased bone mineral density 6 | 126
decreased circulating choleste... 6 | 93
hypoactivity 6 | 132
increased leukocyte cell numbe... 6 | 47
short tibia 6 | 97
small superior vagus ganglion 6 | 74
abnormal bone mineralization 5 | 38
abnormal sleep behavior 5 | 70
decreased blood urea nitrogen ... 5 | 51
decreased mean corpuscular vol... 5 | 79
female infertility 5 | 60
hydrometra 5 | 53
impaired glucose tolerance 5 | 75
increased bone mineral density 5 | 72
increased circulating HDL chol... 5 | 80
increased circulating alkaline... 5 | 122
increased hemoglobin content 5 | 45
increased mean corpuscular hem... 5 | 36
abnormal retinal blood vessel ... 4 | 26
abnormal skin morphology 4 | 50
decreased T cell number 4 | 15
decreased circulating total pr... 4 | 49
decreased hematocrit 4 | 46
decreased mean corpuscular hem... 4 | 50
decreased mean corpuscular hem... 4 | 31
hemorrhage 4 | 23
increased circulating chloride... 4 | 41
increased circulating choleste... 4 | 66
increased circulating sodium l... 4 | 71
increased circulating triglyce... 4 | 42
increased erythrocyte cell num... 4 | 39
increased grip strength 4 | 41
increased heart weight 4 | 62
increased lymphocyte cell numb... 4 | 32
prolonged QT interval 4 | 38
small testis 4 | 58
tremors 4 | 39
abnormal coat-hair pigmentatio... 3 | 64
abnormal epididymis morphology 3 | 42
abnormal gait 3 | 69
abnormal retinal vasculature m... 3 | 27
abnormal spleen morphology 3 | 55
abnormal vertebrae morphology 3 | 18
anophthalmia 3 | 33
cardiovascular system phenotyp... 3 | 36
decreased caudal vertebrae num... 3 | 53
decreased circulating HDL chol... 3 | 68
decreased circulating aspartat... 3 | 34
decreased fasted circulating g... 3 | 65
decreased startle reflex 3 | 75
impaired pupillary reflex 3 | 26
increased hematocrit 3 | 46
increased prepulse inhibition 3 | 32
microphthalmia 3 | 26

