Development Level

Tbio 29 | 10,625
Tchem 10 | 1,890
Tdark 1 | 7,003

IMPC Phenotype

preweaning lethality, complete... 2 | 633
abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
abnormal eye posterior chamber... 1 | 3
decreased IgG1 level 1 | 4
decreased T cell number 1 | 31
decreased bone mineral content 1 | 157
decreased circulating choleste... 1 | 85
decreased circulating creatini... 1 | 31
decreased circulating triglyce... 1 | 83
decreased eosinophil cell numb... 1 | 41
decreased fasted circulating g... 1 | 49
decreased lean body mass 1 | 195
decreased lumbar vertebrae num... 1 | 62
embryonic lethality prior to t... 1 | 187
enlarged spleen 1 | 26
increased bone mineral content 1 | 92
increased grip strength 1 | 83
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
increased rib number 1 | 41
vertebral fusion 1 | 23

Disease

osteosarcoma 23 | 7,933
ovarian cancer 20 | 8,491
psoriasis 17 | 6,685
Cancer 16 | 2,346
medulloblastoma, large-cell 16 | 6,234
glioblastoma 15 | 5,572
lung cancer 13 | 4,473
Breast cancer 12 | 3,098
ependymoma 11 | 2,514
pilocytic astrocytoma 11 | 3,086
atypical teratoid / rhabdoid tumor 10 | 4,369
ulcerative colitis 10 | 2,087
oligodendroglioma 9 | 2,849
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,988
medulloblastoma 8 | 1,524
pancreatic cancer 8 | 2,300
adult high grade glioma 7 | 2,148
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,289
lung carcinoma 7 | 2,844
pediatric high grade glioma 7 | 2,712
astrocytic glioma 6 | 2,241
dermatomyositis 6 | 966
diabetes mellitus 6 | 1,663
ductal carcinoma in situ 6 | 1,745
invasive ductal carcinoma 6 | 2,950
malignant mesothelioma 6 | 3,163
pituitary cancer 6 | 1,972
primitive neuroectodermal tumor 6 | 3,031
tuberculosis 6 | 1,563
Carcinoma 5 | 2,147
Pick disease 5 | 1,893
Renal Cell Carcinoma 5 | 199
adrenocortical carcinoma 5 | 1,427
cutaneous lupus erythematosus 5 | 1,056
juvenile dermatomyositis 5 | 1,189
lung adenocarcinoma 5 | 2,714
non-small cell lung cancer 5 | 2,798
pancreatic carcinoma 5 | 567
primary pancreatic ductal adenocarcinoma 5 | 1,271
subependymal giant cell astrocytoma 5 | 2,287
Down syndrome 4 | 548
Neurodegenerative disease 4 | 383
Vascular disease 4 | 281
Waldenstrons macroglobulinemia 4 | 764
breast carcinoma 4 | 1,614
non primary Sjogren syndrome sicca 4 | 840
sonic hedgehog group medulloblastoma 4 | 1,482
tuberculosis and treatment for 6 months 4 | 686
Atopic dermatitis 3 | 944
Duchenne muscular dystrophy 3 | 602
Inflammatory bowel disease 3 | 142
Kidney disease 3 | 397
Lung Neoplasms 3 | 171
Multiple Sclerosis 3 | 498
Multiple myeloma 3 | 1,327
Obesity 3 | 616
Rheumatoid Arthritis 3 | 1,170
Vasculitis 3 | 64
active Crohn's disease 3 | 918
acute quadriplegic myopathy 3 | 1,157
astrocytoma 3 | 1,493
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 499
cystic fibrosis 3 | 1,670
esophageal adenocarcinoma 3 | 737
fibroadenoma 3 | 557
group 3 medulloblastoma 3 | 2,254
group 4 medulloblastoma 3 | 1,875
interstitial cystitis 3 | 2,299
posterior fossa group B ependymoma 3 | 1,530
spina bifida 3 | 1,064
Alzheimer's disease 2 | 644
Anemia 2 | 252
Arthritis 2 | 248
Atherosclerosis 2 | 275
Colonic Neoplasms 2 | 126
Corneal disease 2 | 32
Crohn's disease 2 | 304
Endometriosis 2 | 535
Exanthem 2 | 39
Heart disease 2 | 279
Influenza 2 | 142
Leukopenia 2 | 42
Manganese Poisoning 2 | 11
Necrosis 2 | 51
Parkinson's disease 2 | 364
Peritonitis 2 | 37
Prostatic Neoplasms 2 | 471
Schizophrenia 2 | 503
Stomach Neoplasms 2 | 282
active ulcerative colitis 2 | 477
acute myeloid leukemia 2 | 785
aldosterone-producing adenoma 2 | 664
atypical teratoid/rhabdoid tumor 2 | 1,095
hepatocellular carcinoma 2 | 550
nasopharyngeal carcinoma 2 | 1,056
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,795
periodontitis 2 | 269
posterior fossa group A ependymoma 2 | 1,511
tuberculosis and treatment for 3 months 2 | 327

Tissue

Blood and immune system 40 | 17,994
Cardiovascular System 40 | 17,957
Digestive Tract 40 | 18,472
Endocrine System 40 | 18,511
Female tissues 40 | 18,646
Liver and Pancreas 40 | 18,135
Male tissues 40 | 17,968
Nervous System 40 | 18,560
Respiratory system 40 | 17,483
Skin and soft tissues 40 | 18,114
Urinary Tract 40 | 18,443

Target Family

Non-IDG 21 | 11,969
Kinase 8 | 634
Enzyme 7 | 4,146
Transcription Factor 3 | 1,400
Ion Channel 1 | 341

GO Process

positive regulation of autopha... 40 | 40
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 367 | 367
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
chemical synaptic transmission 238 | 238
MAPK cascade 237 | 237
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 199 | 199
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 180 | 180
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 175 | 175
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
protein folding 162 | 162
negative regulation of canonic... 161 | 161
response to lipopolysaccharide 161 | 161
T cell receptor signaling path... 160 | 160
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2-M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
type I interferon signaling pa... 130 | 130
endocytosis 129 | 129

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Two pore calcium channel protein 1 TPCN1 Tbio Ion Channel -1.84159 59.3 38
Pleckstrin homology domain-containing family F member 1 PLEKHF1 Tbio Non-IDG -1.78639 62.5 99
Forkhead box protein O1 FOXO1 Tbio Transcription Factor -2.99634 1000.8 1343
Transmembrane protein 59 TMEM59 Tbio Non-IDG -1.33352 18.7 53
Endoribonuclease ZC3H12A ZC3H12A Tbio Enzyme -1.74006 69.5 117
Beclin 1-associated autophagy-related key regulator ATG14 Tbio Non-IDG -1.60946 35.0 103
Serine/threonine-protein kinase PLK2 PLK2 Tchem Kinase -2.42985 250.3 160
5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 Tchem Kinase -1.87050 66.3 830
Beclin-1 BECN1 Tbio Non-IDG -3.16844 1336.3 907
Ubiquitin-like modifier-activating enzyme ATG7 ATG7 Tbio Non-IDG -2.62012 364.0 366