Development Level

Tchem 87 | 1,890
Tbio 28 | 10,625
Tclin 5 | 602
Tdark 2 | 7,003

Collection

Eligible Kinase Proteins 20 | 134

IMPC Term

preweaning lethality, complete... 5 | 633
increased circulating alkaline... 4 | 119
abnormal behavior 3 | 226
decreased body weight 3 | 174
embryonic lethality prior to o... 3 | 148
increased circulating LDL chol... 3 | 15
abnormal bone mineralization 2 | 55
abnormal bone structure 2 | 131
decreased bone mineral content 2 | 157
decreased circulating LDL chol... 2 | 37
decreased circulating triglyce... 2 | 83
decreased leukocyte cell numbe... 2 | 54
embryonic lethality prior to t... 2 | 187
increased circulating choleste... 2 | 53
increased circulating iron lev... 2 | 25
preweaning lethality, incomple... 2 | 260
abnormal behavioral response t... 1 | 52
abnormal cranium morphology 1 | 32
abnormal embryo size 1 | 112
abnormal femur morphology 1 | 14
abnormal glucose homeostasis 1 | 5
abnormal joint morphology 1 | 14
abnormal lens morphology 1 | 73
abnormal maxilla morphology 1 | 16
abnormal optic disc morphology 1 | 10
abnormal respiratory quotient 1 | 9
abnormal response to tactile s... 1 | 16
abnormal retina morphology 1 | 100
abnormal snout morphology 1 | 18
abnormal testis morphology 1 | 30
abnormal tooth morphology 1 | 24
decreased blood urea nitrogen ... 1 | 31
decreased body length 1 | 108
decreased bone mineral density 1 | 126
decreased cervical vertebrae n... 1 | 12
decreased circulating HDL chol... 1 | 77
decreased circulating calcium ... 1 | 33
decreased circulating choleste... 1 | 85
decreased circulating free fat... 1 | 39
decreased circulating glucose ... 1 | 121
decreased circulating iron lev... 1 | 25
decreased circulating serum al... 1 | 79
decreased eosinophil cell numb... 1 | 41
decreased gamma-delta T cell n... 1 | 18
decreased granulocyte number 1 | 8
decreased grip strength 1 | 123
decreased heart weight 1 | 44
decreased lean body mass 1 | 195
decreased respiratory quotient 1 | 12
decreased rib number 1 | 59
decreased startle reflex 1 | 48
decreased total body fat amoun... 1 | 186
enlarged heart 1 | 111
hyperactivity 1 | 108
impaired glucose tolerance 1 | 52
improved glucose tolerance 1 | 56
increased bone mineral content 1 | 92
increased circulating HDL chol... 1 | 63
increased circulating alanine ... 1 | 11
increased circulating aspartat... 1 | 17
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 43
increased circulating glucose ... 1 | 16
increased circulating sodium l... 1 | 71
increased eosinophil cell numb... 1 | 9
increased heart weight 1 | 37
increased kidney weight 1 | 4
increased mature B cell number 1 | 12
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
increased or absent threshold ... 1 | 128
increased total body fat amoun... 1 | 57
increased vertical activity 1 | 18
male infertility 1 | 62
short tibia 1 | 82
small testis 1 | 37
thrombocytosis 1 | 23
tremors 1 | 34

