Development Level

Tbio 95 | 10,625
Tchem 48 | 1,890
Tclin 9 | 602
Tdark 6 | 7,003

Collection

Eligible Kinase Proteins 2 | 134
Eligible Ion Channel Proteins 1 | 117
Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 6 | 633
preweaning lethality, incomple... 4 | 260
abnormal behavior 3 | 226
decreased body weight 3 | 174
enlarged heart 3 | 111
tremors 3 | 34
abnormal bone structure 2 | 131
abnormal lens morphology 2 | 73
abnormal retina morphology 2 | 100
abnormal seminal vesicle morph... 2 | 47
decreased circulating glucose ... 2 | 121
decreased circulating triglyce... 2 | 83
decreased grip strength 2 | 123
decreased heart weight 2 | 44
decreased mean corpuscular vol... 2 | 50
decreased prepulse inhibition 2 | 52
decreased rib number 2 | 59
embryonic lethality prior to t... 2 | 187
hypoactivity 2 | 89
improved glucose tolerance 2 | 56
increased circulating HDL chol... 2 | 63
abnormal bone mineralization 1 | 55
abnormal coat/hair pigmentatio... 1 | 54
abnormal embryo size 1 | 112
abnormal epididymis morphology 1 | 31
abnormal eye morphology 1 | 38
abnormal forebrain development 1 | 18
abnormal head morphology 1 | 10
abnormal hindbrain development 1 | 24
abnormal kidney morphology 1 | 30
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal retinal vasculature m... 1 | 15
abnormal rib morphology 1 | 28
abnormal spleen morphology 1 | 36
abnormal startle reflex 1 | 14
abnormal vocalization 1 | 21
absent vibrissae 1 | 14
decreased KLRG1+ CD8 alpha bet... 1 | 8
decreased blood urea nitrogen ... 1 | 31
decreased body length 1 | 108
decreased bone mineral content 1 | 157
decreased circulating HDL chol... 1 | 77
decreased circulating amylase ... 1 | 24
decreased circulating bilirubi... 1 | 14
decreased circulating choleste... 1 | 85
decreased circulating free fat... 1 | 39
decreased circulating insulin ... 1 | 75
decreased circulating serum al... 1 | 79
decreased fasted circulating g... 1 | 49
decreased lean body mass 1 | 195
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular hem... 1 | 19
decreased monocyte cell number 1 | 28
decreased neutrophil cell numb... 1 | 37
decreased startle reflex 1 | 48
decreased thoracic vertebrae n... 1 | 7
enlarged epididymis 1 | 27
enlarged spleen 1 | 26
immune system phenotype 1 | 17
impaired glucose tolerance 1 | 52
increased NK cell number 1 | 19
increased body weight 1 | 42
increased bone mineral density 1 | 52
increased circulating calcium ... 1 | 32
increased circulating magnesiu... 1 | 10
increased circulating serum al... 1 | 25
increased heart weight 1 | 37
increased or absent threshold ... 1 | 128
increased total body fat amoun... 1 | 57
increased vertical activity 1 | 18
limb grasping 1 | 35
oligodactyly 1 | 14
polydactyly 1 | 22
small superior vagus ganglion 1 | 20
straub tail 1 | 26
thrombocytosis 1 | 23
trunk curl 1 | 15
vertebral fusion 1 | 23

