Development Level

Tbio 291 | 11,445
Tchem 92 | 1,598
Tclin 57 | 613
Tdark 30 | 6,588

Collection

Kinase: IDG Consortium (Comple... 3 | 37
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 40 | 979
abnormal embryo size 12 | 220
embryonic lethality prior to t... 12 | 278
preweaning lethality, incomple... 12 | 499
embryonic lethality prior to o... 10 | 239
enlarged heart 10 | 210
decreased bone mineral content 9 | 151
abnormal bone structure 7 | 187
increased total body fat amoun... 7 | 134
abnormal heart morphology 6 | 162
decreased body weight 6 | 161
decreased lean body mass 6 | 135
decreased vertical activity 6 | 208
increased startle reflex 6 | 112
cataract 5 | 92
decreased circulating glucose ... 5 | 126
impaired glucose tolerance 5 | 75
prolonged QT interval 5 | 38
prolonged ST segment 5 | 36
abnormal lens morphology 4 | 81
abnormal seminal vesicle morph... 4 | 114
abnormal sleep behavior 4 | 70
decreased bone mineral density 4 | 126
decreased circulating insulin ... 4 | 76
decreased fasted circulating g... 4 | 65
decreased hemoglobin content 4 | 68
decreased neutrophil cell numb... 4 | 42
decreased prepulse inhibition 4 | 82
embryonic growth retardation 4 | 106
hyperactivity 4 | 148
increased mean corpuscular vol... 4 | 92
increased monocyte cell number 4 | 63
abnormal behavior 3 | 298
abnormal behavioral response t... 3 | 66
abnormal bone mineralization 3 | 38
abnormal brain morphology 3 | 13
abnormal retina morphology 3 | 71
abnormal retinal blood vessel ... 3 | 26
abnormal retinal vasculature m... 3 | 27
decreased body length 3 | 101
decreased circulating triglyce... 3 | 79
decreased large unstained cell... 3 | 11
decreased lymphocyte cell numb... 3 | 83
decreased startle reflex 3 | 75
decreased threshold for audito... 3 | 26
decreased total body fat amoun... 3 | 207
female infertility 3 | 60
impaired righting response 3 | 26
improved glucose tolerance 3 | 79
increased blood urea nitrogen ... 3 | 48
increased bone mineral content 3 | 108
increased bone mineral density 3 | 72
increased circulating alkaline... 3 | 122
increased circulating creatini... 3 | 38
increased circulating total pr... 3 | 28
increased grip strength 3 | 41
limb grasping 3 | 41
male infertility 3 | 123
thrombocytopenia 3 | 56
thrombocytosis 3 | 27
abnormal coat appearance 2 | 31
abnormal gait 2 | 69
abnormal kidney morphology 2 | 65
abnormal lung morphology 2 | 26
abnormal pericardium morpholog... 2 | 26
abnormal placenta size 2 | 20
abnormal skin morphology 2 | 50
decreased T cell number 2 | 15
decreased circulating LDL chol... 2 | 38
decreased circulating alanine ... 2 | 47
decreased circulating choleste... 2 | 93
decreased grip strength 2 | 116
decreased heart weight 2 | 27
decreased hematocrit 2 | 46
decreased leukocyte cell numbe... 2 | 73
decreased mean corpuscular vol... 2 | 79
edema 2 | 59
hemorrhage 2 | 23
hydroencephaly 2 | 14
increased body length 2 | 32
increased circulating choleste... 2 | 66
increased circulating glucose ... 2 | 24
increased circulating iron lev... 2 | 30
increased circulating magnesiu... 2 | 10
increased circulating triglyce... 2 | 42
increased fasted circulating g... 2 | 76
increased hematocrit 2 | 46
increased lean body mass 2 | 172
increased lymphocyte cell numb... 2 | 32
increased mean corpuscular hem... 2 | 96
increased mean corpuscular hem... 2 | 36
increased neutrophil cell numb... 2 | 46
increased prepulse inhibition 2 | 32
prenatal lethality prior to he... 2 | 87
small superior vagus ganglion 2 | 74
abnormal head morphology 1 | 10
abnormal heart left ventricle ... 1 | 16
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
microphthalmia 1 | 26

