Development Level

Tbio 401 | 11,651
Tchem 88 | 1,388
Tclin 25 | 612
Tdark 15 | 6,593

Collection

Kinase: IDG Consortium (Target... 2 | 125
RFA-RM-18-021 2 | 328
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 47 | 979
preweaning lethality, incomple... 19 | 499
embryonic lethality prior to t... 18 | 278
decreased total body fat amoun... 15 | 207
decreased vertical activity 15 | 208
abnormal bone structure 13 | 187
abnormal embryo size 13 | 220
abnormal behavior 12 | 298
decreased body weight 12 | 161
embryonic lethality prior to o... 11 | 239
increased lean body mass 10 | 172
enlarged heart 9 | 210
increased total body fat amoun... 9 | 134
decreased lean body mass 7 | 135
increased bone mineral content 7 | 108
increased mean corpuscular vol... 7 | 92
abnormal eye morphology 6 | 68
abnormal retina morphology 6 | 71
decreased bone mineral content 6 | 151
decreased leukocyte cell numbe... 6 | 73
decreased prepulse inhibition 6 | 82
increased circulating alkaline... 6 | 122
prenatal lethality prior to he... 6 | 87
abnormal gait 5 | 69
abnormal heart morphology 5 | 162
abnormal lens morphology 5 | 81
abnormal retinal blood vessel ... 5 | 26
abnormal seminal vesicle morph... 5 | 114
cataract 5 | 92
decreased blood urea nitrogen ... 5 | 51
decreased circulating triglyce... 5 | 79
decreased erythrocyte cell num... 5 | 62
edema 5 | 59
embryonic growth retardation 5 | 106
hypoactivity 5 | 132
impaired glucose tolerance 5 | 75
improved glucose tolerance 5 | 79
increased circulating HDL chol... 5 | 80
increased circulating choleste... 5 | 66
increased mean corpuscular hem... 5 | 96
increased monocyte cell number 5 | 63
limb grasping 5 | 41
thrombocytopenia 5 | 56
decreased body length 4 | 101
decreased circulating glucose ... 4 | 126
decreased fasted circulating g... 4 | 65
decreased lymphocyte cell numb... 4 | 83
hydrometra 4 | 53
hyperactivity 4 | 148
increased body weight 4 | 25
increased bone mineral density 4 | 72
increased hemoglobin content 4 | 45
increased or absent threshold ... 4 | 101
increased startle reflex 4 | 112
short tibia 4 | 97
abnormal behavioral response t... 3 | 66
abnormal craniofacial morpholo... 3 | 33
abnormal forebrain development 3 | 20
abnormal head morphology 3 | 10
abnormal kidney morphology 3 | 65
abnormal neural tube closure 3 | 46
abnormal placenta size 3 | 20
abnormal retinal vasculature m... 3 | 27
abnormal sleep behavior 3 | 70
abnormal startle reflex 3 | 15
decreased bone mineral density 3 | 126
decreased circulating alkaline... 3 | 46
decreased circulating choleste... 3 | 93
decreased circulating creatini... 3 | 39
decreased circulating total pr... 3 | 49
decreased mean corpuscular hem... 3 | 31
decreased mean corpuscular vol... 3 | 79
decreased startle reflex 3 | 75
hemorrhage 3 | 23
increased circulating creatine... 3 | 5
increased circulating sodium l... 3 | 71
increased fasted circulating g... 3 | 76
increased neutrophil cell numb... 3 | 46
mammalian phenotype 3 | 17
small superior vagus ganglion 3 | 74
thin ventricular wall 3 | 24
abnormal cornea morphology 2 | 31
abnormal locomotor behavior 2 | 24
abnormal spleen morphology 2 | 55
cardiovascular system phenotyp... 2 | 36
decreased T cell number 2 | 15
decreased caudal vertebrae num... 2 | 53
decreased circulating LDL chol... 2 | 38
decreased circulating amylase ... 2 | 28
decreased circulating insulin ... 2 | 76
decreased circulating iron lev... 2 | 32
decreased circulating serum al... 2 | 82
decreased hemoglobin content 2 | 68
decreased neutrophil cell numb... 2 | 42
impaired pupillary reflex 2 | 26
increased circulating triglyce... 2 | 42
increased heart weight 2 | 62
microphthalmia 2 | 26
pale liver 2 | 6
pale yolk sac 2 | 25

