Development Level

Tbio 298 | 11,651
Tchem 111 | 1,388
Tclin 38 | 612
Tdark 32 | 6,593

Collection

RFA-RM-18-021 8 | 328
Kinase: IDG Consortium (Target... 6 | 125
Kinase: IDG Consortium (Comple... 3 | 37
GPCR: IDG Consortium (Targets) 2 | 126

IMPC Phenotype

preweaning lethality, complete... 47 | 979
abnormal behavior 16 | 298
embryonic lethality prior to t... 16 | 278
preweaning lethality, incomple... 15 | 499
enlarged heart 13 | 210
increased circulating alkaline... 12 | 122
abnormal embryo size 10 | 220
abnormal heart morphology 10 | 162
decreased lean body mass 10 | 135
decreased vertical activity 10 | 208
embryonic lethality prior to o... 10 | 239
abnormal bone structure 8 | 187
decreased body weight 8 | 161
decreased bone mineral content 7 | 151
increased total body fat amoun... 7 | 134
decreased circulating insulin ... 6 | 76
decreased circulating triglyce... 6 | 79
decreased mean corpuscular vol... 6 | 79
decreased total body fat amoun... 6 | 207
embryonic growth retardation 6 | 106
hypoactivity 6 | 132
increased circulating choleste... 6 | 66
abnormal gait 5 | 69
decreased circulating glucose ... 5 | 126
impaired glucose tolerance 5 | 75
increased circulating HDL chol... 5 | 80
small testis 5 | 58
abnormal bone mineralization 4 | 38
abnormal eye morphology 4 | 68
abnormal lens morphology 4 | 81
abnormal placenta size 4 | 20
decreased fasted circulating g... 4 | 65
enlarged spleen 4 | 41
increased circulating calcium ... 4 | 34
increased circulating total pr... 4 | 28
increased circulating triglyce... 4 | 42
increased lean body mass 4 | 172
increased mean corpuscular vol... 4 | 92
limb grasping 4 | 41
pallor 4 | 34
tremors 4 | 39
abnormal femur morphology 3 | 14
abnormal lung morphology 3 | 26
abnormal pericardium morpholog... 3 | 26
abnormal seminal vesicle morph... 3 | 114
abnormal skin morphology 3 | 50
abnormal testis morphology 3 | 43
cardiovascular system phenotyp... 3 | 36
cataract 3 | 92
decreased circulating aspartat... 3 | 34
decreased circulating choleste... 3 | 93
decreased lymphocyte cell numb... 3 | 83
decreased neutrophil cell numb... 3 | 42
decreased red blood cell distr... 3 | 41
edema 3 | 59
hyperactivity 3 | 148
increased bone mineral content 3 | 108
increased hemoglobin content 3 | 45
increased monocyte cell number 3 | 63
increased neutrophil cell numb... 3 | 46
increased red blood cell distr... 3 | 34
increased startle reflex 3 | 112
pale yolk sac 3 | 25
short tibia 3 | 97
abnormal coat appearance 2 | 31
abnormal embryo turning 2 | 31
abnormal facial morphology 2 | 17
abnormal heart left ventricle ... 2 | 16
abnormal kidney morphology 2 | 65
abnormal liver morphology 2 | 17
abnormal neural tube closure 2 | 46
abnormal retina morphology 2 | 71
cyanosis 2 | 7
decreased blood urea nitrogen ... 2 | 51
decreased bone mineral density 2 | 126
decreased circulating HDL chol... 2 | 68
decreased circulating alanine ... 2 | 47
decreased circulating alkaline... 2 | 46
decreased circulating amylase ... 2 | 28
decreased circulating serum al... 2 | 82
decreased grip strength 2 | 116
decreased large unstained cell... 2 | 11
decreased mean corpuscular hem... 2 | 50
decreased mean corpuscular hem... 2 | 31
decreased startle reflex 2 | 75
hemorrhage 2 | 23
increased body length 2 | 32
increased bone mineral density 2 | 72
increased circulating alanine ... 2 | 13
increased circulating aspartat... 2 | 15
increased circulating glucose ... 2 | 24
increased fasted circulating g... 2 | 76
increased grip strength 2 | 41
increased heart weight 2 | 62
increased lymphocyte cell numb... 2 | 32
increased mean corpuscular hem... 2 | 96
long tibia 2 | 25
male infertility 2 | 123
prenatal lethality prior to he... 2 | 87
small seminal vesicle 2 | 10

