Development Level

Tbio 97 | 11,445
Tchem 35 | 1,598
Tclin 14 | 613
Tdark 5 | 6,588

IMPC Phenotype

preweaning lethality, complete... 12 | 979
preweaning lethality, incomple... 8 | 499
embryonic lethality prior to t... 7 | 278
embryonic lethality prior to o... 5 | 239
abnormal embryo size 4 | 220
abnormal heart morphology 4 | 162
abnormal seminal vesicle morph... 4 | 114
enlarged heart 4 | 210
abnormal bone structure 3 | 187
abnormal spleen morphology 3 | 55
decreased body weight 3 | 161
decreased lymphocyte cell numb... 3 | 83
decreased mean platelet volume 3 | 25
increased circulating alkaline... 3 | 122
abnormal behavior 2 | 298
abnormal coat- hair morphology 2 | 19
abnormal kidney morphology 2 | 65
abnormal lens morphology 2 | 81
abnormal lung morphology 2 | 26
cardiovascular system phenotyp... 2 | 36
cataract 2 | 92
decreased T cell number 2 | 15
decreased blood urea nitrogen ... 2 | 51
decreased fasted circulating g... 2 | 65
decreased grip strength 2 | 116
decreased lean body mass 2 | 135
decreased total body fat amoun... 2 | 207
enlarged spleen 2 | 41
increased circulating HDL chol... 2 | 80
increased circulating choleste... 2 | 66
increased leukocyte cell numbe... 2 | 47
increased mean corpuscular vol... 2 | 92
increased neutrophil cell numb... 2 | 46
prolonged ST segment 2 | 36
short tibia 2 | 97
small superior vagus ganglion 2 | 74
small testis 2 | 58
tremors 2 | 39
abnormal behavioral response t... 1 | 66
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal gait 1 | 69
abnormal heart left ventricle ... 1 | 16
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal pericardium morpholog... 1 | 26
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal tail movements 1 | 12
abnormal testis morphology 1 | 43
abnormal vertebrae morphology 1 | 18
absent vibrissae 1 | 12
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating bilirubi... 1 | 19
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased eosinophil cell numb... 1 | 24
decreased heart left ventricle... 1 | 28
decreased heart rate 1 | 18
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
decreased pulmonary respirator... 1 | 5
decreased threshold for audito... 1 | 26
edema 1 | 59
enlarged epididymis 1 | 31
enlarged heart atrium 1 | 4
enlarged stomach 1 | 2
hemorrhage 1 | 23
hydrometra 1 | 53
increased blood urea nitrogen ... 1 | 48
increased circulating amylase ... 1 | 25
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased circulating serum al... 1 | 22
increased fasted circulating g... 1 | 76
increased heart rate variabili... 1 | 7
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
increased red blood cell distr... 1 | 34
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
polycystic kidney 1 | 15
premature death 1 | 5
scaly skin 1 | 4
small adrenal glands 1 | 16
small thymus 1 | 16
thin ventricular wall 1 | 24
thrombocytosis 1 | 27
unresponsive to tactile stimul... 1 | 8
urinary bladder obstruction 1 | 4

