Development Level
Tbio | 513 | 11,445 | |
Tchem | 87 | 1,598 | |
Tdark | 47 | 6,588 | |
Tclin | 36 | 613 |
IMPC Phenotype
preweaning lethality, complete... | 63 | 979 | |
preweaning lethality, incomple... | 28 | 499 | |
embryonic lethality prior to t... | 22 | 278 | |
abnormal embryo size | 18 | 220 | |
enlarged heart | 15 | 210 | |
abnormal behavior | 12 | 298 | |
decreased bone mineral density | 12 | 126 | |
abnormal heart morphology | 11 | 162 | |
embryonic lethality prior to o... | 11 | 239 | |
hypoactivity | 11 | 132 | |
increased lean body mass | 11 | 172 | |
increased startle reflex | 11 | 112 | |
decreased lean body mass | 10 | 135 | |
decreased vertical activity | 10 | 208 | |
increased mean corpuscular hem... | 10 | 96 | |
decreased bone mineral content | 9 | 151 | |
decreased total body fat amoun... | 9 | 207 | |
embryonic growth retardation | 9 | 106 | |
increased total body fat amoun... | 9 | 134 | |
decreased body weight | 8 | 161 | |
increased circulating alkaline... | 8 | 122 | |
abnormal bone structure | 7 | 187 | |
abnormal eye morphology | 7 | 68 | |
decreased heart left ventricle... | 7 | 28 | |
increased bone mineral content | 7 | 108 | |
increased circulating HDL chol... | 7 | 80 | |
increased mean corpuscular vol... | 7 | 92 | |
abnormal retina morphology | 6 | 71 | |
corneal opacity | 6 | 32 | |
decreased circulating glucose ... | 6 | 126 | |
decreased circulating triglyce... | 6 | 79 | |
decreased mean corpuscular vol... | 6 | 79 | |
impaired glucose tolerance | 6 | 75 | |
increased or absent threshold ... | 6 | 101 | |
male infertility | 6 | 123 | |
abnormal bone mineralization | 5 | 38 | |
abnormal cornea morphology | 5 | 31 | |
abnormal gait | 5 | 69 | |
decreased blood urea nitrogen ... | 5 | 51 | |
decreased circulating serum al... | 5 | 82 | |
decreased lymphocyte cell numb... | 5 | 83 | |
decreased neutrophil cell numb... | 5 | 42 | |
decreased prepulse inhibition | 5 | 82 | |
decreased red blood cell distr... | 5 | 41 | |
decreased startle reflex | 5 | 75 | |
improved glucose tolerance | 5 | 79 | |
increased bone mineral density | 5 | 72 | |
increased circulating triglyce... | 5 | 42 | |
increased hemoglobin content | 5 | 45 | |
increased neutrophil cell numb... | 5 | 46 | |
prenatal lethality prior to he... | 5 | 87 | |
thin ventricular wall | 5 | 24 | |
abnormal forebrain development | 4 | 20 | |
abnormal neural tube closure | 4 | 46 | |
abnormal retinal vasculature m... | 4 | 27 | |
abnormal seminal vesicle morph... | 4 | 114 | |
abnormal sleep behavior | 4 | 70 | |
decreased body length | 4 | 101 | |
decreased circulating HDL chol... | 4 | 68 | |
decreased circulating choleste... | 4 | 93 | |
decreased grip strength | 4 | 116 | |
decreased hemoglobin content | 4 | 68 | |
decreased leukocyte cell numbe... | 4 | 73 | |
decreased threshold for audito... | 4 | 26 | |
edema | 4 | 59 | |
female infertility | 4 | 60 | |
increased body length | 4 | 32 | |
increased circulating sodium l... | 4 | 71 | |
increased monocyte cell number | 4 | 63 | |
pale yolk sac | 4 | 25 | |
persistence of hyaloid vascula... | 4 | 33 | |
small superior vagus ganglion | 4 | 74 | |
thrombocytopenia | 4 | 56 | |
abnormal coat-hair pigmentatio... | 3 | 64 | |
abnormal craniofacial morpholo... | 3 | 33 | |
abnormal embryo turning | 3 | 31 | |
abnormal hindbrain development | 3 | 16 | |
abnormal kidney morphology | 3 | 65 | |
abnormal midbrain development | 3 | 20 | |
decreased circulating insulin ... | 3 | 76 | |
decreased circulating sodium l... | 3 | 22 | |
decreased erythrocyte cell num... | 3 | 62 | |
decreased hematocrit | 3 | 46 | |
decreased spleen weight | 3 | 10 | |
enlarged lymph nodes | 3 | 37 | |
hemorrhage | 3 | 23 | |
hyperactivity | 3 | 148 | |
increased body temperature | 3 | 9 | |
increased circulating choleste... | 3 | 66 | |
increased fasted circulating g... | 3 | 76 | |
increased grip strength | 3 | 41 | |
increased lactate dehydrogenas... | 3 | 3 | |
increased lymphocyte cell numb... | 3 | 32 | |
irregularly shaped pupil | 3 | 7 | |
limb grasping | 3 | 41 | |
pallor | 3 | 34 | |
prenatal lethality | 3 | 28 | |
short tibia | 3 | 97 | |
small spleen | 3 | 19 | |
increased prepulse inhibition | 2 | 32 |
Disease
Tissue
Endocrine System | 671 | 18,159 | |
Female tissues | 657 | 17,400 | |
Digestive Tract | 655 | 17,369 | |
Male tissues | 652 | 17,142 | |
Skin and soft tissues | 652 | 17,230 | |
Blood and immune system | 643 | 16,909 | |
Liver and Pancreas | 643 | 16,750 | |
Urinary Tract | 643 | 16,678 | |
Nervous System | 640 | 16,725 | |
