Development Level

Tbio 75 | 11,445
Tchem 18 | 1,598
Tclin 5 | 613
Tdark 2 | 6,588

Collection

Kinase: IDG Consortium (Comple... 2 | 37
Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 8 | 979
preweaning lethality, incomple... 8 | 499
decreased startle reflex 4 | 75
decreased vertical activity 4 | 208
embryonic lethality prior to t... 4 | 278
enlarged heart 4 | 210
abnormal embryo size 3 | 220
embryonic growth retardation 3 | 106
increased circulating alkaline... 3 | 122
increased total body fat amoun... 3 | 134
prenatal lethality prior to he... 3 | 87
abnormal eye morphology 2 | 68
abnormal head morphology 2 | 10
abnormal startle reflex 2 | 15
abnormal tail morphology 2 | 25
decreased prepulse inhibition 2 | 82
embryonic lethality prior to o... 2 | 239
hemorrhage 2 | 23
increased circulating HDL chol... 2 | 80
increased circulating choleste... 2 | 66
mammalian phenotype 2 | 17
prenatal lethality 2 | 28
small superior vagus ganglion 2 | 74
abnormal behavior 1 | 298
abnormal behavioral response t... 1 | 66
abnormal bone mineralization 1 | 38
abnormal craniofacial morpholo... 1 | 33
abnormal duodenum morphology 1 | 4
abnormal epididymis morphology 1 | 42
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal limb morphology 1 | 13
abnormal optic disc morphology 1 | 10
abnormal ovary morphology 1 | 7
abnormal rib morphology 1 | 10
abnormal skin morphology 1 | 50
abnormal snout morphology 1 | 23
abnormal tooth morphology 1 | 24
absent epididymis 1 | 3
cataract 1 | 92
corneal opacity 1 | 32
cyanosis 1 | 7
decreased basophil cell number 1 | 16
decreased body weight 1 | 161
decreased circulating aspartat... 1 | 34
decreased circulating bilirubi... 1 | 19
decreased circulating chloride... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
edema 1 | 59
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
enlarged uterus 1 | 11
hydrometra 1 | 53
impaired glucose tolerance 1 | 75
improved glucose tolerance 1 | 79
increased bone mineral density 1 | 72
increased circulating creatini... 1 | 38
increased circulating phosphat... 1 | 26
increased fasted circulating g... 1 | 76
increased lean body mass 1 | 172
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
irregularly shaped pupil 1 | 7
long tibia 1 | 25
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
respiratory system phenotype 1 | 2
shortened QT interval 1 | 4
small testis 1 | 58
thrombocytopenia 1 | 56

