Development Level

Tbio 42 | 11,445
Tchem 14 | 1,598
Tclin 4 | 613
Tdark 2 | 6,588

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 5 | 979
preweaning lethality, incomple... 4 | 499
abnormal bone structure 3 | 187
abnormal embryo size 3 | 220
enlarged heart 3 | 210
abnormal eye morphology 2 | 68
decreased bone mineral content 2 | 151
decreased total body fat amoun... 2 | 207
decreased vertical activity 2 | 208
increased body weight 2 | 25
increased bone mineral content 2 | 108
increased circulating triglyce... 2 | 42
increased lean body mass 2 | 172
increased mean corpuscular hem... 2 | 96
increased mean corpuscular vol... 2 | 92
abnormal behavior 1 | 298
abnormal digit morphology 1 | 10
abnormal facial morphology 1 | 17
abnormal forebrain development 1 | 20
abnormal head shape 1 | 10
abnormal heart left ventricle ... 1 | 16
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal lens morphology 1 | 81
abnormal limb bud morphology 1 | 17
abnormal liver size 1 | 5
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal outer ear morphology 1 | 3
abnormal placenta size 1 | 20
abnormal seminal vesicle morph... 1 | 114
abnormal social-conspecific in... 1 | 3
abnormal stomach morphology 1 | 10
anophthalmia 1 | 33
cataract 1 | 92
decreased body length 1 | 101
decreased circulating alkaline... 1 | 46
decreased circulating iron lev... 1 | 32
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased lean body mass 1 | 135
decreased mean corpuscular vol... 1 | 79
decreased respiratory quotient 1 | 16
decreased startle reflex 1 | 75
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged lymph nodes 1 | 37
hypoactivity 1 | 132
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating serum al... 1 | 22
increased fasted circulating g... 1 | 76
increased mean corpuscular hem... 1 | 36
microphthalmia 1 | 26
pale liver 1 | 6
pale yolk sac 1 | 25
pallor 1 | 34
small adrenal glands 1 | 16
small heart 1 | 10
small kidney 1 | 16
small liver 1 | 8
small lung 1 | 5
small spleen 1 | 19
small thymus 1 | 16
thin ventricular wall 1 | 24
thrombocytosis 1 | 27

