Development Level

Tbio 95 | 10,625
Tchem 17 | 1,890
Tclin 5 | 602
Tdark 2 | 7,003

Collection

Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 7 | 633
abnormal bone mineralization 3 | 55
abnormal bone structure 3 | 131
decreased body weight 3 | 174
increased mean corpuscular hem... 3 | 93
abnormal behavior 2 | 226
decreased bone mineral content 2 | 157
decreased bone mineral density 2 | 126
decreased circulating alanine ... 2 | 53
decreased fasted circulating g... 2 | 49
decreased grip strength 2 | 123
decreased mature B cell number 2 | 25
enlarged heart 2 | 111
impaired righting response 2 | 19
increased circulating alkaline... 2 | 119
increased circulating calcium ... 2 | 32
increased grip strength 2 | 83
increased heart weight 2 | 37
increased sacral vertebrae num... 2 | 62
preweaning lethality, incomple... 2 | 260
abnormal behavioral response t... 1 | 52
abnormal eye morphology 1 | 38
abnormal iris morphology 1 | 12
abnormal locomotor activation 1 | 26
abnormal retina morphology 1 | 100
abnormal skin coloration 1 | 18
abnormal sleep behavior 1 | 63
decreased B cell number 1 | 30
decreased CD4-positive, CD25-p... 1 | 24
decreased IgE level 1 | 3
decreased NK T cell number 1 | 28
decreased blood urea nitrogen ... 1 | 31
decreased body length 1 | 108
decreased caudal vertebrae num... 1 | 49
decreased circulating alkaline... 1 | 41
decreased circulating aspartat... 1 | 27
decreased circulating insulin ... 1 | 75
decreased circulating triglyce... 1 | 83
decreased erythrocyte cell num... 1 | 43
decreased hematocrit 1 | 25
decreased hemoglobin content 1 | 53
decreased lactate dehydrogenas... 1 | 14
decreased lean body mass 1 | 195
decreased leukocyte cell numbe... 1 | 54
decreased lumbar vertebrae num... 1 | 62
decreased monocyte cell number 1 | 28
decreased respiratory quotient 1 | 12
decreased rib number 1 | 59
decreased startle reflex 1 | 48
decreased total body fat amoun... 1 | 186
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
enlarged spleen 1 | 26
hyperactivity 1 | 108
improved glucose tolerance 1 | 56
increased blood urea nitrogen ... 1 | 44
increased body weight 1 | 42
increased bone mineral content 1 | 92
increased circulating creatini... 1 | 29
increased circulating glucose ... 1 | 16
increased circulating phosphat... 1 | 24
increased circulating triglyce... 1 | 24
increased effector memory CD4-... 1 | 15
increased exploration in new e... 1 | 56
increased gamma-delta T cell n... 1 | 16
increased hematocrit 1 | 36
increased lean body mass 1 | 107
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular vol... 1 | 91
increased or absent threshold ... 1 | 128
tremors 1 | 34

