Development Level

Tbio 54 | 11,445
Tchem 6 | 1,598
Tclin 4 | 613
Tdark 2 | 6,588

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 8 | 979
abnormal bone structure 4 | 187
abnormal behavior 3 | 298
decreased body weight 3 | 161
embryonic lethality prior to t... 3 | 278
preweaning lethality, incomple... 3 | 499
abnormal embryo size 2 | 220
abnormal heart morphology 2 | 162
abnormal sleep behavior 2 | 70
decreased circulating glucose ... 2 | 126
decreased lean body mass 2 | 135
decreased lymphocyte cell numb... 2 | 83
decreased prepulse inhibition 2 | 82
decreased total body fat amoun... 2 | 207
enlarged heart 2 | 210
enlarged spleen 2 | 41
increased fasted circulating g... 2 | 76
increased heart weight 2 | 62
increased mean corpuscular vol... 2 | 92
increased or absent threshold ... 2 | 101
abnormal bone mineralization 1 | 38
abnormal cranium morphology 1 | 36
abnormal esophagus morphology 1 | 5
abnormal gait 1 | 69
abnormal hair texture 1 | 4
abnormal incisor morphology 1 | 4
abnormal limb bud morphology 1 | 17
abnormal maxilla morphology 1 | 17
abnormal pericardium morpholog... 1 | 26
abnormal placenta size 1 | 20
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
abnormal snout morphology 1 | 23
abnormal spleen morphology 1 | 55
abnormal tooth morphology 1 | 24
absent startle reflex 1 | 24
cardiovascular system phenotyp... 1 | 36
decreased B cell number 1 | 5
decreased basophil cell number 1 | 16
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating aspartat... 1 | 34
decreased circulating calcium ... 1 | 36
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating free fat... 1 | 31
decreased circulating fructosa... 1 | 30
decreased circulating glycerol... 1 | 16
decreased exploration in new e... 1 | 11
decreased granulocyte number 1 | 6
decreased grip strength 1 | 116
decreased heart rate variabili... 1 | 13
decreased lactate dehydrogenas... 1 | 16
decreased mean corpuscular vol... 1 | 79
decreased startle reflex 1 | 75
embryonic lethality prior to o... 1 | 239
enlarged gallbladder 1 | 2
enlarged kidney 1 | 14
female infertility 1 | 60
hydrometra 1 | 53
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased T cell number 1 | 6
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased circulating calcium ... 1 | 34
increased circulating phosphat... 1 | 26
increased circulating total pr... 1 | 28
increased eosinophil cell numb... 1 | 11
increased exploration in new e... 1 | 8
increased large unstained cell... 1 | 5
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased neutrophil cell numb... 1 | 46
increased red blood cell distr... 1 | 34
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
male infertility 1 | 123
pallor 1 | 34
prenatal lethality 1 | 28
scaly skin 1 | 4
small superior vagus ganglion 1 | 74
thrombocytopenia 1 | 56
tremors 1 | 39

