Development Level

Tchem 102 | 1,388
Tbio 35 | 11,651
Tclin 7 | 612
Tdark 4 | 6,593

Collection

Kinase: IDG Consortium (Target... 32 | 125
RFA-RM-18-021 32 | 328
Kinase: IDG Consortium (Comple... 7 | 37

IMPC Phenotype

preweaning lethality, complete... 11 | 979
preweaning lethality, incomple... 9 | 499
abnormal behavior 4 | 298
abnormal bone structure 4 | 187
embryonic lethality prior to o... 4 | 239
increased circulating alkaline... 4 | 122
increased total body fat amoun... 4 | 134
decreased body weight 3 | 161
embryonic lethality prior to t... 3 | 278
increased circulating LDL chol... 3 | 13
abnormal behavioral response t... 2 | 66
abnormal embryo size 2 | 220
decreased blood urea nitrogen ... 2 | 51
decreased circulating LDL chol... 2 | 38
decreased circulating glucose ... 2 | 126
decreased lean body mass 2 | 135
decreased total body fat amoun... 2 | 207
decreased vertical activity 2 | 208
hyperactivity 2 | 148
improved glucose tolerance 2 | 79
increased circulating chloride... 2 | 41
increased circulating choleste... 2 | 66
increased circulating iron lev... 2 | 30
increased mean corpuscular hem... 2 | 96
increased mean corpuscular vol... 2 | 92
increased startle reflex 2 | 112
male infertility 2 | 123
thrombocytosis 2 | 27
abnormal bone mineralization 1 | 38
abnormal clavicle morphology 1 | 6
abnormal cranium morphology 1 | 36
abnormal eye morphology 1 | 68
abnormal femur morphology 1 | 14
abnormal glucose homeostasis 1 | 4
abnormal heart shape 1 | 5
abnormal joint morphology 1 | 23
abnormal optic disc morphology 1 | 10
abnormal response to tactile s... 1 | 17
abnormal skin morphology 1 | 50
abnormal spinal cord morpholog... 1 | 9
abnormal testis morphology 1 | 43
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased circulating alkaline... 1 | 46
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating glycerol... 1 | 16
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased circulating unsatura... 1 | 2
decreased eosinophil cell numb... 1 | 24
decreased granulocyte number 1 | 6
decreased heart left ventricle... 1 | 28
decreased heart weight 1 | 27
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased large unstained cell... 1 | 11
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased mean platelet volume 1 | 25
decreased neutrophil cell numb... 1 | 42
decreased startle reflex 1 | 75
decreased total retina thickne... 1 | 17
enlarged heart 1 | 210
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
impaired pupillary reflex 1 | 26
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating creatini... 1 | 38
increased circulating glucose ... 1 | 24
increased circulating sodium l... 1 | 71
increased erythrocyte cell num... 1 | 39
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased kidney weight 1 | 6
increased lean body mass 1 | 172
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
pallor 1 | 34
prenatal lethality 1 | 28
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
small testis 1 | 58
thin ventricular wall 1 | 24
tremors 1 | 39
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 123 | 11,493
osteosarcoma 88 | 7,950
ovarian cancer 81 | 8,520
glioblastoma 76 | 5,792
medulloblastoma, large-cell 73 | 6,241
psoriasis 64 | 6,694
ependymoma 61 | 4,679
atypical teratoid / rhabdoid tumor 57 | 5,112
Cancer 56 | 2,499
Astrocytoma, Pilocytic 50 | 3,081
group 3 medulloblastoma 50 | 4,104
adult high grade glioma 49 | 3,801
Breast cancer 41 | 3,578
lung cancer 41 | 4,740
primitive neuroectodermal tumor 41 | 3,035
intraductal papillary-mucinous neoplasm (IPMN) 39 | 3,291
oligodendroglioma 39 | 2,850
intraductal papillary-mucinous carcinoma (IPMC) 37 | 2,989
Kidney cancer 36 | 2,613
malignant mesothelioma 33 | 3,232
Pick disease 32 | 1,894
astrocytic glioma 32 | 2,597
invasive ductal carcinoma 29 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 28 | 2,955
Schizophrenia 26 | 1,160
non-small cell lung cancer 26 | 2,890
lung carcinoma 25 | 2,843
diabetes mellitus 24 | 1,728
group 4 medulloblastoma 24 | 1,855
subependymal giant cell astrocytoma 24 | 2,287
tuberculosis 22 | 2,010
acute quadriplegic myopathy 21 | 1,158
lung adenocarcinoma 21 | 2,716
Renal Cell Carcinoma 20 | 214
juvenile dermatomyositis 20 | 1,187
pancreatic cancer 20 | 2,398
colon cancer 19 | 1,478
pancreatic ductal adenocarcinoma liver metastasis 19 | 1,962
breast carcinoma 18 | 1,638
Rheumatoid arthritis 17 | 1,191
Alzheimer's disease 16 | 658
adrenocortical carcinoma 16 | 1,428
Parkinson's disease 15 | 392
astrocytoma 15 | 1,146
pituitary cancer 15 | 1,972
spina bifida 15 | 1,074
ulcerative colitis 15 | 1,819
Depressive disorder 14 | 409
Gastrointestinal stromal tumor 14 | 62
Pancreatic Neuroendocrine Tumor 14 | 45
ductal carcinoma in situ 14 | 1,745
Bipolar Disorder 13 | 666
Vascular disease 13 | 319
Epilepsy 12 | 792
Prostatic Neoplasms 12 | 495
cystic fibrosis 12 | 1,696
dermatomyositis 12 | 966
interstitial cystitis 12 | 2,312
pediatric high grade glioma 12 | 1,064
progressive supranuclear palsy 12 | 676
Amyotrophic lateral sclerosis 11 | 451
Autosomal recessive predisposition 11 | 1,442
Hypertensive disease 11 | 292
Kidney disease 11 | 430
Waldenstrons macroglobulinemia 11 | 765
Cardiomegaly 10 | 116
Hypertension 10 | 396
Intellectual disability 10 | 1,016
Multiple myeloma 10 | 1,332
Neurodegenerative disease 10 | 414
Obesity 10 | 678
non primary Sjogren syndrome sicca 10 | 891
Colorectal Neoplasms 9 | 243
Hyperalgesia 9 | 83
Seizures 9 | 596
Small head 9 | 374
nasopharyngeal carcinoma 9 | 1,058
primary Sjogren syndrome 9 | 735
Arthritis 8 | 290
Asthma 8 | 385
Atopic dermatitis 8 | 952
Disease Models, Animal 8 | 155
Liver Cirrhosis, Experimental 8 | 769
Major Depressive Disorder 8 | 301
Nerve Degeneration 8 | 121
Stomach Neoplasms 8 | 300
acute myeloid leukemia 8 | 783
primary pancreatic ductal adenocarcinoma 8 | 1,109
Dull intelligence 7 | 645
Endometrial cancer 7 | 311
Glaucoma 7 | 239
Hepatomegaly 7 | 285
Low intelligence 7 | 645
Mental Depression 7 | 333
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Poor school performance 7 | 645
active ulcerative colitis 7 | 764
esophageal adenocarcinoma 7 | 737
medulloblastoma 7 | 720

