Development Level

Tbio 53 | 11,445
Tchem 12 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 5 | 979
preweaning lethality, incomple... 4 | 499
abnormal bone structure 2 | 187
decreased lean body mass 2 | 135
decreased total body fat amoun... 2 | 207
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
increased circulating choleste... 2 | 66
increased circulating glycerol... 2 | 9
increased lean body mass 2 | 172
increased total body fat amoun... 2 | 134
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal eye morphology 1 | 68
abnormal eyelid morphology 1 | 7
abnormal head size 1 | 6
abnormal heart left ventricle ... 1 | 16
abnormal iris morphology 1 | 13
abnormal placement of pupils 1 | 6
abnormal testis morphology 1 | 43
abnormal vibrissa morphology 1 | 25
absent vibrissae 1 | 12
corneal opacity 1 | 32
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased circulating HDL chol... 1 | 68
decreased circulating amylase ... 1 | 28
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating triglyce... 1 | 79
decreased eosinophil cell numb... 1 | 24
decreased fasted circulating g... 1 | 65
decreased hemoglobin content 1 | 68
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
decreased red blood cell distr... 1 | 41
decreased startle reflex 1 | 75
edema 1 | 59
enlarged lymph nodes 1 | 37
hyperactivity 1 | 148
improved glucose tolerance 1 | 79
increased circulating HDL chol... 1 | 80
increased circulating thyroxin... 1 | 7
increased circulating triglyce... 1 | 42
increased erythrocyte cell num... 1 | 39
increased grip strength 1 | 41
increased heart weight 1 | 62
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
irregularly shaped pupil 1 | 7
limb grasping 1 | 41
narrow eye opening 1 | 12
persistence of hyaloid vascula... 1 | 33
thrombocytopenia 1 | 56
trunk curl 1 | 16
vertebral fusion 1 | 23

Disease

ovarian cancer 39 | 8,520
Carcinoma 36 | 11,493
osteosarcoma 35 | 7,950
Cancer 26 | 2,499
medulloblastoma, large-cell 26 | 6,241
glioblastoma 25 | 5,792
pancreatic cancer 22 | 2,398
Breast cancer 21 | 3,578
invasive ductal carcinoma 21 | 2,951
lung cancer 21 | 4,740
psoriasis 19 | 6,694
Astrocytoma, Pilocytic 18 | 3,081
lung carcinoma 18 | 2,843
atypical teratoid / rhabdoid tumor 17 | 5,112
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,955
ependymoma 16 | 4,679
group 4 medulloblastoma 15 | 1,855
subependymal giant cell astrocytoma 15 | 2,287
tuberculosis 15 | 2,010
group 3 medulloblastoma 14 | 4,104
malignant mesothelioma 14 | 3,232
adult high grade glioma 13 | 3,801
non-small cell lung cancer 13 | 2,890
ulcerative colitis 13 | 1,819
interstitial cystitis 12 | 2,312
lung adenocarcinoma 12 | 2,716
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,962
pituitary cancer 12 | 1,972
primitive neuroectodermal tumor 12 | 3,035
Pick disease 11 | 1,894
astrocytic glioma 11 | 2,597
diabetes mellitus 11 | 1,728
primary pancreatic ductal adenocarcinoma 11 | 1,109
Kidney cancer 10 | 2,613
Liver Cirrhosis, Experimental 10 | 769
ductal carcinoma in situ 10 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
juvenile dermatomyositis 10 | 1,187
oligodendroglioma 10 | 2,850
adrenocortical carcinoma 9 | 1,428
breast carcinoma 9 | 1,638
colon cancer 9 | 1,478
cystic fibrosis 9 | 1,696
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
Pulmonary Fibrosis 8 | 106
acute quadriplegic myopathy 8 | 1,158
astrocytoma 8 | 1,146
autosomal dominant Emery-Dreifuss muscular dystrophy 8 | 510
dermatomyositis 8 | 966
gastric carcinoma 8 | 807
Autosomal recessive predisposition 7 | 1,442
Duchenne muscular dystrophy 7 | 601
Multiple myeloma 7 | 1,332
Acquired scoliosis 6 | 281
Breast Neoplasms 6 | 445
Cleft Palate 6 | 271
Curvature of spine 6 | 282
Hypertensive disease 6 | 292
Kidney disease 6 | 430
Mammary Neoplasms 6 | 425
Orbital separation excessive 6 | 244
Osteoarthritis 6 | 184
Schizophrenia 6 | 1,160
Ureteral obstruction 6 | 33
Vascular disease 6 | 319
progressive supranuclear palsy 6 | 676
Acquired flat foot 5 | 72
Aortic Valve Insufficiency 5 | 40
Arachnodactyly 5 | 49
Cardiomegaly 5 | 116
Cognitive delay 5 | 608
Colorectal Neoplasms 5 | 243
Coronary artery disease 5 | 268
Craniosynostosis 5 | 74
Epilepsy 5 | 792
Flatfoot 5 | 73
Global developmental delay 5 | 608
Inflammatory bowel disease 5 | 151
Liver Cirrhosis 5 | 181
Loeys-Dietz syndrome 5 | 23
Mental and motor retardation 5 | 608
Obesity 5 | 678
Prostatic Neoplasms 5 | 495
Rheumatoid arthritis 5 | 1,191
Seizures 5 | 596
Short stature 5 | 531
active Crohn's disease 5 | 922
acute myeloid leukemia 5 | 783
pancreatic carcinoma 5 | 562
pediatric high grade glioma 5 | 1,064
spina bifida 5 | 1,074
Alzheimer's disease 4 | 658
Atherosclerosis 4 | 291
Bipolar Disorder 4 | 666
Byzanthine arch palate 4 | 194
Down syndrome 4 | 499
Glaucoma 4 | 239
Hypertension 4 | 396
Waldenstrons macroglobulinemia 4 | 765
fibroadenoma 4 | 559

Tissue

Endocrine System 65 | 18,159
Digestive Tract 64 | 17,369
Nervous System 64 | 16,725
Blood and immune system 63 | 16,909
Liver and Pancreas 63 | 16,750
Female tissues 62 | 17,400
Respiratory system 62 | 16,393
Skin and soft tissues 62 | 17,230
Urinary Tract 61 | 16,678
Male tissues 60 | 17,142
Cardiovascular System 59 | 15,192

Target Family

Non-IDG 39 | 12,091
Enzyme 13 | 4,145
Transcription Factor 9 | 1,400
Kinase 3 | 634
Epigenetic 1 | 242
TF/Epigenetic 1 | 38

GO Process

negative regulation of transfo... 66 | 66
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
X-box-binding protein 1 XBP1 Tchem Transcription Factor -2.90444 780.2 514
CD109 antigen CD109 Tbio Non-IDG -1.85817 77.8 239
One cut domain family member 2 ONECUT2 Tbio Transcription Factor -2.25163 169.5 107
Endoglin ENG Tbio Non-IDG -3.10482 1235.9 1622
SKI family transcriptional corepressor 2 SKOR2 Tbio Non-IDG -0.52843 4.42 59
Inner nuclear membrane protein Man1 LEMD3 Tbio Non-IDG -2.30311 196.6 73
E3 SUMO-protein ligase ZNF451 ZNF451 Tbio Transcription Factor -2.42090 254.4 71
Heat shock 70 kDa protein 1A HSPA1B Tchem Non-IDG -3.10995 0.00000 1174
Mothers against decapentaplegic homolog 6 SMAD6 Tbio Transcription Factor -2.07569 106.7 450
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427