Development Level

Tbio 188 | 10,625
Tchem 76 | 1,890
Tclin 20 | 602
Tdark 8 | 7,003

Collection

Eligible Kinase Proteins 4 | 134

IMPC Term

preweaning lethality, complete... 17 | 633
preweaning lethality, incomple... 7 | 260
embryonic lethality prior to t... 6 | 187
abnormal retina morphology 5 | 100
decreased circulating alanine ... 5 | 53
decreased total body fat amoun... 5 | 186
enlarged heart 5 | 111
abnormal behavior 4 | 226
abnormal embryo size 4 | 112
decreased body weight 4 | 174
decreased bone mineral content 4 | 157
decreased bone mineral density 4 | 126
decreased circulating choleste... 4 | 85
increased circulating alkaline... 4 | 119
prenatal lethality prior to he... 4 | 64
thrombocytopenia 4 | 46
abnormal bone mineralization 3 | 55
abnormal bone structure 3 | 131
abnormal hindbrain development 3 | 24
abnormal neural tube closure 3 | 37
abnormal retinal pigmentation 3 | 61
decreased T cell number 3 | 31
decreased circulating HDL chol... 3 | 77
decreased circulating alkaline... 3 | 41
decreased circulating glucose ... 3 | 121
decreased circulating triglyce... 3 | 83
decreased startle reflex 3 | 48
embryonic lethality prior to o... 3 | 148
hydrops fetalis 3 | 22
increased circulating triglyce... 3 | 24
increased mean corpuscular vol... 3 | 91
increased sacral vertebrae num... 3 | 62
abnormal eye morphology 2 | 38
abnormal forebrain development 2 | 18
abnormal heart morphology 2 | 51
abnormal iris morphology 2 | 12
abnormal midbrain development 2 | 22
abnormal seminal vesicle morph... 2 | 47
cyanosis 2 | 6
decreased CD8-positive, alpha-... 2 | 26
decreased circulating aspartat... 2 | 27
decreased eosinophil cell numb... 2 | 41
decreased erythrocyte cell num... 2 | 43
decreased grip strength 2 | 123
decreased lactate dehydrogenas... 2 | 14
decreased lean body mass 2 | 195
decreased lumbar vertebrae num... 2 | 62
decreased mean corpuscular vol... 2 | 50
decreased monocyte cell number 2 | 28
enlarged lymph nodes 2 | 27
hypoactivity 2 | 89
immune system phenotype 2 | 17
increased bone mineral density 2 | 52
increased circulating calcium ... 2 | 32
increased circulating phosphat... 2 | 24
increased grip strength 2 | 83
increased mean corpuscular hem... 2 | 93
increased or absent threshold ... 2 | 128
increased startle reflex 2 | 38
tremors 2 | 34
abnormal behavioral response t... 1 | 52
abnormal coat/ hair morphology 1 | 18
abnormal coping response 1 | 12
abnormal eyelid morphology 1 | 6
abnormal limb bud morphology 1 | 15
abnormal locomotor activation 1 | 26
abnormal snout morphology 1 | 18
abnormal startle reflex 1 | 14
abnormal testis morphology 1 | 30
abnormal tooth morphology 1 | 24
abnormal urinary bladder morph... 1 | 2
cataract 1 | 26
craniofacial phenotype 1 | 9
decreased CD4-positive, CD25-p... 1 | 24
decreased IgG1 level 1 | 4
decreased basophil cell number 1 | 11
decreased caudal vertebrae num... 1 | 49
decreased cervical vertebrae n... 1 | 12
decreased circulating creatini... 1 | 31
decreased effector memory CD8-... 1 | 24
decreased heart weight 1 | 44
decreased mean corpuscular hem... 1 | 34
decreased mean platelet volume 1 | 12
decreased neutrophil cell numb... 1 | 37
decreased spleen weight 1 | 13
female infertility 1 | 34
hemorrhage 1 | 12
increased blood urea nitrogen ... 1 | 44
increased body length 1 | 20
increased circulating HDL chol... 1 | 63
increased circulating choleste... 1 | 53
increased circulating magnesiu... 1 | 10
increased eosinophil cell numb... 1 | 9
irregularly shaped pupil 1 | 7
limb grasping 1 | 35
microphthalmia 1 | 15
oligodactyly 1 | 14
persistence of hyaloid vascula... 1 | 22
short tibia 1 | 82
small superior vagus ganglion 1 | 20