Disease

Carcinoma 39 | 11,493
ovarian cancer 37 | 8,520
Cancer 36 | 2,499
lung cancer 32 | 4,740
osteosarcoma 29 | 7,950
glioblastoma 27 | 5,792
medulloblastoma, large-cell 26 | 6,241
psoriasis 26 | 6,694
pancreatic cancer 19 | 2,398
adult high grade glioma 18 | 3,801
malignant mesothelioma 18 | 3,232
Breast cancer 17 | 3,578
atypical teratoid / rhabdoid tumor 17 | 5,112
ependymoma 15 | 4,679
lung carcinoma 15 | 2,843
non-small cell lung cancer 15 | 2,890
Astrocytoma, Pilocytic 14 | 3,081
diabetes mellitus 14 | 1,728
group 3 medulloblastoma 12 | 4,104
interstitial cystitis 12 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,291
oligodendroglioma 12 | 2,850
adrenocortical carcinoma 11 | 1,428
invasive ductal carcinoma 11 | 2,951
pituitary cancer 11 | 1,972
primitive neuroectodermal tumor 11 | 3,035
Breast Neoplasms 10 | 445
Mammary Neoplasms 10 | 425
primary pancreatic ductal adenocarcinoma 10 | 1,109
subependymal giant cell astrocytoma 10 | 2,287
Autosomal recessive predisposition 9 | 1,442
astrocytic glioma 9 | 2,597
breast carcinoma 9 | 1,638
Cleft Palate 8 | 271
Dull intelligence 8 | 645
Intellectual disability 8 | 1,016
Kidney cancer 8 | 2,613
Low intelligence 8 | 645
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Obesity 8 | 678
Poor school performance 8 | 645
Prostatic Neoplasms 8 | 495
Rheumatoid arthritis 8 | 1,191
Vascular disease 8 | 319
acute quadriplegic myopathy 8 | 1,158
aldosterone-producing adenoma 8 | 665
astrocytoma 8 | 1,146
colon cancer 8 | 1,478
cystic fibrosis 8 | 1,696
group 4 medulloblastoma 8 | 1,855
lung adenocarcinoma 8 | 2,716
Diabetes Mellitus, Non-Insulin-Dependent 7 | 145
Diabetes Mellitus, Type 2 7 | 142
Epilepsy 7 | 792
Schizophrenia 7 | 1,160
Seizures 7 | 596
medulloblastoma 7 | 720
tuberculosis 7 | 2,010
Acquired metabolic disease 6 | 336
Acquired scoliosis 6 | 281
Alzheimer's disease 6 | 658
Bipolar Disorder 6 | 666
Brachydactyly 6 | 156
Cognitive delay 6 | 608
Curvature of spine 6 | 282
Global developmental delay 6 | 608
Heart disease 6 | 306
Liver Cirrhosis, Experimental 6 | 769
Mental and motor retardation 6 | 608
Multiple myeloma 6 | 1,332
Orbital separation excessive 6 | 244
Short stature 6 | 531
Strabismus 6 | 270
esophageal adenocarcinoma 6 | 737
non primary Sjogren syndrome sicca 6 | 891
ulcerative colitis 6 | 1,819
Asthma 5 | 385
Atherosclerosis 5 | 291
Broad flat nasal bridge 5 | 236
Cataract 5 | 297
Chronic obstructive pulmonary disease 5 | 184
Concave bridge of nose 5 | 195
Depressed nasal bridge 5 | 195
Depressed nasal root/bridge 5 | 195
Endometriosis 5 | 540
Hypoplastic mandible condyle 5 | 275
Kidney disease 5 | 430
Mandibular hypoplasia 5 | 275
Micrognathism 5 | 275
Mood Disorders 5 | 184
Muscle hypotonia 5 | 571
Nasal bridge wide 5 | 236
Neoplasm Invasiveness 5 | 161
Uranostaphyloschisis 5 | 167
active ulcerative colitis 5 | 764
acute myeloid leukemia 5 | 783
sonic hedgehog group medulloblastoma 5 | 467

Tissue

Endocrine System 62 | 18,159
Blood and immune system 61 | 16,909
Digestive Tract 61 | 17,369
Female tissues 61 | 17,400
Liver and Pancreas 61 | 16,750
Skin and soft tissues 61 | 17,230
Male tissues 60 | 17,142
Respiratory system 60 | 16,393
Urinary Tract 60 | 16,678
Nervous System 59 | 16,725
Cardiovascular System 58 | 15,192

Target Family

Non-IDG 23 | 12,091
Transcription Factor 20 | 1,400
Epigenetic 6 | 242
Enzyme 5 | 4,145
Kinase 3 | 634
Nuclear Receptor 3 | 48
GPCR 1 | 408
TF/Epigenetic 1 | 38

GO Process

negative regulation of sequenc... 62 | 62
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitogen-activated protein kinase kinase kinase 10 MAP3K10 Tchem Kinase -1.20048 15.1 221
Single Ig IL-1-related receptor SIGIRR Tbio Non-IDG -1.74139 69.6 182
POU domain, class 4, transcription factor 2 POU4F2 Tbio Transcription Factor -1.94397 90.2 145
Wolframin WFS1 Tbio Non-IDG -2.40006 260.2 118
Nuclear receptor subfamily 0 group B member 1 NR0B1 Tbio Nuclear Receptor -2.73235 544.8 477
Zinc finger protein GLIS2 GLIS2 Tbio Transcription Factor -1.92889 80.4 102
DNA damage-inducible transcript 3 protein DDIT3 Tchem Transcription Factor -2.94434 736.0 704
Transcription initiation factor TFIID subunit 3 TAF3 Tbio Epigenetic -0.97631 8.71 103
Class E basic helix-loop-helix protein 40 BHLHE40 Tbio Transcription Factor -1.77841 66.6 224
Retinoblastoma-associated protein RB1 Tchem Non-IDG -3.07052 1137.4 2150