Respiratory system | 634 | 16,393 | |
Cardiovascular System | 604 | 15,192 |
Target Family
Transcription Factor | 294 | 1,400 | |
Non-IDG | 232 | 12,091 | |
Enzyme | 55 | 4,145 | |
Epigenetic | 49 | 242 | |
Nuclear Receptor | 27 | 48 | |
Kinase | 12 | 634 | |
TF/Epigenetic | 8 | 38 | |
GPCR | 4 | 408 | |
Ion Channel | 2 | 344 |
GO Process
negative regulation of transcr... | 683 | 683 | |
transcription, DNA-templated | 1,742 | 1,742 | |
regulation of transcription, D... | 1,135 | 1,135 | |
G-protein coupled receptor sig... | 1,053 | 1,053 | |
signal transduction | 1,005 | 1,005 | |
positive regulation of transcr... | 932 | 932 | |
positive regulation of transcr... | 529 | 529 | |
apoptotic process | 511 | 511 | |
cell differentiation | 511 | 511 | |
negative regulation of transcr... | 492 | 492 | |
neutrophil degranulation | 484 | 484 | |
negative regulation of apoptot... | 479 | 479 | |
positive regulation of cell pr... | 470 | 470 | |
innate immune response | 469 | 469 | |
multicellular organism develop... | 460 | 460 | |
cell adhesion | 458 | 458 | |
immune response | 426 | 426 | |
viral process | 405 | 405 | |
negative regulation of cell pr... | 398 | 398 | |
spermatogenesis | 389 | 389 | |
intracellular signal transduct... | 376 | 376 | |
inflammatory response | 373 | 373 | |
cell proliferation | 366 | 366 | |
post-translational protein mod... | 356 | 356 | |
protein transport | 348 | 348 | |
protein ubiquitination | 347 | 347 | |
cell division | 345 | 345 | |
regulation of transcription fr... | 345 | 345 | |
protein phosphorylation | 334 | 334 | |
nervous system development | 321 | 321 | |
positive regulation of apoptot... | 320 | 320 | |
response to drug | 303 | 303 | |
cell-cell signaling | 300 | 300 | |
positive regulation of gene ex... | 297 | 297 | |
transcription from RNA polymer... | 286 | 286 | |
protein deubiquitination | 271 | 271 | |
cell cycle | 268 | 268 | |
regulation of immune response | 259 | 259 | |
transport | 255 | 255 | |
regulation of apoptotic proces... | 250 | 250 | |
MAPK cascade | 242 | 242 | |
cell surface receptor signalin... | 239 | 239 | |
mRNA splicing, via spliceosome | 236 | 236 | |
protein polyubiquitination | 222 | 222 | |
angiogenesis | 220 | 220 | |
chemical synaptic transmission | 219 | 219 | |
cellular response to DNA damag... | 217 | 217 | |
proteolysis | 217 | 217 | |
proteasome-mediated ubiquitin-... | 210 | 210 | |
adaptive immune response | 209 | 209 | |
intracellular protein transpor... | 209 | 209 | |
DNA repair | 206 | 206 | |
leukocyte migration | 206 | 206 | |
protein homooligomerization | 206 | 206 | |
rRNA processing | 204 | 204 | |
extracellular matrix organizat... | 198 | 198 | |
visual perception | 198 | 198 | |
positive regulation of ERK1 an... | 194 | 194 | |
cellular protein metabolic pro... | 192 | 192 | |
brain development | 188 | 188 | |
axon guidance | 186 | 186 | |
Fc-epsilon receptor signaling ... | 182 | 182 | |
keratinization | 182 | 182 | |
cell migration | 181 | 181 | |
defense response to virus | 181 | 181 | |
positive regulation of cell mi... | 179 | 179 | |
regulation of cell proliferati... | 177 | 177 | |
in utero embryonic development | 176 | 176 | |
Wnt signaling pathway | 175 | 175 | |
cilium assembly | 175 | 175 | |
blood coagulation | 170 | 170 | |
RNA splicing | 169 | 169 | |
translation | 169 | 169 | |
mRNA processing | 168 | 168 | |
protein autophosphorylation | 168 | 168 | |
aging | 167 | 167 | |
response to hypoxia | 166 | 166 | |
T cell receptor signaling path... | 164 | 164 | |
heart development | 164 | 164 | |
negative regulation of canonic... | 164 | 164 | |
positive regulation of I-kappa... | 164 | 164 | |
ubiquitin-dependent protein ca... | 164 | 164 | |
ER to Golgi vesicle-mediated t... | 162 | 162 | |
protein stabilization | 160 | 160 | |
response to lipopolysaccharide | 160 | 160 | |
transcription initiation from ... | 160 | 160 | |
defense response to bacterium | 159 | 159 | |
protein folding | 159 | 159 | |
sensory perception of smell | 157 | 157 | |
homophilic cell adhesion via p... | 156 | 156 | |
transmembrane transport | 154 | 154 | |
negative regulation of gene ex... | 151 | 151 | |
interferon-gamma-mediated sign... | 150 | 150 | |
receptor-mediated endocytosis | 150 | 150 | |
ion transmembrane transport | 148 | 148 | |
peptidyl-serine phosphorylatio... | 148 | 148 | |
positive regulation of protein... | 148 | 148 | |
antigen processing and present... | 143 | 143 | |
DNA replication | 142 | 142 | |
cell cycle arrest | 142 | 142 |
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