Development Level

Tbio 37 | 11,445
Tchem 23 | 1,598
Tclin 4 | 613
Tdark 2 | 6,588

Collection

Kinase: IDG Consortium (Comple... 2 | 37
Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

preweaning lethality, incomple... 3 | 499
increased neutrophil cell numb... 2 | 46
abnormal bone structure 1 | 187
abnormal cecum morphology 1 | 7
abnormal cranium morphology 1 | 36
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral content 1 | 151
decreased circulating bilirubi... 1 | 19
decreased circulating serum al... 1 | 82
decreased heart left ventricle... 1 | 28
decreased heart weight 1 | 27
decreased lymphocyte cell numb... 1 | 83
decreased spleen weight 1 | 10
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged cecum 1 | 5
enlarged heart 1 | 210
enlarged kidney 1 | 14
enlarged uterus 1 | 11
increased blood urea nitrogen ... 1 | 48
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased eosinophil cell numb... 1 | 11
increased kidney weight 1 | 6
increased spleen weight 1 | 10
increased startle reflex 1 | 112
premature death 1 | 5
short tibia 1 | 97
small superior vagus ganglion 1 | 74
thin ventricular wall 1 | 24

Disease

Carcinoma 46 | 11,493
Cancer 34 | 2,499
ovarian cancer 33 | 8,520
osteosarcoma 31 | 7,950
psoriasis 31 | 6,694
glioblastoma 28 | 5,792
lung cancer 23 | 4,740
medulloblastoma, large-cell 21 | 6,241
malignant mesothelioma 20 | 3,232
atypical teratoid / rhabdoid tumor 19 | 5,112
lung carcinoma 18 | 2,843
Rheumatoid arthritis 17 | 1,191
adult high grade glioma 17 | 3,801
ulcerative colitis 16 | 1,819
Astrocytoma, Pilocytic 15 | 3,081
interstitial cystitis 15 | 2,312
lung adenocarcinoma 15 | 2,716
Breast cancer 14 | 3,578
ependymoma 14 | 4,679
tuberculosis 14 | 2,010
group 3 medulloblastoma 13 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
astrocytic glioma 12 | 2,597
Kidney cancer 11 | 2,613
oligodendroglioma 11 | 2,850
subependymal giant cell astrocytoma 11 | 2,287
Schizophrenia 10 | 1,160
diabetes mellitus 10 | 1,728
non-small cell lung cancer 10 | 2,890
pancreatic cancer 10 | 2,398
pituitary cancer 10 | 1,972
Arthritis 9 | 290
colon cancer 9 | 1,478
invasive ductal carcinoma 9 | 2,951
primitive neuroectodermal tumor 9 | 3,035
Pick disease 8 | 1,894
cystic fibrosis 8 | 1,696
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
Melanoma 7 | 711
hepatocellular carcinoma 7 | 547
sarcoidosis 7 | 370
Arthritis, Rheumatoid 6 | 174
Atherosclerosis 6 | 291
Bipolar Disorder 6 | 666
Hypersensitivity reaction type II disease 6 | 253
Hypertension 6 | 396
Inflammation 6 | 120
Influenza 6 | 142
Kidney disease 6 | 430
Liver Cirrhosis, Experimental 6 | 769
Lung Neoplasms 6 | 232
Malaria 6 | 160
Multiple Sclerosis 6 | 540
Systemic lupus erythematosus 6 | 194
adrenocortical carcinoma 6 | 1,428
astrocytoma 6 | 1,146
gastric cancer 6 | 459
group 4 medulloblastoma 6 | 1,855
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
primary Sjogren syndrome 6 | 735
primary pancreatic ductal adenocarcinoma 6 | 1,109
spina bifida 6 | 1,074
Atopic dermatitis 5 | 952
Autosomal recessive predisposition 5 | 1,442
Carcinoma, Hepatocellular 5 | 228
Cerebrovascular disease 5 | 238
Crohn's disease 5 | 321
Diarrhea 5 | 253
Endometriosis 5 | 540
Liver carcinoma 5 | 240
Liver disease 5 | 237
Osteoarthritis 5 | 184
Pancreatitis 5 | 123
Pneumonia 5 | 174
Prostatic Neoplasms 5 | 495
Vascular disease 5 | 319
active Crohn's disease 5 | 922
active ulcerative colitis 5 | 764
aldosterone-producing adenoma 5 | 665
cutaneous lupus erythematosus 5 | 1,057
dermatomyositis 5 | 966
ductal carcinoma in situ 5 | 1,745
gastric carcinoma 5 | 807
periodontitis 5 | 293
Allergic hypersensitivity disease 4 | 126
Alzheimer's disease 4 | 658
Degenerative polyarthritis 4 | 115
Dermatitis 4 | 157
Down syndrome 4 | 499
Epilepsy 4 | 792
Heart disease 4 | 306
Inflammatory bowel disease 4 | 151
Multiple myeloma 4 | 1,332
Stomach Neoplasms 4 | 300
acute myeloid leukemia 4 | 783
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 510
breast carcinoma 4 | 1,638
juvenile dermatomyositis 4 | 1,187
pancreatic carcinoma 4 | 562

Tissue

Blood and immune system 66 | 16,909
Digestive Tract 66 | 17,369
Endocrine System 66 | 18,159
Female tissues 66 | 17,400
Liver and Pancreas 66 | 16,750
Male tissues 66 | 17,142
Skin and soft tissues 66 | 17,230
Urinary Tract 66 | 16,678
Respiratory system 65 | 16,393
Nervous System 64 | 16,725
Cardiovascular System 62 | 15,192

Target Family

Non-IDG 39 | 12,091
Kinase 14 | 634
Enzyme 8 | 4,145
GPCR 3 | 408
Ion Channel 1 | 344
Transcription Factor 1 | 1,400

GO Process

positive regulation of JNK cas... 66 | 66
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein kinase TAO2 TAOK2 Tchem Kinase -1.52454 36.1 154
Mitogen-activated protein kinase kinase kinase 10 MAP3K10 Tchem Kinase -1.20048 15.1 221
Transient receptor potential cation channel subfamily V member 4 TRPV4 Tchem Ion Channel -2.86016 747.3 258
Fibroblast growth factor 19 FGF19 Tbio Non-IDG -2.54882 334.2 305
Mitogen-activated protein kinase kinase kinase kinase 2 MAP4K2 Tchem Kinase -1.60423 35.3 193
Nucleotide-binding oligomerization domain-containing protein 2 NOD2 Tclin Non-IDG -3.13621 1445.5 370
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
TNF receptor-associated factor 4 TRAF4 Tbio Non-IDG -1.67380 54.4 234
Frizzled-7 FZD7 Tbio GPCR -1.81873 66.4 345
Cell division control protein 42 homolog CDC42 Tchem Enzyme -3.37283 2188.5 380