Development Level

Tbio 172 | 10,625
Tdark 37 | 7,003
Tchem 10 | 1,890

Collection

Kinase: IDG Consortium (Targets) 1 | 125

IMPC Phenotype

preweaning lethality, complete... 14 | 633
embryonic lethality prior to o... 6 | 148
embryonic lethality prior to t... 5 | 187
decreased leukocyte cell numbe... 3 | 54
decreased neutrophil cell numb... 3 | 37
preweaning lethality, incomple... 3 | 260
abnormal behavior 2 | 226
abnormal coat-hair pigmentatio... 2 | 54
decreased circulating glucose ... 2 | 121
decreased lymphocyte cell numb... 2 | 9
increased circulating free fat... 2 | 17
increased fasted circulating g... 2 | 68
prenatal lethality prior to he... 2 | 64
thrombocytosis 2 | 23
abnormal bone structure 1 | 131
abnormal embryo size 1 | 112
abnormal esophagus morphology 1 | 4
abnormal lung morphology 1 | 15
abnormal pancreas morphology 1 | 6
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
absent pinna reflex 1 | 21
cardiovascular system phenotyp... 1 | 35
decreased CD5-positive gamma-d... 1 | 3
decreased KLRG1-positive NK ce... 1 | 9
decreased Ly6C high monocyte n... 1 | 18
decreased Ly6C low monocyte nu... 1 | 23
decreased body length 1 | 108
decreased cervical vertebrae n... 1 | 12
decreased circulating calcium ... 1 | 33
decreased circulating sodium l... 1 | 18
decreased circulating triglyce... 1 | 83
decreased grip strength 1 | 123
decreased heart weight 1 | 44
decreased lean body mass 1 | 195
decreased monocyte cell number 1 | 28
enlarged heart 1 | 111
female infertility 1 | 34
hyperactivity 1 | 108
impaired righting response 1 | 19
increased circulating HDL chol... 1 | 63
increased circulating alkaline... 1 | 119
increased circulating calcium ... 1 | 32
increased circulating choleste... 1 | 53
increased circulating creatini... 1 | 29
increased circulating glucose ... 1 | 16
increased circulating serum al... 1 | 25
increased circulating total pr... 1 | 20
increased circulating triglyce... 1 | 24
increased grip strength 1 | 83
increased or absent threshold ... 1 | 128
increased prepulse inhibition 1 | 21
increased total body fat amoun... 1 | 57
male infertility 1 | 62
oligodactyly 1 | 14
sparse hair 1 | 6

