Development Level

Tbio 106 | 11,445
Tchem 17 | 1,598
Tclin 8 | 613
Tdark 8 | 6,588

Collection

GPCR: IDG Consortium (Targets) 1 | 126
Kinase: IDG Consortium (Comple... 1 | 37
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 10 | 979
abnormal behavior 4 | 298
preweaning lethality, incomple... 4 | 499
abnormal bone structure 3 | 187
decreased blood urea nitrogen ... 3 | 51
decreased body weight 3 | 161
decreased vertical activity 3 | 208
enlarged heart 3 | 210
increased startle reflex 3 | 112
abnormal eye morphology 2 | 68
abnormal heart morphology 2 | 162
decreased bone mineral content 2 | 151
decreased lean body mass 2 | 135
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
hyperactivity 2 | 148
impaired righting response 2 | 26
improved glucose tolerance 2 | 79
increased circulating alkaline... 2 | 122
increased circulating calcium ... 2 | 34
increased circulating glucose ... 2 | 24
increased circulating triglyce... 2 | 42
increased heart weight 2 | 62
short tibia 2 | 97
abnormal behavioral response t... 1 | 66
abnormal embryo size 1 | 220
abnormal iris morphology 1 | 13
abnormal kidney morphology 1 | 65
abnormal locomotor activation 1 | 16
abnormal spinal cord morpholog... 1 | 9
abnormal tail morphology 1 | 25
decreased B cell number 1 | 5
decreased IgE level 1 | 6
decreased IgG1 level 1 | 8
decreased IgG2b level 1 | 4
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating aspartat... 1 | 34
decreased circulating choleste... 1 | 93
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased granulocyte number 1 | 6
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lactate dehydrogenas... 1 | 16
decreased leukocyte cell numbe... 1 | 73
decreased mature B cell number 1 | 7
decreased monocyte cell number 1 | 8
decreased respiratory quotient 1 | 16
decreased startle reflex 1 | 75
decreased threshold for audito... 1 | 26
decreased total body fat amoun... 1 | 207
embryonic growth retardation 1 | 106
enlarged spleen 1 | 41
hemorrhage 1 | 23
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating phosphat... 1 | 26
increased grip strength 1 | 41
increased hematocrit 1 | 46
increased lean body mass 1 | 172
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased prepulse inhibition 1 | 32
increased total body fat amoun... 1 | 134
mammalian phenotype 1 | 17
tremors 1 | 39

