Development Level

Tbio 336 | 10,625
Tchem 72 | 1,890
Tdark 58 | 7,003
Tclin 17 | 602

Collection

Eligible Kinase Proteins 2 | 134

IMPC Term

preweaning lethality, complete... 21 | 633
preweaning lethality, incomple... 12 | 260
abnormal behavior 9 | 226
increased mean corpuscular vol... 7 | 91
abnormal bone mineralization 6 | 55
decreased grip strength 5 | 123
decreased lean body mass 5 | 195
decreased rib number 5 | 59
decreased total body fat amoun... 5 | 186
enlarged heart 5 | 111
increased bone mineral content 5 | 92
increased circulating alkaline... 5 | 119
increased grip strength 5 | 83
increased or absent threshold ... 5 | 128
abnormal bone structure 4 | 131
decreased body weight 4 | 174
decreased caudal vertebrae num... 4 | 49
decreased hemoglobin content 4 | 53
embryonic lethality prior to t... 4 | 187
increased bone mineral density 4 | 52
increased circulating choleste... 4 | 53
increased lean body mass 4 | 107
abnormal eye morphology 3 | 38
abnormal gait 3 | 51
abnormal iris morphology 3 | 12
abnormal lens morphology 3 | 73
cataract 3 | 26
decreased body length 3 | 108
decreased bone mineral density 3 | 126
decreased circulating glucose ... 3 | 121
hyperactivity 3 | 108
hypoactivity 3 | 89
increased circulating creatini... 3 | 29
increased fasted circulating g... 3 | 68
increased sacral vertebrae num... 3 | 62
thrombocytopenia 3 | 46
abnormal coat appearance 2 | 25
abnormal coat/ hair morphology 2 | 18
abnormal coping response 2 | 12
abnormal heart morphology 2 | 51
abnormal kidney morphology 2 | 30
abnormal locomotor activation 2 | 26
abnormal retina morphology 2 | 100
abnormal startle reflex 2 | 14
corneal opacity 2 | 25
decreased bone mineral content 2 | 157
decreased circulating alkaline... 2 | 41
decreased circulating insulin ... 2 | 75
decreased circulating triglyce... 2 | 83
decreased erythrocyte cell num... 2 | 43
decreased prepulse inhibition 2 | 52
decreased vertical activity 2 | 22
increased body length 2 | 20
increased circulating HDL chol... 2 | 63
increased circulating sodium l... 2 | 71
increased circulating triglyce... 2 | 24
increased effector memory CD4-... 2 | 15
increased mean corpuscular hem... 2 | 93
increased rib number 2 | 41
increased startle reflex 2 | 38
irregularly shaped pupil 2 | 7
narrow eye opening 2 | 15
oligodactyly 2 | 14
persistence of hyaloid vascula... 2 | 22
prenatal lethality prior to he... 2 | 64
short tibia 2 | 82
thin ventricular wall 2 | 5
trunk curl 2 | 15
abnormal embryo size 1 | 112
abnormal eyelid morphology 1 | 6
abnormal rib morphology 1 | 28
abnormal snout morphology 1 | 18
abnormal testis morphology 1 | 30
abnormal thoracic vertebrae mo... 1 | 16
abnormal tooth morphology 1 | 24
decreased blood urea nitrogen ... 1 | 31
decreased cervical vertebrae n... 1 | 12
decreased circulating chloride... 1 | 32
decreased circulating creatini... 1 | 31
decreased hematocrit 1 | 25
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased monocyte cell number 1 | 28
decreased neutrophil cell numb... 1 | 37
hemorrhage 1 | 12
increased blood urea nitrogen ... 1 | 44
increased blood uric acid leve... 1 | 5
increased circulating amylase ... 1 | 13
increased circulating glucose ... 1 | 16
increased circulating iron lev... 1 | 25
increased gamma-delta T cell n... 1 | 16
increased lactate dehydrogenas... 1 | 3
increased mean corpuscular hem... 1 | 25
increased mean platelet volume 1 | 19
limb grasping 1 | 35
long tibia 1 | 13
small kidney 1 | 10
straub tail 1 | 26
tremors 1 | 34
vertebral fusion 1 | 23

