Development Level

Tbio 256 | 10,625
Tchem 121 | 1,890
Tclin 35 | 602
Tdark 28 | 7,003

Collection

Eligible Kinase Proteins 4 | 134
Eligible non-olfactory GPCR Proteins 2 | 143

IMPC Term

preweaning lethality, complete... 27 | 633
embryonic lethality prior to t... 13 | 187
abnormal behavior 11 | 226
decreased lean body mass 11 | 195
preweaning lethality, incomple... 8 | 260
decreased bone mineral content 7 | 157
enlarged heart 7 | 111
increased circulating alkaline... 7 | 119
abnormal bone structure 6 | 131
decreased body weight 6 | 174
decreased circulating triglyce... 6 | 83
increased or absent threshold ... 6 | 128
small testis 6 | 37
decreased circulating insulin ... 5 | 75
decreased fasted circulating g... 5 | 49
decreased grip strength 5 | 123
decreased total body fat amoun... 5 | 186
embryonic lethality prior to o... 5 | 148
abnormal embryo size 4 | 112
abnormal gait 4 | 51
abnormal testis morphology 4 | 30
decreased mean corpuscular vol... 4 | 50
hypoactivity 4 | 89
increased circulating HDL chol... 4 | 63
increased circulating triglyce... 4 | 24
increased mean corpuscular vol... 4 | 91
limb grasping 4 | 35
tremors 4 | 34
abnormal bone mineralization 3 | 55
abnormal femur morphology 3 | 14
abnormal heart morphology 3 | 51
abnormal lens morphology 3 | 73
abnormal seminal vesicle morph... 3 | 47
decreased body length 3 | 108
decreased bone mineral density 3 | 126
decreased circulating choleste... 3 | 85
decreased circulating glucose ... 3 | 121
decreased rib number 3 | 59
enlarged spleen 3 | 26
impaired glucose tolerance 3 | 52
increased body length 3 | 20
increased circulating choleste... 3 | 53
increased circulating total pr... 3 | 20
increased grip strength 3 | 83
increased hemoglobin content 3 | 45
increased mean corpuscular hem... 3 | 93
short tibia 3 | 82
abnormal iris morphology 2 | 12
abnormal limb bud morphology 2 | 15
abnormal liver morphology 2 | 5
abnormal lung morphology 2 | 15
abnormal neural tube closure 2 | 37
abnormal optic disc morphology 2 | 10
abnormal placenta size 2 | 10
abnormal retina morphology 2 | 100
abnormal skin morphology 2 | 23
abnormal tooth morphology 2 | 24
cyanosis 2 | 6
decreased KLRG1+ CD8 alpha bet... 2 | 8
decreased circulating HDL chol... 2 | 77
decreased circulating alkaline... 2 | 41
decreased circulating serum al... 2 | 79
decreased heart weight 2 | 44
decreased mean corpuscular hem... 2 | 34
decreased startle reflex 2 | 48
hydrops fetalis 2 | 22
increased body weight 2 | 42
increased bone mineral content 2 | 92
increased circulating alanine ... 2 | 11
increased circulating aspartat... 2 | 17
increased circulating calcium ... 2 | 32
increased lean body mass 2 | 107
increased leukocyte cell numbe... 2 | 37
increased total body fat amoun... 2 | 57
male infertility 2 | 62
pale yolk sac 2 | 12
pallor 2 | 13
prenatal lethality prior to he... 2 | 64
abnormal coat appearance 1 | 25
abnormal embryo turning 1 | 15
abnormal retinal pigmentation 1 | 61
abnormal spleen morphology 1 | 36
decreased IgG1 level 1 | 4
decreased T cell number 1 | 31
decreased blood urea nitrogen ... 1 | 31
decreased circulating sodium l... 1 | 18
decreased neutrophil cell numb... 1 | 37
embryonic growth retardation 1 | 28
impaired righting response 1 | 19
increased CD4-positive, CD25-p... 1 | 18
increased NK cell number 1 | 19
increased blood urea nitrogen ... 1 | 44
increased bone mineral density 1 | 52
increased circulating glucose ... 1 | 16
increased circulating iron lev... 1 | 25
increased lactate dehydrogenas... 1 | 3
increased sacral vertebrae num... 1 | 62
long tibia 1 | 13
straub tail 1 | 26
vertebral fusion 1 | 23