Disease

Carcinoma 103 | 11,493
ovarian cancer 100 | 8,520
osteosarcoma 76 | 7,950
psoriasis 76 | 6,694
glioblastoma 71 | 5,792
Cancer 69 | 2,499
medulloblastoma, large-cell 65 | 6,241
lung cancer 64 | 4,740
Breast cancer 49 | 3,578
atypical teratoid / rhabdoid tumor 49 | 5,112
ependymoma 46 | 4,679
lung carcinoma 44 | 2,843
group 3 medulloblastoma 43 | 4,104
Astrocytoma, Pilocytic 39 | 3,081
malignant mesothelioma 38 | 3,232
Kidney cancer 37 | 2,613
adult high grade glioma 37 | 3,801
invasive ductal carcinoma 37 | 2,951
lung adenocarcinoma 37 | 2,716
oligodendroglioma 35 | 2,850
intraductal papillary-mucinous carcinoma (IPMC) 34 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 34 | 3,291
pancreatic cancer 34 | 2,398
intraductal papillary-mucinous adenoma (IPMA) 33 | 2,955
astrocytic glioma 32 | 2,597
diabetes mellitus 32 | 1,728
non-small cell lung cancer 32 | 2,890
primitive neuroectodermal tumor 32 | 3,035
interstitial cystitis 30 | 2,312
ulcerative colitis 29 | 1,819
cystic fibrosis 28 | 1,696
ductal carcinoma in situ 28 | 1,745
tuberculosis 27 | 2,010
Schizophrenia 25 | 1,160
juvenile dermatomyositis 24 | 1,187
subependymal giant cell astrocytoma 24 | 2,287
Breast Neoplasms 23 | 445
Intellectual disability 23 | 1,016
Mammary Neoplasms 23 | 425
astrocytoma 23 | 1,146
group 4 medulloblastoma 23 | 1,855
Rheumatoid arthritis 22 | 1,191
Alzheimer's disease 21 | 658
adrenocortical carcinoma 21 | 1,428
Autosomal recessive predisposition 20 | 1,442
Liver Cirrhosis, Experimental 20 | 769
Multiple myeloma 20 | 1,332
Obesity 20 | 678
Depressive disorder 18 | 409
Heart disease 18 | 306
Prostatic Neoplasms 18 | 495
colon cancer 18 | 1,478
pituitary cancer 18 | 1,972
primary pancreatic ductal adenocarcinoma 18 | 1,109
Dull intelligence 17 | 645
Hypertensive disease 17 | 292
Low intelligence 17 | 645
Mental Retardation 17 | 645
Mental deficiency 17 | 645
Pick disease 17 | 1,894
Poor school performance 17 | 645
breast carcinoma 17 | 1,638
Bipolar Disorder 16 | 666
Hypertension 16 | 396
pancreatic ductal adenocarcinoma liver metastasis 16 | 1,962
Atherosclerosis 15 | 291
Atopic dermatitis 15 | 952
Carcinoma, Hepatocellular 15 | 228
Endometriosis 15 | 540
Epilepsy 15 | 792
Kidney disease 15 | 430
Liver carcinoma 15 | 240
Lung Neoplasms 15 | 232
Parkinson's disease 15 | 392
Seizures 15 | 596
acute quadriplegic myopathy 15 | 1,158
Melanoma 14 | 711
Short stature 14 | 531
Vascular disease 14 | 319
cutaneous lupus erythematosus 14 | 1,057
gastric carcinoma 14 | 807
Anemia 13 | 365
Cognitive delay 13 | 608
Coronary artery disease 13 | 268
Global developmental delay 13 | 608
Major Depressive Disorder 13 | 301
Mental and motor retardation 13 | 608
autosomal dominant Emery-Dreifuss muscular dystrophy 13 | 510
dermatomyositis 13 | 966
spina bifida 13 | 1,074
Cerebrovascular disease 12 | 238
Mental Depression 12 | 333
Waldenstrons macroglobulinemia 12 | 765
primary Sjogren syndrome 12 | 735
Adenoma 11 | 167
Osteoporosis 11 | 363
Pneumonia 11 | 174
Unipolar Depression 11 | 250
fibroadenoma 11 | 559
pediatric high grade glioma 11 | 1,064

Tissue

Digestive Tract 149 | 17,369
Endocrine System 149 | 18,159
Female tissues 147 | 17,400
Respiratory system 147 | 16,393
Skin and soft tissues 147 | 17,230
Blood and immune system 146 | 16,909
Liver and Pancreas 146 | 16,750
Urinary Tract 145 | 16,678
Male tissues 144 | 17,142
Nervous System 144 | 16,725
Cardiovascular System 141 | 15,192

Target Family

Non-IDG 83 | 12,091
Enzyme 23 | 4,145
Transcription Factor 20 | 1,400
Kinase 13 | 634
Epigenetic 4 | 242
GPCR 4 | 408
Nuclear Receptor 3 | 48
Transporter 1 | 473

GO Process

negative regulation of gene ex... 151 | 151
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Bardet-Biedl syndrome 4 protein BBS4 Tbio Non-IDG -1.53435 31.5 200
Endoglin ENG Tbio Non-IDG -3.10482 1235.9 1622
Smoothened homolog SMO Tclin GPCR -1.17466 14.5 415
Copine-1 CPNE1 Tbio Non-IDG -1.04880 11.6 151
NEDD4 family-interacting protein 2 NDFIP2 Tbio Non-IDG -0.67951 5.49 37
Homeobox protein Nkx-3.1 NKX3-1 Tbio Transcription Factor -2.13442 140.5 524
Peptidyl-tRNA hydrolase 2, mitochondrial PTRH2 Tbio Enzyme -1.56520 39.8 293
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Zinc finger protein 281 ZNF281 Tbio Transcription Factor -0.58845 5.38 140
Fibroblast growth factor 19 FGF19 Tbio Non-IDG -2.54882 334.2 305