Development Level

Tbio 359 | 11,651
Tchem 62 | 1,388
Tdark 54 | 6,593
Tclin 17 | 612

Collection

Kinase: IDG Consortium (Target... 2 | 125
RFA-RM-18-021 2 | 328

IMPC Phenotype

preweaning lethality, complete... 32 | 979
preweaning lethality, incomple... 16 | 499
enlarged heart 11 | 210
abnormal behavior 10 | 298
decreased vertical activity 10 | 208
abnormal heart morphology 8 | 162
increased mean corpuscular vol... 8 | 92
embryonic lethality prior to t... 7 | 278
increased circulating alkaline... 7 | 122
increased lean body mass 7 | 172
abnormal embryo size 6 | 220
decreased total body fat amoun... 6 | 207
increased startle reflex 6 | 112
abnormal bone structure 5 | 187
abnormal seminal vesicle morph... 5 | 114
decreased body weight 5 | 161
hypoactivity 5 | 132
increased bone mineral content 5 | 108
abnormal bone mineralization 4 | 38
abnormal eye morphology 4 | 68
abnormal iris morphology 4 | 13
abnormal kidney morphology 4 | 65
abnormal lens morphology 4 | 81
cataract 4 | 92
decreased blood urea nitrogen ... 4 | 51
decreased circulating glucose ... 4 | 126
decreased heart left ventricle... 4 | 28
increased bone mineral density 4 | 72
increased circulating HDL chol... 4 | 80
increased circulating choleste... 4 | 66
thrombocytopenia 4 | 56
decreased hemoglobin content 3 | 68
decreased lean body mass 3 | 135
decreased lymphocyte cell numb... 3 | 83
embryonic lethality prior to o... 3 | 239
increased circulating creatini... 3 | 38
increased circulating sodium l... 3 | 71
increased fasted circulating g... 3 | 76
increased mean corpuscular hem... 3 | 96
increased monocyte cell number 3 | 63
increased neutrophil cell numb... 3 | 46
increased total body fat amoun... 3 | 134
mammalian phenotype 3 | 17
persistence of hyaloid vascula... 3 | 33
thin ventricular wall 3 | 24
abnormal gait 2 | 69
abnormal locomotor activation 2 | 16
abnormal retinal blood vessel ... 2 | 26
abnormal retinal vasculature m... 2 | 27
abnormal skin coloration 2 | 25
abnormal startle reflex 2 | 15
corneal opacity 2 | 32
decreased bone mineral content 2 | 151
decreased circulating alkaline... 2 | 46
decreased circulating insulin ... 2 | 76
decreased erythrocyte cell num... 2 | 62
decreased grip strength 2 | 116
decreased hematocrit 2 | 46
decreased leukocyte cell numbe... 2 | 73
decreased prepulse inhibition 2 | 82
edema 2 | 59
hemorrhage 2 | 23
increased blood urea nitrogen ... 2 | 48
increased body length 2 | 32
increased circulating glucose ... 2 | 24
increased circulating triglyce... 2 | 42
increased hemoglobin content 2 | 45
irregularly shaped pupil 2 | 7
male infertility 2 | 123
prenatal lethality prior to he... 2 | 87
vertebral transformation 2 | 12
abnormal behavioral response t... 1 | 66
abnormal head morphology 1 | 10
abnormal heart left ventricle ... 1 | 16
abnormal lung morphology 1 | 26
abnormal optic disc morphology 1 | 10
abnormal tail movements 1 | 12
abnormal testis morphology 1 | 43
abnormal vertebrae morphology 1 | 18
decreased T cell number 1 | 15
decreased body length 1 | 101
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
decreased total retina thickne... 1 | 17
impaired pupillary reflex 1 | 26
increased blood uric acid leve... 1 | 5
increased circulating amylase ... 1 | 25
increased circulating chloride... 1 | 41
increased circulating creatine... 1 | 5
increased heart weight 1 | 62
increased mean platelet volume 1 | 45
limb grasping 1 | 41
long tibia 1 | 25
small superior vagus ganglion 1 | 74
tremors 1 | 39
vertebral fusion 1 | 23

