Development Level

Tbio 65 | 11,445
Tchem 20 | 1,598
Tclin 7 | 613
Tdark 3 | 6,588

Collection

Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

preweaning lethality, complete... 10 | 979
abnormal behavior 5 | 298
decreased circulating glucose ... 4 | 126
decreased prepulse inhibition 4 | 82
decreased total body fat amoun... 4 | 207
increased lean body mass 4 | 172
abnormal gait 3 | 69
decreased grip strength 3 | 116
hyperactivity 3 | 148
increased blood urea nitrogen ... 3 | 48
increased circulating choleste... 3 | 66
abnormal embryo size 2 | 220
abnormal eye morphology 2 | 68
abnormal heart morphology 2 | 162
anophthalmia 2 | 33
decreased body weight 2 | 161
decreased hemoglobin content 2 | 68
decreased lean body mass 2 | 135
decreased lymphocyte cell numb... 2 | 83
decreased startle reflex 2 | 75
decreased vertical activity 2 | 208
edema 2 | 59
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
hypoactivity 2 | 132
increased body weight 2 | 25
increased bone mineral content 2 | 108
increased circulating triglyce... 2 | 42
increased monocyte cell number 2 | 63
increased neutrophil cell numb... 2 | 46
increased red blood cell distr... 2 | 34
increased total body fat amoun... 2 | 134
male infertility 2 | 123
preweaning lethality, incomple... 2 | 499
small liver 2 | 8
abnormal coat appearance 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal ear morphology 1 | 9
abnormal facial morphology 1 | 17
abnormal head shape 1 | 10
abnormal hindbrain morphology 1 | 10
abnormal midbrain morphology 1 | 10
abnormal neural tube closure 1 | 46
abnormal response to new envir... 1 | 10
abnormal rib morphology 1 | 10
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
abnormal spleen morphology 1 | 55
abnormal tooth morphology 1 | 24
abnormal urinary bladder morph... 1 | 11
absent startle reflex 1 | 24
cleft palate 1 | 8
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating choleste... 1 | 93
decreased circulating insulin ... 1 | 76
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
embryonic growth retardation 1 | 106
enlarged kidney 1 | 14
enlarged lymph nodes 1 | 37
female infertility 1 | 60
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 41
increased circulating creatini... 1 | 38
increased circulating free fat... 1 | 20
increased circulating iron lev... 1 | 30
increased circulating potassiu... 1 | 29
increased heart rate 1 | 23
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased or absent threshold ... 1 | 101
increased spleen weight 1 | 10
limb grasping 1 | 41
microphthalmia 1 | 26
pallor 1 | 34
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
small heart 1 | 10
small kidney 1 | 16
small lung 1 | 5
small spleen 1 | 19
small testis 1 | 58
syndactyly 1 | 23
thrombocytosis 1 | 27
tremors 1 | 39

