Development Level

Tbio 600 | 10,625
Tchem 163 | 1,890
Tclin 45 | 602
Tdark 37 | 7,003

Collection

Kinase: IDG Consortium (Complete/Control) 1 | 37

IMPC Phenotype

preweaning lethality, complete... 45 | 633
embryonic lethality prior to t... 21 | 187
preweaning lethality, incomple... 21 | 260
abnormal behavior 17 | 226
decreased lean body mass 14 | 195
decreased body weight 13 | 174
decreased body length 11 | 108
decreased bone mineral content 11 | 157
increased mean corpuscular vol... 11 | 91
enlarged heart 10 | 111
increased or absent threshold ... 10 | 128
abnormal embryo size 9 | 112
decreased circulating glucose ... 9 | 121
decreased circulating triglyce... 9 | 83
decreased total body fat amoun... 9 | 186
embryonic lethality prior to o... 9 | 148
abnormal bone structure 8 | 131
abnormal retina morphology 8 | 100
decreased prepulse inhibition 8 | 52
prenatal lethality prior to he... 8 | 64
decreased bone mineral density 7 | 126
decreased circulating choleste... 7 | 85
decreased grip strength 7 | 123
hyperactivity 7 | 108
abnormal retinal pigmentation 6 | 61
decreased circulating serum al... 6 | 79
decreased hemoglobin content 6 | 53
increased grip strength 6 | 83
short tibia 6 | 82
abnormal bone mineralization 5 | 55
abnormal coping response 5 | 12
abnormal eye morphology 5 | 38
abnormal lens morphology 5 | 73
abnormal sleep behavior 5 | 63
decreased leukocyte cell numbe... 5 | 54
increased circulating alkaline... 5 | 119
increased lean body mass 5 | 107
thrombocytopenia 5 | 46
abnormal cornea morphology 4 | 24
abnormal heart morphology 4 | 51
abnormal hindbrain development 4 | 24
abnormal neural tube closure 4 | 37
abnormal tooth morphology 4 | 24
corneal opacity 4 | 25
decreased circulating HDL chol... 4 | 77
decreased circulating fructosa... 4 | 31
decreased circulating total pr... 4 | 41
decreased eosinophil cell numb... 4 | 41
decreased erythrocyte cell num... 4 | 43
hypoactivity 4 | 89
increased bone mineral content 4 | 92
increased circulating HDL chol... 4 | 63
increased leukocyte cell numbe... 4 | 37
increased mean corpuscular hem... 4 | 93
increased mean corpuscular hem... 4 | 25
increased monocyte cell number 4 | 27
male infertility 4 | 62
narrow eye opening 4 | 15
small testis 4 | 37
straub tail 4 | 26
abnormal behavioral response t... 3 | 52
abnormal coat-hair pigmentatio... 3 | 54
abnormal forebrain development 3 | 18
abnormal midbrain development 3 | 22
abnormal seminal vesicle morph... 3 | 47
abnormal tail morphology 3 | 17
decreased B cell number 3 | 30
decreased Ly6C low monocyte nu... 3 | 23
decreased T cell number 3 | 31
decreased blood urea nitrogen ... 3 | 31
decreased caudal vertebrae num... 3 | 49
decreased circulating alanine ... 3 | 53
decreased circulating alkaline... 3 | 41
decreased circulating creatini... 3 | 31
decreased circulating free fat... 3 | 39
decreased lumbar vertebrae num... 3 | 62
decreased mean corpuscular hem... 3 | 34
decreased mean corpuscular hem... 3 | 19
decreased mean corpuscular vol... 3 | 50
female infertility 3 | 34
hydrometra 3 | 13
impaired glucose tolerance 3 | 52
impaired pupillary reflex 3 | 14
increased circulating chloride... 3 | 43
increased circulating choleste... 3 | 53
increased circulating sodium l... 3 | 71
increased circulating triglyce... 3 | 24
increased hemoglobin content 3 | 45
increased sacral vertebrae num... 3 | 62
limb grasping 3 | 35
small superior vagus ganglion 3 | 20
thrombocytosis 3 | 23
vertebral fusion 3 | 23
abnormal epididymis morphology 2 | 31
abnormal gait 2 | 51
abnormal optic disc morphology 2 | 10
decreased circulating calcium ... 2 | 33
increased body weight 2 | 42
increased hematocrit 2 | 36
increased total body fat amoun... 2 | 57

