Development Level

Tchem 26 | 1,890
Tbio 7 | 10,625
Tclin 4 | 602

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

decreased blood urea nitrogen ... 2 | 31
decreased body weight 2 | 174
preweaning lethality, complete... 2 | 633
abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
abnormal coat/ hair morphology 1 | 18
abnormal embryo size 1 | 112
abnormal lens morphology 1 | 73
abnormal maxilla morphology 1 | 16
abnormal response to tactile s... 1 | 16
abnormal retina morphology 1 | 100
abnormal snout morphology 1 | 18
abnormal tooth morphology 1 | 24
decreased bone mineral content 1 | 157
decreased cervical vertebrae n... 1 | 12
decreased circulating LDL chol... 1 | 37
decreased circulating calcium ... 1 | 33
decreased granulocyte number 1 | 8
decreased respiratory quotient 1 | 12
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
increased circulating HDL chol... 1 | 63
increased circulating LDL chol... 1 | 15
increased circulating chloride... 1 | 43
increased circulating choleste... 1 | 53
increased circulating phosphat... 1 | 24
increased kidney weight 1 | 4
increased mean corpuscular hem... 1 | 93
increased prepulse inhibition 1 | 21
preweaning lethality, incomple... 1 | 260
small adrenal glands 1 | 15
small superior vagus ganglion 1 | 20
small testis 1 | 37
tremors 1 | 34

Disease

osteosarcoma 26 | 7,933
ovarian cancer 26 | 8,484
glioblastoma 20 | 5,572
medulloblastoma, large-cell 19 | 6,234
psoriasis 18 | 6,685
Cancer 16 | 2,346
atypical teratoid / rhabdoid tumor 13 | 4,369
Breast cancer 12 | 3,094
Carcinoma 12 | 2,147
lung cancer 12 | 4,466
malignant mesothelioma 12 | 3,162
pilocytic astrocytoma 12 | 3,086
Parkinson's disease 10 | 364
Pick disease 10 | 1,893
adult high grade glioma 10 | 2,148
ependymoma 10 | 2,514
Alzheimer's disease 9 | 644
group 3 medulloblastoma 9 | 2,254
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,289
oligodendroglioma 9 | 2,849
pediatric high grade glioma 9 | 2,712
astrocytoma 8 | 1,493
invasive ductal carcinoma 8 | 2,950
non-small cell lung cancer 8 | 2,798
primitive neuroectodermal tumor 8 | 3,031
Hypertensive disease 7 | 193
astrocytic glioma 7 | 2,241
diabetes mellitus 7 | 1,663
juvenile dermatomyositis 7 | 1,189
medulloblastoma 7 | 1,524
subependymal giant cell astrocytoma 7 | 2,287
ulcerative colitis 7 | 2,087
Kidney disease 6 | 396
Vascular disease 6 | 281
acute quadriplegic myopathy 6 | 1,157
colon cancer 6 | 1,475
group 4 medulloblastoma 6 | 1,875
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,956
lung adenocarcinoma 6 | 2,713
tuberculosis 6 | 1,557
IGA Glomerulonephritis 5 | 454
Prostatic Neoplasms 5 | 471
Rheumatoid Arthritis 5 | 1,160
acute myeloid leukemia 5 | 780
dermatomyositis 5 | 933
ductal carcinoma in situ 5 | 1,745
interstitial cystitis 5 | 2,299
lung carcinoma 5 | 2,844
pancreatic cancer 5 | 2,300
Atopic dermatitis 4 | 944
Cardiomyopathies 4 | 90
Hypertension 4 | 287
Mammary Neoplasms 4 | 410
Renal Cell Carcinoma 4 | 199
Toxic encephalopathy 4 | 131
adrenocortical carcinoma 4 | 1,427
atypical teratoid/rhabdoid tumor 4 | 1,095
esophageal adenocarcinoma 4 | 737
posterior fossa group A ependymoma 4 | 1,511
sonic hedgehog group medulloblastoma 4 | 1,482
tuberculosis and treatment for 6 months 4 | 686
Adenoma 3 | 165
Amyotrophic Lateral Sclerosis 3 | 431
Arthritis 3 | 248
Asthma 3 | 349
Autistic Disorder 3 | 320
Brain disease 3 | 83
COPD 3 | 113
Cardiomegaly 3 | 66
Colorectal Neoplasms 3 | 217
Dementia 3 | 129
Diffuse large B-cell lymphoma 3 | 41
Endometriosis 3 | 535
Heart disease 3 | 279
Hyperglycemia 3 | 120
Intellectual disability 3 | 573
Lung Neoplasms 3 | 171
Metabolic syndrome X 3 | 155
Multiple myeloma 3 | 1,327
Myocardial Infarction 3 | 126
Nerve Degeneration 3 | 73
Neurodegenerative disease 3 | 383
Obesity 3 | 616
Peripheral Neuropathy 3 | 303
Schizophrenia 3 | 501
Waldenstrons macroglobulinemia 3 | 765
breast carcinoma 3 | 1,614
cystic fibrosis 3 | 1,665
gastric cancer 3 | 430
non primary Sjogren syndrome sicca 3 | 840
ovarian neoplasm 3 | 97
pituitary cancer 3 | 1,972
posterior fossa group B ependymoma 3 | 1,530
primary Sjogren syndrome 3 | 789
sarcoidosis 3 | 358
spina bifida 3 | 1,064
aldosterone-producing adenoma 2 | 664
mucosa-associated lymphoid tissue lymphoma 2 | 480
nasopharyngeal carcinoma 2 | 1,056

Tissue

Blood and immune system 37 | 17,995
Cardiovascular System 37 | 17,958
Digestive Tract 37 | 18,473
Endocrine System 37 | 18,512
Female tissues 37 | 18,647
Liver and Pancreas 37 | 18,136
Male tissues 37 | 17,969
Nervous System 37 | 18,561
Respiratory system 37 | 17,484
Skin and soft tissues 37 | 18,115
Urinary Tract 37 | 18,444

Target Family

Kinase 32 | 634
Enzyme 2 | 4,146
Non-IDG 2 | 11,971
Transcription Factor 1 | 1,400

GO Process

peptidyl-threonine phosphoryla... 37 | 37
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Glycogen synthase kinase-3 beta GSK3B Tclin Kinase -2.94349 567.7 767
3-phosphoinositide-dependent protein kinase 1 PDPK1 Tchem Kinase -2.24871 191.5 579
Serine/threonine-protein kinase LMTK2 LMTK2 Tbio Kinase -1.45997 32.1 172
Cyclin-dependent-like kinase 5 CDK5 Tchem Kinase -3.02975 1184.8 589
Serine/threonine-protein kinase MARK2 MARK2 Tchem Kinase -2.46742 259.6 291
Dual specificity tyrosine-phosphorylation-regulated kinase 1A DYRK1A Tchem Kinase -2.62311 466.9 306
TGF-beta receptor type-2 TGFBR2 Tchem Kinase -2.72206 519.3 441
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02296 9.59 274
CAD protein CAD Tchem Non-IDG -2.23017 164.6 201
Mitogen-activated protein kinase 1 MAPK1 Tchem Kinase -3.12872 1138.1 1044