1. Home
  2. Targets
Target Filters...

Development Level

Tbio 513 | 11,445
Tchem 87 | 1,598
Tdark 47 | 6,588
Tclin 36 | 613

IMPC Phenotype

preweaning lethality, complete... 63 | 979
preweaning lethality, incomple... 28 | 499
embryonic lethality prior to t... 22 | 278
abnormal embryo size 18 | 220
enlarged heart 15 | 210
abnormal behavior 12 | 298
decreased bone mineral density 12 | 126
abnormal heart morphology 11 | 162
embryonic lethality prior to o... 11 | 239
hypoactivity 11 | 132
increased lean body mass 11 | 172
increased startle reflex 11 | 112
decreased lean body mass 10 | 135
decreased vertical activity 10 | 208
increased mean corpuscular hem... 10 | 96
decreased bone mineral content 9 | 151
decreased total body fat amoun... 9 | 207
embryonic growth retardation 9 | 106
increased total body fat amoun... 9 | 134
decreased body weight 8 | 161
increased circulating alkaline... 8 | 122
abnormal bone structure 7 | 187
abnormal eye morphology 7 | 68
decreased heart left ventricle... 7 | 28
increased bone mineral content 7 | 108
increased circulating HDL chol... 7 | 80
increased mean corpuscular vol... 7 | 92
abnormal retina morphology 6 | 71
corneal opacity 6 | 32
decreased circulating glucose ... 6 | 126
decreased circulating triglyce... 6 | 79
decreased mean corpuscular vol... 6 | 79
impaired glucose tolerance 6 | 75
increased or absent threshold ... 6 | 101
male infertility 6 | 123
abnormal bone mineralization 5 | 38
abnormal cornea morphology 5 | 31
abnormal gait 5 | 69
decreased blood urea nitrogen ... 5 | 51
decreased circulating serum al... 5 | 82
decreased lymphocyte cell numb... 5 | 83
decreased neutrophil cell numb... 5 | 42
decreased prepulse inhibition 5 | 82
decreased red blood cell distr... 5 | 41
decreased startle reflex 5 | 75
improved glucose tolerance 5 | 79
increased bone mineral density 5 | 72
increased circulating triglyce... 5 | 42
increased hemoglobin content 5 | 45
increased neutrophil cell numb... 5 | 46
prenatal lethality prior to he... 5 | 87
thin ventricular wall 5 | 24
abnormal forebrain development 4 | 20
abnormal neural tube closure 4 | 46
abnormal retinal vasculature m... 4 | 27
abnormal seminal vesicle morph... 4 | 114
abnormal sleep behavior 4 | 70
decreased body length 4 | 101
decreased circulating HDL chol... 4 | 68
decreased circulating choleste... 4 | 93
decreased grip strength 4 | 116
decreased hemoglobin content 4 | 68
decreased leukocyte cell numbe... 4 | 73
decreased threshold for audito... 4 | 26
edema 4 | 59
female infertility 4 | 60
increased body length 4 | 32
increased circulating sodium l... 4 | 71
increased monocyte cell number 4 | 63
pale yolk sac 4 | 25
persistence of hyaloid vascula... 4 | 33
small superior vagus ganglion 4 | 74
thrombocytopenia 4 | 56
abnormal coat-hair pigmentatio... 3 | 64
abnormal craniofacial morpholo... 3 | 33
abnormal embryo turning 3 | 31
abnormal hindbrain development 3 | 16
abnormal kidney morphology 3 | 65
abnormal midbrain development 3 | 20
decreased circulating insulin ... 3 | 76
decreased circulating sodium l... 3 | 22
decreased erythrocyte cell num... 3 | 62
decreased hematocrit 3 | 46
decreased spleen weight 3 | 10
enlarged lymph nodes 3 | 37
hemorrhage 3 | 23
hyperactivity 3 | 148
increased body temperature 3 | 9
increased circulating choleste... 3 | 66
increased fasted circulating g... 3 | 76
increased grip strength 3 | 41
increased lactate dehydrogenas... 3 | 3
increased lymphocyte cell numb... 3 | 32
irregularly shaped pupil 3 | 7
limb grasping 3 | 41
pallor 3 | 34
prenatal lethality 3 | 28
short tibia 3 | 97
small spleen 3 | 19
increased prepulse inhibition 2 | 32