Disease

ovarian cancer 174 | 8,484
Cancer 154 | 2,346
osteosarcoma 154 | 7,933
glioblastoma 134 | 5,572
psoriasis 132 | 6,685
medulloblastoma, large-cell 126 | 6,234
lung cancer 112 | 4,466
malignant mesothelioma 92 | 3,162
atypical teratoid / rhabdoid tumor 88 | 4,369
pediatric high grade glioma 79 | 2,712
pilocytic astrocytoma 72 | 3,086
non-small cell lung cancer 71 | 2,798
Breast cancer 70 | 3,094
lung carcinoma 69 | 2,844
oligodendroglioma 69 | 2,849
primitive neuroectodermal tumor 69 | 3,031
invasive ductal carcinoma 68 | 2,950
pancreatic cancer 67 | 2,300
lung adenocarcinoma 66 | 2,713
intraductal papillary-mucinous adenoma (IPMA) 63 | 2,956
subependymal giant cell astrocytoma 62 | 2,287
ependymoma 59 | 2,514
diabetes mellitus 56 | 1,663
intraductal papillary-mucinous carcinoma (IPMC) 55 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 55 | 3,289
pituitary cancer 55 | 1,972
astrocytic glioma 53 | 2,241
interstitial cystitis 49 | 2,299
Carcinoma 48 | 2,147
Pick disease 48 | 1,893
ductal carcinoma in situ 47 | 1,745
Alzheimer's disease 46 | 644
cystic fibrosis 45 | 1,665
ulcerative colitis 45 | 2,087
astrocytoma 44 | 1,493
group 4 medulloblastoma 43 | 1,875
primary pancreatic ductal adenocarcinoma 43 | 1,271
group 3 medulloblastoma 41 | 2,254
tuberculosis 41 | 1,557
breast carcinoma 40 | 1,614
colon cancer 39 | 1,475
posterior fossa group A ependymoma 38 | 1,511
adrenocortical carcinoma 37 | 1,427
adult high grade glioma 37 | 2,148
sonic hedgehog group medulloblastoma 36 | 1,482
Rheumatoid Arthritis 35 | 1,160
medulloblastoma 35 | 1,524
cutaneous lupus erythematosus 34 | 1,056
Mammary Neoplasms 33 | 410
Prostatic Neoplasms 32 | 471
Endometriosis 30 | 535
Vascular disease 29 | 281
Multiple myeloma 28 | 1,327
Obesity 27 | 616
atypical teratoid/rhabdoid tumor 27 | 1,095
pancreatic ductal adenocarcinoma liver metastasis 27 | 1,795
aldosterone-producing adenoma 26 | 664
posterior fossa group B ependymoma 26 | 1,530
juvenile dermatomyositis 25 | 1,189
Stomach Neoplasms 24 | 282
dermatomyositis 24 | 933
gastric carcinoma 24 | 832
acute quadriplegic myopathy 23 | 1,157
nasopharyngeal carcinoma 22 | 1,056
Multiple Sclerosis 20 | 498
Renal Cell Carcinoma 20 | 199
Toxic encephalopathy 20 | 131
Waldenstrons macroglobulinemia 20 | 765
active Crohn's disease 20 | 918
primary Sjogren syndrome 20 | 789
spina bifida 20 | 1,064
Asthma 19 | 349
Colorectal Neoplasms 19 | 217
Parkinson's disease 19 | 364
hepatocellular carcinoma 19 | 532
Atopic dermatitis 18 | 944
Melanoma 18 | 261
Neurodegenerative disease 18 | 383
Schizophrenia 18 | 501
acute myeloid leukemia 18 | 780
pancreatic carcinoma 18 | 567
Arthritis 17 | 248
Down syndrome 17 | 548
Kidney disease 17 | 396
Lung Neoplasms 17 | 171
Osteoporosis 17 | 257
esophageal adenocarcinoma 17 | 737
progressive supranuclear palsy 17 | 674
Amyotrophic Lateral Sclerosis 16 | 431
Cerebrovascular disease 16 | 231
Intellectual disability 16 | 573
Liver carcinoma 16 | 217
autosomal dominant Emery-Dreifuss muscular dystrophy 16 | 499
Diabetes Mellitus, Experimental 15 | 106
Myocardial Infarction 15 | 126
Peripheral Neuropathy 15 | 303
active ulcerative colitis 15 | 477
fibroadenoma 15 | 557
mucosa-associated lymphoid tissue lymphoma 15 | 480
non primary Sjogren syndrome sicca 14 | 840

Tissue

Blood and immune system 291 | 17,995
Female tissues 291 | 18,647
Male tissues 291 | 17,969
Nervous System 291 | 18,561
Cardiovascular System 290 | 17,958
Digestive Tract 290 | 18,473
Liver and Pancreas 290 | 18,136
Urinary Tract 290 | 18,444
Endocrine System 289 | 18,512
Respiratory system 287 | 17,484
Skin and soft tissues 287 | 18,115

Target Family

Non-IDG 178 | 11,971
Enzyme 39 | 4,146
Kinase 31 | 634
Transcription Factor 25 | 1,400
Epigenetic 7 | 242
Ion Channel 5 | 341
GPCR 4 | 406
Nuclear Receptor 2 | 48
Transporter 1 | 473

GO Process

positive regulation of apoptot... 292 | 292
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
High mobility group protein HMGI-C HMGA2 Tbio Transcription Factor -3.21092 1667.7 216
Lymphotoxin-alpha LTA Tbio Non-IDG -2.84770 612.8 461
Calcium/calmodulin-dependent protein kinase type 1D CAMK1D Tchem Kinase -1.06137 12.5 282
Rho guanine nucleotide exchange factor 11 ARHGEF11 Tbio Non-IDG -1.54485 39.7 163
Complement component 1 Q subcomponent-binding protein, mitochondrial C1QBP Tbio Non-IDG -2.51978 332.6 298
DCN1-like protein 3 DCUN1D3 Tdark Non-IDG -0.34242 2.58 44
Tumor necrosis factor receptor superfamily member 6 FAS Tbio Non-IDG -3.27492 2052.7 1794
Cysteine/serine-rich nuclear protein 3 CSRNP3 Tdark Non-IDG 0.56 0.29 86
Mitogen-activated protein kinase kinase kinase MLT MAP3K20 Tchem Kinase -1.14470 13.6 205
Guanine nucleotide exchange factor DBS MCF2L Tbio Non-IDG -0.93602 11.4 104