Development Level

Tbio 49 | 11,651
Tchem 16 | 1,388
Tdark 6 | 6,593
Tclin 2 | 612

IMPC Phenotype

preweaning lethality, complete... 6 | 979
preweaning lethality, incomple... 4 | 499
abnormal embryo size 3 | 220
embryonic lethality prior to t... 3 | 278
abnormal heart morphology 2 | 162
abnormal seminal vesicle morph... 2 | 114
abnormal tail morphology 2 | 25
decreased vertical activity 2 | 208
embryonic lethality prior to o... 2 | 239
enlarged heart 2 | 210
increased circulating calcium ... 2 | 34
abnormal coat- hair morphology 1 | 19
abnormal embryo turning 1 | 31
abnormal facial morphology 1 | 17
abnormal forebrain development 1 | 20
abnormal hair growth 1 | 10
abnormal head shape 1 | 10
abnormal heart left ventricle ... 1 | 16
abnormal hindbrain development 1 | 16
abnormal kidney morphology 1 | 65
abnormal limb morphology 1 | 13
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal outer ear morphology 1 | 3
abnormal skin morphology 1 | 50
abnormal spinal cord morpholog... 1 | 9
abnormal stomach morphology 1 | 10
abnormal urinary bladder morph... 1 | 11
abnormal vocalization 1 | 21
anophthalmia 1 | 33
cyanosis 1 | 7
cystolithiasis 1 | 3
decreased basophil cell number 1 | 16
decreased blood urea nitrogen ... 1 | 51
decreased circulating chloride... 1 | 30
decreased circulating insulin ... 1 | 76
decreased circulating triglyce... 1 | 79
decreased heart left ventricle... 1 | 28
decreased leukocyte cell numbe... 1 | 73
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
decreased total retina thickne... 1 | 17
dilated heart left ventricle 1 | 11
edema 1 | 59
embryonic growth retardation 1 | 106
female infertility 1 | 60
hemorrhage 1 | 23
hyperactivity 1 | 148
increased aggression 1 | 4
increased circulating free fat... 1 | 20
increased circulating magnesiu... 1 | 10
increased fasted circulating g... 1 | 76
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased prepulse inhibition 1 | 32
limb grasping 1 | 41
male infertility 1 | 123
microphthalmia 1 | 26
polycystic kidney 1 | 15
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
respiratory system phenotype 1 | 2
sclerocornea 1 | 2
short tibia 1 | 97
thick skin 1 | 4
thin ventricular wall 1 | 24

