Development Level

Tbio 72 | 10,625
Tchem 48 | 1,890
Tclin 10 | 602
Tdark 1 | 7,003

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 5 | 633
abnormal behavior 2 | 226
decreased body weight 2 | 174
decreased lean body mass 2 | 195
hypoactivity 2 | 89
increased circulating alkaline... 2 | 119
abnormal behavioral response t... 1 | 52
abnormal cornea morphology 1 | 24
abnormal lens morphology 1 | 73
abnormal locomotor activation 1 | 26
abnormal retina morphology 1 | 100
abnormal skin condition 1 | 6
abnormal testis morphology 1 | 30
absent vibrissae 1 | 14
decreased CD11b-low dendritic ... 1 | 3
decreased KLRG1+ CD8 alpha bet... 1 | 8
decreased KLRG1-positive NK ce... 1 | 9
decreased NK cell number 1 | 16
decreased caudal vertebrae num... 1 | 49
decreased circulating amylase ... 1 | 24
decreased circulating chloride... 1 | 32
decreased circulating sodium l... 1 | 18
decreased gamma-delta T cell n... 1 | 18
decreased mean corpuscular hem... 1 | 19
decreased mean corpuscular vol... 1 | 50
decreased monocyte cell number 1 | 28
decreased rib number 1 | 59
decreased thermal nociceptive ... 1 | 4
embryonic lethality prior to t... 1 | 187
increased CD11b-high dendritic... 1 | 5
increased CD4-positive, alpha ... 1 | 15
increased NK cell number 1 | 19
increased aggression 1 | 2
increased body weight 1 | 42
increased circulating alanine ... 1 | 11
increased circulating aspartat... 1 | 17
increased circulating free fat... 1 | 17
increased circulating iron lev... 1 | 25
increased effector memory T-he... 1 | 5
increased leukocyte cell numbe... 1 | 37
increased thermal nociceptive ... 1 | 9
male infertility 1 | 62
polydactyly 1 | 22
small testis 1 | 37

