Development Level

Tbio 93 | 11,651
Tchem 26 | 1,388
Tdark 12 | 6,593
Tclin 4 | 612

Collection

Ion Channel: IDG Consortium (T... 1 | 99
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 8 | 979
embryonic lethality prior to o... 5 | 239
abnormal behavior 4 | 298
embryonic lethality prior to t... 4 | 278
hypoactivity 4 | 132
abnormal lens morphology 3 | 81
cataract 3 | 92
decreased bone mineral content 3 | 151
decreased fasted circulating g... 3 | 65
decreased vertical activity 3 | 208
increased fasted circulating g... 3 | 76
preweaning lethality, incomple... 3 | 499
abnormal bone mineralization 2 | 38
abnormal heart morphology 2 | 162
decreased bone mineral density 2 | 126
decreased caudal vertebrae num... 2 | 53
decreased circulating amylase ... 2 | 28
decreased circulating triglyce... 2 | 79
decreased erythrocyte cell num... 2 | 62
decreased lean body mass 2 | 135
decreased mean corpuscular vol... 2 | 79
decreased prepulse inhibition 2 | 82
enlarged heart 2 | 210
increased bone mineral content 2 | 108
increased circulating amylase ... 2 | 25
increased lean body mass 2 | 172
increased mean corpuscular vol... 2 | 92
increased startle reflex 2 | 112
persistence of hyaloid vascula... 2 | 33
abnormal bone structure 1 | 187
abnormal coat-hair pigmentatio... 1 | 64
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal gait 1 | 69
abnormal head size 1 | 6
abnormal heart left ventricle ... 1 | 16
abnormal iris morphology 1 | 13
abnormal lung morphology 1 | 26
abnormal response to new envir... 1 | 10
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal skin morphology 1 | 50
abnormal sleep behavior 1 | 70
abnormal snout morphology 1 | 23
abnormal spleen morphology 1 | 55
abnormal vibrissa morphology 1 | 25
absent testes 1 | 6
anophthalmia 1 | 33
convulsive seizures 1 | 13
decreased blood urea nitrogen ... 1 | 51
decreased body weight 1 | 161
decreased circulating LDL chol... 1 | 38
decreased circulating bilirubi... 1 | 19
decreased circulating calcium ... 1 | 36
decreased circulating chloride... 1 | 30
decreased circulating insulin ... 1 | 76
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased grip strength 1 | 116
decreased hemoglobin content 1 | 68
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
decreased total body fat amoun... 1 | 207
edema 1 | 59
enlarged heart atrium 1 | 4
enlarged lymph nodes 1 | 37
hydrometra 1 | 53
hyperactivity 1 | 148
impaired pupillary reflex 1 | 26
impaired righting response 1 | 26
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased bone mineral density 1 | 72
increased cardiac muscle contr... 1 | 8
increased circulating alkaline... 1 | 122
increased circulating fructosa... 1 | 13
increased circulating iron lev... 1 | 30
increased circulating magnesiu... 1 | 10
increased circulating potassiu... 1 | 29
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased erythrocyte cell num... 1 | 39
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 96
increased mean platelet volume 1 | 45
increased spleen weight 1 | 10
increased total body fat amoun... 1 | 134
mammalian phenotype 1 | 17
narrow eye opening 1 | 12
pallor 1 | 34
small kidney 1 | 16
stereotypic behavior 1 | 3
tremors 1 | 39
trunk curl 1 | 16