Disease

ovarian cancer 53 | 8,520
Carcinoma 48 | 11,493
osteosarcoma 45 | 7,950
medulloblastoma, large-cell 32 | 6,241
psoriasis 31 | 6,694
atypical teratoid / rhabdoid tumor 28 | 5,112
glioblastoma 27 | 5,792
lung cancer 26 | 4,740
Cancer 24 | 2,499
Breast cancer 20 | 3,578
group 3 medulloblastoma 18 | 4,104
malignant mesothelioma 18 | 3,232
adult high grade glioma 17 | 3,801
invasive ductal carcinoma 16 | 2,951
diabetes mellitus 15 | 1,728
non-small cell lung cancer 15 | 2,890
pancreatic cancer 15 | 2,398
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
lung adenocarcinoma 14 | 2,716
Rheumatoid arthritis 13 | 1,191
astrocytic glioma 13 | 2,597
oligodendroglioma 13 | 2,850
tuberculosis 13 | 2,010
Astrocytoma, Pilocytic 12 | 3,081
breast carcinoma 12 | 1,638
ependymoma 12 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
subependymal giant cell astrocytoma 12 | 2,287
Multiple myeloma 11 | 1,332
Parkinson's disease 11 | 392
Pick disease 11 | 1,894
astrocytoma 11 | 1,146
group 4 medulloblastoma 10 | 1,855
juvenile dermatomyositis 10 | 1,187
lung carcinoma 10 | 2,843
primitive neuroectodermal tumor 10 | 3,035
ulcerative colitis 10 | 1,819
Kidney cancer 9 | 2,613
Neurodegenerative disease 9 | 414
adrenocortical carcinoma 9 | 1,428
Schizophrenia 8 | 1,160
Waldenstrons macroglobulinemia 8 | 765
ductal carcinoma in situ 8 | 1,745
spina bifida 8 | 1,074
Alzheimer's disease 7 | 658
Dementia 7 | 175
acute quadriplegic myopathy 7 | 1,158
interstitial cystitis 7 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
pituitary cancer 7 | 1,972
Autosomal recessive predisposition 6 | 1,442
Bipolar Disorder 6 | 666
Gait abnormality 6 | 135
Prostatic Neoplasms 6 | 495
Toxic encephalopathy 6 | 141
chronic rhinosinusitis 6 | 512
cystic fibrosis 6 | 1,696
hepatocellular carcinoma 6 | 547
primary pancreatic ductal adenocarcinoma 6 | 1,109
Adult onset 5 | 82
Amyotrophic lateral sclerosis 5 | 451
Atopic dermatitis 5 | 952
Chronic Lymphocytic Leukemia 5 | 262
Depressive disorder 5 | 409
Duchenne muscular dystrophy 5 | 601
Dystonia 5 | 164
Epilepsy 5 | 792
Intellectual disability 5 | 1,016
Kidney disease 5 | 430
Renal Cell Carcinoma 5 | 214
Seizures 5 | 596
aldosterone-producing adenoma 5 | 665
dermatomyositis 5 | 966
gastric cancer 5 | 459
Breast Neoplasms 4 | 445
Carcinoma, Non-Small-Cell Lung 4 | 107
Dull intelligence 4 | 645
Dystonic disease 4 | 106
Hypoplastic mandible condyle 4 | 275
Low intelligence 4 | 645
Lung Neoplasms 4 | 232
Mammary Neoplasms 4 | 425
Mandibular hypoplasia 4 | 275
Melanoma 4 | 711
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Micrognathism 4 | 275
Nerve Degeneration 4 | 121
Parkinsonian Disorders 4 | 56
Poor school performance 4 | 645
Vascular disease 4 | 319
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 510
esophageal adenocarcinoma 4 | 737
fibroadenoma 4 | 559
mucosa-associated lymphoid tissue lymphoma 4 | 484
nasopharyngeal carcinoma 4 | 1,058
non-small cell lung carcinoma 4 | 317
primary Sjogren syndrome 4 | 735
progressive supranuclear palsy 4 | 676

Tissue

Cardiovascular System 73 | 15,192
Digestive Tract 73 | 17,369
Endocrine System 73 | 18,159
Male tissues 73 | 17,142
Nervous System 73 | 16,725
Skin and soft tissues 73 | 17,230
Blood and immune system 72 | 16,909
Female tissues 72 | 17,400
Liver and Pancreas 72 | 16,750
Respiratory system 72 | 16,393
Urinary Tract 72 | 16,678

Target Family

Non-IDG 29 | 12,091
Enzyme 26 | 4,145
Kinase 13 | 634
Transcription Factor 4 | 1,400
Epigenetic 1 | 242

GO Process

positive regulation of proteas... 73 | 73
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
AN1-type zinc finger protein 2A ZFAND2A Tbio Non-IDG -0.83223 7.62 72
E3 ubiquitin-protein ligase ARIH1 ARIH1 Tbio Enzyme -2.26078 179.2 81
E3 ubiquitin-protein ligase RNF114 RNF114 Tbio Enzyme -1.03564 12.8 142
RING finger and CHY zinc finger domain-containing protein 1 RCHY1 Tbio Non-IDG -2.47052 287.7 126
E3 ubiquitin-protein ligase CHIP STUB1 Tbio Enzyme -2.96877 926.8 351
Serine/threonine-protein kinase PLK2 PLK2 Tchem Kinase -2.45914 273.4 179
Bardet-Biedl syndrome 7 protein BBS7 Tbio Non-IDG -1.05503 10.4 159
E3 ubiquitin-protein ligase RNF19B RNF19B Tbio Enzyme -0.77784 6.71 95
Disabled homolog 2 DAB2 Tbio Non-IDG -2.26146 184.8 239
Small ubiquitin-related modifier 1 SUMO1 Tbio Non-IDG -2.72599 482.7 786