Disease

Carcinoma 375 | 11,493
ovarian cancer 307 | 8,520
osteosarcoma 277 | 7,950
psoriasis 254 | 6,694
Cancer 241 | 2,499
medulloblastoma, large-cell 205 | 6,241
glioblastoma 204 | 5,792
lung cancer 204 | 4,740
atypical teratoid / rhabdoid tumor 179 | 5,112
Breast cancer 166 | 3,578
group 3 medulloblastoma 153 | 4,104
ependymoma 147 | 4,679
malignant mesothelioma 142 | 3,232
primitive neuroectodermal tumor 120 | 3,035
intraductal papillary-mucinous neoplasm (IPMN) 115 | 3,291
invasive ductal carcinoma 115 | 2,951
adult high grade glioma 113 | 3,801
Kidney cancer 112 | 2,613
non-small cell lung cancer 107 | 2,890
pancreatic cancer 101 | 2,398
diabetes mellitus 95 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 95 | 2,955
lung adenocarcinoma 95 | 2,716
oligodendroglioma 93 | 2,850
interstitial cystitis 92 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 92 | 2,989
Astrocytoma, Pilocytic 90 | 3,081
lung carcinoma 90 | 2,843
subependymal giant cell astrocytoma 86 | 2,287
astrocytic glioma 83 | 2,597
ductal carcinoma in situ 83 | 1,745
breast carcinoma 79 | 1,638
Rheumatoid arthritis 78 | 1,191
Intellectual disability 77 | 1,016
Schizophrenia 76 | 1,160
ulcerative colitis 75 | 1,819
Pick disease 72 | 1,894
astrocytoma 71 | 1,146
tuberculosis 71 | 2,010
pituitary cancer 68 | 1,972
cystic fibrosis 66 | 1,696
group 4 medulloblastoma 66 | 1,855
Short stature 65 | 531
Autosomal recessive predisposition 61 | 1,442
Dull intelligence 61 | 645
Low intelligence 61 | 645
Mental Retardation 61 | 645
Mental deficiency 61 | 645
Poor school performance 61 | 645
Multiple myeloma 59 | 1,332
juvenile dermatomyositis 59 | 1,187
Breast Neoplasms 58 | 445
colon cancer 57 | 1,478
Mammary Neoplasms 55 | 425
acute quadriplegic myopathy 54 | 1,158
primary pancreatic ductal adenocarcinoma 54 | 1,109
dermatomyositis 53 | 966
adrenocortical carcinoma 51 | 1,428
Cognitive delay 50 | 608
Global developmental delay 50 | 608
Mental and motor retardation 50 | 608
pancreatic ductal adenocarcinoma liver metastasis 50 | 1,962
Obesity 49 | 678
pediatric high grade glioma 49 | 1,064
Epilepsy 48 | 792
Endometriosis 47 | 540
Seizures 47 | 596
acute myeloid leukemia 47 | 783
spina bifida 47 | 1,074
Prostatic Neoplasms 46 | 495
cutaneous lupus erythematosus 46 | 1,057
Bipolar Disorder 45 | 666
Cryptorchidism 45 | 296
Muscle hypotonia 45 | 571
Cleft Palate 42 | 271
Kidney disease 42 | 430
Alzheimer's disease 41 | 658
Orbital separation excessive 41 | 244
Small head 41 | 374
Osteoporosis 40 | 363
Atopic dermatitis 39 | 952
Melanoma 39 | 711
nasopharyngeal carcinoma 37 | 1,058
Stomach Neoplasms 36 | 300
primary Sjogren syndrome 36 | 735
Carcinoma, Hepatocellular 35 | 228
Liver Cirrhosis, Experimental 35 | 769
Waldenstrons macroglobulinemia 35 | 765
medulloblastoma 35 | 720
Liver carcinoma 34 | 240
Lung Neoplasms 34 | 232
Depressive disorder 33 | 409
Strabismus 33 | 270
Vascular disease 33 | 319
Broad flat nasal bridge 32 | 236
Nasal bridge wide 32 | 236
gastric carcinoma 32 | 807
Hypertensive disease 31 | 292
active ulcerative colitis 31 | 764
esophageal adenocarcinoma 30 | 737

Tissue

Endocrine System 520 | 18,159
Female tissues 512 | 17,400
Skin and soft tissues 510 | 17,230
Digestive Tract 509 | 17,369
Male tissues 506 | 17,142
Blood and immune system 499 | 16,909
Nervous System 499 | 16,725
Liver and Pancreas 497 | 16,750
Urinary Tract 497 | 16,678
Respiratory system 493 | 16,393
Cardiovascular System 475 | 15,192

Target Family

Transcription Factor 196 | 1,400
Non-IDG 182 | 12,091
Enzyme 50 | 4,145
Epigenetic 37 | 242
Kinase 29 | 634
Nuclear Receptor 20 | 48
TF/Epigenetic 8 | 38
GPCR 7 | 408

GO Process

positive regulation of transcr... 529 | 529
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific NSD1 Tbio Epigenetic -2.16239 142.5 123
ETS-related transcription factor Elf-2 ELF2 Tbio Transcription Factor -2.04794 106.4 92
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 PLCB1 Tbio Enzyme -2.50444 332.8 190
Nuclear factor erythroid 2-related factor 1 NFE2L1 Tbio Transcription Factor -1.57346 40.9 157
Interleukin-6 IL6 Tclin Non-IDG -4.50976 30968.8 2075
Estrogen receptor ESR1 Tclin Nuclear Receptor -4.00480 8421.6 2610
WW domain-containing adapter protein with coiled-coil WAC Tbio Non-IDG -1.93384 84.9 87
Nuclear receptor coactivator 4 NCOA4 Tbio Non-IDG -2.20245 136.0 283
Bone morphogenetic protein 15 BMP15 Tbio Non-IDG -2.33917 221.7 200
B-cell lymphoma/leukemia 10 BCL10 Tbio Non-IDG -0.53932 4.30 895