Development Level

Tbio 70 | 11,445
Tchem 10 | 1,598
Tclin 2 | 613
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 7 | 979
preweaning lethality, incomple... 7 | 499
enlarged heart 6 | 210
abnormal heart morphology 4 | 162
abnormal seminal vesicle morph... 3 | 114
decreased lymphocyte cell numb... 3 | 83
small superior vagus ganglion 3 | 74
abnormal craniofacial morpholo... 2 | 33
abnormal eye morphology 2 | 68
abnormal kidney morphology 2 | 65
decreased body weight 2 | 161
decreased circulating aspartat... 2 | 34
decreased lean body mass 2 | 135
decreased startle reflex 2 | 75
edema 2 | 59
embryonic lethality prior to t... 2 | 278
enlarged lymph nodes 2 | 37
hydrometra 2 | 53
increased circulating alkaline... 2 | 122
abnormal behavior 1 | 298
abnormal embryo size 1 | 220
abnormal facial morphology 1 | 17
abnormal hindbrain morphology 1 | 10
abnormal midbrain morphology 1 | 10
abnormal neural tube closure 1 | 46
abnormal skin morphology 1 | 50
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
cleft palate 1 | 8
cyanosis 1 | 7
decreased body length 1 | 101
decreased circulating HDL chol... 1 | 68
decreased circulating alanine ... 1 | 47
decreased circulating bilirubi... 1 | 19
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased eosinophil cell numb... 1 | 24
decreased lumbar vertebrae num... 1 | 2
decreased prepulse inhibition 1 | 82
enlarged spleen 1 | 41
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
increased circulating phosphat... 1 | 26
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased prepulse inhibition 1 | 32
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
long tibia 1 | 25
pale yolk sac 1 | 25
pallor 1 | 34
scaly skin 1 | 4
shortened QT interval 1 | 4
small spleen 1 | 19

Disease

Carcinoma 63 | 11,493
ovarian cancer 46 | 8,520
lung cancer 41 | 4,740
psoriasis 38 | 6,694
osteosarcoma 37 | 7,950
medulloblastoma, large-cell 34 | 6,241
Cancer 31 | 2,499
Breast cancer 28 | 3,578
Cleft Palate 28 | 271
atypical teratoid / rhabdoid tumor 27 | 5,112
ependymoma 27 | 4,679
glioblastoma 27 | 5,792
invasive ductal carcinoma 26 | 2,951
non-small cell lung cancer 26 | 2,890
group 3 medulloblastoma 25 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 24 | 2,955
pancreatic cancer 24 | 2,398
Kidney cancer 23 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 23 | 2,989
Astrocytoma, Pilocytic 20 | 3,081
lung adenocarcinoma 20 | 2,716
Craniofacial Abnormalities 18 | 151
ductal carcinoma in situ 18 | 1,745
lung carcinoma 18 | 2,843
malignant mesothelioma 18 | 3,232
cystic fibrosis 17 | 1,696
interstitial cystitis 17 | 2,312
Short stature 16 | 531
intraductal papillary-mucinous neoplasm (IPMN) 16 | 3,291
primitive neuroectodermal tumor 16 | 3,035
Hypoplastic mandible condyle 15 | 275
Mandibular hypoplasia 15 | 275
Micrognathism 15 | 275
Orbital separation excessive 15 | 244
Cleft Lip 14 | 141
Intellectual disability 14 | 1,016
adult high grade glioma 14 | 3,801
breast carcinoma 14 | 1,638
colon cancer 14 | 1,478
pituitary cancer 14 | 1,972
acute quadriplegic myopathy 13 | 1,158
tuberculosis 13 | 2,010
Autosomal recessive predisposition 12 | 1,442
Dull intelligence 12 | 645
Low intelligence 12 | 645
Mental Retardation 12 | 645
Mental deficiency 12 | 645
Poor school performance 12 | 645
Uranostaphyloschisis 12 | 167
primary pancreatic ductal adenocarcinoma 12 | 1,109
Epilepsy 11 | 792
Hypotrophic malar bone 11 | 129
Malar flattening 11 | 129
oligodendroglioma 11 | 2,850
ulcerative colitis 11 | 1,819
Pick disease 10 | 1,894
adrenocortical carcinoma 10 | 1,428
astrocytic glioma 10 | 2,597
juvenile dermatomyositis 10 | 1,187
spina bifida 10 | 1,074
Concave bridge of nose 9 | 195
Depressed nasal bridge 9 | 195
Depressed nasal root/bridge 9 | 195
Low set ears 9 | 181
Patent ductus arteriosus 9 | 90
Polydactyly 9 | 107
Seizures 9 | 596
Small head 9 | 374
gastric carcinoma 9 | 807
group 4 medulloblastoma 9 | 1,855
pediatric high grade glioma 9 | 1,064
Abnormally small eyeball 8 | 97
Brachydactyly 8 | 156
Byzanthine arch palate 8 | 194
Congenital heart disease 8 | 93
Congenital hypoplasia of penis 8 | 176
Cryptorchidism 8 | 296
Decreased projection of midface 8 | 105
Decreased size of eyeball 8 | 97
Downward slant of palpebral fissure 8 | 158
Hypertensive disease 8 | 292
Hypotrophic midface 8 | 105
Increase in blood pressure 8 | 119
Liver Cirrhosis, Experimental 8 | 769
Low-set, posteriorly rotated ears 8 | 110
Microphthalmos 8 | 100
Midface retrusion 8 | 105
Muscle hypotonia 8 | 571
Obesity 8 | 678
Small midface 8 | 105
active ulcerative colitis 8 | 764
autosomal dominant Emery-Dreifuss muscular dystrophy 8 | 510
dermatomyositis 8 | 966
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
Atopic dermatitis 7 | 952
Ulnar polydactyly of fingers 7 | 47
cutaneous lupus erythematosus 7 | 1,057
fibroadenoma 7 | 559
sonic hedgehog group medulloblastoma 7 | 467
subependymal giant cell astrocytoma 7 | 2,287

