Development Level

Tbio 16 | 11,651
Tchem 2 | 1,388
Tdark 2 | 6,593
Tclin 1 | 612

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal embryo size 3 | 220
pallor 3 | 34
abnormal placenta size 2 | 20
abnormal skin coloration 2 | 25
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
abnormal embryonic autopod pla... 1 | 2
abnormal hindbrain development 1 | 16
abnormal limb bud morphology 1 | 17
abnormal liver size 1 | 5
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal placenta development 1 | 1
abnormal placenta morphology 1 | 5
decreased circulating phosphat... 1 | 27
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
enlarged heart atrium 1 | 4
hyperactivity 1 | 148
increased circulating glucose ... 1 | 24
increased fasted circulating g... 1 | 76
pale liver 1 | 6
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87

Disease

ovarian cancer 8 | 8,520
Multiple myeloma 7 | 1,332
cytochrome-c oxidase deficiency disease 7 | 19
Acidosis, Lactic 6 | 97
Blepharoptosis 6 | 231
Cerebellar Ataxia 6 | 304
Cytochrome-c Oxidase Deficiency 6 | 17
Increased serum lactate 6 | 60
Lactic acidemia 6 | 95
Sensorineural Hearing Loss (disorder) 6 | 284
Leigh disease 5 | 100
Ophthalmoplegia 5 | 106
Optic Atrophy 5 | 242
lung cancer 5 | 4,740
osteosarcoma 5 | 7,950
psoriasis 5 | 6,694
Autosomal recessive predisposition 4 | 1,442
Brain Ischemia 4 | 110
Breast cancer 4 | 3,578
Carcinoma 4 | 11,493
Cognitive delay 4 | 608
Encephalopathies 4 | 43
Global developmental delay 4 | 608
Mental and motor retardation 4 | 608
Short stature 4 | 531
astrocytic glioma 4 | 2,597
atypical teratoid / rhabdoid tumor 4 | 5,112
diabetes mellitus 4 | 1,728
glioblastoma 4 | 5,792
medulloblastoma, large-cell 4 | 6,241
Abdominal Pain 3 | 98
Abnormality of mitochondrial metabolism 3 | 9
Anorexia 3 | 43
Anxiety 3 | 136
Anxiety disease 3 | 113
Attention deficit hyperactivity disorder 3 | 278
Blindness, Cortical 3 | 24
CSF lactate increased 3 | 33
Cachexia 3 | 50
Cerebellar hypoplasia and atrophy 3 | 41
Cerebral Ischemia 3 | 37
Cerebral atrophy 3 | 178
Cerebral calcification 3 | 43
Clonus 3 | 18
Congenital Bilateral Cataracts 3 | 50
Congenital cataract 3 | 50
Congestive heart failure 3 | 113
Cortical visual impairment 3 | 24
Creatine phosphokinase serum increased 3 | 110
Death in early adulthood 3 | 24
Decreased nerve conduction velocity 3 | 35
Dementia 3 | 175
Depressive disorder 3 | 409
Developmental regression 3 | 95
Diabetes Mellitus, Non-Insulin-Dependent 3 | 145
Dull intelligence 3 | 645
Dystonia 3 | 164
Dystonic disease 3 | 106
Electromyogram abnormal 3 | 49
Elevated creatine kinase 3 | 110
Epilepsy 3 | 792
Episodic vomiting 3 | 10
Failure to gain weight 3 | 365
Fatigue 3 | 182
Forgetful 3 | 40
Frequent vomiting 3 | 10
Hallucinations 3 | 34
Hallucinations, Sensory 3 | 33
Heart failure 3 | 162
Hemianopsia 3 | 15
Hemiparesis 3 | 34
Highly variable severity 3 | 157
Hypertrophic Cardiomyopathy 3 | 117
Intermittent migraine headaches 3 | 68
Left Ventricular Hypertrophy 3 | 47
Leigh syndrome 3 | 28
Loss of developmental milestones 3 | 95
Memory Loss 3 | 40
Memory impairment 3 | 40
Mental deterioration in childhood 3 | 95
Migraine Disorders 3 | 76
Muscle Weakness 3 | 170
Myopathy 3 | 185
Nausea and vomiting 3 | 97
Neurodevelopmental regression 3 | 95
Pancreatitis 3 | 123
Pediatric failure to thrive 3 | 365
Pick disease 3 | 1,894
Psychomotor regression 3 | 95
Psychomotor regression beginning in infancy 3 | 95
Psychomotor regression in infants 3 | 95
Psychomotor regression, progressive 3 | 95
Respiratory Insufficiency 3 | 132
Respiratory function loss 3 | 121
Seizures 3 | 596
Tonic - clonic seizures 3 | 44
Variable expressivity 3 | 157
Waldenstrons macroglobulinemia 3 | 765
Wolff-Parkinson-White syndrome 3 | 19
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962

Tissue

Blood and immune system 21 | 16,909
Cardiovascular System 21 | 15,192
Digestive Tract 21 | 17,369
Endocrine System 21 | 18,159
Female tissues 21 | 17,400
Liver and Pancreas 21 | 16,750
Male tissues 21 | 17,142
Nervous System 21 | 16,725
Skin and soft tissues 21 | 17,230
Urinary Tract 21 | 16,678
Respiratory system 19 | 16,393

Target Family

Enzyme 19 | 4,145
Non-IDG 2 | 12,091

GO Process

mitochondrial electron transpo... 21 | 21
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 Tbio Enzyme -2.34320 203.3 504
Cytochrome c oxidase subunit 6B1 COX6B1 Tbio Enzyme -1.29185 18.7 218
Cytochrome c oxidase subunit 6A1, mitochondrial COX6A1 Tbio Enzyme -1.06552 12.3 194
Cytochrome c oxidase subunit 7B, mitochondrial COX7B Tbio Enzyme -0.61894 3.87 58
Cytochrome c CYCS Tbio Non-IDG -3.76637 4945.6 833
Cytochrome c oxidase subunit 1 MT-CO1 Tchem Enzyme -3.69205 4610.4 141
Cytochrome c oxidase subunit 3 MT-CO3 Tbio Enzyme -3.41708 2551.3 96
Cytochrome c oxidase subunit 7A-related protein, mitochondrial COX7A2L Tbio Enzyme -0.92134 8.99 110
Cytochrome c oxidase subunit 2 MT-CO2 Tchem Enzyme -2.96018 880.4 127
Cytochrome c oxidase subunit 8C, mitochondrial COX8C Tdark Enzyme -0.21560 1.88 12