Disease

osteosarcoma 76 | 7,933
ovarian cancer 74 | 8,484
medulloblastoma, large-cell 64 | 6,234
glioblastoma 58 | 5,572
psoriasis 52 | 6,685
Cancer 48 | 2,346
atypical teratoid / rhabdoid tumor 41 | 4,369
pilocytic astrocytoma 38 | 3,086
intraductal papillary-mucinous neoplasm (IPMN) 35 | 3,289
lung cancer 35 | 4,466
intraductal papillary-mucinous carcinoma (IPMC) 33 | 2,988
Breast cancer 32 | 3,094
oligodendroglioma 32 | 2,849
pediatric high grade glioma 32 | 2,712
primitive neuroectodermal tumor 32 | 3,031
ependymoma 30 | 2,514
invasive ductal carcinoma 28 | 2,950
Pick disease 27 | 1,893
malignant mesothelioma 27 | 3,162
Carcinoma 26 | 2,147
intraductal papillary-mucinous adenoma (IPMA) 25 | 2,956
group 4 medulloblastoma 23 | 1,875
lung carcinoma 23 | 2,844
non-small cell lung cancer 22 | 2,798
astrocytic glioma 21 | 2,241
group 3 medulloblastoma 21 | 2,254
medulloblastoma 20 | 1,524
subependymal giant cell astrocytoma 20 | 2,287
astrocytoma 19 | 1,493
diabetes mellitus 19 | 1,663
acute quadriplegic myopathy 18 | 1,157
adult high grade glioma 18 | 2,148
juvenile dermatomyositis 18 | 1,189
lung adenocarcinoma 18 | 2,713
Rheumatoid Arthritis 17 | 1,160
colon cancer 17 | 1,475
pancreatic cancer 16 | 2,300
ulcerative colitis 16 | 2,087
Parkinson's disease 15 | 364
adrenocortical carcinoma 15 | 1,427
pituitary cancer 15 | 1,972
posterior fossa group B ependymoma 15 | 1,530
spina bifida 15 | 1,064
Alzheimer's disease 14 | 644
tuberculosis 14 | 1,557
Renal Cell Carcinoma 13 | 199
atypical teratoid/rhabdoid tumor 13 | 1,095
breast carcinoma 13 | 1,614
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,795
Kidney disease 12 | 396
Vascular disease 12 | 281
interstitial cystitis 12 | 2,299
progressive supranuclear palsy 12 | 674
ductal carcinoma in situ 11 | 1,745
sonic hedgehog group medulloblastoma 11 | 1,482
Amyotrophic Lateral Sclerosis 10 | 431
Multiple myeloma 10 | 1,327
Prostatic Neoplasms 10 | 471
Waldenstrons macroglobulinemia 10 | 765
posterior fossa group A ependymoma 10 | 1,511
primary Sjogren syndrome 10 | 789
primary pancreatic ductal adenocarcinoma 10 | 1,271
Gastrointestinal stromal tumor 9 | 61
Neurodegenerative disease 9 | 383
Pancreatic Neuroendocrine Tumor 9 | 45
cystic fibrosis 9 | 1,665
dermatomyositis 9 | 933
tuberculosis and treatment for 6 months 9 | 686
Colorectal Neoplasms 8 | 217
Obesity 8 | 616
Schizophrenia 8 | 501
acute myeloid leukemia 8 | 780
nasopharyngeal carcinoma 8 | 1,056
non primary Sjogren syndrome sicca 8 | 840
Arthritis 7 | 248
Asthma 7 | 349
Atopic dermatitis 7 | 944
Cardiomegaly 7 | 66
Cardiomyopathies 7 | 90
Down syndrome 7 | 548
Epilepsy 7 | 346
Intellectual disability 7 | 573
Glaucoma 6 | 134
Hyperalgesia 6 | 71
Hypertensive disease 6 | 193
Lung Neoplasms 6 | 171
Mammary Neoplasms 6 | 410
Myocardial Infarction 6 | 126
Peripheral Neuropathy 6 | 303
Stomach Neoplasms 6 | 282
cutaneous lupus erythematosus 6 | 1,056
esophageal adenocarcinoma 6 | 737
glioblastoma multiforme 6 | 347
sarcoidosis 6 | 358
Cocaine-Related Disorders 5 | 88
Heart disease 5 | 279
Hypertension 5 | 287
IGA Glomerulonephritis 5 | 454
Lissencephaly 5 | 61
Toxic encephalopathy 5 | 131

Tissue

Blood and immune system 121 | 17,995
Cardiovascular System 121 | 17,958
Digestive Tract 121 | 18,473
Endocrine System 121 | 18,512
Female tissues 121 | 18,647
Liver and Pancreas 121 | 18,136
Male tissues 121 | 17,969
Nervous System 121 | 18,561
Skin and soft tissues 121 | 18,115
Urinary Tract 121 | 18,444
Respiratory system 120 | 17,484

Target Family

Kinase 109 | 634
Non-IDG 11 | 11,971
Enzyme 2 | 4,146

GO Process

peptidyl-serine phosphorylatio... 122 | 122
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Erythropoietin EPO Tbio Non-IDG -3.90053 8755.8 628
Teratocarcinoma-derived growth factor 1 TDGF1 Tbio Non-IDG 156.3 371
Calcium/calmodulin-dependent protein kinase type II subunit alpha CAMK2A Tchem Kinase -1.76384 47.5 542
Serine/threonine-protein kinase N3 PKN3 Tchem Kinase -1.11681 14.4 104
Serine/threonine-protein kinase DCLK1 DCLK1 Tchem Kinase -1.97724 113.9 288
Homeodomain-interacting protein kinase 4 HIPK4 Tchem Kinase -0.20862 2.17 190
Glycogen synthase kinase-3 beta GSK3B Tclin Kinase -2.94349 567.7 767
Casein kinase I isoform epsilon CSNK1E Tchem Kinase -1.76876 60.7 272
Mitogen-activated protein kinase 13 MAPK13 Tchem Kinase -2.46715 317.1 405
3-phosphoinositide-dependent protein kinase 1 PDPK1 Tchem Kinase -2.24871 191.5 579