Development Level

Tbio 23 | 11,445
Tchem 14 | 1,598
Tclin 5 | 613

Collection

GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 3 | 979
decreased lean body mass 2 | 135
increased circulating HDL chol... 2 | 80
increased circulating alkaline... 2 | 122
increased total body fat amoun... 2 | 134
short tibia 2 | 97
abnormal bone mineralization 1 | 38
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal lens morphology 1 | 81
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal testis morphology 1 | 43
cataract 1 | 92
corneal opacity 1 | 32
decreased bone mineral content 1 | 151
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased eosinophil cell numb... 1 | 24
decreased grip strength 1 | 116
decreased leukocyte cell numbe... 1 | 73
decreased prepulse inhibition 1 | 82
decreased spleen weight 1 | 10
decreased vertical activity 1 | 208
edema 1 | 59
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged kidney 1 | 14
enlarged lymph nodes 1 | 37
female infertility 1 | 60
fused cornea and lens 1 | 5
hyperactivity 1 | 148
impaired pupillary reflex 1 | 26
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating LDL chol... 1 | 13
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased circulating triglyce... 1 | 42
increased heart weight 1 | 62
increased lean body mass 1 | 172
increased mean corpuscular vol... 1 | 92
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
increased startle reflex 1 | 112
iris synechia 1 | 3
male infertility 1 | 123
narrow eye opening 1 | 12
persistence of hyaloid vascula... 1 | 33
small superior vagus ganglion 1 | 74

Disease

Cancer 29 | 2,499
ovarian cancer 25 | 8,520
glioblastoma 24 | 5,792
medulloblastoma, large-cell 23 | 6,241
Carcinoma 21 | 11,493
atypical teratoid / rhabdoid tumor 21 | 5,112
lung cancer 20 | 4,740
osteosarcoma 20 | 7,950
psoriasis 20 | 6,694
Breast cancer 18 | 3,578
ependymoma 17 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
malignant mesothelioma 14 | 3,232
group 3 medulloblastoma 13 | 4,104
oligodendroglioma 13 | 2,850
pancreatic cancer 13 | 2,398
astrocytic glioma 12 | 2,597
Astrocytoma, Pilocytic 11 | 3,081
adult high grade glioma 11 | 3,801
diabetes mellitus 11 | 1,728
group 4 medulloblastoma 11 | 1,855
Breast Neoplasms 10 | 445
Mammary Neoplasms 10 | 425
lung carcinoma 10 | 2,843
non-small cell lung cancer 10 | 2,890
primitive neuroectodermal tumor 10 | 3,035
Heart disease 9 | 306
Hypertensive disease 9 | 292
Multiple myeloma 9 | 1,332
breast carcinoma 9 | 1,638
cystic fibrosis 9 | 1,696
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
lung adenocarcinoma 9 | 2,716
Alzheimer's disease 8 | 658
Carcinoma, Hepatocellular 8 | 228
Liver carcinoma 8 | 240
Schizophrenia 8 | 1,160
Short stature 8 | 531
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
invasive ductal carcinoma 8 | 2,951
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
pituitary cancer 8 | 1,972
tuberculosis 8 | 2,010
Anemia 7 | 365
Atherosclerosis 7 | 291
Coronary artery disease 7 | 268
Endometriosis 7 | 540
Hypertension 7 | 396
Obesity 7 | 678
Peripheral Neuropathy 7 | 134
Pulmonary Fibrosis 7 | 106
acute quadriplegic myopathy 7 | 1,158
ductal carcinoma in situ 7 | 1,745
interstitial cystitis 7 | 2,312
pediatric high grade glioma 7 | 1,064
ulcerative colitis 7 | 1,819
Acute kidney injury 6 | 70
Asthma 6 | 385
Autosomal recessive predisposition 6 | 1,442
Cerebrovascular disease 6 | 238
Cognitive delay 6 | 608
Global developmental delay 6 | 608
Hyperglycemia 6 | 137
Kidney cancer 6 | 2,613
Kidney disease 6 | 430
Liver Cirrhosis, Experimental 6 | 769
Liver disease 6 | 237
Lung Neoplasms 6 | 232
Lung disease 6 | 142
Mammary Neoplasms, Experimental 6 | 154
Melanoma 6 | 711
Mental and motor retardation 6 | 608
Neoplasm Invasiveness 6 | 161
Neutropenia 6 | 72
Prostatic Neoplasms 6 | 495
Rheumatoid arthritis 6 | 1,191
Small head 6 | 374
Stomach Neoplasms 6 | 300
Thrombocytopenia 6 | 197
Waldenstrons macroglobulinemia 6 | 765
adrenocortical carcinoma 6 | 1,428
astrocytoma 6 | 1,146
spina bifida 6 | 1,074
subependymal giant cell astrocytoma 6 | 2,287
Alzheimer Disease 5 | 83
Animal Mammary Neoplasms 5 | 136
Arthritis 5 | 290
Atopic dermatitis 5 | 952
Bipolar Disorder 5 | 666
Dementia 5 | 175
Depressive disorder 5 | 409
Hypoglycemia 5 | 152
Intrauterine retardation 5 | 176
Myocardial Ischemia 5 | 169
Neoplasm Metastasis 5 | 168
Pick disease 5 | 1,894
Polycystic ovary syndrome 5 | 360
Seizures 5 | 596
colon cancer 5 | 1,478
primary Sjogren syndrome 5 | 735

Tissue

Blood and immune system 42 | 16,909
Endocrine System 42 | 18,159
Female tissues 41 | 17,400
Liver and Pancreas 41 | 16,750
Male tissues 41 | 17,142
Skin and soft tissues 41 | 17,230
Digestive Tract 40 | 17,369
Respiratory system 40 | 16,393
Urinary Tract 40 | 16,678
Nervous System 39 | 16,725
Cardiovascular System 38 | 15,192

Target Family

Non-IDG 25 | 12,091
Enzyme 6 | 4,145
Kinase 6 | 634
Transcription Factor 4 | 1,400
GPCR 1 | 408

GO Process

positive regulation of DNA rep... 42 | 42
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cystatin-C CST3 Tbio Non-IDG -3.52815 3278.8 866
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
Transforming growth factor beta-3 TGFB3 Tbio Non-IDG -3.02749 1062.5 308
Cell division control protein 42 homolog CDC42 Tchem Enzyme -3.37283 2188.5 380
Interleukin-3 IL3 Tbio Non-IDG -3.35359 2101.5 583
Urocortin UCN Tbio Non-IDG -2.78590 622.0 154
Dual specificity mitogen-activated protein kinase kinase 4 MAP2K4 Tchem Kinase -2.43646 236.7 998
ATP-dependent RNA helicase A DHX9 Tbio Enzyme -2.85807 734.3 204
CST complex subunit CTC1 CTC1 Tbio Non-IDG -1.74818 54.2 49
Insulin-like growth factor 1 receptor IGF1R Tclin Kinase -3.37168 2419.5 1686