Development Level

Tbio 3 | 11,445
Tdark 1 | 6,588

IMPC Phenotype

abnormal allantois morphology 1 | 8
abnormal heart morphology 1 | 162
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal skin morphology 1 | 50
embryonic lethality prior to o... 1 | 239
enlarged heart 1 | 210
preweaning lethality, complete... 1 | 979

Disease

ovarian cancer 4 | 8,520
Carcinoma 3 | 11,493
Cleft Lip 3 | 141
Homocystinuria 3 | 21
Hyperhomocysteinemia 3 | 37
Methylmalonic acidemia 3 | 37
Neural tube defect, folate-sensitive 3 | 4
osteosarcoma 3 | 7,950
spina bifida 3 | 1,074
Adverse reaction to drug 2 | 61
Anemia 2 | 365
Anemia, Megaloblastic 2 | 16
Autosomal recessive predisposition 2 | 1,442
Bipolar Disorder 2 | 666
Cancer 2 | 2,499
Cerebral atrophy 2 | 178
Cleft Palate 2 | 271
Cognitive delay 2 | 608
Congenital heart disease 2 | 93
Decreased methionine synthase activity 2 | 4
Decreased methylcobalamin 2 | 4
Degenerative brain disorder 2 | 100
Down syndrome 2 | 499
Drug-Related Side Effects and Adverse Reactions 2 | 62
Epilepsy 2 | 792
Failure to gain weight 2 | 365
Gait abnormality 2 | 135
Global developmental delay 2 | 608
Hyperhomocystinemia 2 | 6
Hypomethioninemia 2 | 4
Infantile onset 2 | 238
Infertility, Male 2 | 46
Male infertility 2 | 206
Mental and motor retardation 2 | 608
Muscle hypotonia 2 | 571
Neural tube defects, folate-sensitive 2 | 2
Pediatric failure to thrive 2 | 365
Schizophrenia 2 | 1,160
Seizures 2 | 596
Supratentorial atrophy 2 | 94
lung cancer 2 | 4,740
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
psoriasis 2 | 6,694
Adenoma 1 | 167
Alcoholic Intoxication 1 | 34
Azoospermia 1 | 110
Breast Neoplasms 1 | 445
Breast cancer 1 | 3,578
Colorectal Neoplasms 1 | 243
Decreased nerve conduction velocity 1 | 35
Depressive disorder 1 | 409
Dull intelligence 1 | 645
Dyskeratosis congenita 1 | 24
Feeding difficulties in infancy 1 | 175
Gastrointestinal Diseases 1 | 12
Gonorrhea 1 | 13
Hematologic Diseases 1 | 8
Hematological Disease 1 | 18
Hemoglobin low 1 | 124
Lethargy 1 | 77
Leukoencephalopathies 1 | 29
Low intelligence 1 | 645
Lymphoma 1 | 81
Lymphoma, Follicular 1 | 18
Malnutrition 1 | 11
Mammary Neoplasms 1 | 425
Megaloblastic anemia 1 | 18
Mental Depression 1 | 333
Mental deficiency 1 | 645
Nervous System Diseases 1 | 53
Neural Tube Defects 1 | 31
OROFACIAL CLEFT 1 1 | 2
Ophthalmia neonatorum 1 | 3
Poor coordination 1 | 11
Poor school performance 1 | 645
Precursor Cell Lymphoblastic Leukemia Lymphoma 1 | 43
Precursor Cell Lymphoblastic Leukemia-Lymphoma 1 | 49
Progressive mental retardation 1 | 37
Respiratory Insufficiency 1 | 132
Respiratory function loss 1 | 121
Severe depression 1 | 5
Vitamin B12 deficiency 1 | 20
Waldenstrons macroglobulinemia 1 | 765
acute quadriplegic myopathy 1 | 1,158
adult high grade glioma 1 | 3,801
astrocytoma 1 | 1,146
atypical teratoid/rhabdoid tumor 1 | 357
colon cancer 1 | 1,478
ductal carcinoma in situ 1 | 1,745
glioblastoma 1 | 5,792
group 3 medulloblastoma 1 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 1 | 3,291
invasive ductal carcinoma 1 | 2,951
nervous system disorder 1 | 53
neural tube defect 1 | 9
pancreatic cancer 1 | 2,398
pancreatic carcinoma 1 | 562
progressive supranuclear palsy 1 | 676
tuberculosis 1 | 2,010
tuberculosis and treatment for 6 months 1 | 409

Tissue

Blood and immune system 4 | 16,909
Cardiovascular System 4 | 15,192
Digestive Tract 4 | 17,369
Endocrine System 4 | 18,159
Female tissues 4 | 17,400
Liver and Pancreas 4 | 16,750
Male tissues 4 | 17,142
Nervous System 4 | 16,725
Respiratory system 4 | 16,393
Skin and soft tissues 4 | 17,230
Urinary Tract 4 | 16,678

Target Family

Enzyme 4 | 4,145

GO Process

methionine biosynthetic proces... 4 | 4
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Methionine synthase MTR Tbio Enzyme -2.56900 300.2 87
Methionine synthase reductase MTRR Tbio Enzyme -2.46986 307.5 53
C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 Tbio Enzyme -1.97029 90.6 101
Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 MTHFD2L Tdark Enzyme -0.45230 2.70 114