Disease

Carcinoma 68 | 11,493
medulloblastoma, large-cell 55 | 6,241
glioblastoma 53 | 5,792
ovarian cancer 53 | 8,520
psoriasis 48 | 6,694
atypical teratoid / rhabdoid tumor 44 | 5,112
osteosarcoma 44 | 7,950
ependymoma 39 | 4,679
lung cancer 39 | 4,740
oligodendroglioma 36 | 2,850
adult high grade glioma 35 | 3,801
astrocytic glioma 33 | 2,597
Cancer 32 | 2,499
group 3 medulloblastoma 31 | 4,104
malignant mesothelioma 30 | 3,232
Breast cancer 29 | 3,578
Astrocytoma, Pilocytic 28 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 26 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 25 | 3,291
Kidney cancer 24 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 24 | 2,989
primitive neuroectodermal tumor 24 | 3,035
lung adenocarcinoma 23 | 2,716
lung carcinoma 21 | 2,843
group 4 medulloblastoma 20 | 1,855
invasive ductal carcinoma 20 | 2,951
non-small cell lung cancer 20 | 2,890
interstitial cystitis 19 | 2,312
pancreatic cancer 19 | 2,398
pituitary cancer 19 | 1,972
Pick disease 18 | 1,894
tuberculosis 18 | 2,010
Bipolar Disorder 17 | 666
Schizophrenia 17 | 1,160
colon cancer 16 | 1,478
cystic fibrosis 16 | 1,696
ductal carcinoma in situ 16 | 1,745
subependymal giant cell astrocytoma 16 | 2,287
ulcerative colitis 16 | 1,819
Alzheimer's disease 14 | 658
Autosomal recessive predisposition 14 | 1,442
diabetes mellitus 13 | 1,728
juvenile dermatomyositis 13 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,962
astrocytoma 12 | 1,146
adrenocortical carcinoma 11 | 1,428
breast carcinoma 11 | 1,638
Intellectual disability 10 | 1,016
Liver cancer 10 | 604
Mental Depression 10 | 333
Parkinson's disease 10 | 392
acute quadriplegic myopathy 10 | 1,158
dermatomyositis 10 | 966
pediatric high grade glioma 10 | 1,064
primary pancreatic ductal adenocarcinoma 10 | 1,109
Atopic dermatitis 9 | 952
Depressive disorder 9 | 409
Epilepsy 9 | 792
esophageal adenocarcinoma 9 | 737
gastric carcinoma 9 | 807
Cerebrovascular disease 8 | 238
Multiple myeloma 8 | 1,332
Obesity 8 | 678
Seizures 8 | 596
non primary Sjogren syndrome sicca 8 | 891
Anemia 7 | 365
Cardiomyopathies 7 | 110
Cognitive delay 7 | 608
Down syndrome 7 | 499
Dull intelligence 7 | 645
Global developmental delay 7 | 608
Hypertensive disease 7 | 292
Kidney disease 7 | 430
Low intelligence 7 | 645
Melanoma 7 | 711
Mental Retardation 7 | 645
Mental and motor retardation 7 | 608
Mental deficiency 7 | 645
Neurodegenerative disease 7 | 414
Orbital separation excessive 7 | 244
Polycystic ovary syndrome 7 | 360
Poor school performance 7 | 645
Proteinuria 7 | 144
Skin cancer 7 | 469
Small head 7 | 374
Status Epilepticus 7 | 98
Toxic encephalopathy 7 | 141
aldosterone-producing adenoma 7 | 665
cutaneous lupus erythematosus 7 | 1,057
Alcoholic Intoxication, Chronic 6 | 289
Amyotrophic lateral sclerosis 6 | 451
Duchenne muscular dystrophy 6 | 601
Endometriosis 6 | 540
Heart disease 6 | 306
Liver Cirrhosis 6 | 181
Liver Cirrhosis, Experimental 6 | 769
Muscle hypotonia 6 | 571
Myocardial Infarction 6 | 151
Neuropathy 6 | 261
hereditary spastic paraplegia 6 | 318

Tissue

Digestive Tract 95 | 17,369
Endocrine System 95 | 18,159
Female tissues 95 | 17,400
Nervous System 94 | 16,725
Skin and soft tissues 94 | 17,230
Male tissues 93 | 17,142
Liver and Pancreas 92 | 16,750
Respiratory system 92 | 16,393
Urinary Tract 91 | 16,678
Blood and immune system 90 | 16,909
Cardiovascular System 86 | 15,192

Target Family

Non-IDG 51 | 12,091
Kinase 22 | 634
Enzyme 15 | 4,145
Transcription Factor 3 | 1,400
Epigenetic 1 | 242
GPCR 1 | 408
Ion Channel 1 | 344
Transporter 1 | 473

GO Process

positive regulation of neuron ... 95 | 95
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Neuroplastin NPTN Tbio Non-IDG -2.31075 211.6 201
Inactive serine/threonine-protein kinase PLK5 PLK5 Tbio Kinase -0.60609 4.07 119
High affinity nerve growth factor receptor NTRK1 Tclin Kinase -3.05841 1050.9 1092
Serine/threonine-protein kinase MARK2 MARK2 Tchem Kinase -2.49873 272.3 322
Rap guanine nucleotide exchange factor 2 RAPGEF2 Tbio Non-IDG -1.41107 29.0 79
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 MAGI2 Tbio Enzyme -1.54170 33.0 178
Abelson tyrosine-protein kinase 2 ABL2 Tchem Kinase -1.86293 71.2 358
Reelin RELN Tbio Non-IDG -2.78255 645.2 121
Calcium/calmodulin-dependent protein kinase type II subunit beta CAMK2B Tchem Kinase -1.14550 13.6 344
Leucine-rich repeat-containing protein 7 LRRC7 Tbio Non-IDG -1.45630 31.2 41