Disease

Carcinoma 76 | 11,493
ovarian cancer 53 | 8,520
medulloblastoma, large-cell 50 | 6,241
glioblastoma 49 | 5,792
psoriasis 48 | 6,694
atypical teratoid / rhabdoid tumor 45 | 5,112
ependymoma 45 | 4,679
lung cancer 44 | 4,740
osteosarcoma 42 | 7,950
Breast cancer 37 | 3,578
Cancer 37 | 2,499
Schizophrenia 36 | 1,160
oligodendroglioma 34 | 2,850
Astrocytoma, Pilocytic 32 | 3,081
adult high grade glioma 31 | 3,801
malignant mesothelioma 31 | 3,232
Kidney cancer 30 | 2,613
lung carcinoma 30 | 2,843
group 3 medulloblastoma 29 | 4,104
non-small cell lung cancer 29 | 2,890
intraductal papillary-mucinous neoplasm (IPMN) 27 | 3,291
pituitary cancer 27 | 1,972
astrocytic glioma 26 | 2,597
primitive neuroectodermal tumor 26 | 3,035
invasive ductal carcinoma 25 | 2,951
Intellectual disability 24 | 1,016
intraductal papillary-mucinous carcinoma (IPMC) 24 | 2,989
colon cancer 23 | 1,478
intraductal papillary-mucinous adenoma (IPMA) 23 | 2,955
lung adenocarcinoma 22 | 2,716
Pick disease 21 | 1,894
interstitial cystitis 20 | 2,312
group 4 medulloblastoma 19 | 1,855
Epilepsy 18 | 792
breast carcinoma 18 | 1,638
pancreatic cancer 18 | 2,398
adrenocortical carcinoma 17 | 1,428
Alzheimer's disease 16 | 658
Cognitive delay 16 | 608
Global developmental delay 16 | 608
Mental and motor retardation 16 | 608
subependymal giant cell astrocytoma 16 | 2,287
Bipolar Disorder 15 | 666
Muscle hypotonia 15 | 571
tuberculosis 15 | 2,010
Dull intelligence 14 | 645
Low intelligence 14 | 645
Mental Retardation 14 | 645
Mental deficiency 14 | 645
Poor school performance 14 | 645
Seizures 14 | 596
cystic fibrosis 14 | 1,696
ductal carcinoma in situ 14 | 1,745
Lissencephaly 13 | 69
Small head 13 | 374
Autosomal recessive predisposition 12 | 1,442
Short stature 12 | 531
medulloblastoma 12 | 720
Autistic Disorder 11 | 364
ulcerative colitis 11 | 1,819
Down syndrome 10 | 499
Major Depressive Disorder 10 | 301
Strabismus 10 | 270
astrocytoma 10 | 1,146
Atopic dermatitis 9 | 952
Unipolar Depression 9 | 250
diabetes mellitus 9 | 1,728
nasopharyngeal carcinoma 9 | 1,058
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
primary pancreatic ductal adenocarcinoma 9 | 1,109
Cerebellar Ataxia 8 | 304
Low set ears 8 | 181
Melanoma 8 | 711
Orbital separation excessive 8 | 244
Skin cancer 8 | 469
spina bifida 8 | 1,074
Blepharoptosis 7 | 231
Congenital hypoplasia of penis 7 | 176
Cryptorchidism 7 | 296
Duchenne muscular dystrophy 7 | 601
High forehead 7 | 102
Hypoplastic mandible condyle 7 | 275
Mandibular hypoplasia 7 | 275
Mental Depression 7 | 333
Microcephaly 7 | 166
Micrognathism 7 | 275
Neoplasm Invasiveness 7 | 161
Neoplasm Metastasis 7 | 168
Nystagmus 7 | 317
Obesity 7 | 678
Rheumatoid arthritis 7 | 1,191
Tall forehead 7 | 102
Vascular disease 7 | 319
atypical teratoid/rhabdoid tumor 7 | 357
autosomal dominant Emery-Dreifuss muscular dystrophy 7 | 510
fibroadenoma 7 | 559
gastric carcinoma 7 | 807
pediatric high grade glioma 7 | 1,064
Uranostaphyloschisis 6 | 167
primary Sjogren syndrome 6 | 735

Tissue

Endocrine System 96 | 18,159
Digestive Tract 92 | 17,369
Skin and soft tissues 92 | 17,230
Nervous System 91 | 16,725
Liver and Pancreas 88 | 16,750
Female tissues 87 | 17,400
Blood and immune system 85 | 16,909
Male tissues 85 | 17,142
Urinary Tract 85 | 16,678
Respiratory system 84 | 16,393
Cardiovascular System 77 | 15,192

Target Family

Non-IDG 48 | 12,091
Transcription Factor 22 | 1,400
Kinase 13 | 634
Enzyme 8 | 4,145
GPCR 6 | 408
Nuclear Receptor 2 | 48
Epigenetic 1 | 242

GO Process

neuron migration 100 | 100
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA damage-inducible transcript 4 protein DDIT4 Tbio Non-IDG -2.11497 150.3 231
Nucleic acid dioxygenase ALKBH1 ALKBH1 Tbio Enzyme -2.09946 119.6 149
Nuclear distribution protein nudE homolog 1 NDE1 Tbio Non-IDG -2.01711 96.0 192
Bardet-Biedl syndrome 4 protein BBS4 Tbio Non-IDG -1.53435 31.5 200
Low-density lipoprotein receptor-related protein 12 LRP12 Tbio Non-IDG -0.57984 4.31 145
Serine/threonine-protein kinase MARK2 MARK2 Tchem Kinase -2.49873 272.3 322
BarH-like 2 homeobox protein BARHL2 Tbio Transcription Factor -0.91713 9.51 53
Reelin RELN Tbio Non-IDG -2.78255 645.2 121
Doublecortin domain-containing protein 2 DCDC2 Tbio Non-IDG -1.71331 52.4 209
Rap guanine nucleotide exchange factor 2 RAPGEF2 Tbio Non-IDG -1.41107 29.0 79