Development Level

Tbio 12 | 11,445

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal embryo size 1 | 220
abnormal lens morphology 1 | 81
cataract 1 | 92
decreased circulating chloride... 1 | 30
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239

Disease

ovarian cancer 9 | 8,520
Multiple myeloma 7 | 1,332
osteosarcoma 6 | 7,950
Autosomal recessive predisposition 5 | 1,442
Carcinoma 4 | 11,493
Waldenstrons macroglobulinemia 4 | 765
atypical teratoid / rhabdoid tumor 4 | 5,112
ependymoma 4 | 4,679
glioblastoma 4 | 5,792
medulloblastoma, large-cell 4 | 6,241
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
psoriasis 4 | 6,694
Breast cancer 3 | 3,578
group 3 medulloblastoma 3 | 4,104
lung cancer 3 | 4,740
Cerebellar Ataxia 2 | 304
Dysarthria 2 | 192
Epilepsy 2 | 792
Hypoglycemia 2 | 152
Increased serum lactate 2 | 60
Metabolic acidosis 2 | 90
Mitochondrial Complex III Deficiency 2 | 9
Muscle hypotonia 2 | 571
Neurodegenerative disease 2 | 414
Neuropathy 2 | 261
Nystagmus 2 | 317
Optic Atrophy 2 | 242
Seizures 2 | 596
adult high grade glioma 2 | 3,801
breast carcinoma 2 | 1,638
cystic fibrosis 2 | 1,696
diabetes mellitus 2 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
medulloblastoma 2 | 720
tuberculosis 2 | 2,010
Abnormal respiratory patterns 1 | 20
Abnormal visual evoked potential 1 | 26
Action Tremor 1 | 22
Areflexia of lower limbs 1 | 9
Ataxia, Appendicular 1 | 25
Basal cell carcinoma 1 | 54
Basal cell nevi 1 | 23
Birthmark 1 | 35
Brain disease 1 | 96
Cafe au lait spots, multiple 1 | 17
Cafe-au-Lait Spots 1 | 37
Central nervous system demyelination 1 | 28
Cerebellar Dysmetria 1 | 56
Charcot-Marie-Tooth disease 1 | 62
Colon diverticulum anatomic structure 1 | 15
Colorectal Neoplasms, Hereditary Nonpolyposis 1 | 9
Colorectal cancer 1 | 25
Congenital myasthenic syndrome, acetazolamide-responsive 1 | 5
Death in early adulthood 1 | 24
Decreased amplitude of sensory action potentials 1 | 2
Decreased sensory nerve conduction velocities (NCV) 1 | 8
Diverticular disease of colon 1 | 15
Familial adenomatous polyposis 1 | 32
Fatal familial insomnia 1 | 10
Fibrous skin tumor of tuberous sclerosis 1 | 18
Friedreich ataxia 1 | 24
Gait imbalance 1 | 17
Gastrointestinal Hemorrhage 1 | 52
Glioma 1 | 74
Glioma Susceptibility 1 1 | 5
Hematologic Neoplasms 1 | 22
Hepatocellular necrosis 1 | 14
Hereditary Nonpolyposis Colorectal Cancer 1 | 11
Hereditary Nonpolyposis Colorectal Neoplasms 1 | 8
Hyperpigmented macules 1 | 42
Hypertrichosis 1 | 46
Increased gastric cancer 1 | 21
Intermittent migraine headaches 1 | 68
Irritation - emotion 1 | 68
Kyphoscoliosis deformity of spine 1 | 60
Leigh disease 1 | 100
Leigh syndrome 1 | 28
Leigh syndrome , French Canadian type 1 | 2
Leigh syndrome, French Canadian type 1 | 2
Lynch Syndrome 1 1 | 4
Lynch syndrome 1 | 35
Lynch syndrome I (site-specific colonic cancer) 1 | 3
Malignant tumor of colon 1 | 19
Migraine Disorders 1 | 76
Mitochondrial myopathy 1 | 26
Neurofibroma 1 | 8
Ovarian Neoplasms 1 | 102
Rectal Neoplasms 1 | 18
Rhabdomyosarcoma 1 | 39
Scoliosis 1 | 44
Sebaceous adenoma 1 | 26
Sensory neuropathy 1 | 20
Sideroblastic anemia 1 | 20
Spastic Ataxia 1 | 18
Terminal tremor 1 | 20
Xeroderma pigmentosum 1 | 43
cytochrome-c oxidase deficiency disease 1 | 19
ovarian neoplasm 1 | 99

Tissue

Blood and immune system 12 | 16,909
Cardiovascular System 12 | 15,192
Digestive Tract 12 | 17,369
Endocrine System 12 | 18,159
Female tissues 12 | 17,400
Liver and Pancreas 12 | 16,750
Male tissues 12 | 17,142
Nervous System 12 | 16,725
Respiratory system 12 | 16,393
Skin and soft tissues 12 | 17,230
Urinary Tract 12 | 16,678

Target Family

Non-IDG 8 | 12,091
Enzyme 4 | 4,145

GO Process

oxidative phosphorylation 12 | 12
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cytochrome b-c1 complex subunit 1, mitochondrial UQCRC1 Tbio Enzyme -1.46124 30.0 217
Cytochrome b-c1 complex subunit 2, mitochondrial UQCRC2 Tbio Enzyme -1.36380 22.0 162
Frataxin, mitochondrial FXN Tbio Non-IDG -3.02739 1114.8 403
Protein NipSnap homolog 2 NIPSNAP2 Tbio Non-IDG -1.14418 12.4 214
Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial CHCHD10 Tbio Non-IDG -1.66971 48.9 60
Transcription elongation factor, mitochondrial TEFM Tbio Non-IDG -0.67099 4.91 61
ATP synthase subunit gamma, mitochondrial ATP5F1C Tbio Enzyme -0.64361 3.84 139
Cytochrome b-c1 complex subunit 7 UQCRB Tbio Non-IDG -1.29421 22.8 112
Surfeit locus protein 1 SURF1 Tbio Non-IDG -2.05564 112.5 104
DNA mismatch repair protein Msh2 MSH2 Tbio Non-IDG -3.15616 1465.0 503