Disease

ovarian cancer 144 | 8,491
osteosarcoma 100 | 7,933
psoriasis 74 | 6,685
medulloblastoma, large-cell 73 | 6,234
group 3 medulloblastoma 69 | 2,254
lung cancer 67 | 4,473
glioblastoma 63 | 5,572
Multiple myeloma 59 | 1,327
ependymoma 45 | 2,514
atypical teratoid / rhabdoid tumor 44 | 4,369
malignant mesothelioma 44 | 3,163
oligodendroglioma 44 | 2,849
primitive neuroectodermal tumor 38 | 3,031
astrocytoma 37 | 1,493
intraductal papillary-mucinous carcinoma (IPMC) 36 | 2,988
acute quadriplegic myopathy 35 | 1,157
Breast cancer 34 | 3,098
Waldenstrons macroglobulinemia 33 | 764
dermatomyositis 31 | 966
diabetes mellitus 30 | 1,663
Pick disease 28 | 1,893
intraductal papillary-mucinous adenoma (IPMA) 28 | 2,956
astrocytic glioma 25 | 2,241
pediatric high grade glioma 25 | 2,712
lung adenocarcinoma 22 | 2,714
subependymal giant cell astrocytoma 22 | 2,287
intraductal papillary-mucinous neoplasm (IPMN) 21 | 3,289
non-small cell lung cancer 21 | 2,798
pancreatic ductal adenocarcinoma liver metastasis 20 | 1,795
progressive supranuclear palsy 20 | 674
Cancer 19 | 2,346
Carcinoma 19 | 2,147
acute myeloid leukemia 19 | 785
invasive ductal carcinoma 18 | 2,950
atypical teratoid/rhabdoid tumor 15 | 1,095
juvenile dermatomyositis 15 | 1,189
sonic hedgehog group medulloblastoma 15 | 1,482
adult high grade glioma 14 | 2,148
breast carcinoma 14 | 1,614
Gaucher disease type 1 13 | 171
non primary Sjogren syndrome sicca 13 | 840
Amyotrophic Lateral Sclerosis 12 | 432
group 4 medulloblastoma 12 | 1,875
hepatocellular carcinoma 12 | 550
pancreatic cancer 12 | 2,300
tuberculosis and treatment for 6 months 12 | 686
Intellectual disability 11 | 573
Rheumatoid Arthritis 11 | 1,170
adrenocortical carcinoma 9 | 1,427
medulloblastoma 9 | 1,524
pilocytic astrocytoma 9 | 3,086
pituitary cancer 9 | 1,972
aldosterone-producing adenoma 8 | 664
colon cancer 8 | 1,475
HIV Infections 7 | 99
Polycystic Ovary Syndrome 7 | 334
Retinitis pigmentosa 7 | 156
gastric cancer 7 | 436
nasopharyngeal carcinoma 7 | 1,056
pancreatic carcinoma 7 | 567
posterior fossa group A ependymoma 7 | 1,511
relapsing-remitting multiple sclerosis 7 | 18
Mixed connective tissue disease 6 | 16
Subcutaneous panniculitis-like T-cell lymphoma 6 | 16
autosomal dominant Emery-Dreifuss muscular dystrophy 6 | 499
spina bifida 6 | 1,064
Alzheimer's disease 5 | 644
Frontotemporal dementia 5 | 47
Lupus erythematosus 5 | 80
Mammary Neoplasms 5 | 410
Spinal muscular atrophy 5 | 24
Stomach Neoplasms 5 | 282
cystic fibrosis 5 | 1,670
posterior fossa group B ependymoma 5 | 1,530
Animal Mammary Neoplasms 4 | 135
Atopic dermatitis 4 | 944
Cockayne syndrome 4 | 54
Disease Progression 4 | 125
Immune system cancer 4 | 38
Mammary Neoplasms, Experimental 4 | 149
Muscular atrophy 4 | 67
Nager acrofacial dysostosis 4 | 21
ductal carcinoma in situ 4 | 1,745
glioblastoma multiforme 4 | 347
inflammatory breast cancer 4 | 404
interstitial lung disease 4 | 292
lung carcinoma 4 | 2,844
primary Sjogren syndrome 4 | 788
primary pancreatic ductal adenocarcinoma 4 | 1,271
tuberculosis 4 | 1,563
Down syndrome 3 | 548
Duchenne muscular dystrophy 3 | 602
Epilepsy 3 | 346
Kidney disease 3 | 397
Multiple Sclerosis 3 | 498
Neurodegenerative disease 3 | 383
active Crohn's disease 3 | 918
gastric carcinoma 3 | 832
interstitial cystitis 3 | 2,299
tuberculosis and treatment for 3 months 3 | 327

Tissue

Blood and immune system 217 | 17,994
Cardiovascular System 217 | 17,957
Digestive Tract 217 | 18,472
Endocrine System 217 | 18,511
Female tissues 217 | 18,646
Liver and Pancreas 217 | 18,135
Male tissues 217 | 17,968
Nervous System 217 | 18,560
Respiratory system 217 | 17,483
Urinary Tract 217 | 18,443
Skin and soft tissues 216 | 18,114

Target Family

Non-IDG 176 | 11,969
Enzyme 39 | 4,146
Transcription Factor 2 | 1,400
Epigenetic 1 | 242
Kinase 1 | 634

GO Process

mRNA splicing, via spliceosome 219 | 219
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 367 | 367
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
chemical synaptic transmission 238 | 238
MAPK cascade 237 | 237
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 199 | 199
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 180 | 180
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 175 | 175
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
protein folding 162 | 162
negative regulation of canonic... 161 | 161
response to lipopolysaccharide 161 | 161
T cell receptor signaling path... 160 | 160
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2-M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
type I interferon signaling pa... 130 | 130
endocytosis 129 | 129

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA-directed RNA polymerase II subunit RPB2 POLR2B Tbio Enzyme -2.47495 286.5 135
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 DHX15 Tbio Enzyme -1.70052 49.6 108
U4/U6 small nuclear ribonucleoprotein Prp4 PRPF4 Tchem Non-IDG -0.55879 7.56 79
Msx2-interacting protein SPEN Tbio Non-IDG -2.91140 781.7 40
Nuclear cap-binding protein subunit 1 NCBP1 Tbio Non-IDG -2.31776 194.4 161
DNA-directed RNA polymerases I, II, and III subunit RPABC3 POLR2H Tbio Enzyme -1.14104 13.5 159
DNA-directed RNA polymerase II subunit RPB11-a POLR2J Tbio Enzyme -1.42612 28.8 182
RNA-binding motif protein, X chromosome RBMX Tbio Non-IDG -1.49173 32.8 82
Peptidyl-prolyl cis-trans isomerase E PPIE Tbio Enzyme -1.30532 19.4 143
Pleiotropic regulator 1 PLRG1 Tbio Non-IDG -0.93540 8.69 172