Tissue

Endocrine System 147 | 18,159
Digestive Tract 145 | 17,369
Nervous System 145 | 16,725
Skin and soft tissues 145 | 17,230
Blood and immune system 144 | 16,909
Female tissues 144 | 17,400
Liver and Pancreas 144 | 16,750
Male tissues 144 | 17,142
Urinary Tract 143 | 16,678
Respiratory system 140 | 16,393
Cardiovascular System 136 | 15,192

Target Family

Kinase 135 | 634
Non-IDG 10 | 12,091
Enzyme 3 | 4,145

GO Process

peptidyl-serine phosphorylatio... 148 | 148
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
MAP kinase-interacting serine/threonine-protein kinase 1 MKNK1 Tchem Kinase -1.71576 46.7 408
Serine/threonine-protein kinase DCLK2 DCLK2 Tchem Kinase -0.89222 8.01 148
STE20/SPS1-related proline-alanine-rich protein kinase STK39 Tbio Kinase -2.11714 148.9 575
Serine/threonine-protein kinase DCLK3 DCLK3 Tchem Kinase -2.33084 205.9 71
Mitogen-activated protein kinase 7 MAPK7 Tbio Kinase -2.48754 340.0 422
Tyrosine-protein kinase SYK SYK Tchem Kinase -3.14835 1437.4 1136
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.09531 11.7 331
Serine/threonine-protein kinase PLK2 PLK2 Tchem Kinase -2.45914 273.4 179
Cyclin-dependent-like kinase 5 CDK5 Tchem Kinase -3.06393 1238.4 694
Protein kinase C iota type PRKCI Tchem Kinase -1.71694 51.2 148