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Development Level

Tbio 456 | 10,625
Tchem 89 | 1,890
Tdark 42 | 7,003
Tclin 33 | 602

IMPC Phenotype

preweaning lethality, complete... 42 | 633
preweaning lethality, incomple... 19 | 260
embryonic lethality prior to t... 15 | 187
decreased lean body mass 14 | 195
abnormal behavior 11 | 226
decreased body weight 9 | 174
increased or absent threshold ... 9 | 128
abnormal embryo size 8 | 112
decreased total body fat amoun... 8 | 186
embryonic lethality prior to o... 8 | 148
increased circulating alkaline... 8 | 119
increased lean body mass 8 | 107
abnormal bone structure 7 | 131
decreased bone mineral content 7 | 157
decreased circulating HDL chol... 7 | 77
enlarged heart 7 | 111
increased mean corpuscular hem... 7 | 93
corneal opacity 6 | 25
decreased bone mineral density 6 | 126
decreased circulating choleste... 6 | 85
decreased circulating glucose ... 6 | 121
decreased circulating triglyce... 6 | 83
decreased grip strength 6 | 123
increased bone mineral content 6 | 92
increased mean corpuscular vol... 6 | 91
abnormal bone mineralization 5 | 55
abnormal cornea morphology 5 | 24
abnormal retina morphology 5 | 100
decreased hemoglobin content 5 | 53
hypoactivity 5 | 89
increased bone mineral density 5 | 52
increased circulating HDL chol... 5 | 63
increased grip strength 5 | 83
abnormal coat-hair pigmentatio... 4 | 54
abnormal forebrain development 4 | 18
abnormal hindbrain development 4 | 24
abnormal midbrain development 4 | 22
abnormal neural tube closure 4 | 37
abnormal retinal pigmentation 4 | 61
abnormal sleep behavior 4 | 63
decreased caudal vertebrae num... 4 | 49
decreased circulating serum al... 4 | 79
decreased mean corpuscular vol... 4 | 50
decreased prepulse inhibition 4 | 52
decreased rib number 4 | 59
decreased startle reflex 4 | 48
hyperactivity 4 | 108
increased circulating sodium l... 4 | 71
increased sacral vertebrae num... 4 | 62
increased total body fat amoun... 4 | 57
persistence of hyaloid vascula... 4 | 22
thrombocytopenia 4 | 46
abnormal coping response 3 | 12
abnormal embryo turning 3 | 15
abnormal eye morphology 3 | 38
abnormal gait 3 | 51
abnormal tooth morphology 3 | 24
decreased B cell number 3 | 30
decreased T cell number 3 | 31
decreased blood urea nitrogen ... 3 | 31
decreased body length 3 | 108
decreased circulating LDL chol... 3 | 37
decreased circulating insulin ... 3 | 75
decreased erythrocyte cell num... 3 | 43
decreased fasted circulating g... 3 | 49
decreased leukocyte cell numbe... 3 | 54
decreased lumbar vertebrae num... 3 | 62
decreased mean corpuscular hem... 3 | 34
female infertility 3 | 34
impaired glucose tolerance 3 | 52
improved glucose tolerance 3 | 56
increased circulating choleste... 3 | 53
increased circulating iron lev... 3 | 25
increased circulating triglyce... 3 | 24
increased fasted circulating g... 3 | 68
increased lactate dehydrogenas... 3 | 3
increased startle reflex 3 | 38
limb grasping 3 | 35
male infertility 3 | 62
narrow eye opening 3 | 15
short tibia 3 | 82
abnormal behavioral response t... 2 | 52
abnormal heart morphology 2 | 51
abnormal optic disc morphology 2 | 10
decreased circulating calcium ... 2 | 33
decreased circulating chloride... 2 | 32
decreased circulating glycerol... 2 | 19
decreased effector memory CD8-... 2 | 24
embryonic growth retardation 2 | 28
increased body length 2 | 20
increased body weight 2 | 42
increased hematocrit 2 | 36
increased hemoglobin content 2 | 45
increased respiratory quotient 2 | 12
long tibia 2 | 13
prenatal lethality 2 | 16
prenatal lethality prior to he... 2 | 64
small testis 2 | 37
tremors 2 | 34
vertebral fusion 2 | 23

