Development Level

Tbio 45 | 11,445
Tchem 17 | 1,598
Tclin 3 | 613
Tdark 2 | 6,588

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 7 | 979
preweaning lethality, incomple... 5 | 499
abnormal embryo size 4 | 220
embryonic lethality prior to t... 4 | 278
decreased total body fat amoun... 3 | 207
embryonic growth retardation 3 | 106
increased mean corpuscular hem... 3 | 96
abnormal limb bud morphology 2 | 17
abnormal pericardium morpholog... 2 | 26
cardiovascular system phenotyp... 2 | 36
decreased circulating alkaline... 2 | 46
decreased circulating total pr... 2 | 49
decreased vertical activity 2 | 208
embryonic lethality prior to o... 2 | 239
increased lean body mass 2 | 172
increased mean corpuscular vol... 2 | 92
increased startle reflex 2 | 112
pallor 2 | 34
abnormal allantois morphology 1 | 8
abnormal behavior 1 | 298
abnormal blood vessel morpholo... 1 | 5
abnormal bone structure 1 | 187
abnormal chorioallantoic fusio... 1 | 8
abnormal embryo turning 1 | 31
abnormal forebrain development 1 | 20
abnormal heart looping 1 | 5
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal left-right axis patte... 1 | 2
abnormal lens morphology 1 | 81
abnormal limb morphology 1 | 13
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal optic vesicle formati... 1 | 4
abnormal otic vesicle morpholo... 1 | 3
abnormal pharyngeal arch morph... 1 | 8
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
abnormal sleep behavior 1 | 70
abnormal somite shape 1 | 5
abnormal tail bud morphology 1 | 8
abnormal tail morphology 1 | 25
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
cyanosis 1 | 7
decreased basophil cell number 1 | 16
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating bilirubi... 1 | 19
decreased circulating fructosa... 1 | 30
decreased circulating glycerol... 1 | 16
decreased exploration in new e... 1 | 11
decreased heart rate variabili... 1 | 13
decreased lactate dehydrogenas... 1 | 16
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
edema 1 | 59
female infertility 1 | 60
hemorrhage 1 | 23
hydrometra 1 | 53
hyperactivity 1 | 148
hypoactivity 1 | 132
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased circulating bilirubi... 1 | 16
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating creatini... 1 | 38
increased heart weight 1 | 62
increased kidney weight 1 | 6
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 36
pale yolk sac 1 | 25
premature death 1 | 5
prolonged PR interval 1 | 15
prolonged ST segment 1 | 36
respiratory system phenotype 1 | 2
small superior vagus ganglion 1 | 74
thrombocytopenia 1 | 56
thrombocytosis 1 | 27

