Development Level

Tbio 31 | 11,445
Tchem 10 | 1,598
Tclin 2 | 613

Collection

GPCR: IDG Consortium (Targets) 2 | 126
RFA-RM-18-021 2 | 328

IMPC Phenotype

preweaning lethality, complete... 5 | 979
abnormal behavior 2 | 298
abnormal bone structure 2 | 187
embryonic lethality prior to o... 2 | 239
impaired glucose tolerance 2 | 75
abnormal behavioral response t... 1 | 66
abnormal bone mineralization 1 | 38
abnormal embryo size 1 | 220
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal tail movements 1 | 12
decreased blood urea nitrogen ... 1 | 51
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased circulating chloride... 1 | 30
decreased circulating creatini... 1 | 39
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased lean body mass 1 | 135
decreased vertical activity 1 | 208
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
hyperactivity 1 | 148
increased lymphocyte cell numb... 1 | 32
increased respiratory quotient 1 | 2
increased spleen weight 1 | 10
increased startle reflex 1 | 112
kinked tail 1 | 2
mammalian phenotype 1 | 17
prenatal lethality 1 | 28
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 31 | 11,493
ovarian cancer 29 | 8,520
Breast cancer 21 | 3,578
Cancer 21 | 2,499
medulloblastoma, large-cell 21 | 6,241
osteosarcoma 21 | 7,950
psoriasis 20 | 6,694
malignant mesothelioma 18 | 3,232
glioblastoma 17 | 5,792
lung cancer 17 | 4,740
invasive ductal carcinoma 16 | 2,951
atypical teratoid / rhabdoid tumor 15 | 5,112
interstitial cystitis 14 | 2,312
adult high grade glioma 13 | 3,801
lung adenocarcinoma 13 | 2,716
non-small cell lung cancer 13 | 2,890
ductal carcinoma in situ 12 | 1,745
ependymoma 12 | 4,679
lung carcinoma 12 | 2,843
oligodendroglioma 12 | 2,850
Astrocytoma, Pilocytic 11 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
breast carcinoma 10 | 1,638
group 3 medulloblastoma 10 | 4,104
pancreatic cancer 10 | 2,398
Congenital heart disease 9 | 93
cystic fibrosis 9 | 1,696
group 4 medulloblastoma 9 | 1,855
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
Breast Neoplasms 8 | 445
Kidney cancer 8 | 2,613
Mammary Neoplasms 8 | 425
Obesity 8 | 678
Rheumatoid arthritis 8 | 1,191
acute quadriplegic myopathy 8 | 1,158
Epilepsy 7 | 792
Schizophrenia 7 | 1,160
astrocytic glioma 7 | 2,597
astrocytoma 7 | 1,146
dermatomyositis 7 | 966
primitive neuroectodermal tumor 7 | 3,035
tuberculosis 7 | 2,010
Brachydactyly 6 | 156
Cleft Palate 6 | 271
Craniofacial Abnormalities 6 | 151
Hypertension 6 | 396
Intellectual disability 6 | 1,016
Muscle hypotonia 6 | 571
Short stature 6 | 531
Small head 6 | 374
autosomal dominant Emery-Dreifuss muscular dystrophy 6 | 510
colon cancer 6 | 1,478
gastric carcinoma 6 | 807
juvenile dermatomyositis 6 | 1,187
Bipolar Disorder 5 | 666
Byzanthine arch palate 5 | 194
Colonic Neoplasms 5 | 142
Concave bridge of nose 5 | 195
Conductive hearing loss 5 | 123
Congenital Heart Defects 5 | 58
Cryptorchidism 5 | 296
Depressed nasal bridge 5 | 195
Depressed nasal root/bridge 5 | 195
Dull intelligence 5 | 645
Exophthalmos 5 | 112
Feeding difficulties in infancy 5 | 175
Fetal Growth Retardation 5 | 189
Glaucoma 5 | 239
Heart Defects, Congenital 5 | 37
Hernia, Inguinal 5 | 89
Hypertensive disease 5 | 292
Infant, Small for Gestational Age 5 | 176
Intrauterine retardation 5 | 176
Low intelligence 5 | 645
Low set ears 5 | 181
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Narrow face 5 | 54
Poor school performance 5 | 645
Preauricular Fistulae, Congenital 5 | 27
Preauricular dimple 5 | 27
Preauricular sinus 5 | 27
Prominent eyes 5 | 96
Prominent globes 5 | 96
Protruding eyes 5 | 96
Seizures 5 | 596
Strabismus 5 | 270
Tetralogy of Fallot 5 | 63
Thin face 5 | 54
Vesico-Ureteral Reflux 5 | 33
aldosterone-producing adenoma 5 | 665
diabetes mellitus 5 | 1,728
fibroadenoma 5 | 559
pediatric high grade glioma 5 | 1,064
pituitary cancer 5 | 1,972
mucosa-associated lymphoid tissue lymphoma 4 | 484
primary pancreatic ductal adenocarcinoma 4 | 1,109
subependymal giant cell astrocytoma 4 | 2,287
ulcerative colitis 4 | 1,819

Tissue

Digestive Tract 43 | 17,369
Endocrine System 43 | 18,159
Nervous System 43 | 16,725
Skin and soft tissues 43 | 17,230
Blood and immune system 42 | 16,909
Female tissues 42 | 17,400
Male tissues 42 | 17,142
Liver and Pancreas 41 | 16,750
Respiratory system 41 | 16,393
Urinary Tract 40 | 16,678
Cardiovascular System 39 | 15,192

Target Family

Transcription Factor 18 | 1,400
Non-IDG 13 | 12,091
GPCR 5 | 408
Kinase 4 | 634
Enzyme 2 | 4,145
Ion Channel 1 | 344

GO Process

outflow tract morphogenesis 43 | 43
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Plexin-D1 PLXND1 Tbio Non-IDG -1.64721 46.3 171
T-box transcription factor TBX1 TBX1 Tbio Transcription Factor -1.99519 95.5 207
Bone morphogenetic protein receptor type-2 BMPR2 Tchem Kinase -2.66587 458.1 390
Claudin-5 CLDN5 Tbio Non-IDG -2.58968 349.4 300
T-box transcription factor TBX3 TBX3 Tbio Transcription Factor -2.42253 255.6 328
Gap junction alpha-5 protein GJA5 Tbio Non-IDG -2.59423 377.5 194
Insulin gene enhancer protein ISL-1 ISL1 Tbio Transcription Factor -2.63352 410.3 382
Bone morphogenetic protein receptor type-1A BMPR1A Tchem Kinase -2.34984 211.0 622
Short-chain dehydrogenase/reductase 3 DHRS3 Tbio Enzyme -1.18257 14.7 125
Transcription factor SOX-11 SOX11 Tbio Transcription Factor -2.01545 106.1 219