Disease

Carcinoma 50 | 11,493
ovarian cancer 42 | 8,520
osteosarcoma 38 | 7,950
psoriasis 38 | 6,694
lung cancer 31 | 4,740
glioblastoma 28 | 5,792
atypical teratoid / rhabdoid tumor 24 | 5,112
Cancer 22 | 2,499
medulloblastoma, large-cell 22 | 6,241
Breast cancer 20 | 3,578
ependymoma 20 | 4,679
primitive neuroectodermal tumor 18 | 3,035
invasive ductal carcinoma 17 | 2,951
malignant mesothelioma 17 | 3,232
non-small cell lung cancer 17 | 2,890
Astrocytoma, Pilocytic 15 | 3,081
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,291
adult high grade glioma 14 | 3,801
diabetes mellitus 14 | 1,728
lung adenocarcinoma 14 | 2,716
lung carcinoma 14 | 2,843
oligodendroglioma 14 | 2,850
pancreatic cancer 14 | 2,398
Kidney cancer 13 | 2,613
astrocytic glioma 13 | 2,597
breast carcinoma 13 | 1,638
ductal carcinoma in situ 13 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
spina bifida 13 | 1,074
Alzheimer's disease 11 | 658
Schizophrenia 11 | 1,160
group 3 medulloblastoma 11 | 4,104
tuberculosis 10 | 2,010
active ulcerative colitis 9 | 764
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
Intellectual disability 8 | 1,016
Lung Neoplasms 8 | 232
Pick disease 8 | 1,894
Rheumatoid arthritis 8 | 1,191
adrenocortical carcinoma 8 | 1,428
cystic fibrosis 8 | 1,696
group 4 medulloblastoma 8 | 1,855
interstitial cystitis 8 | 2,312
Bipolar Disorder 7 | 666
Major Depressive Disorder 7 | 301
Multiple myeloma 7 | 1,332
colon cancer 7 | 1,478
subependymal giant cell astrocytoma 7 | 2,287
Dementia 6 | 175
Hypertension 6 | 396
Parkinson's disease 6 | 392
Prostatic Neoplasms 6 | 495
Unipolar Depression 6 | 250
acute myeloid leukemia 6 | 783
acute quadriplegic myopathy 6 | 1,158
astrocytoma 6 | 1,146
esophageal adenocarcinoma 6 | 737
fibroadenoma 6 | 559
medulloblastoma 6 | 720
pituitary cancer 6 | 1,972
ulcerative colitis 6 | 1,819
Adenoma 5 | 167
Atopic dermatitis 5 | 952
Big calvaria 5 | 147
Carcinoma, Hepatocellular 5 | 228
Crohn's disease 5 | 321
Endometriosis 5 | 540
Hypertensive disease 5 | 292
Increased head circumference 5 | 147
Increased size of cranium 5 | 147
Increased size of skull 5 | 147
Liver carcinoma 5 | 240
Multiple Sclerosis 5 | 540
Muscular atrophy 5 | 71
Pain 5 | 103
Waldenstrons macroglobulinemia 5 | 765
active Crohn's disease 5 | 922
dermatomyositis 5 | 966
hepatocellular carcinoma 5 | 547
pediatric high grade glioma 5 | 1,064
Alzheimer Disease 4 | 83
Autosomal recessive predisposition 4 | 1,442
Cleft Palate 4 | 271
Congenital hypoplasia of penis 4 | 176
Depressive disorder 4 | 409
Dull intelligence 4 | 645
Low intelligence 4 | 645
Melanoma 4 | 711
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Neurodegenerative disease 4 | 414
Obesity 4 | 678
Orbital separation excessive 4 | 244
Poor school performance 4 | 645
Short stature 4 | 531
Stomach Neoplasms 4 | 300
Vascular disease 4 | 319
cutaneous lupus erythematosus 4 | 1,057
gastric carcinoma 4 | 807

Tissue

Digestive Tract 66 | 17,369
Endocrine System 66 | 18,159
Female tissues 66 | 17,400
Male tissues 66 | 17,142
Nervous System 66 | 16,725
Respiratory system 66 | 16,393
Skin and soft tissues 66 | 17,230
Urinary Tract 66 | 16,678
Blood and immune system 65 | 16,909
Liver and Pancreas 65 | 16,750
Cardiovascular System 62 | 15,192

Target Family

Non-IDG 36 | 12,091
Enzyme 21 | 4,145
Kinase 5 | 634
Transcription Factor 4 | 1,400

GO Process

positive regulation of protein... 66 | 66
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cysteine protease ATG4B ATG4B Tbio Enzyme -1.79492 58.3 416
NEDD4 family-interacting protein 1 NDFIP1 Tbio Non-IDG -1.24333 24.3 147
Rhomboid domain-containing protein 3 RHBDD3 Tbio Non-IDG -1.78723 54.5 62
Forkhead box protein O1 FOXO1 Tbio Transcription Factor -3.05358 1143.3 1478
Tumor necrosis factor ligand superfamily member 12 TNFSF12 Tbio Non-IDG -2.49751 362.7 413
Dapper homolog 1 DACT1 Tbio Non-IDG -1.86707 79.6 106
Ras-related protein Rab-7a RAB7A Tbio Enzyme -2.66545 435.4 248
Insulin-degrading enzyme IDE Tchem Enzyme -2.57779 392.8 331
Protein naked cuticle homolog 1 NKD1 Tbio Non-IDG -1.58873 38.5 99
Transcription factor SOX-9 SOX9 Tbio Transcription Factor -3.14522 1332.4 657