Disease

Carcinoma 462 | 11,493
ovarian cancer 394 | 8,520
osteosarcoma 364 | 7,950
psoriasis 315 | 6,694
medulloblastoma, large-cell 283 | 6,241
Cancer 275 | 2,499
lung cancer 269 | 4,740
glioblastoma 265 | 5,792
atypical teratoid / rhabdoid tumor 235 | 5,112
Breast cancer 209 | 3,578
group 3 medulloblastoma 191 | 4,104
ependymoma 181 | 4,679
malignant mesothelioma 181 | 3,232
invasive ductal carcinoma 160 | 2,951
primitive neuroectodermal tumor 152 | 3,035
adult high grade glioma 147 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 147 | 3,291
non-small cell lung cancer 141 | 2,890
intraductal papillary-mucinous carcinoma (IPMC) 139 | 2,989
lung adenocarcinoma 128 | 2,716
intraductal papillary-mucinous adenoma (IPMA) 124 | 2,955
pancreatic cancer 119 | 2,398
Kidney cancer 118 | 2,613
oligodendroglioma 117 | 2,850
Astrocytoma, Pilocytic 115 | 3,081
astrocytic glioma 108 | 2,597
lung carcinoma 108 | 2,843
tuberculosis 104 | 2,010
interstitial cystitis 103 | 2,312
subependymal giant cell astrocytoma 100 | 2,287
breast carcinoma 98 | 1,638
pituitary cancer 96 | 1,972
ulcerative colitis 95 | 1,819
group 4 medulloblastoma 94 | 1,855
ductal carcinoma in situ 91 | 1,745
diabetes mellitus 90 | 1,728
Multiple myeloma 86 | 1,332
Pick disease 86 | 1,894
Rheumatoid arthritis 83 | 1,191
cystic fibrosis 83 | 1,696
Intellectual disability 80 | 1,016
pancreatic ductal adenocarcinoma liver metastasis 79 | 1,962
Breast Neoplasms 76 | 445
Schizophrenia 76 | 1,160
colon cancer 75 | 1,478
Mammary Neoplasms 74 | 425
astrocytoma 73 | 1,146
adrenocortical carcinoma 71 | 1,428
acute quadriplegic myopathy 67 | 1,158
spina bifida 64 | 1,074
juvenile dermatomyositis 63 | 1,187
cutaneous lupus erythematosus 60 | 1,057
Short stature 56 | 531
Epilepsy 55 | 792
primary pancreatic ductal adenocarcinoma 54 | 1,109
Dull intelligence 53 | 645
Low intelligence 53 | 645
Mental Retardation 53 | 645
Mental deficiency 53 | 645
Poor school performance 53 | 645
pediatric high grade glioma 53 | 1,064
Autosomal recessive predisposition 51 | 1,442
Obesity 51 | 678
Seizures 51 | 596
Prostatic Neoplasms 49 | 495
acute myeloid leukemia 49 | 783
aldosterone-producing adenoma 49 | 665
dermatomyositis 48 | 966
Bipolar Disorder 46 | 666
Alzheimer's disease 45 | 658
Atopic dermatitis 45 | 952
Cognitive delay 45 | 608
Global developmental delay 45 | 608
Mental and motor retardation 45 | 608
Cleft Palate 44 | 271
Muscle hypotonia 44 | 571
Waldenstrons macroglobulinemia 44 | 765
medulloblastoma 43 | 720
Small head 39 | 374
Strabismus 38 | 270
active ulcerative colitis 38 | 764
Cryptorchidism 37 | 296
Craniofacial Abnormalities 36 | 151
Lung Neoplasms 36 | 232
gastric cancer 36 | 459
hepatocellular carcinoma 36 | 547
active Crohn's disease 35 | 922
Depressive disorder 34 | 409
Down syndrome 34 | 499
nasopharyngeal carcinoma 34 | 1,058
non primary Sjogren syndrome sicca 34 | 891
primary Sjogren syndrome 34 | 735
Carcinoma, Hepatocellular 33 | 228
Endometriosis 33 | 540
Liver Cirrhosis, Experimental 33 | 769
Liver carcinoma 32 | 240
Multiple Sclerosis 32 | 540
Stomach Neoplasms 32 | 300
Amyotrophic lateral sclerosis 31 | 451
Polycystic ovary syndrome 31 | 360

Tissue

Endocrine System 671 | 18,159
Female tissues 657 | 17,400
Digestive Tract 655 | 17,369
Male tissues 652 | 17,142
Skin and soft tissues 652 | 17,230
Blood and immune system 643 | 16,909
Liver and Pancreas 643 | 16,750
Urinary Tract 643 | 16,678
Nervous System 640 | 16,725
Respiratory system 634 | 16,393
Cardiovascular System 604 | 15,192

Target Family

Transcription Factor 294 | 1,400
Non-IDG 232 | 12,091
Enzyme 55 | 4,145
Epigenetic 49 | 242
Nuclear Receptor 27 | 48
Kinase 12 | 634
TF/Epigenetic 8 | 38
GPCR 4 | 408
Ion Channel 2 | 344

GO Process

negative regulation of transcr... 683 | 683
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
Peroxisome biogenesis factor 2 PEX2 Tbio Non-IDG -1.76849 57.3 170
Putative methyl-CpG-binding domain protein 3-like 4 MBD3L4 Tdark Non-IDG 0.00000 0
Unconventional prefoldin RPB5 interactor 1 URI1 Tbio Enzyme -2.15409 134.8 150
Putative methyl-CpG-binding domain protein 3-like 3 MBD3L3 Tdark Non-IDG 0.00000 56
Transcription factor Sp5 SP5 Tdark Transcription Factor 0.30 0.34 21
KN motif and ankyrin repeat domain-containing protein 2 KANK2 Tbio Non-IDG -0.97803 8.39 131
Metastasis-associated protein MTA2 MTA2 Tbio Transcription Factor -1.59201 32.3 283
Homeobox protein Hox-D9 HOXD9 Tbio Transcription Factor -1.52954 36.2 137
Chromodomain-helicase-DNA-binding protein 4 CHD4 Tbio Epigenetic -2.22229 159.7 203