Development Level

Tbio 21 | 11,445
Tdark 5 | 6,588
Tchem 4 | 1,598
Tclin 2 | 613

IMPC Phenotype

embryonic lethality prior to o... 3 | 239
preweaning lethality, complete... 3 | 979
male infertility 2 | 123
abnormal bone structure 1 | 187
abnormal heart morphology 1 | 162
abnormal retina morphology 1 | 71
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
female infertility 1 | 60
increased heart weight 1 | 62
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
prenatal lethality prior to he... 1 | 87
prolonged QRS complex duration 1 | 8
short tibia 1 | 97
small testis 1 | 58

Disease

Carcinoma 24 | 11,493
ovarian cancer 19 | 8,520
Cancer 18 | 2,499
Lynch syndrome 13 | 35
group 3 medulloblastoma 13 | 4,104
Familial adenomatous polyposis 10 | 32
glioblastoma 10 | 5,792
psoriasis 10 | 6,694
Adenoma 9 | 167
Autosomal recessive predisposition 9 | 1,442
ependymoma 9 | 4,679
lung cancer 9 | 4,740
malignant mesothelioma 9 | 3,232
Breast cancer 8 | 3,578
Fatigue 8 | 182
atypical teratoid / rhabdoid tumor 8 | 5,112
osteosarcoma 8 | 7,950
Epilepsy 7 | 792
Intermittent migraine headaches 7 | 68
Kidney cancer 7 | 2,613
Migraine Disorders 7 | 76
Muscle hypotonia 7 | 571
Sebaceous adenoma 7 | 26
Seizures 7 | 596
medulloblastoma, large-cell 7 | 6,241
primitive neuroectodermal tumor 7 | 3,035
Abdominal Pain 6 | 98
Anxiety 6 | 136
Anxiety disease 6 | 113
Attention deficit hyperactivity disorder 6 | 278
Colorectal Neoplasms 6 | 243
Constipation 6 | 181
Death in early adulthood 6 | 24
Death in early childhood 6 | 82
Death in infancy 6 | 82
Depressive disorder 6 | 409
Dyschezia 6 | 135
Gastrointestinal Hemorrhage 6 | 52
Hereditary Nonpolyposis Colorectal Cancer 6 | 11
Intracranial hypertension 6 | 32
Irritation - emotion 6 | 68
Malabsorption 6 | 82
Malignant tumor of colon 6 | 19
Muscle Hypertonia 6 | 88
Nausea and vomiting 6 | 97
Rectal Neoplasms 6 | 18
Weight decreased 6 | 103
lung adenocarcinoma 6 | 2,716
non-small cell lung cancer 6 | 2,890
Basal cell carcinoma 5 | 54
Basal cell nevi 5 | 23
Colorectal Neoplasms, Hereditary Nonpolyposis 5 | 9
Hereditary Nonpolyposis Colorectal Neoplasms 5 | 8
Hyperpigmented macules 5 | 42
Leukemia 5 | 104
Waldenstrons macroglobulinemia 5 | 765
Xeroderma pigmentosum 5 | 43
dermatomyositis 5 | 966
invasive ductal carcinoma 5 | 2,951
Abnormality of the abdomen 4 | 14
Axillary freckling 4 | 5
Birthmark 4 | 35
Breast Neoplasms 4 | 445
Cafe-au-Lait Spots 4 | 37
Endometrial Neoplasms 4 | 55
Endometrial cancer 4 | 311
Hematologic Neoplasms 4 | 22
Lymphoma 4 | 81
Neuroblastoma 4 | 80
Rhabdomyosarcoma 4 | 39
Stomach Neoplasms 4 | 300
Turcot syndrome 4 | 5
Turcot syndrome (disorder) 4 | 5
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
medulloblastoma 4 | 720
Adenocarcinoma of lung 3 | 142
Colonic Neoplasms 3 | 142
Elevated hepatic transaminases 3 | 81
Endometrial carcinoma 3 | 15
Fever 3 | 138
Hepatic enzyme increased 3 | 81
Liver Dysfunction 3 | 99
Liver enzymes abnormal 3 | 81
Liver function test increased 3 | 81
Liver function tests abnormal finding 3 | 81
Lung Neoplasms 3 | 232
Male infertility 3 | 206
Mammary Neoplasms 3 | 425
Microsatellite Instability 3 | 12
Neoplasm Metastasis 3 | 168
Subclinical abnormal liver function tests 3 | 81
Thrombocytopenia 3 | 197
Transaminases increased 3 | 81
adult high grade glioma 3 | 3,801
astrocytoma 3 | 1,146
breast carcinoma 3 | 1,638
diabetes mellitus 3 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
juvenile dermatomyositis 3 | 1,187
nasopharyngeal carcinoma 3 | 1,058

Tissue

Blood and immune system 27 | 16,909
Digestive Tract 27 | 17,369
Endocrine System 27 | 18,159
Female tissues 27 | 17,400
Liver and Pancreas 27 | 16,750
Male tissues 27 | 17,142
Nervous System 27 | 16,725
Respiratory system 27 | 16,393
Skin and soft tissues 27 | 17,230
Urinary Tract 27 | 16,678
Cardiovascular System 25 | 15,192

Target Family

Enzyme 16 | 4,145
Non-IDG 11 | 12,091
Epigenetic 2 | 242
Transcription Factor 2 | 1,400
Kinase 1 | 634

GO Process

mismatch repair 32 | 32
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Putative postmeiotic segregation increased 2-like protein 1 PMS2P1 Tdark Enzyme -2.19299 339.5 0
Adenine DNA glycosylase MUTYH Tbio Enzyme -2.86910 750.8 255
Putative postmeiotic segregation increased 2-like protein 3 PMS2P3 Tdark Enzyme -2.19299 339.5 0
G/T mismatch-specific thymine DNA glycosylase TDG Tbio Enzyme -2.46252 297.6 225
DNA polymerase delta subunit 4 POLD4 Tbio Enzyme -0.84887 7.32 24
Putative postmeiotic segregation increased 2-like protein 2 PMS2P2 Tdark Enzyme 0.00000 0
Histone-lysine N-methyltransferase SETD2 SETD2 Tchem Epigenetic -2.83266 645.3 214
Putative postmeiotic segregation increased 2-like protein 11 PMS2P11 Tdark Enzyme -2.19299 339.5 0
MutS protein homolog 4 MSH4 Tbio Non-IDG -1.85065 67.5 94
Replication protein A 14 kDa subunit RPA3 Tbio Non-IDG -1.85941 67.1 171