Disease

Carcinoma 264 | 11,493
Cancer 234 | 2,499
ovarian cancer 221 | 8,520
osteosarcoma 203 | 7,950
psoriasis 189 | 6,694
glioblastoma 175 | 5,792
lung cancer 169 | 4,740
medulloblastoma, large-cell 164 | 6,241
Breast cancer 147 | 3,578
malignant mesothelioma 142 | 3,232
group 3 medulloblastoma 132 | 4,104
ependymoma 129 | 4,679
atypical teratoid / rhabdoid tumor 124 | 5,112
invasive ductal carcinoma 119 | 2,951
non-small cell lung cancer 116 | 2,890
intraductal papillary-mucinous neoplasm (IPMN) 113 | 3,291
adult high grade glioma 112 | 3,801
interstitial cystitis 101 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 100 | 2,955
lung adenocarcinoma 98 | 2,716
Astrocytoma, Pilocytic 96 | 3,081
pancreatic cancer 96 | 2,398
intraductal papillary-mucinous carcinoma (IPMC) 93 | 2,989
oligodendroglioma 92 | 2,850
primitive neuroectodermal tumor 86 | 3,035
diabetes mellitus 85 | 1,728
lung carcinoma 85 | 2,843
ulcerative colitis 82 | 1,819
cystic fibrosis 79 | 1,696
colon cancer 78 | 1,478
ductal carcinoma in situ 77 | 1,745
Schizophrenia 74 | 1,160
subependymal giant cell astrocytoma 74 | 2,287
astrocytic glioma 73 | 2,597
breast carcinoma 73 | 1,638
tuberculosis 73 | 2,010
pituitary cancer 67 | 1,972
Kidney cancer 64 | 2,613
adrenocortical carcinoma 59 | 1,428
Breast Neoplasms 56 | 445
Mammary Neoplasms 55 | 425
Multiple myeloma 54 | 1,332
Rheumatoid arthritis 52 | 1,191
cutaneous lupus erythematosus 50 | 1,057
Autosomal recessive predisposition 49 | 1,442
Obesity 49 | 678
pancreatic ductal adenocarcinoma liver metastasis 49 | 1,962
group 4 medulloblastoma 48 | 1,855
Atopic dermatitis 47 | 952
Bipolar Disorder 46 | 666
Liver Cirrhosis, Experimental 46 | 769
Pick disease 46 | 1,894
nasopharyngeal carcinoma 45 | 1,058
acute quadriplegic myopathy 44 | 1,158
primary pancreatic ductal adenocarcinoma 43 | 1,109
Kidney disease 42 | 430
Hypertension 41 | 396
Depressive disorder 39 | 409
Epilepsy 39 | 792
astrocytoma 38 | 1,146
esophageal adenocarcinoma 38 | 737
gastric carcinoma 38 | 807
juvenile dermatomyositis 38 | 1,187
Melanoma 37 | 711
Seizures 37 | 596
Endometriosis 36 | 540
Prostatic Neoplasms 36 | 495
Heart disease 35 | 306
Intellectual disability 34 | 1,016
Short stature 34 | 531
pediatric high grade glioma 34 | 1,064
spina bifida 34 | 1,074
Alzheimer's disease 33 | 658
Asthma 33 | 385
Lung Neoplasms 33 | 232
Mental Depression 33 | 333
Vascular disease 33 | 319
Atherosclerosis 31 | 291
Carcinoma, Hepatocellular 31 | 228
Liver carcinoma 31 | 240
Polycystic ovary syndrome 31 | 360
Stomach Neoplasms 30 | 300
non primary Sjogren syndrome sicca 29 | 891
Arthritis 28 | 290
Cleft Palate 28 | 271
Cognitive delay 28 | 608
Duchenne muscular dystrophy 28 | 601
Global developmental delay 28 | 608
Major Depressive Disorder 28 | 301
Mental and motor retardation 28 | 608
Osteoporosis 28 | 363
active Crohn's disease 28 | 922
autosomal dominant Emery-Dreifuss muscular dystrophy 28 | 510
Cerebrovascular disease 27 | 238
Parkinson's disease 27 | 392
non-small cell lung carcinoma 27 | 317
Coronary artery disease 26 | 268
Hypertensive disease 26 | 292
Multiple Sclerosis 26 | 540
active ulcerative colitis 26 | 764

Tissue

Endocrine System 439 | 18,159
Digestive Tract 429 | 17,369
Skin and soft tissues 427 | 17,230
Female tissues 424 | 17,400
Liver and Pancreas 422 | 16,750
Male tissues 422 | 17,142
Urinary Tract 421 | 16,678
Blood and immune system 419 | 16,909
Respiratory system 414 | 16,393
Nervous System 413 | 16,725
Cardiovascular System 386 | 15,192

Target Family

Non-IDG 274 | 12,091
Transcription Factor 50 | 1,400
Enzyme 49 | 4,145
Kinase 49 | 634
GPCR 26 | 408
Epigenetic 11 | 242
Nuclear Receptor 4 | 48
Transporter 4 | 473
Ion Channel 3 | 344

GO Process

positive regulation of cell pr... 470 | 470
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
Proteinase-activated receptor 1 F2R Tclin GPCR -2.78393 551.0 453
Endothelin-3 EDN3 Tbio Non-IDG -2.96371 794.0 219
Alpha-1D adrenergic receptor ADRA1D Tclin GPCR -2.25789 174.5 120
Cystatin-C CST3 Tbio Non-IDG -3.52815 3278.8 866
Centrosomal protein of 131 kDa CEP131 Tbio Non-IDG -1.78486 61.9 82
Fibrocystin PKHD1 Tbio Non-IDG -1.71770 56.1 82
Eukaryotic translation initiation factor 5A-1 EIF5A Tbio Non-IDG -2.10288 142.0 231
Vascular endothelial growth factor receptor 1 FLT1 Tclin Kinase -3.38913 2189.4 953
Speedy protein A SPDYA Tbio Non-IDG -1.58097 42.8 145