Development Level

Tbio 11 | 11,651
Tchem 1 | 1,388
Tdark 1 | 6,593

IMPC Phenotype

abnormal behavior 1 | 298
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal locomotor behavior 1 | 24
abnormal lung morphology 1 | 26
abnormal seminal vesicle morph... 1 | 114
decreased circulating creatini... 1 | 39
decreased hemoglobin content 1 | 68
decreased lymphocyte cell numb... 1 | 83
enlarged heart 1 | 210
enlarged lung 1 | 2
hypoactivity 1 | 132
increased bone mineral content 1 | 108
increased monocyte cell number 1 | 63
preweaning lethality, incomple... 1 | 499
small kidney 1 | 16

Disease

ovarian cancer 8 | 8,520
Carcinoma 7 | 11,493
lung adenocarcinoma 7 | 2,716
glioblastoma 6 | 5,792
medulloblastoma, large-cell 6 | 6,241
atypical teratoid / rhabdoid tumor 5 | 5,112
cystic fibrosis 5 | 1,696
group 4 medulloblastoma 5 | 1,855
lung cancer 5 | 4,740
osteosarcoma 5 | 7,950
psoriasis 5 | 6,694
adult high grade glioma 4 | 3,801
ependymoma 4 | 4,679
interstitial cystitis 4 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
oligodendroglioma 4 | 2,850
Astrocytoma, Pilocytic 3 | 3,081
Autosomal recessive predisposition 3 | 1,442
Breast cancer 3 | 3,578
Congenital disorder of glycosylation 3 | 54
Pick disease 3 | 1,894
astrocytic glioma 3 | 2,597
invasive ductal carcinoma 3 | 2,951
malignant mesothelioma 3 | 3,232
non-small cell lung cancer 3 | 2,890
non-small cell lung carcinoma 3 | 317
pancreatic cancer 3 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
tuberculosis 3 | 2,010
Big calvaria 2 | 147
Cancer 2 | 2,499
Cognitive delay 2 | 608
Epilepsy 2 | 792
Failure to gain weight 2 | 365
Global developmental delay 2 | 608
Increased head circumference 2 | 147
Increased size of cranium 2 | 147
Increased size of skull 2 | 147
Mental and motor retardation 2 | 608
Muscle hypotonia 2 | 571
Pediatric failure to thrive 2 | 365
Schizophrenia 2 | 1,160
Seizures 2 | 596
Small head 2 | 374
active Crohn's disease 2 | 922
adrenocortical carcinoma 2 | 1,428
diabetes mellitus 2 | 1,728
group 3 medulloblastoma 2 | 4,104
lung carcinoma 2 | 2,843
nasopharyngeal carcinoma 2 | 1,058
non primary Sjogren syndrome sicca 2 | 891
Absent speech 1 | 43
Antithrombin III deficiency 1 | 14
Barrett's esophagus 1 | 182
Blood Coagulation Disorders 1 | 42
Brachycephaly 1 | 88
Broad cranium shape 1 | 88
Cardiovascular system disease 1 | 246
Coagulation abnormalities 1 | 27
Congenital Disorder Of Glycosylation, Type IIID 1 | 1
Congenital disorder of glycosylation type 2D 1 | 1
Coxa valga 1 | 22
Coxa valga deformity 1 | 22
Cystinosis 1 | 14
Degenerative brain disorder 1 | 100
Downward slant of palpebral fissure 1 | 158
Dry skin 1 | 75
Factor XI Deficiency 1 | 12
Flexion contracture 1 | 93
Flexion contractures of joints 1 | 93
Generalized osteopenia 1 | 99
Gout 1 | 104
Hemorrhagic Disorders 1 | 30
Impaired cognition 1 | 96
Large auricle 1 | 87
Large dysplastic ears 1 | 87
Large pinnae 1 | 87
Large prominent ears 1 | 87
Large protruding ears 1 | 87
Large, floppy ears 1 | 87
Long eyelashes 1 | 37
Macrotia 1 | 87
Mental impairment 1 | 95
Osteopenia 1 | 99
Prenatal onset 1 | 139
Protrusion of tongue 1 | 11
Retrognathia 1 | 54
Salivary Gland Neoplasms 1 | 46
Sensorineural Hearing Loss (disorder) 1 | 284
Severe mental retardation (I.Q. 20-34) 1 | 99
Slender, gracile long tubular bones 1 | 21
Stereotyped Behavior 1 | 37
Stereotypic Movement Disorder 1 | 42
Supratentorial atrophy 1 | 94
Tall stature 1 | 34
Wide skull shape 1 | 88
Xerosis 1 | 75
nonverbal 1 | 43

Tissue

Blood and immune system 13 | 16,909
Digestive Tract 13 | 17,369
Endocrine System 13 | 18,159
Female tissues 13 | 17,400
Liver and Pancreas 13 | 16,750
Male tissues 13 | 17,142
Nervous System 13 | 16,725
Respiratory system 13 | 16,393
Skin and soft tissues 13 | 17,230
Urinary Tract 13 | 16,678
Cardiovascular System 12 | 15,192

Target Family

Enzyme 12 | 4,145
Non-IDG 1 | 12,091

GO Process

oligosaccharide biosynthetic p... 13 | 13
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

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