Tissue

Female tissues 81 | 17,400
Endocrine System 79 | 18,159
Skin and soft tissues 79 | 17,230
Digestive Tract 78 | 17,369
Male tissues 78 | 17,142
Liver and Pancreas 76 | 16,750
Nervous System 76 | 16,725
Respiratory system 75 | 16,393
Urinary Tract 75 | 16,678
Blood and immune system 74 | 16,909
Cardiovascular System 71 | 15,192

Target Family

Non-IDG 34 | 12,091
Transcription Factor 30 | 1,400
Kinase 8 | 634
Enzyme 7 | 4,145
Epigenetic 2 | 242
Ion Channel 1 | 344
TF/Epigenetic 1 | 38

GO Process

palate development 83 | 83
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Homeobox protein MSX-1 MSX1 Tbio Transcription Factor -2.59245 390.1 298
p21-activated protein kinase-interacting protein 1 PAK1IP1 Tbio Enzyme -1.02033 9.87 62
Insulin-induced gene 2 protein INSIG2 Tbio Non-IDG -1.94599 88.7 78
Extracellular matrix protein FRAS1 FRAS1 Tbio Non-IDG -1.51346 36.5 22
Paired mesoderm homeobox protein 1 PRRX1 Tbio Transcription Factor -1.58479 38.8 304
Extracellular tyrosine-protein kinase PKDCC PKDCC Tbio Kinase -1.15951 16.2 51
Gamma-aminobutyric acid receptor subunit beta-3 GABRB3 Tclin Ion Channel -2.13205 136.0 202
Ephrin type-B receptor 3 EPHB3 Tchem Kinase -1.68968 47.7 409
AT-rich interactive domain-containing protein 5B ARID5B Tbio Transcription Factor -1.71561 54.6 97
WD repeat-containing and planar cell polarity effector protein fritz homolog WDPCP Tbio Non-IDG -0.84019 7.08 68