Disease

Carcinoma 74 | 11,493
ovarian cancer 65 | 8,520
osteosarcoma 60 | 7,950
psoriasis 57 | 6,694
lung cancer 47 | 4,740
medulloblastoma, large-cell 44 | 6,241
ependymoma 39 | 4,679
pancreatic ductal adenocarcinoma liver metastasis 37 | 1,962
atypical teratoid / rhabdoid tumor 36 | 5,112
glioblastoma 34 | 5,792
Autosomal recessive predisposition 32 | 1,442
non-small cell lung cancer 32 | 2,890
Cancer 31 | 2,499
tuberculosis 31 | 2,010
intraductal papillary-mucinous neoplasm (IPMN) 30 | 3,291
interstitial cystitis 29 | 2,312
adult high grade glioma 28 | 3,801
group 3 medulloblastoma 28 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 28 | 2,955
malignant mesothelioma 28 | 3,232
invasive ductal carcinoma 27 | 2,951
lung carcinoma 26 | 2,843
pancreatic cancer 24 | 2,398
Astrocytoma, Pilocytic 22 | 3,081
primitive neuroectodermal tumor 22 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 21 | 2,989
astrocytic glioma 19 | 2,597
Breast cancer 18 | 3,578
lung adenocarcinoma 18 | 2,716
ulcerative colitis 18 | 1,819
Pick disease 17 | 1,894
adrenocortical carcinoma 17 | 1,428
cystic fibrosis 17 | 1,696
diabetes mellitus 17 | 1,728
oligodendroglioma 17 | 2,850
Epilepsy 16 | 792
ductal carcinoma in situ 16 | 1,745
Intellectual disability 15 | 1,016
breast carcinoma 15 | 1,638
subependymal giant cell astrocytoma 15 | 2,287
Atopic dermatitis 14 | 952
Hypertension 14 | 396
Schizophrenia 14 | 1,160
colon cancer 14 | 1,478
primary pancreatic ductal adenocarcinoma 14 | 1,109
Cognitive delay 13 | 608
Dull intelligence 13 | 645
Global developmental delay 13 | 608
Liver Cirrhosis, Experimental 13 | 769
Low intelligence 13 | 645
Mental Retardation 13 | 645
Mental and motor retardation 13 | 608
Mental deficiency 13 | 645
Muscle hypotonia 13 | 571
Poor school performance 13 | 645
esophageal adenocarcinoma 13 | 737
pituitary cancer 13 | 1,972
Kidney disease 12 | 430
Seizures 12 | 596
gastric carcinoma 12 | 807
nasopharyngeal carcinoma 12 | 1,058
Failure to gain weight 11 | 365
Kidney cancer 11 | 2,613
Multiple myeloma 11 | 1,332
Pediatric failure to thrive 11 | 365
Prostatic Neoplasms 11 | 495
cutaneous lupus erythematosus 11 | 1,057
non primary Sjogren syndrome sicca 11 | 891
Breast Neoplasms 10 | 445
active Crohn's disease 10 | 922
acute myeloid leukemia 10 | 783
acute quadriplegic myopathy 10 | 1,158
group 4 medulloblastoma 10 | 1,855
Chemical and Drug Induced Liver Injury 9 | 195
Hepatomegaly 9 | 285
Mammary Neoplasms 9 | 425
head and neck cancer and chronic obstructive pulmonary disease 9 | 239
Atherosclerosis 8 | 291
Dysarthria 8 | 192
Dystonia 8 | 164
Obesity 8 | 678
aldosterone-producing adenoma 8 | 665
nephrosclerosis 8 | 333
Alcoholic Intoxication, Chronic 7 | 289
Cerebellar Ataxia 7 | 304
Chronic granulomatous disease 7 | 13
Drug-Related Side Effects and Adverse Reactions 7 | 62
Liver disease 7 | 237
Malaria 7 | 160
Muscle Spasticity 7 | 195
Nystagmus 7 | 317
Small head 7 | 374
astrocytoma 7 | 1,146
Alzheimer's disease 6 | 658
Contact Dermatitis 6 | 81
Dermatitis, Contact 6 | 71
Endometriosis 6 | 540
Polycystic ovary syndrome 6 | 360
autosomal dominant Emery-Dreifuss muscular dystrophy 6 | 510
juvenile dermatomyositis 6 | 1,187

Tissue

Digestive Tract 131 | 17,369
Skin and soft tissues 130 | 17,230
Blood and immune system 129 | 16,909
Female tissues 129 | 17,400
Endocrine System 128 | 18,159
Liver and Pancreas 128 | 16,750
Male tissues 127 | 17,142
Urinary Tract 127 | 16,678
Nervous System 123 | 16,725
Respiratory system 122 | 16,393
Cardiovascular System 113 | 15,192

Target Family

Enzyme 84 | 4,145
Non-IDG 48 | 12,091
Ion Channel 3 | 344

GO Process

oxidation-reduction process 135 | 135
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Myeloperoxidase MPO Tchem Enzyme -3.51470 3209.3 1255
Carbonyl reductase family member 4 CBR4 Tbio Enzyme -1.69083 48.5 128
Dual oxidase 2 DUOX2 Tbio Enzyme -2.45061 251.8 126
Dual oxidase 1 DUOX1 Tbio Enzyme -2.50131 279.5 85
Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 Tchem Enzyme -2.12624 141.3 310
NADPH oxidase 1 NOX1 Tchem Enzyme -2.59188 397.6 233
Hypoxia-inducible factor 1-alpha inhibitor HIF1AN Tbio Non-IDG -1.91636 75.1 429
Long-chain specific acyl-CoA dehydrogenase, mitochondrial ACADL Tbio Enzyme -1.52646 31.4 231
NADPH oxidase 5 NOX5 Tbio Enzyme -1.82693 76.8 174
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 PLOD1 Tbio Enzyme -2.10120 119.8 88