Development Level

Tbio 21 | 10,625

Collection

GPCR: IDG Consortium (Targets) 1 | 127

IMPC Phenotype

preweaning lethality, complete... 3 | 633
abnormal behavior 2 | 226
preweaning lethality, incomple... 2 | 260
abnormal behavioral response t... 1 | 52
abnormal coat-hair pigmentatio... 1 | 54
abnormal gait 1 | 51
abnormal retina morphology 1 | 100
cardiovascular system phenotyp... 1 | 35
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 49
decreased circulating bilirubi... 1 | 14
decreased circulating chloride... 1 | 32
decreased effector memory CD4-... 1 | 6
decreased effector memory CD8-... 1 | 24
decreased granulocyte number 1 | 8
decreased grip strength 1 | 123
decreased heart rate variabili... 1 | 11
decreased lean body mass 1 | 195
decreased pre-pro B cell numbe... 1 | 2
decreased respiratory quotient 1 | 12
enlarged liver 1 | 3
hyperactivity 1 | 108
impaired glucose tolerance 1 | 52
increased B cell number 1 | 23
increased circulating HDL chol... 1 | 63
increased circulating alanine ... 1 | 11
increased circulating aspartat... 1 | 17
increased circulating choleste... 1 | 53
increased circulating creatini... 1 | 29
increased circulating glucose ... 1 | 16
increased fasted circulating g... 1 | 68
increased hematocrit 1 | 36
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
increased plasma cell number 1 | 5
increased prepulse inhibition 1 | 21
increased total body fat amoun... 1 | 57
short tibia 1 | 82
thrombocytopenia 1 | 46

Disease

ovarian cancer 13 | 8,491
osteosarcoma 12 | 7,933
psoriasis 11 | 6,685
medulloblastoma, large-cell 9 | 6,234
atypical teratoid / rhabdoid tumor 8 | 4,369
Obesity 7 | 616
glioblastoma 7 | 5,572
malignant mesothelioma 7 | 3,163
Bardet-Biedl Syndrome 6 | 40
Bardet-Biedl syndrome 1 6 | 22
Ciliopathy 6 | 57
Intellectual disability 6 | 573
Pick disease 6 | 1,893
Polydactyly 6 | 93
oligodendroglioma 6 | 2,849
Breast cancer 5 | 3,098
Hermansky-Pudlak syndrome 5 | 43
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,956
invasive ductal carcinoma 5 | 2,950
pancreatic cancer 5 | 2,300
pilocytic astrocytoma 5 | 3,086
posterior fossa group B ependymoma 5 | 1,530
Cone dystrophy 4 | 59
Fundus dystrophy 4 | 77
Oculocutaneous albinism 4 | 28
Platelet storage pool deficiency 4 | 21
Retinitis pigmentosa 4 | 156
adult high grade glioma 4 | 2,148
interstitial cystitis 4 | 2,299
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,289
lung cancer 4 | 4,473
medulloblastoma 4 | 1,524
pituitary cancer 4 | 1,972
Chediak-Higashi syndrome 3 | 24
Choroideremia 3 | 13
Hemophagocytic lymphohistiocytosis 3 | 30
acute quadriplegic myopathy 3 | 1,157
astrocytic glioma 3 | 2,241
ductal carcinoma in situ 3 | 1,745
ependymoma 3 | 2,514
gastric cancer 3 | 436
gastric carcinoma 3 | 832
group 3 medulloblastoma 3 | 2,254
group 4 medulloblastoma 3 | 1,875
lung carcinoma 3 | 2,844
non-small cell lung cancer 3 | 2,798
primitive neuroectodermal tumor 3 | 3,031
subependymal giant cell astrocytoma 3 | 2,287
IGA Glomerulonephritis 2 | 454
Multiple myeloma 2 | 1,327
Neurodegenerative disease 2 | 383
Rectum cancer 2 | 12
aldosterone-producing adenoma 2 | 664
cutaneous lupus erythematosus 2 | 1,056
diabetes mellitus 2 | 1,663
hepatocellular carcinoma 2 | 550
pancreatic carcinoma 2 | 567
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,795
pediatric high grade glioma 2 | 2,712
posterior fossa group A ependymoma 2 | 1,511
primary Sjogren syndrome 2 | 788
spina bifida 2 | 1,064
ulcerative colitis 2 | 2,087
AMYOTROPHIC LATERAL SCLEROSIS 1 1 | 49
Amyotrophic Lateral Sclerosis 1 | 432
Anterior ischemic optic neuropathy 1 | 7
Bardet-Biedl syndrome 4 1 | 1
Basal cell carcinoma 1 | 31
Cerebrovascular disease 1 | 231
Charcot-Marie-Tooth disease 1 | 74
Congenital heart disease 1 | 63
Congenital nystagmus 1 | 26
Coronary artery disease 1 | 240
Ellis-Van Creveld syndrome 1 | 19
Eye disease 1 | 55
Frontotemporal dementia 1 | 47
HIV Infections 1 | 99
Heart disease 1 | 279
Hereditary spherocytosis 1 | 20
Hermansky-Pudlak syndrome 9 1 | 1
Hypertension 1 | 293
Hypogonadism 1 | 70
Lipid metabolism disorder 1 | 102
Megalocornea 1 | 15
Melanoma 1 | 261
Ocular albinism 1 | 29
Pallister-Hall syndrome 1 | 11
Paraplegia 1 | 71
Parkinson's disease 1 | 364
Peripheral Neuropathy 1 | 303
Retinal Degeneration 1 | 49
Vitiligo 1 | 71
active Crohn's disease 1 | 918
active ulcerative colitis 1 | 477
cystic fibrosis and chronic rhinosinusitis 1 | 213
facioscapulohumeral dystrophy 1 | 286
glioblastoma multiforme 1 | 347
substance-related disorder 1 | 104
tuberculosis and treatment for 3 months 1 | 327

