Development Level

Tbio 54 | 11,445
Tchem 6 | 1,598
Tclin 4 | 613
Tdark 2 | 6,588

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 8 | 979
abnormal bone structure 4 | 187
abnormal behavior 3 | 298
decreased body weight 3 | 161
embryonic lethality prior to t... 3 | 278
preweaning lethality, incomple... 3 | 499
abnormal embryo size 2 | 220
abnormal heart morphology 2 | 162
abnormal sleep behavior 2 | 70
decreased circulating glucose ... 2 | 126
decreased lean body mass 2 | 135
decreased lymphocyte cell numb... 2 | 83
decreased prepulse inhibition 2 | 82
decreased total body fat amoun... 2 | 207
enlarged heart 2 | 210
enlarged spleen 2 | 41
increased fasted circulating g... 2 | 76
increased heart weight 2 | 62
increased mean corpuscular vol... 2 | 92
increased or absent threshold ... 2 | 101
abnormal bone mineralization 1 | 38
abnormal cranium morphology 1 | 36
abnormal esophagus morphology 1 | 5
abnormal gait 1 | 69
abnormal hair texture 1 | 4
abnormal incisor morphology 1 | 4
abnormal limb bud morphology 1 | 17
abnormal maxilla morphology 1 | 17
abnormal pericardium morpholog... 1 | 26
abnormal placenta size 1 | 20
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
abnormal snout morphology 1 | 23
abnormal spleen morphology 1 | 55
abnormal tooth morphology 1 | 24
absent startle reflex 1 | 24
cardiovascular system phenotyp... 1 | 36
decreased B cell number 1 | 5
decreased basophil cell number 1 | 16
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating aspartat... 1 | 34
decreased circulating calcium ... 1 | 36
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating free fat... 1 | 31
decreased circulating fructosa... 1 | 30
decreased circulating glycerol... 1 | 16
decreased exploration in new e... 1 | 11
decreased granulocyte number 1 | 6
decreased grip strength 1 | 116
decreased heart rate variabili... 1 | 13
decreased lactate dehydrogenas... 1 | 16
decreased mean corpuscular vol... 1 | 79
decreased startle reflex 1 | 75
embryonic lethality prior to o... 1 | 239
enlarged gallbladder 1 | 2
enlarged kidney 1 | 14
female infertility 1 | 60
hydrometra 1 | 53
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased T cell number 1 | 6
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased circulating calcium ... 1 | 34
increased circulating phosphat... 1 | 26
increased circulating total pr... 1 | 28
increased eosinophil cell numb... 1 | 11
increased exploration in new e... 1 | 8
increased large unstained cell... 1 | 5
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased neutrophil cell numb... 1 | 46
increased red blood cell distr... 1 | 34
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
male infertility 1 | 123
pallor 1 | 34
prenatal lethality 1 | 28
scaly skin 1 | 4
small superior vagus ganglion 1 | 74
thrombocytopenia 1 | 56
tremors 1 | 39