Disease

ovarian cancer 65 | 8,484
glioblastoma 55 | 5,572
psoriasis 53 | 6,685
medulloblastoma, large-cell 47 | 6,234
osteosarcoma 47 | 7,933
lung cancer 45 | 4,466
Cancer 43 | 2,346
atypical teratoid / rhabdoid tumor 40 | 4,369
pilocytic astrocytoma 35 | 3,086
oligodendroglioma 31 | 2,849
interstitial cystitis 29 | 2,299
intraductal papillary-mucinous carcinoma (IPMC) 29 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 29 | 3,289
pediatric high grade glioma 28 | 2,712
primitive neuroectodermal tumor 28 | 3,031
Breast cancer 27 | 3,094
lung adenocarcinoma 26 | 2,713
lung carcinoma 26 | 2,844
malignant mesothelioma 26 | 3,162
non-small cell lung cancer 26 | 2,798
subependymal giant cell astrocytoma 26 | 2,287
ulcerative colitis 25 | 2,087
invasive ductal carcinoma 24 | 2,950
pancreatic cancer 24 | 2,300
astrocytic glioma 23 | 2,241
posterior fossa group A ependymoma 22 | 1,511
tuberculosis 22 | 1,557
intraductal papillary-mucinous adenoma (IPMA) 21 | 2,956
adult high grade glioma 18 | 2,148
cystic fibrosis 18 | 1,665
Asthma 17 | 349
Carcinoma 16 | 2,147
colon cancer 16 | 1,475
ependymoma 16 | 2,514
Pick disease 15 | 1,893
astrocytoma 15 | 1,493
group 4 medulloblastoma 15 | 1,875
Multiple Sclerosis 14 | 498
diabetes mellitus 14 | 1,663
ductal carcinoma in situ 14 | 1,745
sonic hedgehog group medulloblastoma 14 | 1,482
cutaneous lupus erythematosus 13 | 1,056
nasopharyngeal carcinoma 12 | 1,056
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,795
spina bifida 12 | 1,064
Atopic dermatitis 11 | 944
Hypersensitivity 11 | 63
Kidney disease 11 | 396
active Crohn's disease 11 | 918
atypical teratoid/rhabdoid tumor 11 | 1,095
breast carcinoma 11 | 1,614
medulloblastoma 11 | 1,524
posterior fossa group B ependymoma 11 | 1,530
Pneumonia 10 | 133
Rheumatoid Arthritis 10 | 1,160
adrenocortical carcinoma 10 | 1,427
juvenile dermatomyositis 10 | 1,189
pituitary cancer 10 | 1,972
primary Sjogren syndrome 10 | 789
Allergic hypersensitivity disease 9 | 123
Arthritis 9 | 248
Eosinophilia 9 | 65
Schizophrenia 9 | 501
group 3 medulloblastoma 9 | 2,254
primary pancreatic ductal adenocarcinoma 9 | 1,271
Crohn's disease 8 | 304
Endometriosis 8 | 535
Intellectual disability 8 | 573
Lung disease 8 | 132
Mammary Neoplasms 8 | 410
Prostatic Neoplasms 8 | 471
Atherosclerosis 7 | 275
Dermatitis 7 | 107
Down syndrome 7 | 548
Inflammatory bowel disease 7 | 142
Influenza 7 | 142
Multiple myeloma 7 | 1,327
Myocardial Ischemia 7 | 169
esophageal adenocarcinoma 7 | 737
Adenoma 6 | 165
Coronary artery disease 6 | 240
Duchenne muscular dystrophy 6 | 602
Glomerulonephritis 6 | 36
Human immunodeficiency virus infectious disease 6 | 92
Hypersensitivity reaction type II disease 6 | 235
Peripheral Neuropathy 6 | 303
aldosterone-producing adenoma 6 | 664
fibroadenoma 6 | 557
interstitial lung disease 6 | 291
non-small cell lung carcinoma 6 | 413
tuberculosis and treatment for 6 months 6 | 686
Allergic rhinitis 5 | 91
Alzheimer's disease 5 | 644
Brain Ischemia 5 | 87
Obesity 5 | 616
Vascular disease 5 | 281
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 499
hepatocellular carcinoma 5 | 532
periodontitis 5 | 269
urothelial carcinoma 5 | 318

Tissue

Digestive Tract 111 | 18,473
Liver and Pancreas 110 | 18,136
Nervous System 110 | 18,561
Female tissues 109 | 18,647
Blood and immune system 108 | 17,995
Cardiovascular System 108 | 17,958
Endocrine System 108 | 18,512
Male tissues 108 | 17,969
Urinary Tract 107 | 18,444
Respiratory system 106 | 17,484
Skin and soft tissues 106 | 18,115

Target Family

Non-IDG 94 | 11,971
Enzyme 16 | 4,146
Kinase 4 | 634
GPCR 3 | 406
Epigenetic 1 | 242
Transcription Factor 1 | 1,400

GO Process

positive regulation of GTPase ... 119 | 119
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Glycogen synthase kinase-3 beta GSK3B Tclin Kinase -2.94349 567.7 767
Regulator of G-protein signaling 16 RGS16 Tbio Non-IDG -1.59717 42.2 162
Tumor necrosis factor receptor superfamily member 5 CD40 Tchem Non-IDG -3.44068 3018.0 1385
Integrin alpha-6 ITGA6 Tchem Non-IDG -2.25486 168.8 756
C-C motif chemokine 4-like CCL4L2 Tbio Non-IDG -2.01543 361.7 43
Reticulon-4 receptor RTN4R Tbio Non-IDG -2.54684 385.1 166
C-C motif chemokine 16 CCL16 Tbio Non-IDG -2.39462 252.3 212
Regulator of G-protein signaling 7 RGS7 Tbio Non-IDG -1.66114 49.5 132
C-C motif chemokine 25 CCL25 Tbio Non-IDG -1.75030 57.4 217
SLIT-ROBO Rho GTPase-activating protein 2 SRGAP2 Tbio Enzyme 21.4 0