Disease

Carcinoma 282 | 11,493
ovarian cancer 269 | 8,520
Cancer 247 | 2,499
psoriasis 217 | 6,694
osteosarcoma 211 | 7,950
lung cancer 196 | 4,740
glioblastoma 180 | 5,792
medulloblastoma, large-cell 167 | 6,241
Breast cancer 137 | 3,578
atypical teratoid / rhabdoid tumor 134 | 5,112
ependymoma 130 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 117 | 3,291
invasive ductal carcinoma 116 | 2,951
malignant mesothelioma 114 | 3,232
intraductal papillary-mucinous adenoma (IPMA) 108 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 107 | 2,989
non-small cell lung cancer 106 | 2,890
diabetes mellitus 96 | 1,728
group 3 medulloblastoma 96 | 4,104
pancreatic cancer 96 | 2,398
lung carcinoma 94 | 2,843
interstitial cystitis 92 | 2,312
adult high grade glioma 88 | 3,801
lung adenocarcinoma 88 | 2,716
oligodendroglioma 88 | 2,850
tuberculosis 87 | 2,010
ulcerative colitis 83 | 1,819
subependymal giant cell astrocytoma 80 | 2,287
Astrocytoma, Pilocytic 77 | 3,081
astrocytic glioma 75 | 2,597
ductal carcinoma in situ 73 | 1,745
Kidney cancer 72 | 2,613
breast carcinoma 71 | 1,638
primitive neuroectodermal tumor 70 | 3,035
Schizophrenia 67 | 1,160
cystic fibrosis 67 | 1,696
Autosomal recessive predisposition 66 | 1,442
Multiple myeloma 66 | 1,332
adrenocortical carcinoma 65 | 1,428
group 4 medulloblastoma 64 | 1,855
Breast Neoplasms 63 | 445
Mammary Neoplasms 61 | 425
colon cancer 59 | 1,478
pancreatic ductal adenocarcinoma liver metastasis 59 | 1,962
Rheumatoid arthritis 58 | 1,191
pituitary cancer 57 | 1,972
acute quadriplegic myopathy 52 | 1,158
cutaneous lupus erythematosus 52 | 1,057
Pick disease 48 | 1,894
Prostatic Neoplasms 48 | 495
Vascular disease 47 | 319
astrocytoma 47 | 1,146
primary pancreatic ductal adenocarcinoma 47 | 1,109
Alzheimer's disease 46 | 658
Obesity 46 | 678
juvenile dermatomyositis 45 | 1,187
Bipolar Disorder 43 | 666
Kidney disease 43 | 430
Intellectual disability 42 | 1,016
Hypertension 41 | 396
Liver Cirrhosis, Experimental 41 | 769
nasopharyngeal carcinoma 41 | 1,058
Seizures 39 | 596
esophageal adenocarcinoma 39 | 737
spina bifida 38 | 1,074
Endometriosis 36 | 540
Epilepsy 35 | 792
Stomach Neoplasms 35 | 300
Waldenstrons macroglobulinemia 35 | 765
Carcinoma, Hepatocellular 34 | 228
Liver carcinoma 34 | 240
Lung Neoplasms 34 | 232
Short stature 34 | 531
pediatric high grade glioma 34 | 1,064
Asthma 33 | 385
Hypertensive disease 33 | 292
Melanoma 33 | 711
dermatomyositis 33 | 966
Atopic dermatitis 32 | 952
gastric carcinoma 32 | 807
Cognitive delay 31 | 608
Global developmental delay 31 | 608
Mental and motor retardation 31 | 608
active Crohn's disease 31 | 922
Depressive disorder 30 | 409
Dull intelligence 30 | 645
Heart disease 30 | 306
Low intelligence 30 | 645
Mental Retardation 30 | 645
Mental deficiency 30 | 645
Poor school performance 30 | 645
Renal Cell Carcinoma 30 | 214
Arthritis 29 | 290
Cryptorchidism 29 | 296
Amyotrophic lateral sclerosis 28 | 451
Anemia 28 | 365
Down syndrome 28 | 499
Neurodegenerative disease 27 | 414
autosomal dominant Emery-Dreifuss muscular dystrophy 27 | 510
primary Sjogren syndrome 27 | 735

Tissue

Endocrine System 450 | 18,159
Digestive Tract 444 | 17,369
Skin and soft tissues 443 | 17,230
Female tissues 442 | 17,400
Blood and immune system 440 | 16,909
Male tissues 439 | 17,142
Urinary Tract 438 | 16,678
Liver and Pancreas 434 | 16,750
Nervous System 434 | 16,725
Respiratory system 430 | 16,393
Cardiovascular System 405 | 15,192

Target Family

Non-IDG 265 | 12,091
Enzyme 80 | 4,145
Kinase 56 | 634
Transcription Factor 52 | 1,400
GPCR 10 | 408
Epigenetic 6 | 242
Nuclear Receptor 6 | 48
Transporter 3 | 473
Ion Channel 1 | 344

GO Process

negative regulation of apoptot... 479 | 479
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Myeloperoxidase MPO Tchem Enzyme -3.51470 3209.3 1255
Ras GTPase-activating protein 1 RASA1 Tbio Enzyme -2.61637 404.4 402
Thrombospondin-1 THBS1 Tbio Non-IDG -3.06622 1281.6 504
cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A Tclin Enzyme -2.09039 125.7 168
Sphingosine kinase 2 SPHK2 Tchem Kinase -2.21878 154.9 314
Interleukin-6 IL6 Tclin Non-IDG -4.50976 30968.8 2075
Ankyrin repeat and LEM domain-containing protein 2 ANKLE2 Tbio Non-IDG -1.07238 11.8 76
Interleukin-6 receptor subunit beta IL6ST Tclin Non-IDG -1.72489 55.4 555