Development Level

Tbio 12 | 11,445
Tchem 12 | 1,598
Tclin 6 | 613
Tdark 2 | 6,588

Collection

Kinase: IDG Consortium (Target... 3 | 125

IMPC Phenotype

preweaning lethality, complete... 4 | 979
decreased circulating alanine ... 2 | 47
decreased circulating creatini... 2 | 39
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased body weight 1 | 161
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating triglyce... 1 | 79
decreased lactate dehydrogenas... 1 | 16
decreased lean body mass 1 | 135
decreased red blood cell distr... 1 | 41
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged lymph nodes 1 | 37
increased circulating triglyce... 1 | 42
increased grip strength 1 | 41
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased total body fat amoun... 1 | 134
preweaning lethality, incomple... 1 | 499
vertebral fusion 1 | 23

Disease

Carcinoma 26 | 11,493
ovarian cancer 19 | 8,520
Cancer 18 | 2,499
glioblastoma 17 | 5,792
atypical teratoid / rhabdoid tumor 16 | 5,112
medulloblastoma, large-cell 16 | 6,241
osteosarcoma 16 | 7,950
Breast cancer 15 | 3,578
psoriasis 15 | 6,694
Kidney cancer 14 | 2,613
ependymoma 14 | 4,679
lung cancer 14 | 4,740
invasive ductal carcinoma 13 | 2,951
interstitial cystitis 11 | 2,312
breast carcinoma 10 | 1,638
ductal carcinoma in situ 10 | 1,745
primitive neuroectodermal tumor 10 | 3,035
Astrocytoma, Pilocytic 9 | 3,081
Schizophrenia 9 | 1,160
adult high grade glioma 9 | 3,801
group 3 medulloblastoma 9 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
ulcerative colitis 9 | 1,819
Autosomal recessive predisposition 8 | 1,442
Obesity 8 | 678
astrocytic glioma 8 | 2,597
diabetes mellitus 8 | 1,728
lung carcinoma 8 | 2,843
malignant mesothelioma 8 | 3,232
oligodendroglioma 8 | 2,850
pancreatic cancer 8 | 2,398
pituitary cancer 8 | 1,972
Breast Neoplasms 7 | 445
Mammary Neoplasms 7 | 425
Prostatic Neoplasms 7 | 495
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
lung adenocarcinoma 7 | 2,716
non-small cell lung cancer 7 | 2,890
Alzheimer's disease 6 | 658
Bipolar Disorder 6 | 666
Heart disease 6 | 306
Hyperglycemia 6 | 137
Hypoplastic mandible condyle 6 | 275
Mandibular hypoplasia 6 | 275
Micrognathism 6 | 275
adrenocortical carcinoma 6 | 1,428
group 4 medulloblastoma 6 | 1,855
juvenile dermatomyositis 6 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
spina bifida 6 | 1,074
subependymal giant cell astrocytoma 6 | 2,287
Adenoma 5 | 167
Cardiomegaly 5 | 116
DOID:2627 5 | 94
Dull intelligence 5 | 645
Endometrial cancer 5 | 311
Hyperinsulinism 5 | 133
Intellectual disability 5 | 1,016
Liver cancer 5 | 604
Low intelligence 5 | 645
Major Depressive Disorder 5 | 301
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Neoplasm Metastasis 5 | 168
Pick disease 5 | 1,894
Poor school performance 5 | 645
cutaneous lupus erythematosus 5 | 1,057
fibroadenoma 5 | 559
Attention deficit hyperactivity disorder 4 | 278
Autistic Disorder 4 | 364
Big calvaria 4 | 147
Blepharoptosis 4 | 231
Cardiovascular Diseases 4 | 59
Cognitive delay 4 | 608
Concave bridge of nose 4 | 195
Depressed nasal bridge 4 | 195
Depressed nasal root/bridge 4 | 195
Depressive disorder 4 | 409
Global developmental delay 4 | 608
Hypertension 4 | 396
Hypertensive disease 4 | 292
Hypothyroidism 4 | 122
Increased head circumference 4 | 147
Increased size of cranium 4 | 147
Increased size of skull 4 | 147
Lung Neoplasms 4 | 232
Mental Depression 4 | 333
Mental and motor retardation 4 | 608
Mood Disorders 4 | 184
Neurodegenerative disease 4 | 414
Orbital separation excessive 4 | 244
Parkinson's disease 4 | 392
Somatic mutation 4 | 61
Waldenstrons macroglobulinemia 4 | 765
acute quadriplegic myopathy 4 | 1,158
cystic fibrosis 4 | 1,696
nasopharyngeal carcinoma 4 | 1,058
pediatric high grade glioma 4 | 1,064
progressive supranuclear palsy 4 | 676

Tissue

Blood and immune system 32 | 16,909
Digestive Tract 32 | 17,369
Endocrine System 32 | 18,159
Respiratory system 32 | 16,393
Skin and soft tissues 32 | 17,230
Urinary Tract 32 | 16,678
Female tissues 31 | 17,400
Liver and Pancreas 31 | 16,750
Male tissues 31 | 17,142
Nervous System 31 | 16,725
Cardiovascular System 29 | 15,192

Target Family

Kinase 14 | 634
Non-IDG 8 | 12,091
Enzyme 5 | 4,145
GPCR 2 | 408
Transcription Factor 2 | 1,400
Epigenetic 1 | 242

GO Process

phosphatidylinositol 3-kinase ... 32 | 32
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

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