Development Level

Tbio 363 | 10,625
Tchem 100 | 1,890
Tclin 24 | 602
Tdark 17 | 7,003

Collection

Eligible Kinase Proteins 2 | 134

IMPC Term

preweaning lethality, complete... 31 | 633
preweaning lethality, incomple... 14 | 260
decreased lean body mass 12 | 195
embryonic lethality prior to t... 12 | 187
abnormal behavior 11 | 226
decreased body weight 11 | 174
decreased bone mineral content 11 | 157
decreased total body fat amoun... 10 | 186
abnormal bone structure 9 | 131
abnormal embryo size 8 | 112
abnormal retina morphology 7 | 100
decreased body length 6 | 108
decreased bone mineral density 6 | 126
increased mean corpuscular vol... 6 | 91
prenatal lethality prior to he... 6 | 64
short tibia 6 | 82
hypoactivity 5 | 89
impaired glucose tolerance 5 | 52
increased bone mineral content 5 | 92
increased lean body mass 5 | 107
limb grasping 5 | 35
abnormal behavioral response t... 4 | 52
abnormal bone mineralization 4 | 55
abnormal eye morphology 4 | 38
abnormal lens morphology 4 | 73
abnormal retinal pigmentation 4 | 61
decreased caudal vertebrae num... 4 | 49
decreased circulating alkaline... 4 | 41
decreased circulating creatini... 4 | 31
decreased erythrocyte cell num... 4 | 43
decreased grip strength 4 | 123
decreased mean corpuscular vol... 4 | 50
decreased prepulse inhibition 4 | 52
embryonic lethality prior to o... 4 | 148
enlarged heart 4 | 111
hydrops fetalis 4 | 22
improved glucose tolerance 4 | 56
increased body weight 4 | 42
increased circulating HDL chol... 4 | 63
increased mean corpuscular hem... 4 | 93
increased or absent threshold ... 4 | 128
abnormal digit morphology 3 | 13
abnormal gait 3 | 51
abnormal head morphology 3 | 10
abnormal iris morphology 3 | 12
abnormal sleep behavior 3 | 63
abnormal startle reflex 3 | 14
decreased blood urea nitrogen ... 3 | 31
decreased circulating alanine ... 3 | 53
decreased circulating choleste... 3 | 85
decreased circulating serum al... 3 | 79
decreased circulating triglyce... 3 | 83
decreased fasted circulating g... 3 | 49
decreased hemoglobin content 3 | 53
decreased leukocyte cell numbe... 3 | 54
decreased mean corpuscular hem... 3 | 19
decreased spleen weight 3 | 13
hyperactivity 3 | 108
increased B cell number 3 | 23
increased NK cell number 3 | 19
increased circulating alkaline... 3 | 119
increased circulating sodium l... 3 | 71
increased grip strength 3 | 83
thrombocytopenia 3 | 46
abnormal coat/ hair morphology 2 | 18
abnormal coping response 2 | 12
abnormal cornea morphology 2 | 24
abnormal forebrain development 2 | 18
abnormal hindbrain development 2 | 24
abnormal limb bud morphology 2 | 15
abnormal locomotor activation 2 | 26
abnormal neural tube closure 2 | 37
abnormal tooth morphology 2 | 24
cataract 2 | 26
decreased basophil cell number 2 | 11
decreased circulating LDL chol... 2 | 37
decreased circulating glucose ... 2 | 121
decreased circulating insulin ... 2 | 75
decreased circulating iron lev... 2 | 25
decreased circulating total pr... 2 | 41
decreased eosinophil cell numb... 2 | 41
decreased kidney weight 2 | 7
decreased mean corpuscular hem... 2 | 34
decreased respiratory quotient 2 | 12
decreased vertical activity 2 | 22
edema 2 | 11
hemorrhage 2 | 12
hydrometra 2 | 13
impaired pupillary reflex 2 | 14
increased circulating choleste... 2 | 53
increased circulating creatini... 2 | 29
increased circulating triglyce... 2 | 24
increased hematocrit 2 | 36
increased hemoglobin content 2 | 45
increased sacral vertebrae num... 2 | 62
increased startle reflex 2 | 38
increased total body fat amoun... 2 | 57
increased vertical activity 2 | 18
pale liver 2 | 5
thin ventricular wall 2 | 5