Disease

ovarian cancer 455 | 8,491
osteosarcoma 431 | 7,933
psoriasis 381 | 6,685
Cancer 356 | 2,346
medulloblastoma, large-cell 350 | 6,234
glioblastoma 308 | 5,572
lung cancer 292 | 4,473
atypical teratoid / rhabdoid tumor 232 | 4,369
malignant mesothelioma 207 | 3,163
Breast cancer 206 | 3,098
invasive ductal carcinoma 196 | 2,950
intraductal papillary-mucinous neoplasm (IPMN) 180 | 3,289
non-small cell lung cancer 175 | 2,798
oligodendroglioma 167 | 2,849
intraductal papillary-mucinous adenoma (IPMA) 158 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 157 | 2,988
lung adenocarcinoma 157 | 2,714
lung carcinoma 157 | 2,844
pediatric high grade glioma 157 | 2,712
primitive neuroectodermal tumor 157 | 3,031
pilocytic astrocytoma 147 | 3,086
ulcerative colitis 145 | 2,087
interstitial cystitis 142 | 2,299
pancreatic cancer 142 | 2,300
ependymoma 137 | 2,514
Carcinoma 133 | 2,147
group 4 medulloblastoma 133 | 1,875
ductal carcinoma in situ 132 | 1,745
diabetes mellitus 131 | 1,663
pituitary cancer 127 | 1,972
Rheumatoid Arthritis 120 | 1,170
breast carcinoma 119 | 1,614
astrocytic glioma 116 | 2,241
subependymal giant cell astrocytoma 115 | 2,287
tuberculosis 115 | 1,563
adult high grade glioma 104 | 2,148
Pick disease 99 | 1,893
astrocytoma 98 | 1,493
group 3 medulloblastoma 97 | 2,254
cystic fibrosis 96 | 1,670
juvenile dermatomyositis 91 | 1,189
acute quadriplegic myopathy 89 | 1,157
sonic hedgehog group medulloblastoma 88 | 1,482
adrenocortical carcinoma 87 | 1,427
pancreatic ductal adenocarcinoma liver metastasis 86 | 1,795
posterior fossa group A ependymoma 86 | 1,511
primary pancreatic ductal adenocarcinoma 83 | 1,271
medulloblastoma 81 | 1,524
Mammary Neoplasms 80 | 410
colon cancer 80 | 1,475
Multiple myeloma 78 | 1,327
Obesity 74 | 616
cutaneous lupus erythematosus 70 | 1,056
spina bifida 66 | 1,064
Prostatic Neoplasms 64 | 471
dermatomyositis 63 | 966
Kidney disease 61 | 397
acute myeloid leukemia 60 | 785
posterior fossa group B ependymoma 58 | 1,530
primary Sjogren syndrome 58 | 788
Alzheimer's disease 57 | 644
Atopic dermatitis 54 | 944
Endometriosis 54 | 535
atypical teratoid/rhabdoid tumor 54 | 1,095
Heart disease 52 | 279
aldosterone-producing adenoma 52 | 664
Waldenstrons macroglobulinemia 51 | 764
Multiple Sclerosis 49 | 498
gastric carcinoma 49 | 832
Arthritis 48 | 248
Asthma 47 | 349
Intellectual disability 47 | 573
nasopharyngeal carcinoma 47 | 1,056
autosomal dominant Emery-Dreifuss muscular dystrophy 46 | 499
Vascular disease 44 | 281
Inflammatory bowel disease 43 | 142
Parkinson's disease 43 | 364
Schizophrenia 43 | 503
Amyotrophic Lateral Sclerosis 42 | 432
Liver carcinoma 42 | 217
Lung Neoplasms 42 | 171
Liver disease 41 | 219
hepatocellular carcinoma 41 | 550
fibroadenoma 40 | 557
non primary Sjogren syndrome sicca 40 | 840
Craniofacial Abnormalities 39 | 147
active Crohn's disease 39 | 918
Crohn's disease 38 | 304
esophageal adenocarcinoma 38 | 737
progressive supranuclear palsy 38 | 674
Atherosclerosis 37 | 275
pancreatic carcinoma 37 | 567
Duchenne muscular dystrophy 36 | 602
Lung disease 36 | 136
Osteoporosis 36 | 259
Stomach Neoplasms 36 | 282
Cleft palate 35 | 125
Down syndrome 35 | 548
Hypersensitivity reaction type II disease 35 | 235
gastric cancer 35 | 436

Tissue

Female tissues 838 | 18,646
Digestive Tract 837 | 18,472
Nervous System 836 | 18,560
Endocrine System 832 | 18,511
Urinary Tract 827 | 18,443
Liver and Pancreas 823 | 18,135
Skin and soft tissues 823 | 18,114
Blood and immune system 822 | 17,994
Cardiovascular System 821 | 17,957
Male tissues 821 | 17,968
Respiratory system 805 | 17,483

Target Family

Transcription Factor 333 | 1,400
Non-IDG 293 | 11,969
Enzyme 76 | 4,146
Epigenetic 43 | 242
Kinase 42 | 634
Nuclear Receptor 31 | 48
GPCR 15 | 408
TF/Epigenetic 5 | 38
Transporter 5 | 473
Ion Channel 2 | 341

GO Process

positive regulation of transcr... 845 | 845
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 367 | 367
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
chemical synaptic transmission 238 | 238
MAPK cascade 237 | 237
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 199 | 199
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 180 | 180
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 175 | 175
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
protein folding 162 | 162
negative regulation of canonic... 161 | 161
response to lipopolysaccharide 161 | 161
T cell receptor signaling path... 160 | 160
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2-M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
type I interferon signaling pa... 130 | 130
endocytosis 129 | 129

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Proto-oncogene Wnt-1 WNT1 Tbio Non-IDG -2.73870 492.7 294
Transcription factor PU.1 SPI1 Tbio Transcription Factor -3.03044 1092.0 356
Paired box protein Pax-2 PAX2 Tbio Transcription Factor -2.66256 471.8 306
Spexin SPX Tbio Non-IDG -2.76281 568.1 18
Methylcytosine dioxygenase TET3 TET3 Tbio Enzyme -1.88050 66.7 105
Tumor suppressor p53-binding protein 1 TP53BP1 Tbio Epigenetic -2.65153 422.5 514
Transcription initiation factor IIA subunit 2 GTF2A2 Tbio Non-IDG -1.17322 15.5 31
Breast cancer type 1 susceptibility protein BRCA1 Tchem Non-IDG -3.74239 5756.8 1322
Mediator of RNA polymerase II transcription subunit 25 MED25 Tbio Enzyme -1.76765 56.0 62