Development Level

Tchem 9 | 1,890
Tbio 6 | 10,625

IMPC Term

decreased lean body mass 3 | 195
abnormal bone structure 2 | 131
increased circulating alkaline... 2 | 119
abnormal bone mineralization 1 | 55
abnormal cornea morphology 1 | 24
abnormal digit morphology 1 | 13
abnormal gait 1 | 51
abnormal skin condition 1 | 6
abnormal vibrissa morphology 1 | 17
decreased B cell number 1 | 30
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased circulating alkaline... 1 | 41
decreased circulating amylase ... 1 | 24
decreased circulating sodium l... 1 | 18
decreased granulocyte number 1 | 8
decreased mean corpuscular hem... 1 | 19
decreased thermal nociceptive ... 1 | 4
decreased total body fat amoun... 1 | 186
increased T cell number 1 | 15
increased body weight 1 | 42
increased circulating free fat... 1 | 17
increased leukocyte cell numbe... 1 | 37
increased thermal nociceptive ... 1 | 9
limb grasping 1 | 35
polydactyly 1 | 22
preweaning lethality, complete... 1 | 633
preweaning lethality, incomple... 1 | 260
tremors 1 | 34

Disease

glioblastoma 10 | 5,572
osteosarcoma 10 | 7,933
Alzheimer's disease 8 | 644
atypical teratoid / rhabdoid tumor 7 | 4,369
ependymoma 7 | 2,514
ovarian cancer 7 | 8,492
medulloblastoma, large-cell 6 | 6,234
pediatric high grade glioma 6 | 2,712
pilocytic astrocytoma 6 | 3,086
Cancer 5 | 2,346
primitive neuroectodermal tumor 5 | 3,031
diabetes mellitus 4 | 1,663
oligodendroglioma 4 | 2,849
ulcerative colitis 4 | 2,087
Hidradenitis suppurativa 3 | 12
Rheumatoid Arthritis 3 | 1,171
group 4 medulloblastoma 3 | 1,875
lung cancer 3 | 4,473
lung carcinoma 3 | 2,844
medulloblastoma 3 | 1,524
psoriasis 3 | 6,685
Acne 2 | 20
Amyloidosis 2 | 68
Amyotrophic Lateral Sclerosis 2 | 432
Brain Ischemia 2 | 87
Colitis 2 | 46
Colonic Neoplasms 2 | 126
Crohn's disease 2 | 304
Diabetes Mellitus, Non-Insulin-Dependent 2 | 161
Heat Stroke 2 | 12
Hidradenitis suppurativa, familial 2 | 3
Inflammatory bowel disease 2 | 142
Kidney Failure, Chronic 2 | 45
Liver carcinoma 2 | 217
Mantle cell lymphoma 2 | 20
Multiple myeloma 2 | 1,328
Neoplastic Cell Transformation 2 | 81
Prostatic Neoplasms 2 | 471
adult high grade glioma 2 | 2,148
astrocytoma 2 | 1,493
atypical teratoid/rhabdoid tumor 2 | 1,095
group 3 medulloblastoma 2 | 2,254
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,795
tuberculosis 2 | 1,563
Acquired thrombocytopenia 1 | 7
Adrenogenital disorder 1 | 6
Allergic bronchopulmonary aspergillosis 1 | 4
Articular gout 1 | 11
Autoimmune disease 1 | 5
Autoimmune hemolytic anemia 1 | 17
Bacterial keratitis 1 | 5
Blepharoconjunctivitis 1 | 5
Bursitis 1 | 10
Cerebral edema 1 | 5
Congenital hypoplastic anemia 1 | 8
Corneal abrasion 1 | 6
Corneal ulcer 1 | 9
Cyclitis 1 | 6
Dermatitis herpetiformis 1 | 11
Diagnostic Test for Cushing's Syndrome 1 | 5
Discoid lupus erythematosus 1 | 7
Disorder of eye 1 | 7
Disorder of musculoskeletal system 1 | 5
Disorder of skin 1 | 5
Eosinophilic asthma 1 | 5
Eruption of skin 1 | 5
Erythroblastic Anemia 1 | 5
Erythroderma 1 | 5
Exacerbation of asthma 1 | 11
Extrinsic allergic alveolitis 1 | 6
Giant cell arteritis 1 | 5
Granuloma annulare 1 | 5
Herpes zoster keratitis 1 | 6
Idiopathic thrombocytopenic purpura 1 | 5
Infective blepharitis 1 | 5
Iridocyclitis 1 | 12
Iritis 1 | 9
Löffler's syndrome 1 | 5
Meibomianitis 1 | 4
Ocular rosacea 1 | 4
Plaque psoriasis 1 | 14
Polymyalgia rheumatica 1 | 10
Post traumatic osteoarthritis 1 | 5
Post-Op Ocular Inflammation 1 | 10
Primary adrenocortical insufficiency 1 | 6
Pruritus of genital organs 1 | 5
Psoriasis with arthropathy 1 | 11
Punctate Epithelial Keratopathy 1 | 6
Rheumatic heart disease 1 | 8
Rosacea 1 | 18
Scalp psoriasis 1 | 6
Seborrheic dermatitis 1 | 19
Severe adrenal insufficiency 1 | 5
Sjögren's syndrome 1 | 5
Sympathetic uveitis 1 | 4
Synovitis due to Osteoarthritis 1 | 5
Tenosynovitis 1 | 15
Transfusion Reaction Urticaria 1 | 5
Transfusion reaction due to serum protein reaction 1 | 5
Transplanted organ rejection 1 | 10

Tissue

Blood and immune system 15 | 17,995
Cardiovascular System 15 | 17,958
Digestive Tract 15 | 18,473
Endocrine System 15 | 18,512
Female tissues 15 | 18,647
Liver and Pancreas 15 | 18,136
Male tissues 15 | 17,969
Nervous System 15 | 18,561
Respiratory system 15 | 17,484
Skin and soft tissues 15 | 18,115
Urinary Tract 15 | 18,444

Target Family

Enzyme 10 | 4,146
Non-IDG 3 | 11,969
Transcription Factor 2 | 1,400

GO Process

membrane protein intracellular... 15 | 15
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Gamma-secretase subunit APH-1B APH1B Tchem Enzyme -1.15543 13.7 52
TNF receptor-associated factor 6 TRAF6 Tbio Non-IDG -2.67984 438.1 349
Membrane-bound transcription factor site-1 protease MBTPS1 Tchem Enzyme -1.48741 36.1 38
Membrane-bound transcription factor site-2 protease MBTPS2 Tbio Enzyme -1.92161 81.2 93
Disintegrin and metalloproteinase domain-containing protein 17 ADAM17 Tchem Enzyme -3.50934 3251.4 604
Presenilin-2 PSEN2 Tchem Enzyme -2.55846 585.2 282
Gamma-secretase subunit PEN-2 PSENEN Tchem Enzyme -2.84368 678.2 177
Nicastrin NCSTN Tbio Non-IDG -2.13111 143.4 321
Tumor necrosis factor receptor superfamily member 16 NGFR Tchem Non-IDG -3.04691 1125.0 687
Transcription factor p65 RELA Tchem Transcription Factor -2.97168 941.6 2003