Disease

ovarian cancer 249 | 8,484
Cancer 223 | 2,346
psoriasis 203 | 6,685
osteosarcoma 193 | 7,933
lung cancer 173 | 4,466
glioblastoma 163 | 5,572
medulloblastoma, large-cell 156 | 6,234
intraductal papillary-mucinous neoplasm (IPMN) 114 | 3,289
invasive ductal carcinoma 112 | 2,950
Breast cancer 109 | 3,094
atypical teratoid / rhabdoid tumor 104 | 4,369
intraductal papillary-mucinous adenoma (IPMA) 101 | 2,956
malignant mesothelioma 100 | 3,162
intraductal papillary-mucinous carcinoma (IPMC) 99 | 2,988
non-small cell lung cancer 99 | 2,798
ulcerative colitis 90 | 2,087
lung carcinoma 89 | 2,844
diabetes mellitus 87 | 1,663
interstitial cystitis 86 | 2,299
pancreatic cancer 85 | 2,300
lung adenocarcinoma 82 | 2,713
oligodendroglioma 82 | 2,849
pediatric high grade glioma 77 | 2,712
pilocytic astrocytoma 76 | 3,086
subependymal giant cell astrocytoma 73 | 2,287
tuberculosis 73 | 1,557
ductal carcinoma in situ 70 | 1,745
primitive neuroectodermal tumor 67 | 3,031
breast carcinoma 66 | 1,614
ependymoma 63 | 2,514
posterior fossa group A ependymoma 61 | 1,511
cystic fibrosis 60 | 1,665
adrenocortical carcinoma 59 | 1,427
Multiple myeloma 58 | 1,327
colon cancer 58 | 1,475
Mammary Neoplasms 57 | 410
group 4 medulloblastoma 57 | 1,875
Carcinoma 56 | 2,147
astrocytic glioma 56 | 2,241
astrocytoma 56 | 1,493
Rheumatoid Arthritis 54 | 1,160
pancreatic ductal adenocarcinoma liver metastasis 52 | 1,795
group 3 medulloblastoma 51 | 2,254
pituitary cancer 51 | 1,972
acute quadriplegic myopathy 50 | 1,157
primary pancreatic ductal adenocarcinoma 48 | 1,271
cutaneous lupus erythematosus 47 | 1,056
Prostatic Neoplasms 45 | 471
Pick disease 43 | 1,893
Vascular disease 43 | 281
juvenile dermatomyositis 43 | 1,189
sonic hedgehog group medulloblastoma 43 | 1,482
Alzheimer's disease 42 | 644
Kidney disease 42 | 396
Obesity 39 | 616
nasopharyngeal carcinoma 38 | 1,056
adult high grade glioma 37 | 2,148
esophageal adenocarcinoma 37 | 737
spina bifida 36 | 1,064
medulloblastoma 34 | 1,524
Asthma 33 | 349
Stomach Neoplasms 33 | 282
Atopic dermatitis 32 | 944
atypical teratoid/rhabdoid tumor 32 | 1,095
dermatomyositis 32 | 933
gastric carcinoma 32 | 832
Endometriosis 31 | 535
Waldenstrons macroglobulinemia 30 | 765
active Crohn's disease 29 | 918
Down syndrome 28 | 548
Liver carcinoma 28 | 217
Lung Neoplasms 28 | 171
Amyotrophic Lateral Sclerosis 27 | 431
Renal Cell Carcinoma 27 | 199
primary Sjogren syndrome 27 | 789
Arthritis 25 | 248
Duchenne muscular dystrophy 25 | 602
Heart disease 25 | 279
Multiple Sclerosis 25 | 498
Neoplasm Metastasis 25 | 138
Adenoma 24 | 165
Liver disease 24 | 219
acute myeloid leukemia 24 | 780
non-small cell lung carcinoma 24 | 413
Diabetes Mellitus, Non-Insulin-Dependent 23 | 157
Neurodegenerative disease 23 | 383
autosomal dominant Emery-Dreifuss muscular dystrophy 23 | 499
facioscapulohumeral dystrophy 23 | 286
Hypertensive disease 22 | 193
Mammary Neoplasms, Experimental 22 | 150
Schizophrenia 22 | 501
fibroadenoma 22 | 557
posterior fossa group B ependymoma 22 | 1,530
Colonic Neoplasms 21 | 126
Hypertension 21 | 287
IGA Glomerulonephritis 21 | 454
Neoplasm Invasiveness 21 | 127
Parkinson's disease 21 | 364
non primary Sjogren syndrome sicca 20 | 840
tuberculosis and treatment for 6 months 20 | 686

Tissue

Digestive Tract 429 | 18,473
Endocrine System 425 | 18,512
Female tissues 425 | 18,647
Liver and Pancreas 422 | 18,136
Urinary Tract 422 | 18,444
Blood and immune system 420 | 17,995
Skin and soft tissues 420 | 18,115
Nervous System 419 | 18,561
Male tissues 416 | 17,969
Cardiovascular System 415 | 17,958
Respiratory system 407 | 17,484

Target Family

Non-IDG 236 | 11,971
Enzyme 73 | 4,146
Kinase 53 | 634
Transcription Factor 52 | 1,400
GPCR 10 | 406
Epigenetic 6 | 242
Nuclear Receptor 6 | 48
Transporter 3 | 473
Ion Channel 1 | 341

GO Process

negative regulation of apoptot... 440 | 440
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Achaete-scute homolog 1 ASCL1 Tbio Transcription Factor -2.39907 258.0 359
Glial cell line-derived neurotrophic factor GDNF Tbio Non-IDG -3.30206 2301.5 303
Endoplasmin HSP90B1 Tchem Non-IDG -2.72785 604.5 748
Teratocarcinoma-derived growth factor 1 TDGF1 Tbio Non-IDG 156.3 371
Interleukin-1 receptor-associated kinase 1 IRAK1 Tchem Kinase -2.51851 320.4 729
Basic helix-loop-helix transcription factor scleraxis SCX Tbio Transcription Factor -2.80657 344.1 42
Programmed cell death protein 4 PDCD4 Tchem Non-IDG -2.40380 284.9 546
High mobility group protein HMGI-C HMGA2 Tbio Transcription Factor -3.21092 1667.7 216
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
Apoptosis inhibitor 5 API5 Tbio Non-IDG -1.32754 23.5 171