Development Level

Tbio 16 | 11,445
Tchem 4 | 1,598
Tclin 3 | 613
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 5 | 979
embryonic lethality prior to t... 3 | 278
embryonic lethality prior to o... 2 | 239
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal gait 1 | 69
abnormal maxilla morphology 1 | 17
decreased body weight 1 | 161
decreased circulating glucose ... 1 | 126
decreased granulocyte number 1 | 6
decreased hemoglobin content 1 | 68
decreased large unstained cell... 1 | 11
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
enlarged heart 1 | 210
impaired glucose tolerance 1 | 75
increased blood urea nitrogen ... 1 | 48
increased circulating alkaline... 1 | 122
increased mean corpuscular hem... 1 | 96
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
short tibia 1 | 97
thrombocytopenia 1 | 56

Disease

Carcinoma 18 | 11,493
osteosarcoma 14 | 7,950
ovarian cancer 13 | 8,520
ependymoma 12 | 4,679
glioblastoma 12 | 5,792
medulloblastoma, large-cell 12 | 6,241
Epilepsy 11 | 792
Seizures 10 | 596
lung cancer 10 | 4,740
Muscle hypotonia 9 | 571
atypical teratoid / rhabdoid tumor 9 | 5,112
psoriasis 9 | 6,694
Astrocytoma, Pilocytic 8 | 3,081
Cancer 8 | 2,499
group 3 medulloblastoma 8 | 4,104
malignant mesothelioma 8 | 3,232
pancreatic cancer 8 | 2,398
oligodendroglioma 7 | 2,850
primitive neuroectodermal tumor 7 | 3,035
subependymal giant cell astrocytoma 7 | 2,287
Big calvaria 6 | 147
Brain hypomyelination 6 | 11
Breast cancer 6 | 3,578
Increased head circumference 6 | 147
Increased size of cranium 6 | 147
Increased size of skull 6 | 147
Mood swings 6 | 77
Muscle Spasticity 6 | 195
Schizophrenia 6 | 1,160
adult high grade glioma 6 | 3,801
Autosomal recessive predisposition 5 | 1,442
Central nervous system demyelination 5 | 28
Cessation of head growth 5 | 5
Childhood Ataxia with Central Nervous System Hypomyelinization 5 | 6
Decreased serum progesterone 5 | 5
Delusions 5 | 11
Developmental regression 5 | 95
Down syndrome 5 | 499
Dull intelligence 5 | 645
Dysarthria 5 | 192
Forgetful 5 | 40
Gait, Unsteady 5 | 29
Intellectual disability 5 | 1,016
Lethargy 5 | 77
Leukodystrophy 5 | 55
Leukoencephalopathies 5 | 29
Leukoencephalopathy with vanishing white matter 5 | 20
Loss of developmental milestones 5 | 95
Low intelligence 5 | 645
Memory Loss 5 | 40
Memory impairment 5 | 40
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Mental deterioration in childhood 5 | 95
Neurodevelopmental regression 5 | 95
OVARIOLEUKODYSTROPHY 5 | 6
Optic Atrophy 5 | 242
Personality change 5 | 23
Poor school performance 5 | 645
Premature Menopause 5 | 31
Primary gonadal insufficiency 5 | 9
Prostatic Neoplasms 5 | 495
Psychomotor regression 5 | 95
Psychomotor regression beginning in infancy 5 | 95
Psychomotor regression in infants 5 | 95
Psychomotor regression, progressive 5 | 95
Secondary physiologic amenorrhea 5 | 32
Vanishing White Matter Leukodystrophy with Ovarian Failure 5 | 5
interstitial cystitis 5 | 2,312
lung carcinoma 5 | 2,843
pediatric high grade glioma 5 | 1,064
Cognitive delay 4 | 608
Congenital deafness 4 | 185
Deafness 4 | 198
Global developmental delay 4 | 608
Hearing Loss, Partial 4 | 185
Mental and motor retardation 4 | 608
Strabismus 4 | 270
active ulcerative colitis 4 | 764
astrocytic glioma 4 | 2,597
astrocytoma 4 | 1,146
breast carcinoma 4 | 1,638
cystic fibrosis 4 | 1,696
diabetes mellitus 4 | 1,728
ductal carcinoma in situ 4 | 1,745
esophageal adenocarcinoma 4 | 737
group 4 medulloblastoma 4 | 1,855
hearing impairment 4 | 199
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
invasive ductal carcinoma 4 | 2,951
pituitary cancer 4 | 1,972
Duchenne muscular dystrophy 3 | 601
Multiple myeloma 3 | 1,332
adrenocortical carcinoma 3 | 1,428
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 510
gastric carcinoma 3 | 807
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
primary pancreatic ductal adenocarcinoma 3 | 1,109

Tissue

Digestive Tract 24 | 17,369
Endocrine System 24 | 18,159
Nervous System 24 | 16,725
Skin and soft tissues 24 | 17,230
Female tissues 23 | 17,400
Liver and Pancreas 23 | 16,750
Male tissues 23 | 17,142
Urinary Tract 23 | 16,678
Blood and immune system 22 | 16,909
Respiratory system 22 | 16,393
Cardiovascular System 21 | 15,192

Target Family

Non-IDG 11 | 12,091
Transcription Factor 6 | 1,400
Enzyme 2 | 4,145
Epigenetic 2 | 242
GPCR 1 | 408
Kinase 1 | 634
TF/Epigenetic 1 | 38

GO Process

oligodendrocyte development 24 | 24
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Translation initiation factor eIF-2B subunit delta EIF2B4 Tbio Non-IDG -1.06082 11.3 145
Achaete-scute homolog 1 ASCL1 Tbio Transcription Factor -2.44791 277.6 405
Transcription factor HES-5 HES5 Tbio Transcription Factor -2.08501 97.6 139
Mediator of RNA polymerase II transcription subunit 12 MED12 Tbio Enzyme -2.60835 402.9 124
Transcription factor SOX-10 SOX10 Tbio Transcription Factor -2.69195 478.2 389
Gelsolin GSN Tbio Non-IDG -3.11676 1340.4 481
Transcription factor SOX-11 SOX11 Tbio Transcription Factor -2.01545 106.1 219
Translation initiation factor eIF-2B subunit gamma EIF2B3 Tbio Non-IDG -1.21999 16.3 170
PR domain zinc finger protein 8 PRDM8 Tbio TF/Epigenetic -1.04610 12.6 94
Homeobox protein Nkx-2.2 NKX2-2 Tbio Transcription Factor -2.06202 108.0 379