Disease

Carcinoma 54 | 11,493
ovarian cancer 43 | 8,520
osteosarcoma 38 | 7,950
medulloblastoma, large-cell 32 | 6,241
psoriasis 30 | 6,694
Cancer 28 | 2,499
glioblastoma 28 | 5,792
ependymoma 23 | 4,679
Breast cancer 22 | 3,578
malignant mesothelioma 22 | 3,232
lung cancer 21 | 4,740
astrocytic glioma 19 | 2,597
atypical teratoid / rhabdoid tumor 18 | 5,112
intraductal papillary-mucinous neoplasm (IPMN) 18 | 3,291
invasive ductal carcinoma 18 | 2,951
subependymal giant cell astrocytoma 18 | 2,287
Kidney cancer 17 | 2,613
adult high grade glioma 17 | 3,801
non-small cell lung cancer 17 | 2,890
Astrocytoma, Pilocytic 16 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 16 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,989
lung carcinoma 16 | 2,843
oligodendroglioma 16 | 2,850
group 3 medulloblastoma 14 | 4,104
pancreatic cancer 14 | 2,398
Pick disease 13 | 1,894
Rheumatoid arthritis 13 | 1,191
lung adenocarcinoma 13 | 2,716
tuberculosis 13 | 2,010
cystic fibrosis 12 | 1,696
diabetes mellitus 12 | 1,728
interstitial cystitis 12 | 2,312
Alzheimer's disease 11 | 658
Schizophrenia 11 | 1,160
ductal carcinoma in situ 11 | 1,745
juvenile dermatomyositis 11 | 1,187
pituitary cancer 11 | 1,972
ulcerative colitis 11 | 1,819
colon cancer 10 | 1,478
Autosomal recessive predisposition 9 | 1,442
group 4 medulloblastoma 9 | 1,855
spina bifida 9 | 1,074
Anemia 8 | 365
Dementia 8 | 175
Hypertension 8 | 396
Parkinson's disease 8 | 392
adrenocortical carcinoma 8 | 1,428
primary pancreatic ductal adenocarcinoma 8 | 1,109
Amyotrophic lateral sclerosis 7 | 451
Bipolar Disorder 7 | 666
Cognitive delay 7 | 608
Global developmental delay 7 | 608
Intellectual disability 7 | 1,016
Mental and motor retardation 7 | 608
Neurodegenerative disease 7 | 414
Prostatic Neoplasms 7 | 495
Toxic encephalopathy 7 | 141
breast carcinoma 7 | 1,638
Alzheimer Disease 6 | 83
Breast Neoplasms 6 | 445
Cerebrovascular disease 6 | 238
Heart failure 6 | 162
Hypertensive disease 6 | 292
Liver Cirrhosis, Experimental 6 | 769
Major Depressive Disorder 6 | 301
Mammary Neoplasms 6 | 425
Melanoma 6 | 711
Multiple myeloma 6 | 1,332
Osteoporosis 6 | 363
Short stature 6 | 531
active Crohn's disease 6 | 922
acute quadriplegic myopathy 6 | 1,158
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
pediatric high grade glioma 6 | 1,064
Atopic dermatitis 5 | 952
Depressive disorder 5 | 409
Down syndrome 5 | 499
Dull intelligence 5 | 645
Endometrial cancer 5 | 311
Epilepsy 5 | 792
Kidney Diseases 5 | 114
Liver disease 5 | 237
Low intelligence 5 | 645
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Obesity 5 | 678
Poor school performance 5 | 645
Renal Cell Carcinoma 5 | 214
Seizures 5 | 596
Weight Gain 5 | 100
fibroadenoma 5 | 559
medulloblastoma 5 | 720
nasopharyngeal carcinoma 5 | 1,058
pancreatic carcinoma 5 | 562
primitive neuroectodermal tumor 5 | 3,035
Duchenne muscular dystrophy 4 | 601
acute myeloid leukemia 4 | 783
dermatomyositis 4 | 966
gastric carcinoma 4 | 807

Tissue

Blood and immune system 66 | 16,909
Digestive Tract 66 | 17,369
Endocrine System 66 | 18,159
Female tissues 66 | 17,400
Skin and soft tissues 66 | 17,230
Liver and Pancreas 65 | 16,750
Male tissues 65 | 17,142
Respiratory system 65 | 16,393
Nervous System 64 | 16,725
Urinary Tract 64 | 16,678
Cardiovascular System 63 | 15,192

Target Family

Non-IDG 38 | 12,091
Enzyme 16 | 4,145
Kinase 10 | 634
Transcription Factor 2 | 1,400
Epigenetic 1 | 242

GO Process

positive regulation of protein... 67 | 67
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Beta-1,3-N-acetylglucosaminyltransferase radical fringe RFNG Tdark Enzyme -0.37913 1.57 92
E3 ubiquitin-protein ligase AMFR AMFR Tbio Enzyme -2.46909 292.8 203
Sperm-associated antigen 8 SPAG8 Tbio Non-IDG -0.96272 9.29 158
Derlin-1 DERL1 Tbio Non-IDG -1.88253 69.7 178
Rap guanine nucleotide exchange factor 2 RAPGEF2 Tbio Non-IDG -1.41107 29.0 79
Plexin-D1 PLXND1 Tbio Non-IDG -1.64721 46.3 171
Dapper homolog 1 DACT1 Tbio Non-IDG -1.86707 79.6 106
Spectrin alpha chain, erythrocytic 1 SPTA1 Tbio Non-IDG -2.93650 850.7 86
Bone morphogenetic protein 2 BMP2 Tbio Non-IDG -3.65728 4647.9 684
Polycystin-1 PKD1 Tbio Non-IDG -2.60276 379.9 123