Disease

ovarian cancer 94 | 8,484
osteosarcoma 87 | 7,933
psoriasis 77 | 6,685
glioblastoma 70 | 5,572
lung cancer 65 | 4,466
Cancer 60 | 2,346
medulloblastoma, large-cell 49 | 6,234
lung carcinoma 44 | 2,844
ulcerative colitis 41 | 2,087
pilocytic astrocytoma 39 | 3,086
subependymal giant cell astrocytoma 39 | 2,287
intraductal papillary-mucinous neoplasm (IPMN) 38 | 3,289
malignant mesothelioma 37 | 3,162
atypical teratoid / rhabdoid tumor 35 | 4,369
pediatric high grade glioma 34 | 2,712
pancreatic cancer 33 | 2,300
tuberculosis 33 | 1,557
intraductal papillary-mucinous adenoma (IPMA) 31 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 31 | 2,988
Breast cancer 30 | 3,094
non-small cell lung cancer 29 | 2,798
oligodendroglioma 29 | 2,849
pituitary cancer 28 | 1,972
astrocytoma 27 | 1,493
ependymoma 27 | 2,514
cutaneous lupus erythematosus 26 | 1,056
lung adenocarcinoma 26 | 2,713
primitive neuroectodermal tumor 26 | 3,031
cystic fibrosis 25 | 1,665
interstitial cystitis 25 | 2,299
invasive ductal carcinoma 24 | 2,950
primary pancreatic ductal adenocarcinoma 24 | 1,271
juvenile dermatomyositis 23 | 1,189
Rheumatoid Arthritis 22 | 1,160
diabetes mellitus 21 | 1,663
group 4 medulloblastoma 21 | 1,875
astrocytic glioma 19 | 2,241
colon cancer 19 | 1,475
dermatomyositis 19 | 933
pancreatic ductal adenocarcinoma liver metastasis 19 | 1,795
Pick disease 18 | 1,893
Atopic dermatitis 17 | 944
breast carcinoma 17 | 1,614
posterior fossa group A ependymoma 17 | 1,511
Multiple myeloma 16 | 1,327
adrenocortical carcinoma 16 | 1,427
adult high grade glioma 16 | 2,148
esophageal adenocarcinoma 16 | 737
Alzheimer's disease 15 | 644
active Crohn's disease 15 | 918
sonic hedgehog group medulloblastoma 15 | 1,482
Multiple Sclerosis 14 | 498
acute quadriplegic myopathy 14 | 1,157
gastric carcinoma 14 | 832
medulloblastoma 14 | 1,524
nasopharyngeal carcinoma 14 | 1,056
Arthritis 13 | 248
Waldenstrons macroglobulinemia 13 | 765
acute myeloid leukemia 13 | 780
ductal carcinoma in situ 13 | 1,745
spina bifida 13 | 1,064
Carcinoma 12 | 2,147
Kidney disease 12 | 396
Mammary Neoplasms 12 | 410
mucosa-associated lymphoid tissue lymphoma 12 | 480
primary Sjogren syndrome 12 | 789
Crohn's disease 11 | 304
Hypersensitivity reaction type II disease 11 | 235
IGA Glomerulonephritis 11 | 454
Neurodegenerative disease 11 | 383
atypical teratoid/rhabdoid tumor 11 | 1,095
Down syndrome 10 | 548
Inflammation 10 | 109
Inflammatory bowel disease 10 | 142
Influenza 10 | 142
Prostatic Neoplasms 10 | 471
active ulcerative colitis 10 | 477
group 3 medulloblastoma 10 | 2,254
posterior fossa group B ependymoma 10 | 1,530
Duchenne muscular dystrophy 9 | 602
Hypertensive disease 9 | 193
Melanoma 9 | 261
Obesity 9 | 616
Pneumonia 9 | 133
Stomach Neoplasms 9 | 282
Vascular disease 9 | 281
aldosterone-producing adenoma 9 | 664
pancreatic carcinoma 9 | 567
Chronic Lymphocytic Leukemia 8 | 242
Coronary artery disease 8 | 240
Dermatitis 8 | 107
Heart disease 8 | 279
Hypertension 8 | 287
Myocardial Ischemia 8 | 169
Osteoporosis 8 | 257
Reperfusion Injury 8 | 84
fibroadenoma 8 | 557
glioblastoma multiforme 8 | 347
hepatocellular carcinoma 8 | 532
tuberculosis and treatment for 6 months 8 | 686

Tissue

Blood and immune system 158 | 17,995
Digestive Tract 158 | 18,473
Female tissues 158 | 18,647
Nervous System 158 | 18,561
Urinary Tract 158 | 18,444
Cardiovascular System 157 | 17,958
Endocrine System 157 | 18,512
Liver and Pancreas 157 | 18,136
Male tissues 156 | 17,969
Respiratory system 156 | 17,484
Skin and soft tissues 155 | 18,115

Target Family

Non-IDG 89 | 11,971
Enzyme 32 | 4,146
Kinase 21 | 634
GPCR 6 | 406
Transcription Factor 4 | 1,400
Transporter 4 | 473
Epigenetic 1 | 242
Ion Channel 1 | 341

GO Process

positive regulation of I-kappa... 158 | 158
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Interleukin-1 receptor-associated kinase 1 IRAK1 Tchem Kinase -2.51851 320.4 729
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 TAB2 Tbio Enzyme -1.83055 69.0 145
E3 ubiquitin-protein ligase TRIM62 TRIM62 Tbio Enzyme -0.57145 6.96 129
Choline transporter-like protein 2 SLC44A2 Tbio Transporter -1.57202 38.4 77
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150
Ankyrin repeat domain-containing protein 17 ANKRD17 Tbio Non-IDG -1.21583 17.0 94
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG 56.7 150
Peptidyl-prolyl cis-trans isomerase FKBP1A FKBP1A Tclin Enzyme -2.75744 370.6 255
Tumor necrosis factor receptor superfamily member 5 CD40 Tchem Non-IDG -3.44068 3018.0 1385
E3 ubiquitin-protein ligase TRIM22 TRIM22 Tbio Enzyme -1.46578 40.5 140