Development Level

Tbio 168 | 10,625
Tchem 41 | 1,890
Tdark 29 | 7,003
Tclin 3 | 602

Collection

Eligible Kinase Proteins 7 | 134
Eligible Ion Channel Proteins 1 | 117

IMPC Term

preweaning lethality, complete... 23 | 633
embryonic lethality prior to t... 7 | 187
decreased body weight 6 | 174
embryonic lethality prior to o... 6 | 148
abnormal coat/hair pigmentatio... 4 | 54
embryonic growth retardation 4 | 28
abnormal embryo size 3 | 112
abnormal gait 3 | 51
decreased circulating choleste... 3 | 85
decreased circulating glucose ... 3 | 121
decreased circulating serum al... 3 | 79
decreased lean body mass 3 | 195
increased bone mineral density 3 | 52
abnormal bone structure 2 | 131
abnormal craniofacial morpholo... 2 | 12
abnormal cranium morphology 2 | 32
abnormal placenta morphology 2 | 4
abnormal placenta size 2 | 10
abnormal snout morphology 2 | 18
decreased body length 2 | 108
decreased bone mineral content 2 | 157
decreased circulating HDL chol... 2 | 77
decreased circulating triglyce... 2 | 83
decreased lumbar vertebrae num... 2 | 62
decreased mean corpuscular hem... 2 | 34
decreased mean corpuscular vol... 2 | 50
decreased rib number 2 | 59
decreased thoracic vertebrae n... 2 | 7
decreased total body fat amoun... 2 | 186
increased circulating HDL chol... 2 | 63
increased circulating choleste... 2 | 53
increased circulating sodium l... 2 | 71
increased exploration in new e... 2 | 56
increased fasted circulating g... 2 | 68
increased grip strength 2 | 83
increased mean corpuscular vol... 2 | 91
preweaning lethality, incomple... 2 | 260
thrombocytopenia 2 | 46
vertebral fusion 2 | 23
abnormal QRS complex 1 | 25
abnormal behavioral response t... 1 | 52
abnormal brain morphology 1 | 6
abnormal cornea morphology 1 | 24
abnormal forebrain morphology 1 | 4
abnormal head shape 1 | 4
abnormal humerus morphology 1 | 11
abnormal joint morphology 1 | 14
abnormal kidney morphology 1 | 30
abnormal maxilla morphology 1 | 16
abnormal neural tube closure 1 | 37
abnormal optic disc morphology 1 | 10
abnormal pelvic girdle bone mo... 1 | 11
abnormal placenta vasculature 1 | 2
abnormal retina morphology 1 | 100
abnormal rib morphology 1 | 28
abnormal skin coloration 1 | 18
abnormal tail morphology 1 | 17
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 14
anophthalmia 1 | 20
decreased CD8-positive, alpha-... 1 | 26
decreased IgG1 level 1 | 4
decreased basophil cell number 1 | 11
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 49
decreased circulating LDL chol... 1 | 37
decreased circulating creatini... 1 | 31
decreased effector memory CD4-... 1 | 6
decreased eosinophil cell numb... 1 | 41
decreased fasted circulating g... 1 | 49
decreased gamma-delta T cell n... 1 | 18
decreased hematocrit 1 | 25
decreased mean corpuscular hem... 1 | 19
edema 1 | 11
enlarged lymph nodes 1 | 27
excessive tearing 1 | 2
hydroencephaly 1 | 6
hyperactivity 1 | 108
increased B cell number 1 | 23
increased alpha-beta T cell nu... 1 | 9
increased circulating alanine ... 1 | 11
increased circulating alkaline... 1 | 119
increased circulating chloride... 1 | 43
increased circulating creatini... 1 | 29
increased circulating glucose ... 1 | 16
increased circulating iron lev... 1 | 25
increased circulating total pr... 1 | 20
increased hematocrit 1 | 36
increased lean body mass 1 | 107
increased leukocyte cell numbe... 1 | 37
increased mature B cell number 1 | 12
increased mean corpuscular hem... 1 | 93
increased or absent threshold ... 1 | 128
increased red blood cell distr... 1 | 21
microphthalmia 1 | 15
narrow eye opening 1 | 15
pallor 1 | 13
prenatal lethality 1 | 16
short tibia 1 | 82
tremors 1 | 34