Disease

ovarian cancer 356 | 8,491
osteosarcoma 323 | 7,933
psoriasis 282 | 6,685
Cancer 250 | 2,346
medulloblastoma, large-cell 250 | 6,234
lung cancer 241 | 4,473
glioblastoma 234 | 5,572
atypical teratoid / rhabdoid tumor 184 | 4,369
malignant mesothelioma 160 | 3,163
Breast cancer 158 | 3,098
invasive ductal carcinoma 148 | 2,950
primitive neuroectodermal tumor 138 | 3,031
intraductal papillary-mucinous neoplasm (IPMN) 135 | 3,289
non-small cell lung cancer 127 | 2,798
intraductal papillary-mucinous carcinoma (IPMC) 126 | 2,988
pediatric high grade glioma 119 | 2,712
lung adenocarcinoma 115 | 2,714
group 4 medulloblastoma 113 | 1,875
intraductal papillary-mucinous adenoma (IPMA) 113 | 2,956
oligodendroglioma 109 | 2,849
ependymoma 104 | 2,514
pilocytic astrocytoma 101 | 3,086
pancreatic cancer 98 | 2,300
lung carcinoma 97 | 2,844
Carcinoma 95 | 2,147
ulcerative colitis 94 | 2,087
interstitial cystitis 93 | 2,299
subependymal giant cell astrocytoma 93 | 2,287
astrocytoma 92 | 1,493
pituitary cancer 89 | 1,972
ductal carcinoma in situ 87 | 1,745
group 3 medulloblastoma 86 | 2,254
breast carcinoma 82 | 1,614
Pick disease 78 | 1,893
Rheumatoid Arthritis 78 | 1,170
Multiple myeloma 77 | 1,327
diabetes mellitus 77 | 1,663
cystic fibrosis 76 | 1,670
tuberculosis 71 | 1,563
astrocytic glioma 70 | 2,241
colon cancer 70 | 1,475
Mammary Neoplasms 69 | 410
adult high grade glioma 66 | 2,148
adrenocortical carcinoma 64 | 1,427
posterior fossa group A ependymoma 64 | 1,511
primary pancreatic ductal adenocarcinoma 63 | 1,271
acute quadriplegic myopathy 62 | 1,157
pancreatic ductal adenocarcinoma liver metastasis 61 | 1,795
sonic hedgehog group medulloblastoma 59 | 1,482
spina bifida 59 | 1,064
cutaneous lupus erythematosus 56 | 1,056
juvenile dermatomyositis 56 | 1,189
medulloblastoma 56 | 1,524
atypical teratoid/rhabdoid tumor 51 | 1,095
acute myeloid leukemia 47 | 785
dermatomyositis 46 | 966
Intellectual disability 45 | 573
aldosterone-producing adenoma 45 | 664
Obesity 43 | 616
Waldenstrons macroglobulinemia 41 | 764
Atopic dermatitis 40 | 944
Prostatic Neoplasms 40 | 471
posterior fossa group B ependymoma 37 | 1,530
Alzheimer's disease 35 | 644
Craniofacial Abnormalities 35 | 147
Down syndrome 35 | 548
primary Sjogren syndrome 35 | 788
hepatocellular carcinoma 33 | 550
nasopharyngeal carcinoma 33 | 1,056
Endometriosis 31 | 535
tuberculosis and treatment for 6 months 31 | 686
Lung Neoplasms 30 | 171
esophageal adenocarcinoma 30 | 737
gastric cancer 30 | 436
inflammatory breast cancer 30 | 404
Heart disease 29 | 279
active Crohn's disease 29 | 918
autosomal dominant Emery-Dreifuss muscular dystrophy 29 | 499
non primary Sjogren syndrome sicca 29 | 840
Cleft palate 28 | 125
gastric carcinoma 28 | 832
Amyotrophic Lateral Sclerosis 27 | 432
Stomach Neoplasms 27 | 282
Kidney disease 26 | 397
Multiple Sclerosis 26 | 498
active ulcerative colitis 26 | 477
fibroadenoma 26 | 557
pancreatic carcinoma 26 | 567
Diabetes Mellitus, Non-Insulin-Dependent 25 | 161
sarcoidosis 25 | 368
Liver carcinoma 24 | 217
Polycystic Ovary Syndrome 24 | 334
Vascular disease 24 | 281
progressive supranuclear palsy 24 | 674
Schizophrenia 23 | 503
Atherosclerosis 22 | 275
Colonic Neoplasms 22 | 126
Colorectal Neoplasms 22 | 217
nephrosclerosis 22 | 329
urothelial carcinoma 22 | 318

Tissue

Nervous System 616 | 18,560
Female tissues 612 | 18,646
Digestive Tract 611 | 18,472
Endocrine System 611 | 18,511
Liver and Pancreas 608 | 18,135
Urinary Tract 608 | 18,443
Blood and immune system 606 | 17,994
Male tissues 606 | 17,968
Skin and soft tissues 603 | 18,114
Cardiovascular System 601 | 17,957
Respiratory system 592 | 17,483

Target Family

Transcription Factor 264 | 1,400
Non-IDG 213 | 11,969
Epigenetic 49 | 242
Enzyme 45 | 4,146
Nuclear Receptor 24 | 48
Kinase 10 | 634
TF/Epigenetic 9 | 38
GPCR 4 | 408
Ion Channel 2 | 341

GO Process

negative regulation of transcr... 620 | 620
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 367 | 367
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
chemical synaptic transmission 238 | 238
MAPK cascade 237 | 237
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 199 | 199
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 180 | 180
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 175 | 175
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
protein folding 162 | 162
negative regulation of canonic... 161 | 161
response to lipopolysaccharide 161 | 161
T cell receptor signaling path... 160 | 160
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2-M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
type I interferon signaling pa... 130 | 130
endocytosis 129 | 129

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein fosB FOSB Tbio Transcription Factor -2.64139 409.7 306
E3 ubiquitin-protein ligase RLIM RLIM Tbio Enzyme -1.57212 36.3 141
Transcription factor PU.1 SPI1 Tbio Transcription Factor -3.03044 1092.0 356
E3 ubiquitin-protein ligase NEDD4-like NEDD4L Tbio Enzyme -2.50001 312.7 133
Hemoglobin subunit zeta HBZ Tbio Non-IDG -2.36868 235.4 158
Von Hippel-Lindau disease tumor suppressor VHL Tchem Enzyme -2.45725 283.9 450
Zinc finger protein RFP TRIM27 Tbio Non-IDG -1.50884 32.8 154
Mediator of RNA polymerase II transcription subunit 25 MED25 Tbio Enzyme -1.76765 56.0 62
Histone-lysine N-methyltransferase SUV39H1 SUV39H1 Tchem Epigenetic -2.21810 149.4 267
Signal transducer and activator of transcription 3 STAT3 Tchem Transcription Factor -3.75815 5706.6 1539