Disease

Carcinoma 83 | 11,493
ovarian cancer 73 | 8,520
glioblastoma 70 | 5,792
osteosarcoma 64 | 7,950
psoriasis 63 | 6,694
atypical teratoid / rhabdoid tumor 60 | 5,112
medulloblastoma, large-cell 60 | 6,241
Cancer 52 | 2,499
ependymoma 52 | 4,679
lung cancer 51 | 4,740
adult high grade glioma 48 | 3,801
Astrocytoma, Pilocytic 44 | 3,081
primitive neuroectodermal tumor 37 | 3,035
oligodendroglioma 36 | 2,850
Breast cancer 35 | 3,578
astrocytic glioma 35 | 2,597
intraductal papillary-mucinous carcinoma (IPMC) 34 | 2,989
subependymal giant cell astrocytoma 34 | 2,287
interstitial cystitis 33 | 2,312
tuberculosis 33 | 2,010
malignant mesothelioma 32 | 3,232
non-small cell lung cancer 32 | 2,890
ulcerative colitis 31 | 1,819
invasive ductal carcinoma 30 | 2,951
lung adenocarcinoma 30 | 2,716
lung carcinoma 30 | 2,843
group 3 medulloblastoma 28 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 28 | 3,291
pancreatic cancer 26 | 2,398
Kidney cancer 25 | 2,613
intraductal papillary-mucinous adenoma (IPMA) 24 | 2,955
group 4 medulloblastoma 21 | 1,855
cystic fibrosis 20 | 1,696
ductal carcinoma in situ 19 | 1,745
Asthma 18 | 385
spina bifida 18 | 1,074
Pick disease 17 | 1,894
Rheumatoid arthritis 16 | 1,191
colon cancer 16 | 1,478
cutaneous lupus erythematosus 16 | 1,057
Intellectual disability 15 | 1,016
Multiple Sclerosis 15 | 540
diabetes mellitus 15 | 1,728
Bipolar Disorder 14 | 666
pituitary cancer 14 | 1,972
Schizophrenia 13 | 1,160
active Crohn's disease 13 | 922
juvenile dermatomyositis 13 | 1,187
Kidney disease 12 | 430
Liver Cirrhosis, Experimental 12 | 769
breast carcinoma 12 | 1,638
nasopharyngeal carcinoma 12 | 1,058
Atopic dermatitis 11 | 952
Crohn's disease 11 | 321
Hypersensitivity 11 | 63
adrenocortical carcinoma 11 | 1,428
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
primary Sjogren syndrome 11 | 735
Cognitive delay 10 | 608
Dermatitis 10 | 157
Global developmental delay 10 | 608
Hypereosinophilic syndrome 10 | 71
Mental and motor retardation 10 | 608
Pneumonia 10 | 174
Prostatic Neoplasms 10 | 495
astrocytoma 10 | 1,146
esophageal adenocarcinoma 10 | 737
Allergic hypersensitivity disease 9 | 126
Autosomal recessive predisposition 9 | 1,442
Down syndrome 9 | 499
Lung disease 9 | 142
Obesity 9 | 678
Arthritis 8 | 290
Atherosclerosis 8 | 291
Dull intelligence 8 | 645
Endometriosis 8 | 540
Influenza 8 | 142
Liver cancer 8 | 604
Low intelligence 8 | 645
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Myocardial Ischemia 8 | 169
Poor school performance 8 | 645
Vascular disease 8 | 319
medulloblastoma 8 | 720
pediatric high grade glioma 8 | 1,064
primary pancreatic ductal adenocarcinoma 8 | 1,109
Breast Neoplasms 7 | 445
Chronic Lymphocytic Leukemia 7 | 262
Coronary artery disease 7 | 268
Hypersensitivity reaction type II disease 7 | 253
Inflammation 7 | 120
Inflammatory bowel disease 7 | 151
Mammary Neoplasms 7 | 425
Melanoma 7 | 711
Multiple myeloma 7 | 1,332
Muscle hypotonia 7 | 571
aldosterone-producing adenoma 7 | 665
interstitial lung disease 7 | 298
sonic hedgehog group medulloblastoma 6 | 467

Tissue

Blood and immune system 134 | 16,909
Endocrine System 134 | 18,159
Female tissues 134 | 17,400
Digestive Tract 133 | 17,369
Liver and Pancreas 133 | 16,750
Male tissues 132 | 17,142
Respiratory system 132 | 16,393
Skin and soft tissues 132 | 17,230
Urinary Tract 130 | 16,678
Nervous System 127 | 16,725
Cardiovascular System 120 | 15,192

Target Family

Non-IDG 112 | 12,091
Enzyme 16 | 4,145
GPCR 5 | 408
Kinase 4 | 634
Epigenetic 1 | 242
Transcription Factor 1 | 1,400

GO Process

positive regulation of GTPase ... 139 | 139
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sorting nexin-13 SNX13 Tbio Non-IDG -0.67169 5.24 65
C-C motif chemokine 3-like 1 CCL3L1 Tbio Non-IDG -1.80717 51.3 142
High affinity nerve growth factor receptor NTRK1 Tclin Kinase -3.05841 1050.9 1092
Small G protein signaling modulator 2 SGSM2 Tbio Non-IDG -0.35954 1.93 67
Junctional adhesion molecule A F11R Tbio Non-IDG -2.56739 380.0 394
Sorting nexin-18 SNX18 Tbio Non-IDG -0.76724 7.20 156
C-C motif chemokine 13 CCL13 Tbio Non-IDG -2.02640 99.2 264
C-C motif chemokine 20 CCL20 Tbio Non-IDG -3.10283 1250.3 496
Rap guanine nucleotide exchange factor 2 RAPGEF2 Tbio Non-IDG -1.41107 29.0 79
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 ARAP1 Tbio Non-IDG -0.99923 14.5 99