Disease

ovarian cancer 71 | 8,484
osteosarcoma 69 | 7,933
psoriasis 66 | 6,685
glioblastoma 59 | 5,572
lung cancer 59 | 4,466
Cancer 54 | 2,346
medulloblastoma, large-cell 41 | 6,234
lung carcinoma 36 | 2,844
subependymal giant cell astrocytoma 36 | 2,287
ulcerative colitis 35 | 2,087
tuberculosis 34 | 1,557
non-small cell lung cancer 33 | 2,798
malignant mesothelioma 32 | 3,162
pancreatic cancer 32 | 2,300
atypical teratoid / rhabdoid tumor 30 | 4,369
lung adenocarcinoma 29 | 2,713
pediatric high grade glioma 29 | 2,712
pilocytic astrocytoma 29 | 3,086
intraductal papillary-mucinous neoplasm (IPMN) 28 | 3,289
Rheumatoid Arthritis 27 | 1,160
intraductal papillary-mucinous adenoma (IPMA) 26 | 2,956
invasive ductal carcinoma 26 | 2,950
interstitial cystitis 25 | 2,299
intraductal papillary-mucinous carcinoma (IPMC) 25 | 2,988
Breast cancer 24 | 3,094
cutaneous lupus erythematosus 24 | 1,056
diabetes mellitus 24 | 1,663
cystic fibrosis 23 | 1,665
oligodendroglioma 23 | 2,849
pituitary cancer 22 | 1,972
astrocytoma 21 | 1,493
ependymoma 20 | 2,514
Carcinoma 19 | 2,147
pancreatic ductal adenocarcinoma liver metastasis 19 | 1,795
dermatomyositis 18 | 933
Arthritis 17 | 248
Atherosclerosis 17 | 275
primitive neuroectodermal tumor 17 | 3,031
Kidney disease 16 | 396
astrocytic glioma 16 | 2,241
juvenile dermatomyositis 16 | 1,189
posterior fossa group A ependymoma 16 | 1,511
Asthma 15 | 349
Obesity 15 | 616
Pick disease 15 | 1,893
acute quadriplegic myopathy 15 | 1,157
primary pancreatic ductal adenocarcinoma 15 | 1,271
Inflammatory bowel disease 14 | 142
Multiple myeloma 14 | 1,327
Waldenstrons macroglobulinemia 14 | 765
group 4 medulloblastoma 14 | 1,875
Atopic dermatitis 13 | 944
IGA Glomerulonephritis 13 | 454
adult high grade glioma 13 | 2,148
Coronary artery disease 12 | 240
Hypersensitivity reaction type II disease 12 | 235
Hypertension 12 | 287
Inflammation 12 | 109
Influenza 12 | 142
Osteoporosis 12 | 257
acute myeloid leukemia 12 | 780
gastric carcinoma 12 | 832
nasopharyngeal carcinoma 12 | 1,056
Allergic hypersensitivity disease 11 | 123
Cerebrovascular disease 11 | 231
Dermatitis 11 | 107
Malaria 11 | 140
Multiple Sclerosis 11 | 498
Pneumonia 11 | 133
Prostatic Neoplasms 11 | 471
Reperfusion Injury 11 | 84
colon cancer 11 | 1,475
group 3 medulloblastoma 11 | 2,254
medulloblastoma 11 | 1,524
primary Sjogren syndrome 11 | 789
sonic hedgehog group medulloblastoma 11 | 1,482
Endometriosis 10 | 535
Mammary Neoplasms 10 | 410
breast carcinoma 10 | 1,614
ductal carcinoma in situ 10 | 1,745
hepatocellular carcinoma 10 | 532
Alzheimer's disease 9 | 644
Bipolar Disorder 9 | 266
Colorectal Neoplasms 9 | 217
Crohn's disease 9 | 304
Hyperglycemia 9 | 120
Hypertensive disease 9 | 193
Lung disease 9 | 132
Peritonitis 9 | 37
adrenocortical carcinoma 9 | 1,427
aldosterone-producing adenoma 9 | 664
esophageal adenocarcinoma 9 | 737
gastric cancer 9 | 430
mucosa-associated lymphoid tissue lymphoma 9 | 480
pancreatic carcinoma 9 | 567
periodontitis 9 | 269
Amyotrophic Lateral Sclerosis 8 | 431
Diabetes Mellitus, Non-Insulin-Dependent 8 | 157
Heart disease 8 | 279
active Crohn's disease 8 | 918

Tissue

Digestive Tract 131 | 18,473
Nervous System 131 | 18,561
Urinary Tract 131 | 18,444
Blood and immune system 130 | 17,995
Female tissues 130 | 18,647
Liver and Pancreas 130 | 18,136
Cardiovascular System 129 | 17,958
Endocrine System 129 | 18,512
Male tissues 129 | 17,969
Respiratory system 128 | 17,484
Skin and soft tissues 128 | 18,115

Target Family

Non-IDG 73 | 11,971
Kinase 29 | 634
Enzyme 24 | 4,146
Transcription Factor 3 | 1,400
Nuclear Receptor 1 | 48
TF/Epigenetic 1 | 38

GO Process

positive regulation of NF-kapp... 131 | 131
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
Muellerian-inhibiting factor AMH Tbio Non-IDG -3.34520 2413.2 212
Interleukin-1 receptor-associated kinase 1 IRAK1 Tchem Kinase -2.51851 320.4 729
TNF receptor-associated factor 2 TRAF2 Tbio Non-IDG -1.85843 68.9 516
Calcium/calmodulin-dependent protein kinase type II subunit alpha CAMK2A Tchem Kinase -1.76384 47.5 542
Insulin INS Tbio Non-IDG -5.14691 141255.4 1549
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 TAB2 Tbio Enzyme -1.83055 69.0 145
E3 ubiquitin-protein ligase TRIM62 TRIM62 Tbio Enzyme -0.57145 6.96 129
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150