Development Level

Tchem 53 | 1,388
Tbio 10 | 11,651
Tclin 5 | 612
Tdark 2 | 6,593

Collection

Kinase: IDG Consortium (Target... 12 | 125
RFA-RM-18-021 12 | 328
Kinase: IDG Consortium (Comple... 4 | 37

IMPC Phenotype

preweaning lethality, complete... 6 | 979
preweaning lethality, incomple... 5 | 499
decreased blood urea nitrogen ... 3 | 51
abnormal bone structure 2 | 187
abnormal embryo size 2 | 220
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
increased or absent threshold ... 2 | 101
abnormal behavior 1 | 298
abnormal coat- hair morphology 1 | 19
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal response to tactile s... 1 | 17
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating LDL chol... 1 | 38
decreased circulating calcium ... 1 | 36
decreased circulating magnesiu... 1 | 13
decreased fasted circulating g... 1 | 65
decreased granulocyte number 1 | 6
decreased heart left ventricle... 1 | 28
decreased prepulse inhibition 1 | 82
hyperactivity 1 | 148
hypoactivity 1 | 132
improved glucose tolerance 1 | 79
increased blood urea nitrogen ... 1 | 48
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating sodium l... 1 | 71
increased erythrocyte cell num... 1 | 39
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased kidney weight 1 | 6
increased mean corpuscular hem... 1 | 96
increased prepulse inhibition 1 | 32
increased startle reflex 1 | 112
pallor 1 | 34
prenatal lethality 1 | 28
small adrenal glands 1 | 16
small superior vagus ganglion 1 | 74
small testis 1 | 58
thin ventricular wall 1 | 24
tremors 1 | 39
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 58 | 11,493
osteosarcoma 43 | 7,950
ovarian cancer 39 | 8,520
glioblastoma 38 | 5,792
ependymoma 37 | 4,679
medulloblastoma, large-cell 36 | 6,241
atypical teratoid / rhabdoid tumor 31 | 5,112
adult high grade glioma 29 | 3,801
Astrocytoma, Pilocytic 28 | 3,081
Cancer 26 | 2,499
primitive neuroectodermal tumor 25 | 3,035
psoriasis 25 | 6,694
Breast cancer 22 | 3,578
group 3 medulloblastoma 22 | 4,104
lung cancer 22 | 4,740
malignant mesothelioma 22 | 3,232
Kidney cancer 21 | 2,613
oligodendroglioma 21 | 2,850
astrocytic glioma 20 | 2,597
Pick disease 16 | 1,894
Schizophrenia 16 | 1,160
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,291
non-small cell lung cancer 15 | 2,890
subependymal giant cell astrocytoma 15 | 2,287
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,989
Renal Cell Carcinoma 13 | 214
group 4 medulloblastoma 13 | 1,855
invasive ductal carcinoma 13 | 2,951
Hypertensive disease 12 | 292
Parkinson's disease 11 | 392
diabetes mellitus 11 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,955
lung carcinoma 11 | 2,843
tuberculosis 11 | 2,010
Alzheimer's disease 10 | 658
Gastrointestinal stromal tumor 10 | 62
Pancreatic Neuroendocrine Tumor 10 | 45
breast carcinoma 10 | 1,638
ductal carcinoma in situ 10 | 1,745
lung adenocarcinoma 10 | 2,716
ulcerative colitis 10 | 1,819
Depressive disorder 9 | 409
Hypertension 9 | 396
dermatomyositis 9 | 966
juvenile dermatomyositis 9 | 1,187
Rheumatoid arthritis 8 | 1,191
acute quadriplegic myopathy 8 | 1,158
astrocytoma 8 | 1,146
colon cancer 8 | 1,478
pediatric high grade glioma 8 | 1,064
Intellectual disability 7 | 1,016
Prostatic Neoplasms 7 | 495
Vascular disease 7 | 319
cystic fibrosis 7 | 1,696
pancreatic cancer 7 | 2,398
Amyotrophic lateral sclerosis 6 | 451
Atopic dermatitis 6 | 952
Bipolar Disorder 6 | 666
Breast Neoplasms 6 | 445
Colorectal Neoplasms 6 | 243
Kidney disease 6 | 430
Mammary Neoplasms 6 | 425
Obesity 6 | 678
Squamous cell carcinoma 6 | 129
Toxic encephalopathy 6 | 141
adrenocortical carcinoma 6 | 1,428
interstitial cystitis 6 | 2,312
non primary Sjogren syndrome sicca 6 | 891
pituitary cancer 6 | 1,972
Acquired scoliosis 5 | 281
Carcinoma, Squamous Cell 5 | 110
Cardiomegaly 5 | 116
Cognitive delay 5 | 608
Curvature of spine 5 | 282
Endometrial cancer 5 | 311
Epilepsy 5 | 792
Global developmental delay 5 | 608
Hypoplastic mandible condyle 5 | 275
Lung Neoplasms 5 | 232
Mandibular hypoplasia 5 | 275
Mental Depression 5 | 333
Mental and motor retardation 5 | 608
Micrognathism 5 | 275
Multiple myeloma 5 | 1,332
Nerve Degeneration 5 | 121
Neurodegenerative disease 5 | 414
Seizures 5 | 596
Skin Neoplasms 5 | 69
acute myeloid leukemia 5 | 783
esophageal adenocarcinoma 5 | 737
medulloblastoma 5 | 720
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
Asthma 4 | 385
Autosomal recessive predisposition 4 | 1,442
Duchenne muscular dystrophy 4 | 601
Dull intelligence 4 | 645
Glaucoma 4 | 239
primary Sjogren syndrome 4 | 735
sonic hedgehog group medulloblastoma 4 | 467
spina bifida 4 | 1,074

Tissue

Endocrine System 70 | 18,159
Female tissues 69 | 17,400
Nervous System 69 | 16,725
Skin and soft tissues 69 | 17,230
Blood and immune system 68 | 16,909
Digestive Tract 68 | 17,369
Liver and Pancreas 68 | 16,750
Male tissues 68 | 17,142
Urinary Tract 68 | 16,678
Respiratory system 67 | 16,393
Cardiovascular System 66 | 15,192

Target Family

Kinase 65 | 634
Enzyme 2 | 4,145
Non-IDG 2 | 12,091
Transcription Factor 1 | 1,400

GO Process

peptidyl-threonine phosphoryla... 70 | 70
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein kinase DCLK2 DCLK2 Tchem Kinase -0.89222 8.01 148
STE20/SPS1-related proline-alanine-rich protein kinase STK39 Tbio Kinase -2.11714 148.9 575
Serine/threonine-protein kinase DCLK3 DCLK3 Tchem Kinase -2.33084 205.9 71
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.09531 11.7 331
Cyclin-dependent-like kinase 5 CDK5 Tchem Kinase -3.06393 1238.4 694
Myosin light chain kinase family member 4 MYLK4 Tchem Kinase -0.25307 1.48 83
TGF-beta receptor type-2 TGFBR2 Tchem Kinase -2.84120 665.1 548
Serine/threonine-protein kinase TBK1 TBK1 Tchem Kinase -2.76728 569.1 455
Calcium/calmodulin-dependent protein kinase type II subunit delta CAMK2D Tchem Kinase -1.37613 16.9 229
Casein kinase II subunit beta CSNK2B Tbio Kinase -2.72925 527.4 422