Disease

ovarian cancer 260 | 8,484
osteosarcoma 242 | 7,933
psoriasis 210 | 6,685
medulloblastoma, large-cell 197 | 6,234
glioblastoma 176 | 5,572
lung cancer 175 | 4,466
Cancer 173 | 2,346
atypical teratoid / rhabdoid tumor 141 | 4,369
Breast cancer 111 | 3,094
primitive neuroectodermal tumor 111 | 3,031
malignant mesothelioma 109 | 3,162
invasive ductal carcinoma 103 | 2,950
non-small cell lung cancer 99 | 2,798
lung adenocarcinoma 93 | 2,713
pilocytic astrocytoma 91 | 3,086
intraductal papillary-mucinous carcinoma (IPMC) 90 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 89 | 3,289
pediatric high grade glioma 89 | 2,712
intraductal papillary-mucinous adenoma (IPMA) 85 | 2,956
oligodendroglioma 84 | 2,849
pancreatic cancer 81 | 2,300
group 4 medulloblastoma 79 | 1,875
ductal carcinoma in situ 72 | 1,745
ependymoma 72 | 2,514
group 3 medulloblastoma 72 | 2,254
pituitary cancer 72 | 1,972
subependymal giant cell astrocytoma 69 | 2,287
interstitial cystitis 68 | 2,299
Carcinoma 67 | 2,147
breast carcinoma 67 | 1,614
lung carcinoma 67 | 2,844
cystic fibrosis 64 | 1,665
ulcerative colitis 63 | 2,087
astrocytoma 62 | 1,493
adult high grade glioma 59 | 2,148
diabetes mellitus 59 | 1,663
sonic hedgehog group medulloblastoma 58 | 1,482
Rheumatoid Arthritis 56 | 1,160
astrocytic glioma 56 | 2,241
posterior fossa group A ependymoma 54 | 1,511
primary pancreatic ductal adenocarcinoma 52 | 1,271
tuberculosis 52 | 1,557
adrenocortical carcinoma 51 | 1,427
Multiple myeloma 50 | 1,327
acute quadriplegic myopathy 49 | 1,157
colon cancer 48 | 1,475
dermatomyositis 47 | 933
juvenile dermatomyositis 46 | 1,189
Pick disease 45 | 1,893
Mammary Neoplasms 43 | 410
atypical teratoid/rhabdoid tumor 42 | 1,095
medulloblastoma 38 | 1,524
Atopic dermatitis 34 | 944
cutaneous lupus erythematosus 34 | 1,056
pancreatic ductal adenocarcinoma liver metastasis 33 | 1,795
Obesity 32 | 616
Waldenstrons macroglobulinemia 32 | 765
aldosterone-producing adenoma 32 | 664
posterior fossa group B ependymoma 31 | 1,530
spina bifida 31 | 1,064
Prostatic Neoplasms 29 | 471
Intellectual disability 28 | 573
gastric carcinoma 28 | 832
autosomal dominant Emery-Dreifuss muscular dystrophy 27 | 499
nasopharyngeal carcinoma 27 | 1,056
Kidney disease 26 | 396
fibroadenoma 26 | 557
esophageal adenocarcinoma 25 | 737
Alzheimer's disease 24 | 644
Endometriosis 24 | 535
acute myeloid leukemia 24 | 780
facioscapulohumeral dystrophy 24 | 286
primary Sjogren syndrome 23 | 789
Amyotrophic Lateral Sclerosis 22 | 431
non primary Sjogren syndrome sicca 22 | 840
Duchenne muscular dystrophy 21 | 602
Liver carcinoma 21 | 217
Osteoporosis 21 | 257
Stomach Neoplasms 20 | 282
inflammatory breast cancer 20 | 404
Down syndrome 19 | 548
Lung Neoplasms 19 | 171
Neoplasm Invasiveness 19 | 127
active Crohn's disease 19 | 918
tuberculosis and treatment for 6 months 19 | 686
Colorectal Neoplasms 18 | 217
hepatocellular carcinoma 18 | 532
Cleft palate 16 | 125
Colonic Neoplasms 16 | 126
Heart disease 16 | 279
Melanoma 16 | 261
pancreatic carcinoma 16 | 567
tuberculosis and treatment for 3 months 16 | 327
Adenoma 15 | 165
Metabolic syndrome X 15 | 155
Multiple Sclerosis 15 | 498
active ulcerative colitis 15 | 477
chronic rhinosinusitis 15 | 512
gastric cancer 15 | 430
nephrosclerosis 15 | 329

Tissue

Endocrine System 468 | 18,512
Female tissues 468 | 18,647
Urinary Tract 467 | 18,444
Digestive Tract 466 | 18,473
Liver and Pancreas 462 | 18,136
Nervous System 462 | 18,561
Skin and soft tissues 461 | 18,115
Blood and immune system 460 | 17,995
Cardiovascular System 460 | 17,958
Male tissues 456 | 17,969
Respiratory system 446 | 17,484

Target Family

Non-IDG 193 | 11,971
Transcription Factor 179 | 1,400
Epigenetic 45 | 242
Enzyme 31 | 4,146
Nuclear Receptor 13 | 48
TF/Epigenetic 13 | 38
Kinase 6 | 634
GPCR 2 | 406
Transporter 1 | 473

GO Process

negative regulation of transcr... 483 | 483
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Achaete-scute homolog 1 ASCL1 Tbio Transcription Factor -2.39907 258.0 359
Histone deacetylase 5 HDAC5 Tclin Epigenetic -2.11372 127.6 466
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.09305 1275.4 345
Transmembrane protease serine 6 TMPRSS6 Tchem Enzyme -1.99222 118.1 102
Basic helix-loop-helix transcription factor scleraxis SCX Tbio Transcription Factor -2.80657 344.1 42
Zinc finger protein 148 ZNF148 Tbio Transcription Factor -1.71996 60.7 178
Programmed cell death protein 4 PDCD4 Tchem Non-IDG -2.40380 284.9 546
High mobility group protein HMGI-C HMGA2 Tbio Transcription Factor -3.21092 1667.7 216
Methyl-CpG-binding protein 2 MECP2 Tchem Transcription Factor -3.22710 1827.6 567
Interferon lambda-1 IFNL1 Tbio Non-IDG -1.90881 86.4 137