Disease

Carcinoma 326 | 11,493
ovarian cancer 263 | 8,520
osteosarcoma 244 | 7,950
psoriasis 211 | 6,694
medulloblastoma, large-cell 196 | 6,241
Cancer 188 | 2,499
glioblastoma 188 | 5,792
lung cancer 183 | 4,740
atypical teratoid / rhabdoid tumor 165 | 5,112
group 3 medulloblastoma 142 | 4,104
Breast cancer 138 | 3,578
ependymoma 133 | 4,679
primitive neuroectodermal tumor 112 | 3,035
malignant mesothelioma 111 | 3,232
adult high grade glioma 105 | 3,801
invasive ductal carcinoma 101 | 2,951
non-small cell lung cancer 98 | 2,890
lung adenocarcinoma 93 | 2,716
intraductal papillary-mucinous carcinoma (IPMC) 90 | 2,989
Astrocytoma, Pilocytic 89 | 3,081
intraductal papillary-mucinous neoplasm (IPMN) 88 | 3,291
intraductal papillary-mucinous adenoma (IPMA) 86 | 2,955
pancreatic cancer 85 | 2,398
oligodendroglioma 84 | 2,850
Kidney cancer 83 | 2,613
breast carcinoma 72 | 1,638
ductal carcinoma in situ 72 | 1,745
subependymal giant cell astrocytoma 72 | 2,287
pituitary cancer 71 | 1,972
astrocytic glioma 70 | 2,597
tuberculosis 70 | 2,010
interstitial cystitis 69 | 2,312
diabetes mellitus 65 | 1,728
lung carcinoma 65 | 2,843
cystic fibrosis 64 | 1,696
group 4 medulloblastoma 64 | 1,855
Rheumatoid arthritis 60 | 1,191
ulcerative colitis 57 | 1,819
Multiple myeloma 55 | 1,332
Schizophrenia 53 | 1,160
primary pancreatic ductal adenocarcinoma 50 | 1,109
acute quadriplegic myopathy 49 | 1,158
adrenocortical carcinoma 49 | 1,428
astrocytoma 49 | 1,146
Breast Neoplasms 47 | 445
Intellectual disability 47 | 1,016
dermatomyositis 47 | 966
colon cancer 46 | 1,478
juvenile dermatomyositis 46 | 1,187
Mammary Neoplasms 45 | 425
Pick disease 44 | 1,894
pediatric high grade glioma 43 | 1,064
Obesity 38 | 678
Short stature 36 | 531
Dull intelligence 35 | 645
Low intelligence 35 | 645
Mental Retardation 35 | 645
Mental deficiency 35 | 645
Poor school performance 35 | 645
pancreatic ductal adenocarcinoma liver metastasis 35 | 1,962
Atopic dermatitis 34 | 952
Epilepsy 34 | 792
Waldenstrons macroglobulinemia 34 | 765
cutaneous lupus erythematosus 34 | 1,057
aldosterone-producing adenoma 32 | 665
Prostatic Neoplasms 31 | 495
spina bifida 31 | 1,074
Autosomal recessive predisposition 30 | 1,442
Cognitive delay 29 | 608
Cryptorchidism 29 | 296
Global developmental delay 29 | 608
Kidney disease 29 | 430
Mental and motor retardation 29 | 608
Muscle hypotonia 29 | 571
Small head 29 | 374
Bipolar Disorder 28 | 666
Seizures 28 | 596
autosomal dominant Emery-Dreifuss muscular dystrophy 28 | 510
Osteoporosis 27 | 363
gastric carcinoma 27 | 807
nasopharyngeal carcinoma 27 | 1,058
Alzheimer's disease 26 | 658
Lung Neoplasms 26 | 232
Melanoma 26 | 711
fibroadenoma 26 | 559
acute myeloid leukemia 25 | 783
esophageal adenocarcinoma 25 | 737
facioscapulohumeral dystrophy 25 | 288
Neoplasm Invasiveness 24 | 161
medulloblastoma 24 | 720
Amyotrophic lateral sclerosis 23 | 451
Carcinoma, Hepatocellular 23 | 228
Liver carcinoma 23 | 240
Strabismus 23 | 270
Colorectal Neoplasms 22 | 243
Endometriosis 22 | 540
Liver Cirrhosis, Experimental 22 | 769
Stomach Neoplasms 22 | 300
primary Sjogren syndrome 22 | 735
non primary Sjogren syndrome sicca 21 | 891

Tissue

Endocrine System 467 | 18,159
Female tissues 458 | 17,400
Digestive Tract 453 | 17,369
Skin and soft tissues 452 | 17,230
Male tissues 450 | 17,142
Blood and immune system 448 | 16,909
Nervous System 447 | 16,725
Liver and Pancreas 445 | 16,750
Urinary Tract 445 | 16,678
Respiratory system 442 | 16,393
Cardiovascular System 425 | 15,192

Target Family

Non-IDG 200 | 12,091
Transcription Factor 180 | 1,400
Epigenetic 45 | 242
Enzyme 32 | 4,145
Nuclear Receptor 13 | 48
TF/Epigenetic 13 | 38
Kinase 6 | 634
GPCR 2 | 408
Transporter 1 | 473

GO Process

negative regulation of transcr... 492 | 492
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA-binding death effector domain-containing protein 2 DEDD2 Tbio Non-IDG -0.55115 3.37 164
Paraspeckle component 1 PSPC1 Tbio Non-IDG -1.75415 48.3 19
Transcription factor HES-1 HES1 Tbio Transcription Factor -1.77409 55.5 444
ETS-related transcription factor Elf-2 ELF2 Tbio Transcription Factor -2.04794 106.4 92
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 PLCB1 Tbio Enzyme -2.50444 332.8 190
Tumor necrosis factor receptor superfamily member 4 TNFRSF4 Tbio Non-IDG -2.60147 430.2 524
Chromobox protein homolog 3 CBX3 Tbio Epigenetic -2.00023 90.5 366
Zinc finger protein 154 ZNF154 Tdark Transcription Factor -0.59081 4.13 76
EP300-interacting inhibitor of differentiation 2 EID2 Tbio Non-IDG -1.36642 21.1 65
BRCA1-A complex subunit RAP80 UIMC1 Tbio Non-IDG -1.69622 52.7 176