Development Level

Tbio 16 | 11,445

IMPC Phenotype

embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
preweaning lethality, complete... 2 | 979
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal heart morphology 1 | 162
abnormal tail movements 1 | 12
decreased body weight 1 | 161
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased lean body mass 1 | 135
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
enlarged heart 1 | 210
hydrometra 1 | 53
impaired glucose tolerance 1 | 75
increased circulating insulin ... 1 | 3
increased startle reflex 1 | 112
kinked tail 1 | 2
mammalian phenotype 1 | 17
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
small superior vagus ganglion 1 | 74

Disease

ovarian cancer 13 | 8,520
Carcinoma 12 | 11,493
ependymoma 10 | 4,679
psoriasis 9 | 6,694
Breast cancer 8 | 3,578
Cancer 8 | 2,499
atypical teratoid / rhabdoid tumor 8 | 5,112
interstitial cystitis 8 | 2,312
osteosarcoma 8 | 7,950
glioblastoma 7 | 5,792
group 3 medulloblastoma 7 | 4,104
medulloblastoma, large-cell 7 | 6,241
Astrocytoma, Pilocytic 6 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
non-small cell lung cancer 5 | 2,890
pancreatic cancer 5 | 2,398
Robinow syndrome 4 | 11
ductal carcinoma in situ 4 | 1,745
lung cancer 4 | 4,740
pediatric high grade glioma 4 | 1,064
primitive neuroectodermal tumor 4 | 3,035
Autosomal recessive predisposition 3 | 1,442
Colorectal Neoplasms 3 | 243
Duchenne muscular dystrophy 3 | 601
adult high grade glioma 3 | 3,801
astrocytic glioma 3 | 2,597
breast carcinoma 3 | 1,638
cutaneous lupus erythematosus 3 | 1,057
cystic fibrosis 3 | 1,696
gastric carcinoma 3 | 807
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
invasive ductal carcinoma 3 | 2,951
limb girdle muscular dystrophy 2A 3 | 213
lung adenocarcinoma 3 | 2,716
lung carcinoma 3 | 2,843
malignant mesothelioma 3 | 3,232
oligodendroglioma 3 | 2,850
pituitary cancer 3 | 1,972
primary pancreatic ductal adenocarcinoma 3 | 1,109
tuberculosis 3 | 2,010
Atopic dermatitis 2 | 952
Autosomal dominant Robinow syndrome 1 2 | 15
Breast Neoplasms 2 | 445
Broad flat nasal bridge 2 | 236
Congenital clinodactyly 2 | 57
Congenital hypoplasia of penis 2 | 176
Cryptorchidism 2 | 296
Curvature of digit 2 | 57
Dental caries 2 | 164
Female Urogenital Diseases 2 | 18
Frontal bossing 2 | 157
Hypoplastic mandible condyle 2 | 275
Hypotrophic malar bone 2 | 129
Long philtrum 2 | 137
Malar flattening 2 | 129
Mammary Neoplasms 2 | 425
Mandibular hypoplasia 2 | 275
Micrognathism 2 | 275
Nasal bridge wide 2 | 236
Obesity 2 | 678
Orbital separation excessive 2 | 244
Robinow Syndrome, Autosomal Dominant 2 | 3
active Crohn's disease 2 | 922
acute myeloid leukemia 2 | 783
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
diabetes mellitus 2 | 1,728
fibroadenoma 2 | 559
glioblastoma multiforme 2 | 142
head and neck cancer 2 | 271
interstitial lung disease 2 | 298
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
medulloblastoma 2 | 720
non diabetic and post-ischemic heart failure 2 | 200
sonic hedgehog group medulloblastoma 2 | 467
subependymal giant cell astrocytoma 2 | 2,287
type II diabetes mellitus and post-ischemic heart failure 2 | 88
ulcerative colitis 2 | 1,819
Absent carpal bones 1 | 2
Absent finger 1 | 4
Absent wrist bone 1 | 2
Cell Transformation, Neoplastic 1 | 97
Claw hand 1 | 26
Clitoral hypoplasia 1 | 11
Coloboma of eyelid 1 | 15
Coloboma of lens 1 | 4
Congenital coloboma of iris 1 | 4
Congenital hypoplasia of radius 1 | 23
Congenital pectus carinatum 1 | 52
Flexion contracture - elbow 1 | 32
Genitourinary Neoplasms 1 | 3
Hypoplastic pelvis 1 | 9
Inflammatory Bowel Diseases 1 | 35
Neoplastic Cell Transformation 1 | 89
Norrie disease 1 | 14
Ovarian Cysts 1 | 41
Platyspondyly 1 | 56
Radial ray hypoplasia 1 | 23
Short hands 1 | 50
Urogenital Neoplasms 1 | 3
substance-induced psychosis 1 | 8

Tissue

Blood and immune system 16 | 16,909
Digestive Tract 16 | 17,369
Endocrine System 16 | 18,159
Female tissues 16 | 17,400
Male tissues 16 | 17,142
Nervous System 16 | 16,725
Skin and soft tissues 16 | 17,230
Liver and Pancreas 15 | 16,750
Respiratory system 15 | 16,393
Urinary Tract 15 | 16,678
Cardiovascular System 14 | 15,192

Target Family

Non-IDG 8 | 12,091
GPCR 7 | 408
Kinase 1 | 634

GO Process

non-canonical Wnt signaling pa... 16 | 16
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Frizzled-9 FZD9 Tbio GPCR -1.77240 61.8 380
Frizzled-8 FZD8 Tbio GPCR -1.64874 42.5 233
Secreted frizzled-related protein 3 FRZB Tbio Non-IDG -2.51623 308.4 252
Secreted frizzled-related protein 5 SFRP5 Tbio Non-IDG -1.81796 74.9 180
Frizzled-6 FZD6 Tbio GPCR -1.63747 44.5 260
Frizzled-5 FZD5 Tbio GPCR -1.54924 30.5 307
Frizzled-1 FZD1 Tbio GPCR -2.07049 78.4 286
Protein Wnt-5a WNT5A Tbio Non-IDG -2.77525 650.2 321
Segment polarity protein dishevelled homolog DVL-2 DVL2 Tbio Non-IDG -1.87063 68.4 288
Frizzled-3 FZD3 Tbio GPCR -1.76528 56.4 314