Development Level

Tbio 5 | 11,445
Tchem 2 | 1,598

IMPC Phenotype

embryonic lethality prior to t... 3 | 278
abnormal embryo size 2 | 220
embryonic lethality prior to o... 2 | 239
preweaning lethality, complete... 2 | 979
abnormal eye morphology 1 | 68
abnormal forebrain development 1 | 20
abnormal hindbrain development 1 | 16
abnormal neural tube closure 1 | 46
decreased circulating glucose ... 1 | 126
decreased granulocyte number 1 | 6
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
enlarged heart 1 | 210
short tibia 1 | 97

Disease

Leukoencephalopathy with vanishing white matter 5 | 20
osteosarcoma 5 | 7,950
ovarian cancer 5 | 8,520
Autosomal recessive predisposition 4 | 1,442
Muscle hypotonia 4 | 571
Big calvaria 3 | 147
Brain hypomyelination 3 | 11
Cancer 3 | 2,499
Carcinoma 3 | 11,493
Central nervous system demyelination 3 | 28
Cessation of head growth 3 | 5
Childhood Ataxia with Central Nervous System Hypomyelinization 3 | 6
Decreased serum progesterone 3 | 5
Delusions 3 | 11
Developmental regression 3 | 95
Dysarthria 3 | 192
Epilepsy 3 | 792
Forgetful 3 | 40
Gait, Unsteady 3 | 29
Increased head circumference 3 | 147
Increased size of cranium 3 | 147
Increased size of skull 3 | 147
Lethargy 3 | 77
Leukodystrophy 3 | 55
Leukoencephalopathies 3 | 29
Loss of developmental milestones 3 | 95
Memory Loss 3 | 40
Memory impairment 3 | 40
Mental deterioration in childhood 3 | 95
Mood swings 3 | 77
Muscle Spasticity 3 | 195
Neurodevelopmental regression 3 | 95
OVARIOLEUKODYSTROPHY 3 | 6
Optic Atrophy 3 | 242
Personality change 3 | 23
Premature Menopause 3 | 31
Primary gonadal insufficiency 3 | 9
Psychomotor regression 3 | 95
Psychomotor regression beginning in infancy 3 | 95
Psychomotor regression in infants 3 | 95
Psychomotor regression, progressive 3 | 95
Secondary physiologic amenorrhea 3 | 32
Seizures 3 | 596
Vanishing White Matter Leukodystrophy with Ovarian Failure 3 | 5
Adenocarcinoma of lung 2 | 142
Adenocarcinoma of lung (disorder) 2 | 60
Schizophrenia 2 | 1,160
Status Epilepticus 2 | 98
Vascular disease 2 | 319
Wolcott-Rallison syndrome 2 | 10
diabetes mellitus 2 | 1,728
lung cancer 2 | 4,740
psoriasis 2 | 6,694
Abnormality of the metaphyses 1 | 48
Amino Acid Metabolism, Inborn Errors 1 | 13
Biotinidase deficiency 1 | 14
Brachydactyly 1 | 156
Carcinoma, Ductal, Breast 1 | 11
Congenital Heart Defects 1 | 58
Congenital heart disease 1 | 93
Coxa valga 1 | 22
Coxa valga deformity 1 | 22
Decreased size of teeth 1 | 62
Decreased width of tooth 1 | 59
Dehydration 1 | 40
Enlarged thorax 1 | 18
Familial primary pulmonary hypertension 1 | 11
Fatty Liver 1 | 70
Generalized osteopenia 1 | 99
Globe disease 1 | 67
Glycine encephalopathy 1 | 29
Glycosuria 1 | 29
Hyperglycemia 1 | 137
Hyperopia 1 | 70
Hypertension, Pulmonary 1 | 37
Hyperuricemia 1 | 49
Invasive Ductal Breast Carcinoma 1 | 9
Irregular vertebral endplates 1 | 16
Knee joint valgus deformity 1 | 56
Lordosis 1 | 54
Microdontia (disorder) 1 | 59
Necrosis 1 | 53
Nerve Degeneration 1 | 121
Neutrophil count decreased 1 | 47
ODONTOID HYPOPLASIA 1 | 16
Osteopenia 1 | 99
Platyspondyly 1 | 56
Preauricular Fistulae, Congenital 1 | 27
Preauricular dimple 1 | 27
Preauricular sinus 1 | 27
Primary pulmonary hypertension 1 | 14
Pulmonary capillary hemangiomatosis 1 | 2
Pulmonary hypertension 1 | 85
Renal tubular disorder 1 | 12
Short thorax 1 | 21
Small epiphyses 1 | 9
Transient neonatal diabetes mellitus 1 | 14
Vaccinia 1 | 36
Weight decreased 1 | 103
ileal Crohn's disease 1 | 9

Tissue

Blood and immune system 7 | 16,909
Cardiovascular System 7 | 15,192
Digestive Tract 7 | 17,369
Endocrine System 7 | 18,159
Female tissues 7 | 17,400
Liver and Pancreas 7 | 16,750
Male tissues 7 | 17,142
Nervous System 7 | 16,725
Respiratory system 7 | 16,393
Skin and soft tissues 7 | 17,230
Urinary Tract 7 | 16,678

Target Family

Non-IDG 4 | 12,091
Kinase 2 | 634
Transcription Factor 1 | 1,400

GO Process

negative regulation of transla... 7 | 7
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Translation initiation factor eIF-2B subunit delta EIF2B4 Tbio Non-IDG -1.06082 11.3 145
Eukaryotic translation initiation factor 2-alpha kinase 3 EIF2AK3 Tchem Kinase -3.05781 896.8 450
eIF-2-alpha kinase GCN2 EIF2AK4 Tchem Kinase -2.43702 276.5 301
Translation initiation factor eIF-2B subunit gamma EIF2B3 Tbio Non-IDG -1.21999 16.3 170
Eukaryotic translation initiation factor 2 subunit 1 EIF2S1 Tbio Non-IDG -2.81111 643.5 577
Cyclic AMP-dependent transcription factor ATF-4 ATF4 Tbio Transcription Factor -2.80910 618.1 809
Translation initiation factor eIF-2B subunit epsilon EIF2B5 Tbio Non-IDG -1.90942 82.1 117