Disease

ovarian cancer 154 | 8,484
medulloblastoma, large-cell 127 | 6,234
osteosarcoma 120 | 7,933
psoriasis 109 | 6,685
glioblastoma 107 | 5,572
primitive neuroectodermal tumor 87 | 3,031
lung cancer 85 | 4,466
Breast cancer 80 | 3,094
atypical teratoid / rhabdoid tumor 79 | 4,369
pediatric high grade glioma 74 | 2,712
non-small cell lung cancer 72 | 2,798
group 3 medulloblastoma 71 | 2,254
intraductal papillary-mucinous neoplasm (IPMN) 69 | 3,289
intraductal papillary-mucinous carcinoma (IPMC) 67 | 2,988
adrenocortical carcinoma 65 | 1,427
malignant mesothelioma 60 | 3,162
Cancer 58 | 2,346
invasive ductal carcinoma 58 | 2,950
lung adenocarcinoma 55 | 2,713
oligodendroglioma 46 | 2,849
ductal carcinoma in situ 45 | 1,745
breast carcinoma 42 | 1,614
pancreatic cancer 42 | 2,300
pilocytic astrocytoma 42 | 3,086
posterior fossa group A ependymoma 41 | 1,511
Atopic dermatitis 39 | 944
colon cancer 38 | 1,475
nasopharyngeal carcinoma 38 | 1,056
Endometriosis 36 | 535
ependymoma 35 | 2,514
Carcinoma 34 | 2,147
sonic hedgehog group medulloblastoma 34 | 1,482
Multiple myeloma 32 | 1,327
Pick disease 31 | 1,893
atypical teratoid/rhabdoid tumor 29 | 1,095
astrocytoma 28 | 1,493
ulcerative colitis 28 | 2,087
adult high grade glioma 27 | 2,148
subependymal giant cell astrocytoma 26 | 2,287
astrocytic glioma 23 | 2,241
interstitial cystitis 23 | 2,299
IGA Glomerulonephritis 22 | 454
Rheumatoid Arthritis 22 | 1,160
intraductal papillary-mucinous adenoma (IPMA) 22 | 2,956
pituitary cancer 22 | 1,972
medulloblastoma 21 | 1,524
posterior fossa group B ependymoma 21 | 1,530
group 4 medulloblastoma 20 | 1,875
tuberculosis 20 | 1,557
Waldenstrons macroglobulinemia 19 | 765
dermatomyositis 19 | 933
inflammatory breast cancer 18 | 404
pancreatic ductal adenocarcinoma liver metastasis 18 | 1,795
primary pancreatic ductal adenocarcinoma 16 | 1,271
acute quadriplegic myopathy 15 | 1,157
diabetes mellitus 15 | 1,663
juvenile dermatomyositis 15 | 1,189
lung carcinoma 15 | 2,844
non primary Sjogren syndrome sicca 14 | 840
progressive supranuclear palsy 14 | 674
esophageal adenocarcinoma 12 | 737
primary Sjogren syndrome 12 | 789
Intellectual disability 11 | 573
Microcephaly 11 | 149
gastric carcinoma 11 | 832
spina bifida 10 | 1,064
tuberculosis and treatment for 6 months 10 | 686
Alzheimer's disease 9 | 644
Polycystic Ovary Syndrome 9 | 332
active Crohn's disease 9 | 918
acute myeloid leukemia 9 | 780
aldosterone-producing adenoma 8 | 664
Acquired metabolic disease 7 | 267
Amyotrophic Lateral Sclerosis 7 | 431
Down syndrome 7 | 548
chronic rhinosinusitis 7 | 512
cutaneous lupus erythematosus 7 | 1,056
gastric cancer 7 | 430
non-small cell lung carcinoma 7 | 413
pancreatic carcinoma 7 | 567
Gaucher disease type 1 6 | 171
Mammary Neoplasms 6 | 410
Melanoma 6 | 261
Peripheral Neuropathy 6 | 303
Type 2 diabetes mellitus 6 | 189
Crohn's disease 5 | 304
Neurodegenerative disease 5 | 383
cystic fibrosis 5 | 1,665
cystic fibrosis and chronic rhinosinusitis 5 | 213
mucosa-associated lymphoid tissue lymphoma 5 | 480
periodontitis 5 | 269
Kidney disease 4 | 396
Lissencephaly 4 | 61
Liver carcinoma 4 | 217
Neuroblastoma 4 | 78
Schizophrenia 4 | 501
Stomach Neoplasms 4 | 282
glioblastoma multiforme 4 | 347
hereditary spastic paraplegia 4 | 313
tuberculosis and treatment for 3 months 4 | 327

Tissue

Blood and immune system 239 | 17,995
Cardiovascular System 239 | 17,958
Digestive Tract 239 | 18,473
Endocrine System 239 | 18,512
Female tissues 239 | 18,647
Liver and Pancreas 239 | 18,136
Male tissues 239 | 17,969
Nervous System 239 | 18,561
Urinary Tract 239 | 18,444
Skin and soft tissues 238 | 18,115
Respiratory system 237 | 17,484

Target Family

Non-IDG 160 | 11,971
Enzyme 43 | 4,146
Kinase 29 | 634
Transcription Factor 3 | 1,400
Epigenetic 2 | 242
TF/Epigenetic 2 | 38
Ion Channel 1 | 341
Nuclear Receptor 1 | 48

GO Process

mitotic nuclear division 241 | 241
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
Microtubule-associated protein RP/EB family member 3 MAPRE3 Tbio Non-IDG -2.14681 132.5 161
High mobility group protein HMGI-C HMGA2 Tbio Transcription Factor -3.21092 1667.7 216
Kinetochore protein Nuf2 NUF2 Tbio Non-IDG -1.66072 48.8 98
Centrosomal protein of 164 kDa CEP164 Tbio Non-IDG -0.96655 10.2 84
A-kinase anchor protein 8 AKAP8 Tbio Enzyme -1.32097 22.6 240
Dynein light chain Tctex-type 1 DYNLT1 Tbio Non-IDG -2.32941 210.3 40
Centromere protein F CENPF Tbio Non-IDG -1.98596 103.0 180
Transcription factor E4F1 E4F1 Tbio Transcription Factor -1.47845 33.6 74
Probable ubiquitin carboxyl-terminal hydrolase FAF-X USP9X Tbio Enzyme -1.79254 69.5 187