Development Level

Tbio 67 | 11,651
Tchem 7 | 1,388
Tdark 5 | 6,593
Tclin 2 | 612

Collection

GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 7 | 979
preweaning lethality, incomple... 3 | 499
abnormal gait 2 | 69
increased bone mineral content 2 | 108
prenatal lethality prior to he... 2 | 87
abnormal bone structure 1 | 187
abnormal coat- hair morphology 1 | 19
abnormal cranium morphology 1 | 36
abnormal ear morphology 1 | 9
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal facial morphology 1 | 17
abnormal heart morphology 1 | 162
abnormal retinal inner nuclear... 1 | 8
abnormal seminal vesicle morph... 1 | 114
abnormal vitreous body morphol... 1 | 10
cataract 1 | 92
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating chloride... 1 | 30
decreased circulating glycerol... 1 | 16
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
decreased heart weight 1 | 27
decreased hemoglobin content 1 | 68
decreased mean platelet volume 1 | 25
decreased prepulse inhibition 1 | 82
decreased total body fat amoun... 1 | 207
decreased total retina thickne... 1 | 17
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
hydrometra 1 | 53
increased blood urea nitrogen ... 1 | 48
increased circulating creatini... 1 | 38
increased circulating fructosa... 1 | 13
increased circulating lipase l... 1 | 3
increased circulating potassiu... 1 | 29
increased circulating serum al... 1 | 22
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 28
increased heart weight 1 | 62
increased lean body mass 1 | 172
increased mean platelet volume 1 | 45
increased red blood cell distr... 1 | 34
increased startle reflex 1 | 112
long tibia 1 | 25
persistence of hyaloid vascula... 1 | 33
prolonged QRS complex duration 1 | 8

Disease

Carcinoma 49 | 11,493
ovarian cancer 46 | 8,520
osteosarcoma 40 | 7,950
medulloblastoma, large-cell 33 | 6,241
lung cancer 32 | 4,740
glioblastoma 28 | 5,792
Cancer 27 | 2,499
psoriasis 24 | 6,694
atypical teratoid / rhabdoid tumor 23 | 5,112
group 3 medulloblastoma 22 | 4,104
Multiple myeloma 18 | 1,332
non-small cell lung cancer 18 | 2,890
Neurodegenerative disease 17 | 414
malignant mesothelioma 17 | 3,232
adult high grade glioma 16 | 3,801
diabetes mellitus 16 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 16 | 2,955
invasive ductal carcinoma 15 | 2,951
Parkinson's disease 14 | 392
lung adenocarcinoma 14 | 2,716
Astrocytoma, Pilocytic 13 | 3,081
Breast cancer 13 | 3,578
ependymoma 13 | 4,679
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,962
Kidney cancer 12 | 2,613
astrocytic glioma 12 | 2,597
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,989
oligodendroglioma 12 | 2,850
primitive neuroectodermal tumor 12 | 3,035
Alzheimer's disease 11 | 658
Intellectual disability 11 | 1,016
Obesity 11 | 678
Pick disease 11 | 1,894
Rheumatoid arthritis 11 | 1,191
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
tuberculosis 11 | 2,010
ulcerative colitis 10 | 1,819
interstitial cystitis 9 | 2,312
lung carcinoma 9 | 2,843
Dull intelligence 8 | 645
Low intelligence 8 | 645
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Poor school performance 8 | 645
breast carcinoma 8 | 1,638
spina bifida 8 | 1,074
Autosomal recessive predisposition 7 | 1,442
Muscle hypotonia 7 | 571
Schizophrenia 7 | 1,160
colon cancer 7 | 1,478
ductal carcinoma in situ 7 | 1,745
Anemia 6 | 365
Breast Neoplasms 6 | 445
Cerebellar Ataxia 6 | 304
Cognitive delay 6 | 608
Depressive disorder 6 | 409
Epilepsy 6 | 792
Global developmental delay 6 | 608
Mammary Neoplasms 6 | 425
Mental and motor retardation 6 | 608
Nerve Degeneration 6 | 121
Neuropathy 6 | 261
Optic Atrophy 6 | 242
Osteoporosis 6 | 363
PARKINSON DISEASE 19, JUVENILE-ONSET 6 | 10
Parkinsonian Disorders 6 | 56
Short stature 6 | 531
Young onset Parkinson disease 6 | 10
acute quadriplegic myopathy 6 | 1,158
gastric carcinoma 6 | 807
group 4 medulloblastoma 6 | 1,855
pituitary cancer 6 | 1,972
Brain disease 5 | 96
Carcinoma, Hepatocellular 5 | 228
Fetal Growth Retardation 5 | 189
Hypoglycemia 5 | 152
Liver carcinoma 5 | 240
Melanoma 5 | 711
Muscle Spasticity 5 | 195
Parkinson Disease 5 | 64
Prostatic Neoplasms 5 | 495
Seizures 5 | 596
Small head 5 | 374
Toxic encephalopathy 5 | 141
Vascular disease 5 | 319
Waldenstrons macroglobulinemia 5 | 765
adrenocortical carcinoma 5 | 1,428
cutaneous lupus erythematosus 5 | 1,057
dermatomyositis 5 | 966
interstitial lung disease 5 | 298
nasopharyngeal carcinoma 5 | 1,058
pancreatic cancer 5 | 2,398
pediatric high grade glioma 5 | 1,064
subependymal giant cell astrocytoma 5 | 2,287
Bipolar Disorder 4 | 666
aldosterone-producing adenoma 4 | 665
cystic fibrosis 4 | 1,696
juvenile dermatomyositis 4 | 1,187
primary Sjogren syndrome 4 | 735
progressive supranuclear palsy 4 | 676

Tissue

Blood and immune system 79 | 16,909
Digestive Tract 79 | 17,369
Endocrine System 79 | 18,159
Cardiovascular System 78 | 15,192
Female tissues 78 | 17,400
Liver and Pancreas 78 | 16,750
Male tissues 78 | 17,142
Nervous System 78 | 16,725
Respiratory system 78 | 16,393
Skin and soft tissues 78 | 17,230
Urinary Tract 78 | 16,678

Target Family

Non-IDG 36 | 12,091
Enzyme 31 | 4,145
Transcription Factor 4 | 1,400
Epigenetic 3 | 242
Kinase 2 | 634
Transporter 2 | 473
GPCR 1 | 408
Ion Channel 1 | 344
Nuclear Receptor 1 | 48

GO Process

mitochondrion organization 81 | 81
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

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