Development Level

Tbio 10 | 11,445

IMPC Phenotype

abnormal coat-hair pigmentatio... 1 | 64
abnormal heart morphology 1 | 162
abnormal spleen morphology 1 | 55
decreased vertical activity 1 | 208
enlarged heart 1 | 210
enlarged spleen 1 | 41

Disease

osteosarcoma 5 | 7,950
ovarian cancer 5 | 8,520
psoriasis 5 | 6,694
Carcinoma 4 | 11,493
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
lung cancer 3 | 4,740
Breast cancer 2 | 3,578
Waldenstrons macroglobulinemia 2 | 765
acute myeloid leukemia 2 | 783
atypical teratoid / rhabdoid tumor 2 | 5,112
diabetes mellitus 2 | 1,728
ependymoma 2 | 4,679
glioblastoma 2 | 5,792
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
lung adenocarcinoma 2 | 2,716
medulloblastoma, large-cell 2 | 6,241
non primary Sjogren syndrome sicca 2 | 891
Absent reflex 1 | 92
Absent tendon reflex 1 | 92
Acidosis, Lactic 1 | 97
Angioedema 1 | 38
Astrocytoma, Pilocytic 1 | 3,081
Autosomal recessive predisposition 1 | 1,442
Avian influenza 1 | 7
Breast Neoplasms 1 | 445
CNS hypomyelination 1 | 17
COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 11 1 | 1
COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 30 1 | 1
CSF lactate increased 1 | 33
Cancer 1 | 2,499
Cerebral atrophy 1 | 178
Chromosome 1p32-p31 deletion syndrome 1 | 4
Combined oxidative phosphorylation deficiency 1 | 14
Congenital deafness 1 | 185
Cytochrome-c Oxidase Deficiency 1 | 17
Deafness 1 | 198
Death in early childhood 1 | 82
Death in infancy 1 | 82
Decreased liver function 1 | 24
Decreased tendon reflex 1 | 122
Feeding difficulties 1 | 127
Hearing Loss, Partial 1 | 185
Hypomyelination 1 | 17
Hypoplasia of corpus callosum 1 | 90
Hypotonia, severe 1 | 33
Increased serum lactate 1 | 60
Juvenile xanthogranuloma 1 | 7
Lactic acidemia 1 | 95
Lactic acidosis 1 | 51
Lethargy 1 | 77
Liver Dysfunction 1 | 99
Liver dysfunction, mild 1 | 24
Mammary Neoplasms 1 | 425
Mikulicz disease 1 | 3
Mitochondrial Complex 3 Deficiency, Nuclear Type 7 1 | 1
Mitochondrial Complex III Deficiency 1 | 9
Multiple myeloma 1 | 1,332
Myopathy 1 | 185
Neuronal ceroid lipofuscinosis 1 | 28
Pachygyria 1 | 41
Peliosis Hepatis 1 | 4
Pick disease 1 | 1,894
Prenatal onset 1 | 139
RENAL ADYSPLASIA 1 | 25
Reflex, Deep Tendon, Absent 1 | 92
Renal dysplasia 1 | 28
Renal tubular acidosis 1 | 24
Rheumatoid arthritis 1 | 1,191
Uveal melanoma 1 | 20
adult high grade glioma 1 | 3,801
astrocytic glioma 1 | 2,597
cytochrome-c oxidase deficiency disease 1 | 19
ductal carcinoma in situ 1 | 1,745
group 3 medulloblastoma 1 | 4,104
hearing impairment 1 | 199
interstitial cystitis 1 | 2,312
invasive ductal carcinoma 1 | 2,951
lung carcinoma 1 | 2,843
nasopharyngeal carcinoma 1 | 1,058
non-small cell lung cancer 1 | 2,890
pancreatic cancer 1 | 2,398
subependymal giant cell astrocytoma 1 | 2,287

Tissue

Blood and immune system 10 | 16,909
Cardiovascular System 10 | 15,192
Digestive Tract 10 | 17,369
Endocrine System 10 | 18,159
Female tissues 10 | 17,400
Liver and Pancreas 10 | 16,750
Male tissues 10 | 17,142
Nervous System 10 | 16,725
Respiratory system 10 | 16,393
Skin and soft tissues 10 | 17,230
Urinary Tract 10 | 16,678

Target Family

Enzyme 5 | 4,145
Non-IDG 5 | 12,091

GO Process

positive regulation of mitocho... 10 | 10
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

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