Disease

Carcinoma 50 | 11,493
ovarian cancer 42 | 8,520
osteosarcoma 38 | 7,950
psoriasis 38 | 6,694
lung cancer 31 | 4,740
glioblastoma 28 | 5,792
atypical teratoid / rhabdoid tumor 24 | 5,112
Cancer 22 | 2,499
medulloblastoma, large-cell 22 | 6,241
Breast cancer 20 | 3,578
ependymoma 20 | 4,679
primitive neuroectodermal tumor 18 | 3,035
invasive ductal carcinoma 17 | 2,951
malignant mesothelioma 17 | 3,232
non-small cell lung cancer 17 | 2,890
Astrocytoma, Pilocytic 15 | 3,081
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,291
adult high grade glioma 14 | 3,801
diabetes mellitus 14 | 1,728
lung adenocarcinoma 14 | 2,716
lung carcinoma 14 | 2,843
oligodendroglioma 14 | 2,850
pancreatic cancer 14 | 2,398
Kidney cancer 13 | 2,613
astrocytic glioma 13 | 2,597
breast carcinoma 13 | 1,638
ductal carcinoma in situ 13 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
spina bifida 13 | 1,074
Alzheimer's disease 11 | 658
Schizophrenia 11 | 1,160
group 3 medulloblastoma 11 | 4,104
tuberculosis 10 | 2,010
active ulcerative colitis 9 | 764
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
Intellectual disability 8 | 1,016
Lung Neoplasms 8 | 232
Pick disease 8 | 1,894
Rheumatoid arthritis 8 | 1,191
adrenocortical carcinoma 8 | 1,428
cystic fibrosis 8 | 1,696
group 4 medulloblastoma 8 | 1,855
interstitial cystitis 8 | 2,312
Bipolar Disorder 7 | 666
Major Depressive Disorder 7 | 301
Multiple myeloma 7 | 1,332
colon cancer 7 | 1,478
subependymal giant cell astrocytoma 7 | 2,287
Dementia 6 | 175
Hypertension 6 | 396
Parkinson's disease 6 | 392
Prostatic Neoplasms 6 | 495
Unipolar Depression 6 | 250
acute myeloid leukemia 6 | 783
acute quadriplegic myopathy 6 | 1,158
astrocytoma 6 | 1,146
esophageal adenocarcinoma 6 | 737
fibroadenoma 6 | 559
medulloblastoma 6 | 720
pituitary cancer 6 | 1,972
ulcerative colitis 6 | 1,819
Adenoma 5 | 167
Atopic dermatitis 5 | 952
Big calvaria 5 | 147
Carcinoma, Hepatocellular 5 | 228
Crohn's disease 5 | 321
Endometriosis 5 | 540
Hypertensive disease 5 | 292
Increased head circumference 5 | 147
Increased size of cranium 5 | 147
Increased size of skull 5 | 147
Liver carcinoma 5 | 240
Multiple Sclerosis 5 | 540
Muscular atrophy 5 | 71
Pain 5 | 103
Waldenstrons macroglobulinemia 5 | 765
active Crohn's disease 5 | 922
dermatomyositis 5 | 966
hepatocellular carcinoma 5 | 547
pediatric high grade glioma 5 | 1,064
Alzheimer Disease 4 | 83
Autosomal recessive predisposition 4 | 1,442
Cleft Palate 4 | 271
Congenital hypoplasia of penis 4 | 176
Depressive disorder 4 | 409
Dull intelligence 4 | 645
Low intelligence 4 | 645
Melanoma 4 | 711
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Neurodegenerative disease 4 | 414
Obesity 4 | 678
Orbital separation excessive 4 | 244
Poor school performance 4 | 645
Short stature 4 | 531
Stomach Neoplasms 4 | 300
Vascular disease 4 | 319
cutaneous lupus erythematosus 4 | 1,057
gastric carcinoma 4 | 807

Tissue

Digestive Tract 66 | 17,369
Endocrine System 66 | 18,159
Female tissues 66 | 17,400
Male tissues 66 | 17,142
Nervous System 66 | 16,725
Respiratory system 66 | 16,393
Skin and soft tissues 66 | 17,230
Urinary Tract 66 | 16,678
Blood and immune system 65 | 16,909
Liver and Pancreas 65 | 16,750
Cardiovascular System 62 | 15,192

Target Family

Non-IDG 36 | 12,091
Enzyme 21 | 4,145
Kinase 5 | 634
Transcription Factor 4 | 1,400

GO Process

positive regulation of protein... 66 | 66
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tumor necrosis factor ligand superfamily member 12 TNFSF12 Tbio Non-IDG -2.49751 362.7 413
Forkhead box protein O1 FOXO1 Tbio Transcription Factor -3.05358 1143.3 1478
NEDD4 family-interacting protein 1 NDFIP1 Tbio Non-IDG -1.24333 24.3 147
Cysteine protease ATG4B ATG4B Tbio Enzyme -1.79492 58.3 416
Rhomboid domain-containing protein 3 RHBDD3 Tbio Non-IDG -1.78723 54.5 62
Dapper homolog 1 DACT1 Tbio Non-IDG -1.86707 79.6 106
Insulin-degrading enzyme IDE Tchem Enzyme -2.57779 392.8 331
Ras-related protein Rab-7a RAB7A Tbio Enzyme -2.66545 435.4 248
Transcription factor SOX-9 SOX9 Tbio Transcription Factor -3.14522 1332.4 657
Casein kinase II subunit alpha 3 CSNK2A3 Tdark Kinase -2.35622 377.7 6