Disease

Carcinoma 624 | 11,493
ovarian cancer 500 | 8,520
osteosarcoma 473 | 7,950
psoriasis 417 | 6,694
Cancer 389 | 2,499
medulloblastoma, large-cell 384 | 6,241
glioblastoma 365 | 5,792
lung cancer 340 | 4,740
atypical teratoid / rhabdoid tumor 293 | 5,112
Breast cancer 267 | 3,578
ependymoma 259 | 4,679
malignant mesothelioma 237 | 3,232
group 3 medulloblastoma 232 | 4,104
adult high grade glioma 210 | 3,801
invasive ductal carcinoma 208 | 2,951
non-small cell lung cancer 196 | 2,890
intraductal papillary-mucinous neoplasm (IPMN) 192 | 3,291
oligodendroglioma 187 | 2,850
primitive neuroectodermal tumor 175 | 3,035
lung adenocarcinoma 174 | 2,716
intraductal papillary-mucinous adenoma (IPMA) 172 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 172 | 2,989
lung carcinoma 169 | 2,843
pancreatic cancer 168 | 2,398
Kidney cancer 161 | 2,613
Astrocytoma, Pilocytic 160 | 3,081
astrocytic glioma 157 | 2,597
interstitial cystitis 154 | 2,312
diabetes mellitus 145 | 1,728
ductal carcinoma in situ 144 | 1,745
ulcerative colitis 143 | 1,819
tuberculosis 141 | 2,010
pituitary cancer 137 | 1,972
group 4 medulloblastoma 135 | 1,855
Rheumatoid arthritis 134 | 1,191
breast carcinoma 132 | 1,638
subependymal giant cell astrocytoma 131 | 2,287
Pick disease 113 | 1,894
Schizophrenia 112 | 1,160
cystic fibrosis 107 | 1,696
pancreatic ductal adenocarcinoma liver metastasis 107 | 1,962
acute quadriplegic myopathy 98 | 1,158
Intellectual disability 96 | 1,016
juvenile dermatomyositis 95 | 1,187
adrenocortical carcinoma 94 | 1,428
astrocytoma 93 | 1,146
Multiple myeloma 92 | 1,332
colon cancer 92 | 1,478
Autosomal recessive predisposition 88 | 1,442
Breast Neoplasms 84 | 445
Obesity 83 | 678
primary pancreatic ductal adenocarcinoma 81 | 1,109
Mammary Neoplasms 80 | 425
cutaneous lupus erythematosus 80 | 1,057
pediatric high grade glioma 78 | 1,064
Prostatic Neoplasms 75 | 495
dermatomyositis 73 | 966
spina bifida 72 | 1,074
Dull intelligence 71 | 645
Low intelligence 71 | 645
Mental Retardation 71 | 645
Mental deficiency 71 | 645
Poor school performance 71 | 645
Short stature 70 | 531
Bipolar Disorder 69 | 666
Epilepsy 67 | 792
Kidney disease 67 | 430
acute myeloid leukemia 67 | 783
Seizures 66 | 596
Alzheimer's disease 61 | 658
aldosterone-producing adenoma 60 | 665
Atopic dermatitis 58 | 952
Liver Cirrhosis, Experimental 58 | 769
Waldenstrons macroglobulinemia 58 | 765
primary Sjogren syndrome 57 | 735
Cognitive delay 56 | 608
Depressive disorder 56 | 409
Global developmental delay 56 | 608
Mental and motor retardation 56 | 608
Cleft Palate 55 | 271
Multiple Sclerosis 55 | 540
Muscle hypotonia 55 | 571
Arthritis 54 | 290
Endometriosis 54 | 540
Asthma 53 | 385
Heart disease 52 | 306
Vascular disease 52 | 319
gastric carcinoma 52 | 807
nasopharyngeal carcinoma 51 | 1,058
Liver carcinoma 50 | 240
Lung Neoplasms 50 | 232
non primary Sjogren syndrome sicca 50 | 891
Parkinson's disease 49 | 392
Mental Depression 48 | 333
Osteoporosis 48 | 363
autosomal dominant Emery-Dreifuss muscular dystrophy 48 | 510
Cryptorchidism 47 | 296
medulloblastoma 47 | 720
Carcinoma, Hepatocellular 46 | 228
Orbital separation excessive 46 | 244

Tissue

Endocrine System 910 | 18,159
Digestive Tract 893 | 17,369
Skin and soft tissues 887 | 17,230
Female tissues 877 | 17,400
Male tissues 871 | 17,142
Blood and immune system 864 | 16,909
Liver and Pancreas 859 | 16,750
Urinary Tract 859 | 16,678
Nervous System 858 | 16,725
Respiratory system 838 | 16,393
Cardiovascular System 789 | 15,192

Target Family

Transcription Factor 382 | 1,400
Non-IDG 320 | 12,091
Enzyme 79 | 4,145
Kinase 45 | 634
Epigenetic 44 | 242
Nuclear Receptor 33 | 48
GPCR 15 | 408
TF/Epigenetic 7 | 38
Transporter 5 | 473
Ion Channel 2 | 344

GO Process

positive regulation of transcr... 932 | 932
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nicotinamide phosphoribosyltransferase NAMPT Tchem Enzyme -2.94790 1054.3 667
Transcription factor HES-1 HES1 Tbio Transcription Factor -1.77409 55.5 444
Endothelin-1 EDN1 Tbio Non-IDG -4.07520 12851.9 607
General transcription factor IIH subunit 1 GTF2H1 Tbio Non-IDG -1.65323 46.0 231
Zinc finger and BTB domain-containing protein 17 ZBTB17 Tbio Transcription Factor -1.57508 40.4 92
Mitogen-activated protein kinase 7 MAPK7 Tbio Kinase -2.48754 340.0 422
CCAAT/enhancer-binding protein epsilon CEBPE Tbio Transcription Factor -1.71776 57.4 246
Interleukin-6 IL6 Tclin Non-IDG -4.50976 30968.8 2075
Estrogen receptor ESR1 Tclin Nuclear Receptor -4.00480 8421.6 2610
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 CHCHD2 Tbio Non-IDG -1.33813 39.8 99