Development Level

Tbio 4 | 11,651

IMPC Phenotype

preweaning lethality, complete... 3 | 979
decreased hemoglobin content 2 | 68
decreased leukocyte cell numbe... 2 | 73
vertebral fusion 2 | 23
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal femur morphology 1 | 14
abnormal pelvic girdle bone mo... 1 | 12
abnormal rib morphology 1 | 10
abnormal tail morphology 1 | 25
abnormal vertebrae morphology 1 | 18
abnormal vertebral arch morpho... 1 | 9
abnormal vocalization 1 | 21
corneal opacity 1 | 32
decreased body length 1 | 101
decreased body weight 1 | 161
decreased caudal vertebrae num... 1 | 53
decreased circulating glucose ... 1 | 126
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased hematocrit 1 | 46
decreased mean corpuscular hem... 1 | 50
hypoactivity 1 | 132
impaired pupillary reflex 1 | 26
increased blood uric acid leve... 1 | 5
increased body weight 1 | 25
increased bone mineral density 1 | 72
increased circulating chloride... 1 | 41
increased circulating phosphat... 1 | 26
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 36
increased mean corpuscular vol... 1 | 92
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 134
long tibia 1 | 25
narrow eye opening 1 | 12
thrombocytosis 1 | 27

Disease

Carcinoma 4 | 11,493
Cancer 2 | 2,499
Pick disease 2 | 1,894
atypical teratoid / rhabdoid tumor 2 | 5,112
glioblastoma 2 | 5,792
juvenile dermatomyositis 2 | 1,187
malignant mesothelioma 2 | 3,232
medulloblastoma, large-cell 2 | 6,241
osteosarcoma 2 | 7,950
ovarian cancer 2 | 8,520
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
progressive supranuclear palsy 2 | 676
tuberculosis and treatment for 6 months 2 | 409
Abnormality of the lymphatic system 1 | 14
Acute Promyelocytic Leukemia 1 | 40
Adenocarcinoma of lung 1 | 142
Adenocarcinoma of lung (disorder) 1 | 60
Alzheimer's disease 1 | 658
Anemia 1 | 365
Basal cell carcinoma 1 | 54
Bladder Neoplasm 1 | 112
Bohring syndrome 1 | 2
Bohring-Opitz syndrome 1 | 2
Bone neoplasms 1 | 8
Breast Neoplasms 1 | 445
Carcinoma, Basal Cell 1 | 28
Carcinoma, Renal Cell 1 | 124
Central Nervous System Neoplasms 1 | 2
Cholangiocarcinoma 1 | 35
Colonic Neoplasms 1 | 142
Craniosynostosis 1 | 74
DOID:9917 1 | 31
Down syndrome 1 | 499
Dry skin 1 | 75
Freckles 1 | 33
Genetic Predisposition to Disease 1 | 27
Hair shaft abnormalities 1 | 30
Head and Neck Neoplasms 1 | 26
Hematologic cancer 1 | 12
Hereditary Melanoma 1 | 12
Juvenile Myelomonocytic Leukemia 1 | 21
Kidney Neoplasm 1 | 29
Kidney Neoplasms 1 | 37
Large intestine cancer 1 | 126
Leukemia 1 | 104
Leukemia, Myelomonocytic, Juvenile 1 | 20
Leukemia, Promyelocytic, Acute 1 | 36
Lipoma 1 | 32
Liver neoplasms 1 | 130
Lung Neoplasms 1 | 232
Lymphatic Diseases 1 | 14
Lymphopenia 1 | 67
MELANOMA, CUTANEOUS MALIGNANT, 1 1 | 13
MYELODYSPLASTIC SYNDROME 1 | 53
Mammary Neoplasms 1 | 425
Mastocytosis 1 | 27
Melanocytic nevus 1 | 43
Melanoma 1 | 711
Meningioma 1 | 41
Mesothelioma 1 | 38
Mesothelioma, Malignant 1 | 105
Mucoepidermoid carcinoma 1 | 26
Myelodysplastic Syndromes 1 | 26
Neoplasm Recurrence, Local 1 | 37
Neuroendocrine Tumors 1 | 11
Nevus 1 | 19
Ocular cancer 1 | 7
Ovarian Neoplasms 1 | 102
Pancreatic Neoplasm 1 | 85
Pancreatic Neoplasms 1 | 85
Paraganglioma 1 | 15
Polycythemia vera 1 | 27
Renal Cell Carcinoma 1 | 214
Retinal disease 1 | 25
Skin atrophy 1 | 16
Stomach Neoplasms 1 | 300
Stomach cancer 1 | 30
Testicular Neoplasms 1 | 6
Thrombocytosis 1 | 38
Thymoma 1 | 16
Tumor Predisposition Syndrome 1 | 6
Urinary Bladder Neoplasms 1 | 114
Uterine Neoplasms 1 | 9
Uveal melanoma 1 | 20
Wilms Tumor 1 | 28
Xerosis 1 | 75
adrenocortical carcinoma 1 | 1,428
dermatomyositis 1 | 966
familial melanoma 1 | 10
hair abnormalities (non-specific) 1 | 30
hereditary spastic paraplegia 1 | 318
intraductal papillary-mucinous adenoma (IPMA) 1 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 1 | 2,989
lung adenocarcinoma 1 | 2,716
nasopharyngeal carcinoma 1 | 1,058
ovarian neoplasm 1 | 99
pituitary cancer 1 | 1,972
skin melanoma 1 | 14
spina bifida 1 | 1,074
subependymal giant cell astrocytoma 1 | 2,287

Tissue

Blood and immune system 4 | 16,909
Cardiovascular System 4 | 15,192
Digestive Tract 4 | 17,369
Endocrine System 4 | 18,159
Female tissues 4 | 17,400
Liver and Pancreas 4 | 16,750
Male tissues 4 | 17,142
Nervous System 4 | 16,725
Respiratory system 4 | 16,393
Skin and soft tissues 4 | 17,230
Urinary Tract 4 | 16,678

Target Family

Enzyme 2 | 4,145
Epigenetic 1 | 242
Transcription Factor 1 | 1,400

GO Process

monoubiquitinated histone H2A ... 4 | 4
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ubiquitin carboxyl-terminal hydrolase 16 USP16 Tbio Enzyme -0.67094 5.97 248
Ubiquitin carboxyl-terminal hydrolase BAP1 BAP1 Tbio Enzyme -2.13819 132.3 304
Histone H2A deubiquitinase MYSM1 MYSM1 Tbio Transcription Factor -1.76987 62.1 184
Putative Polycomb group protein ASXL1 ASXL1 Tbio Epigenetic -2.25248 173.8 84