Development Level

Tbio 10 | 11,445

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal coat- hair morphology 1 | 19
abnormal vitreous body morphol... 1 | 10
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating choleste... 1 | 93
increased circulating bilirubi... 1 | 16
persistence of hyaloid vascula... 1 | 33

Disease

Optic Atrophy 6 | 242
ovarian cancer 5 | 8,520
Carcinoma 4 | 11,493
Death in early childhood 4 | 82
Death in infancy 4 | 82
Failure to gain weight 4 | 365
Muscle hypotonia 4 | 571
Pediatric failure to thrive 4 | 365
Zellweger syndrome 4 | 37
medulloblastoma, large-cell 4 | 6,241
osteosarcoma 4 | 7,950
psoriasis 4 | 6,694
Abnormality of metabolism/homeostasis 3 | 134
Broad flat nasal bridge 3 | 236
Cognitive delay 3 | 608
Concave bridge of nose 3 | 195
Congenital Epicanthus 3 | 177
Depressed nasal bridge 3 | 195
Depressed nasal root/bridge 3 | 195
Developmental regression 3 | 95
Electroencephalogram abnormal 3 | 101
Epilepsy 3 | 792
Global developmental delay 3 | 608
Global developmental delay, severe 3 | 47
Hepatomegaly 3 | 285
Hyperreflexia 3 | 209
Loss of developmental milestones 3 | 95
Mental and motor retardation 3 | 608
Mental deterioration in childhood 3 | 95
Nasal bridge wide 3 | 236
Neurodevelopmental regression 3 | 95
Nystagmus 3 | 317
Psychomotor regression 3 | 95
Psychomotor regression beginning in infancy 3 | 95
Psychomotor regression in infants 3 | 95
Psychomotor regression, progressive 3 | 95
Respiratory Insufficiency 3 | 132
Respiratory function loss 3 | 121
Retinitis Pigmentosa 3 | 226
Seizures 3 | 596
Sensorineural Hearing Loss (disorder) 3 | 284
Severe psychomotor retardation 3 | 47
Small head 3 | 374
Strabismus 3 | 270
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
Abnormal behavior 2 | 52
Abnormality of retinal pigmentation 2 | 111
Addison Disease 2 | 18
Adrenal cortical hypofunction 2 | 23
Adrenoleukodystrophy 2 | 29
Adrenoleukodystrophy, Neonatal 2 | 13
Bilateral single transverse palmar creases 2 | 34
Blepharoptosis 2 | 231
Clouding of corneal stroma 2 | 50
Corneal Opacity 2 | 53
Decreased to absent deep tendon reflexes 2 | 42
Elevated hepatic transaminases 2 | 81
Embryotoxon 2 | 28
Flat face 2 | 52
Flat occiput 2 | 26
Hepatic enzyme increased 2 | 81
High forehead 2 | 102
Hydronephrosis 2 | 89
Hypotonia, severe 2 | 33
Icterus 2 | 82
Impaired cognition 2 | 96
Infantile Refsum Disease (disorder) 2 | 13
Infantile Refsum disease 2 | 23
Liver Dysfunction 2 | 99
Liver Failure 2 | 73
Liver diseases 2 | 87
Liver enzymes abnormal 2 | 81
Liver function test increased 2 | 81
Liver function tests abnormal finding 2 | 81
Long narrow head 2 | 75
Low Vision 2 | 174
Malformations of Cortical Development, Group II 2 | 31
Malformed pinnae 2 | 37
Mental impairment 2 | 95
Movement Disorders 2 | 55
Muscle Spasticity 2 | 195
Muscle weakness, progressive 2 | 22
Night Blindness 2 | 101
Osteochondrodysplasias 2 | 72
Penile hypospadias 2 | 106
Peroxisomal disease 2 | 22
Polymicrogyria 2 | 48
Posterior embryotoxon 2 | 28
Premature Birth 2 | 77
Premature birth of newborn 2 | 67
Psychomotor retardation, profound 2 | 17
Pyloric Stenosis 2 | 47
Retinal pigment epithelial abnormality 2 | 111
Stippled epiphyses 2 | 28
Subclinical abnormal liver function tests 2 | 81
Transaminases increased 2 | 81
Underdeveloped supraorbital ridges 2 | 38
Visual Impairment 2 | 174
Visual field constriction 2 | 36
active ulcerative colitis 2 | 764

Tissue

Blood and immune system 10 | 16,909
Cardiovascular System 10 | 15,192
Digestive Tract 10 | 17,369
Endocrine System 10 | 18,159
Female tissues 10 | 17,400
Liver and Pancreas 10 | 16,750
Male tissues 10 | 17,142
Nervous System 10 | 16,725
Respiratory system 10 | 16,393
Skin and soft tissues 10 | 17,230
Urinary Tract 10 | 16,678

Target Family

Non-IDG 8 | 12,091
Enzyme 2 | 4,145

GO Process

peroxisome fission 10 | 10
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Peroxisomal membrane protein 11C PEX11G Tbio Non-IDG -0.26324 0.99 45
Dynamin-1-like protein DNM1L Tbio Non-IDG -2.65717 476.9 426
Peroxisomal membrane protein 11B PEX11B Tbio Non-IDG -1.00971 10.5 80
Peroxisomal acyl-coenzyme A oxidase 1 ACOX1 Tbio Enzyme -2.10178 116.1 292
Mitochondrial fission 1 protein FIS1 Tbio Non-IDG -2.19572 143.4 224
Peroxisomal membrane protein 11A PEX11A Tbio Non-IDG -1.72726 55.8 122
Peroxisomal biogenesis factor 19 PEX19 Tbio Non-IDG -2.28877 200.1 264
Acyl-coenzyme A thioesterase 8 ACOT8 Tbio Enzyme -2.41856 254.6 180
Mitochondrial fission factor MFF Tbio Non-IDG -2.26188 175.4 119
Protein transport protein Sec16B SEC16B Tbio Non-IDG -1.08675 11.0 76