Tissue

Blood and immune system 21 | 17,994
Cardiovascular System 21 | 17,957
Digestive Tract 21 | 18,472
Endocrine System 21 | 18,511
Female tissues 21 | 18,646
Liver and Pancreas 21 | 18,135
Male tissues 21 | 17,968
Nervous System 21 | 18,560
Respiratory system 21 | 17,483
Skin and soft tissues 21 | 18,114
Urinary Tract 21 | 18,443

Target Family

Non-IDG 13 | 11,969
Enzyme 7 | 4,146
GPCR 1 | 408

GO Process

melanosome transport 21 | 21
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 367 | 367
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
chemical synaptic transmission 238 | 238
MAPK cascade 237 | 237
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 199 | 199
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 180 | 180
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 175 | 175
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
protein folding 162 | 162
negative regulation of canonic... 161 | 161
response to lipopolysaccharide 161 | 161
T cell receptor signaling path... 160 | 160
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2-M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
type I interferon signaling pa... 130 | 130
endocytosis 129 | 129

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras-related protein Rab-11A RAB11A Tbio Enzyme -2.62399 398.9 288
Ras-related protein Rab-27A RAB27A Tbio Enzyme -2.26523 184.9 247
Melanoregulin MREG Tbio Non-IDG -1.89992 78.4 92
Agouti-signaling protein ASIP Tbio Non-IDG -1.73744 52.4 27
McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin MKKS Tbio Non-IDG -2.09482 131.5 87
Ras-related protein Rab-17 RAB17 Tbio Enzyme -1.20733 20.8 133
Ras-related protein Rab-1A RAB1A Tbio Enzyme -2.36973 242.5 102
ADP-ribosylation factor-like protein 6 ARL6 Tbio Enzyme -0.49485 35.9 75
Ras-related protein Rab-27B RAB27B Tbio Enzyme -1.59886 41.3 152
G-protein coupled receptor 143 GPR143 Tbio GPCR -1.67825 46.2 86