Development Level

Tbio 5 | 11,445
Tchem 1 | 1,598

IMPC Phenotype

abnormal allantois morphology 1 | 8
abnormal heart morphology 1 | 162
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating glucose ... 1 | 126
decreased circulating potassiu... 1 | 20
decreased lean body mass 1 | 135
embryonic lethality prior to o... 1 | 239
increased blood urea nitrogen ... 1 | 48
male infertility 1 | 123
preweaning lethality, complete... 1 | 979

Disease

Bipolar Disorder 4 | 666
Hyperhomocysteinemia 4 | 37
osteosarcoma 4 | 7,950
ovarian cancer 4 | 8,520
Autosomal recessive predisposition 3 | 1,442
Carcinoma 3 | 11,493
Cleft Lip 3 | 141
Cleft Palate 3 | 271
Congenital heart disease 3 | 93
Epilepsy 3 | 792
Homocystinuria 3 | 21
Neural tube defect, folate-sensitive 3 | 4
Schizophrenia 3 | 1,160
Seizures 3 | 596
malignant mesothelioma 3 | 3,232
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
spina bifida 3 | 1,074
Adverse reaction to drug 2 | 61
Anemia 2 | 365
Arthritis, Rheumatoid 2 | 174
Cancer 2 | 2,499
Cognitive delay 2 | 608
Colorectal Neoplasms 2 | 243
Congenital clubfoot 2 | 109
Down syndrome 2 | 499
Drug-Related Side Effects and Adverse Reactions 2 | 62
Essential Hypertension 2 | 94
Gait abnormality 2 | 135
Global developmental delay 2 | 608
Hyperhomocystinemia 2 | 6
Infertility, Male 2 | 46
Male infertility 2 | 206
Mental and motor retardation 2 | 608
Methylmalonic acidemia 2 | 37
Mood Disorders 2 | 184
Muscle hypotonia 2 | 571
Nervous System Diseases 2 | 53
Neural Tube Defects 2 | 31
Precursor Cell Lymphoblastic Leukemia Lymphoma 2 | 43
Precursor Cell Lymphoblastic Leukemia-Lymphoma 2 | 49
Prostatic Neoplasms 2 | 495
Rheumatoid arthritis 2 | 1,191
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
lung cancer 2 | 4,740
nervous system disorder 2 | 53
neural tube defect 2 | 9
non-small cell lung cancer 2 | 2,890
tuberculosis 2 | 2,010
Abnormal coordination 1 | 15
Acute kidney injury 1 | 70
Arsenic Poisoning 1 | 62
Azoospermia 1 | 110
Blood Coagulation Disorders, Inherited 1 | 1
Breast Neoplasms 1 | 445
Cervical Intraepithelial Neoplasia 1 | 2
Chemical and Drug Induced Liver Injury 1 | 195
Class III malocclusion 1 | 78
Clubfoot 1 | 39
Coronary Disease 1 | 25
Coronary Restenosis 1 | 8
Crohn Disease 1 | 45
Decreased nerve conduction velocity 1 | 35
Depression, Postpartum 1 | 7
Graft vs Host Disease 1 | 6
HOMOCYSTINURIA DUE TO DEFICIENCY OF N(5,10)-METHYLENETETRAHYDROFOLATE REDUCTASE ACTIVITY 1 | 1
Heart Defects, Congenital 1 | 37
Hematologic Diseases 1 | 8
Hemochromatosis type 1 1 | 9
Hereditary factor IX deficiency disease 1 | 2
Homocysteinemia due to MTHFR deficiency 1 | 1
Hypertrophy of lower jaw 1 | 78
Increased size of mandible 1 | 78
Infertility, Female 1 | 28
Inflammatory disease of mucous membrane 1 | 8
Lethargy 1 | 77
Leukemia, Lymphocytic, Chronic, B-Cell 1 | 34
Mammary Neoplasms 1 | 425
Mandibular hyperplasia 1 | 78
Maxillofacial Abnormalities 1 | 1
Methylenetetrahydrofolate reductase deficiency 1 | 1
Microsatellite Instability 1 | 12
Microvascular Angina 1 | 1
Muscle Weakness 1 | 170
OROFACIAL CLEFT 1 1 | 2
Occult macular dystrophy 1 | 7
Skin Diseases 1 | 71
Spinal Dysraphism 1 | 12
Steinert myotonic dystrophy syndrome 1 | 2
Thrombocytopenia 1 | 197
Thyrotoxicosis 1 | 38
Tooth Crowding 1 | 45
Tooth mass arch size discrepancy 1 | 45
Tooth size discrepancy 1 | 45
Uterine Cervical Neoplasms 1 | 26
Vascular Diseases 1 | 16
Venous Thrombosis 1 | 47
drug-induced hepatitis 1 | 44
inflammatory breast cancer 1 | 286
mandibular excess (physical finding) 1 | 78
nutritional deficiency disease 1 | 9

Tissue

Blood and immune system 6 | 16,909
Cardiovascular System 6 | 15,192
Digestive Tract 6 | 17,369
Endocrine System 6 | 18,159
Female tissues 6 | 17,400
Liver and Pancreas 6 | 16,750
Male tissues 6 | 17,142
Nervous System 6 | 16,725
Respiratory system 6 | 16,393
Skin and soft tissues 6 | 17,230
Urinary Tract 6 | 16,678

Target Family

Enzyme 6 | 4,145

GO Process

methionine metabolic process 6 | 6
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Methylenetetrahydrofolate reductase MTHFR Tbio Enzyme -3.68447 5032.2 275
Glycine N-methyltransferase GNMT Tbio Enzyme -1.56517 40.8 216
Mitochondrial peptide methionine sulfoxide reductase MSRA Tbio Enzyme -1.92325 88.1 167
Spermine synthase SMS Tchem Enzyme -1.50353 28.6 215
Methionine synthase reductase MTRR Tbio Enzyme -2.46986 307.5 53
C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 Tbio Enzyme -1.97029 90.6 101