Development Level

Tbio 32 | 11,651
Tchem 3 | 1,388
Tclin 2 | 612

IMPC Phenotype

preweaning lethality, complete... 7 | 979
embryonic lethality prior to o... 5 | 239
embryonic lethality prior to t... 2 | 278
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal pharyngeal arch morph... 1 | 8
abnormal retina morphology 1 | 71
abnormal retinal inner nuclear... 1 | 8
decreased KLRG1+ CD4 alpha bet... 1 | 5
decreased circulating glucose ... 1 | 126
decreased circulating triglyce... 1 | 79
decreased total retina thickne... 1 | 17
embryonic growth retardation 1 | 106
increased anti-nuclear antigen... 1 | 19
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating potassiu... 1 | 29
increased heart weight 1 | 62
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499

Disease

ovarian cancer 25 | 8,520
Carcinoma 20 | 11,493
osteosarcoma 17 | 7,950
lung cancer 16 | 4,740
Cockayne syndrome 15 | 60
Xeroderma pigmentosum 13 | 43
Cancer 12 | 2,499
malignant mesothelioma 12 | 3,232
group 3 medulloblastoma 11 | 4,104
medulloblastoma, large-cell 11 | 6,241
atypical teratoid / rhabdoid tumor 10 | 5,112
glioblastoma 10 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
psoriasis 10 | 6,694
Autosomal recessive predisposition 9 | 1,442
Hypogonadism 9 | 173
Photosensitive trichothiodystrophy 9 | 30
Sensorineural Hearing Loss (disorder) 9 | 284
Cryptorchidism 8 | 296
Intellectual disability 8 | 1,016
Melanoma 8 | 711
Photosensitivity of skin 8 | 51
Short stature 8 | 531
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
Arthralgia 7 | 90
Atrophic condition of skin 7 | 25
Cataract 7 | 297
Conjunctival telangiectasis 7 | 14
Dull intelligence 7 | 645
Electroencephalogram abnormal 7 | 101
Lens Opacities 7 | 231
Low intelligence 7 | 645
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Poor school performance 7 | 645
Small head 7 | 374
Strabismus 7 | 270
non-small cell lung cancer 7 | 2,890
primitive neuroectodermal tumor 7 | 3,035
Basal cell carcinoma 6 | 54
Breast cancer 6 | 3,578
Cerebellar Ataxia 6 | 304
Dental abnormalities 6 | 60
Developmental regression 6 | 95
Dry skin 6 | 75
Erythema 6 | 58
Failure to gain weight 6 | 365
Fatigue 6 | 182
Fever 6 | 138
Flushing 6 | 60
Freckles 6 | 33
Hyperkeratosis 6 | 50
Hyperpigmented macules 6 | 42
Hypoplastic mandible condyle 6 | 275
Impaired cognition 6 | 96
Keratitis 6 | 62
Loss of developmental milestones 6 | 95
Mandibular hypoplasia 6 | 275
Mental deterioration in childhood 6 | 95
Mental impairment 6 | 95
Micrognathism 6 | 275
Muscle Spasticity 6 | 195
Neurodevelopmental regression 6 | 95
Optic Atrophy 6 | 242
Papilloma 6 | 44
Pediatric failure to thrive 6 | 365
Poikiloderma 6 | 14
Progressive mental retardation 6 | 37
Psychomotor regression 6 | 95
Psychomotor regression beginning in infancy 6 | 95
Psychomotor regression in infants 6 | 95
Psychomotor regression, progressive 6 | 95
Telangiectasia of the skin 6 | 39
Thin skin 6 | 47
Tooth Abnormalities 6 | 69
Xerosis 6 | 75
ependymoma 6 | 4,679
hypopigmented skin patch 6 | 59
nasopharyngeal carcinoma 6 | 1,058
Basal cell nevi 5 | 23
Cachexia 5 | 50
Cognitive delay 5 | 608
Deafness 5 | 198
Defective DNA repair after ultraviolet radiation damage 5 | 7
Epilepsy 5 | 792
Global developmental delay 5 | 608
Low Vision 5 | 174
Mental and motor retardation 5 | 608
Muscle hypotonia 5 | 571
Seizures 5 | 596
Squamous cell carcinoma of skin 5 | 11
Visual Impairment 5 | 174
Xeroderma pigmentosum group B 5 | 20
Xeroderma pigmentosum group D 5 | 33
Xeroderma pigmentosum group G 5 | 16
acute myeloid leukemia 5 | 783
astrocytoma 5 | 1,146
diabetes mellitus 5 | 1,728
Abnormally small eyeball 4 | 97
Decreased size of eyeball 4 | 97

Tissue

Blood and immune system 37 | 16,909
Cardiovascular System 37 | 15,192
Digestive Tract 37 | 17,369
Endocrine System 37 | 18,159
Female tissues 37 | 17,400
Liver and Pancreas 37 | 16,750
Male tissues 37 | 17,142
Nervous System 37 | 16,725
Respiratory system 37 | 16,393
Skin and soft tissues 37 | 17,230
Urinary Tract 37 | 16,678

Target Family

Non-IDG 24 | 12,091
Enzyme 13 | 4,145

GO Process

nucleotide-excision repair, DN... 37 | 37
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
General transcription factor IIH subunit 1 GTF2H1 Tbio Non-IDG -1.65323 46.0 231
Chromodomain-helicase-DNA-binding protein 1-like CHD1L Tbio Enzyme -2.22453 176.8 129
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.06760 110.4 225
General transcription factor IIH subunit 3 GTF2H3 Tbio Non-IDG -0.87291 7.21 78
Cullin-4A CUL4A Tbio Non-IDG -1.92199 80.1 276
Cullin-4B CUL4B Tbio Non-IDG -1.68710 54.9 251
DNA polymerase delta subunit 2 POLD2 Tbio Enzyme -0.95222 8.52 115
Replication protein A 70 kDa DNA-binding subunit RPA1 Tchem Non-IDG -2.48277 297.9 350
E3 ubiquitin-protein ligase RBX1 RBX1 Tbio Enzyme -1.94266 72.1 260
Replication factor C subunit 4 RFC4 Tbio Non-IDG -1.17661 13.7 195