Development Level

Tbio 8 | 11,445
Tdark 2 | 6,588

IMPC Phenotype

preweaning lethality, complete... 2 | 979
absent vibrissae 1 | 12
decreased cardiac stroke volum... 1 | 6
decreased mean platelet volume 1 | 25
decreased neutrophil cell numb... 1 | 42
embryonic lethality prior to t... 1 | 278
enlarged spleen 1 | 41
enlarged testis 1 | 6
impaired righting response 1 | 26
increased fasted circulating g... 1 | 76
increased total body fat amoun... 1 | 134
long tibia 1 | 25
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
small seminal vesicle 1 | 10

Disease

ovarian cancer 7 | 8,520
Carcinoma 5 | 11,493
osteosarcoma 5 | 7,950
adult high grade glioma 4 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
malignant mesothelioma 4 | 3,232
Autosomal recessive predisposition 3 | 1,442
ependymoma 3 | 4,679
glioblastoma 3 | 5,792
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
medulloblastoma, large-cell 3 | 6,241
oligodendroglioma 3 | 2,850
psoriasis 3 | 6,694
ulcerative colitis 3 | 1,819
Astrocytoma, Pilocytic 2 | 3,081
Atrophy of cerebellum 2 | 103
Babinski Reflex 2 | 100
Blepharoptosis 2 | 231
Breast cancer 2 | 3,578
Cerebellar Ataxia 2 | 304
Cerebellar degeneration 2 | 103
Chronic progressive external ophthalmoplegia 2 | 26
Infratentorial atrophy 2 | 103
Muscle Spasticity 2 | 195
Myopathy 2 | 185
Neurodegenerative disease 2 | 414
astrocytic glioma 2 | 2,597
atypical teratoid / rhabdoid tumor 2 | 5,112
group 4 medulloblastoma 2 | 1,855
interstitial cystitis 2 | 2,312
pancreatic cancer 2 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
primary pancreatic ductal adenocarcinoma 2 | 1,109
tuberculosis 2 | 2,010
Abnormal auditory evoked potential 1 | 7
Abnormal color vision 1 | 31
Ataxia, Appendicular 1 | 25
Ataxia, Spinocerebellar 1 | 16
Autosomal dominant cerebellar ataxia 1 | 33
Bladder Diverticulum 1 | 15
Blue/yellow color vision defect 1 | 3
Cardiomyopathy 1 | 116
Cerebellar Dysmetria 1 | 56
Chagas disease 1 | 39
Color Blindness, Blue 1 | 3
Color Blindness, Red-Green 1 | 4
Color vision defect 1 | 33
Decreased to absent deep tendon reflexes 1 | 42
Degenerative polyarthritis 1 | 115
Deglutition Disorders 1 | 132
Dermatitis herpetiformis 1 | 12
Dysarthria 1 | 192
Dysdiadochokinesis 1 | 25
Dysmetric saccades 1 | 9
Early myoclonic encephalopathy 1 | 15
Enterobiasis 1 | 5
Epilepsies, Myoclonic 1 | 32
Generalized myoclonic seizures 1 | 30
Highly variable severity 1 | 157
Hydronephrosis 1 | 89
Increased intramyocellular lipid droplets 1 | 13
Low Vision 1 | 174
Lower limb hyperreflexia 1 | 10
Macular degeneration 1 | 65
Muscle Weakness 1 | 170
Muscular Diseases 1 | 27
Myoclonic Epilepsies, Progressive 1 | 44
Myoclonus 1 | 74
Neurogenic Muscular Atrophy 1 | 139
Neurogenic muscle atrophy, especially in the lower limbs 1 | 139
Nystagmus, End-Position 1 | 12
Ophthalmoparesis 1 | 11
Ophthalmoplegia 1 | 106
Osteoarthritis 1 | 184
Paraparesis, Spastic 1 | 16
Peripheral Neuropathy 1 | 134
Progressive spasticity 1 | 6
Ptosis 1 | 48
Red/green color vision defect 1 | 3
Reduced visual acuity 1 | 63
Retinitis pigmentosa 3 1 | 16
SPASTIC ATAXIA 5, AUTOSOMAL RECESSIVE 1 | 1
SPINOCEREBELLAR ATAXIA 28 1 | 1
Sensorineural Hearing Loss (disorder) 1 | 284
Skeletal muscle atrophy 1 | 139
Slow progression 1 | 89
Slowed saccades 1 | 12
Spastic Ataxia 1 | 18
Spinocerebellar Ataxias 1 | 34
Tonic - clonic seizures 1 | 44
Urethral diverticulum 1 | 3
Usher syndrome 1 | 32
Variable expressivity 1 | 157
Visual Impairment 1 | 174
Wolf-Hirschhorn syndrome 1 | 32
hereditary spastic paraplegia 1 | 318
inflammatory breast cancer 1 | 286
muscle degeneration 1 | 139
spinocerebellar ataxia type 28 1 | 3

Tissue

Blood and immune system 10 | 16,909
Cardiovascular System 10 | 15,192
Digestive Tract 10 | 17,369
Endocrine System 10 | 18,159
Female tissues 10 | 17,400
Liver and Pancreas 10 | 16,750
Male tissues 10 | 17,142
Nervous System 10 | 16,725
Respiratory system 10 | 16,393
Skin and soft tissues 10 | 17,230
Urinary Tract 10 | 16,678

Target Family

Non-IDG 7 | 12,091
Enzyme 1 | 4,145
Ion Channel 1 | 344
Transporter 1 | 473

GO Process

mitochondrial calcium uptake 10 | 10
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Calcium-binding mitochondrial carrier protein SCaMC-3 SLC25A23 Tbio Transporter -0.72246 7.27 53
Calcium uniporter protein, mitochondrial MCU Tbio Ion Channel -2.67075 458.1 25
Calcium uniporter regulatory subunit MCUb, mitochondrial MCUB Tdark Non-IDG -0.76467 3.88 57
AFG3-like protein 2 AFG3L2 Tbio Enzyme -1.58716 39.9 164
Dynamin-like 120 kDa protein, mitochondrial OPA1 Tbio Non-IDG -2.51554 307.1 210
m-AAA protease-interacting protein 1, mitochondrial MAIP1 Tdark Non-IDG 0.30 0.23 82
Calcium uptake protein 2, mitochondrial MICU2 Tbio Non-IDG -0.94183 7.15 63
Essential MCU regulator, mitochondrial SMDT1 Tbio Non-IDG -1.60735 39.4 11
Calcium uptake protein 1, mitochondrial MICU1 Tbio Non-IDG -2.51836 321.6 110
Mitochondrial calcium uniporter regulator 1 MCUR1 Tbio Non-IDG -0.72431 5.39 54