Disease

ovarian cancer 287 | 8,484
osteosarcoma 265 | 7,933
psoriasis 247 | 6,685
Cancer 215 | 2,346
medulloblastoma, large-cell 197 | 6,234
lung cancer 187 | 4,466
glioblastoma 183 | 5,572
atypical teratoid / rhabdoid tumor 149 | 4,369
Breast cancer 133 | 3,094
malignant mesothelioma 131 | 3,162
primitive neuroectodermal tumor 117 | 3,031
intraductal papillary-mucinous neoplasm (IPMN) 114 | 3,289
invasive ductal carcinoma 107 | 2,950
non-small cell lung cancer 96 | 2,798
intraductal papillary-mucinous adenoma (IPMA) 95 | 2,956
Carcinoma 93 | 2,147
pancreatic cancer 93 | 2,300
lung adenocarcinoma 92 | 2,713
intraductal papillary-mucinous carcinoma (IPMC) 91 | 2,988
pediatric high grade glioma 91 | 2,712
oligodendroglioma 88 | 2,849
diabetes mellitus 84 | 1,663
astrocytoma 83 | 1,493
pilocytic astrocytoma 83 | 3,086
interstitial cystitis 81 | 2,299
lung carcinoma 81 | 2,844
ductal carcinoma in situ 79 | 1,745
group 4 medulloblastoma 79 | 1,875
ulcerative colitis 78 | 2,087
subependymal giant cell astrocytoma 76 | 2,287
Rheumatoid Arthritis 74 | 1,160
ependymoma 74 | 2,514
Pick disease 68 | 1,893
group 3 medulloblastoma 67 | 2,254
breast carcinoma 66 | 1,614
pituitary cancer 65 | 1,972
cystic fibrosis 64 | 1,665
astrocytic glioma 62 | 2,241
sonic hedgehog group medulloblastoma 61 | 1,482
colon cancer 59 | 1,475
adult high grade glioma 58 | 2,148
primary pancreatic ductal adenocarcinoma 57 | 1,271
Multiple myeloma 56 | 1,327
juvenile dermatomyositis 55 | 1,189
medulloblastoma 55 | 1,524
tuberculosis 54 | 1,557
acute quadriplegic myopathy 52 | 1,157
Mammary Neoplasms 51 | 410
dermatomyositis 51 | 933
posterior fossa group A ependymoma 51 | 1,511
Endometriosis 45 | 535
adrenocortical carcinoma 45 | 1,427
posterior fossa group B ependymoma 43 | 1,530
acute myeloid leukemia 42 | 780
cutaneous lupus erythematosus 42 | 1,056
pancreatic ductal adenocarcinoma liver metastasis 41 | 1,795
atypical teratoid/rhabdoid tumor 40 | 1,095
spina bifida 40 | 1,064
Alzheimer's disease 39 | 644
Kidney disease 39 | 396
Obesity 39 | 616
Prostatic Neoplasms 39 | 471
Atopic dermatitis 38 | 944
nasopharyngeal carcinoma 35 | 1,056
Waldenstrons macroglobulinemia 34 | 765
gastric carcinoma 34 | 832
primary Sjogren syndrome 34 | 789
Osteoporosis 33 | 257
Intellectual disability 32 | 573
Stomach Neoplasms 32 | 282
aldosterone-producing adenoma 30 | 664
Cleft palate 29 | 125
Liver carcinoma 29 | 217
fibroadenoma 29 | 557
esophageal adenocarcinoma 28 | 737
Vascular disease 27 | 281
Craniofacial Abnormalities 26 | 147
Lung Neoplasms 26 | 171
Peripheral Neuropathy 25 | 303
active Crohn's disease 25 | 918
non primary Sjogren syndrome sicca 25 | 840
Amyotrophic Lateral Sclerosis 24 | 431
Down syndrome 24 | 548
Melanoma 24 | 261
Multiple Sclerosis 24 | 498
Asthma 23 | 349
autosomal dominant Emery-Dreifuss muscular dystrophy 23 | 499
Adenocarcinoma 22 | 115
Adenoma 22 | 165
Atherosclerosis 22 | 275
Colorectal Neoplasms 22 | 217
Heart disease 22 | 279
Liver disease 22 | 219
tuberculosis and treatment for 6 months 22 | 686
Bladder Neoplasm 21 | 109
Inflammatory bowel disease 21 | 142
Parkinson's disease 21 | 364
Prostate cancer 21 | 172
Schizophrenia 21 | 501
pancreatic carcinoma 21 | 567

Tissue

Female tissues 499 | 18,647
Digestive Tract 498 | 18,473
Endocrine System 498 | 18,512
Nervous System 498 | 18,561
Urinary Tract 497 | 18,444
Cardiovascular System 496 | 17,958
Skin and soft tissues 496 | 18,115
Liver and Pancreas 495 | 18,136
Male tissues 494 | 17,969
Blood and immune system 493 | 17,995
Respiratory system 492 | 17,484

Target Family

Transcription Factor 194 | 1,400
Non-IDG 166 | 11,971
Enzyme 47 | 4,146
Epigenetic 38 | 242
Kinase 25 | 634
Nuclear Receptor 19 | 48
TF/Epigenetic 8 | 38
GPCR 7 | 406

GO Process

positive regulation of transcr... 504 | 504
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
Erythropoietin EPO Tbio Non-IDG -3.90053 8755.8 628
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.09305 1275.4 345
Interleukin-1 receptor-associated kinase 1 IRAK1 Tchem Kinase -2.51851 320.4 729
Basic helix-loop-helix transcription factor scleraxis SCX Tbio Transcription Factor -2.80657 344.1 42
Microtubule-associated protein RP/EB family member 3 MAPRE3 Tbio Non-IDG -2.14681 132.5 161
High mobility group protein HMGI-C HMGA2 Tbio Transcription Factor -3.21092 1667.7 216
Methyl-CpG-binding protein 2 MECP2 Tchem Transcription Factor -3.22710 1827.6 567
Ubiquitin carboxyl-terminal hydrolase 22 USP22 Tbio Enzyme -1.59877 51.0 199