Development Level

Tbio 88 | 11,445
Tchem 19 | 1,598
Tdark 11 | 6,588
Tclin 8 | 613

Collection

GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 5 | 979
preweaning lethality, incomple... 4 | 499
decreased circulating HDL chol... 3 | 68
decreased vertical activity 3 | 208
embryonic lethality prior to t... 3 | 278
abnormal embryo size 2 | 220
abnormal retina morphology 2 | 71
abnormal retinal blood vessel ... 2 | 26
abnormal retinal vasculature m... 2 | 27
abnormal sleep behavior 2 | 70
cardiovascular system phenotyp... 2 | 36
decreased body length 2 | 101
decreased body weight 2 | 161
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
decreased circulating choleste... 2 | 93
decreased heart rate variabili... 2 | 13
decreased lean body mass 2 | 135
decreased mean corpuscular vol... 2 | 79
hydrometra 2 | 53
increased body length 2 | 32
increased mean corpuscular vol... 2 | 92
persistence of hyaloid vascula... 2 | 33
abnormal behavior 1 | 298
abnormal body wall morphology 1 | 9
abnormal bone structure 1 | 187
abnormal brain morphology 1 | 13
abnormal coat appearance 1 | 31
abnormal coat- hair morphology 1 | 19
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal limb bud morphology 1 | 17
abnormal pericardium morpholog... 1 | 26
abnormal seminal vesicle morph... 1 | 114
abnormal skin coloration 1 | 25
abnormal spleen morphology 1 | 55
abnormal tibia morphology 1 | 14
anophthalmia 1 | 33
decreased circulating calcium ... 1 | 36
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating potassiu... 1 | 20
decreased circulating unsatura... 1 | 2
decreased coping response 1 | 8
decreased exploration in new e... 1 | 11
decreased grip strength 1 | 116
decreased heart weight 1 | 27
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
hydroencephaly 1 | 14
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased aggression 1 | 4
increased body weight 1 | 25
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating iron lev... 1 | 30
increased circulating potassiu... 1 | 29
increased circulating triglyce... 1 | 42
increased heart rate 1 | 23
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased mean platelet volume 1 | 45
increased or absent threshold ... 1 | 101
increased red blood cell distr... 1 | 34
increased startle reflex 1 | 112
increased total retina thickne... 1 | 4
microphthalmia 1 | 26
pallor 1 | 34
shortened RR interval 1 | 17
small superior vagus ganglion 1 | 74
thrombocytopenia 1 | 56

Disease

Carcinoma 78 | 11,493
psoriasis 65 | 6,694
ovarian cancer 59 | 8,520
osteosarcoma 50 | 7,950
lung cancer 44 | 4,740
glioblastoma 39 | 5,792
medulloblastoma, large-cell 38 | 6,241
atypical teratoid / rhabdoid tumor 34 | 5,112
intraductal papillary-mucinous neoplasm (IPMN) 34 | 3,291
ependymoma 33 | 4,679
invasive ductal carcinoma 33 | 2,951
malignant mesothelioma 32 | 3,232
pancreatic ductal adenocarcinoma liver metastasis 30 | 1,962
diabetes mellitus 29 | 1,728
group 3 medulloblastoma 29 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 27 | 2,989
non-small cell lung cancer 27 | 2,890
ductal carcinoma in situ 25 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 25 | 2,955
lung carcinoma 25 | 2,843
Breast cancer 24 | 3,578
Obesity 24 | 678
lung adenocarcinoma 24 | 2,716
interstitial cystitis 22 | 2,312
pancreatic cancer 22 | 2,398
subependymal giant cell astrocytoma 22 | 2,287
tuberculosis 22 | 2,010
Autosomal recessive predisposition 21 | 1,442
Cancer 21 | 2,499
colon cancer 21 | 1,478
Schizophrenia 20 | 1,160
adult high grade glioma 19 | 3,801
Astrocytoma, Pilocytic 18 | 3,081
breast carcinoma 18 | 1,638
Atherosclerosis 17 | 291
oligodendroglioma 17 | 2,850
ulcerative colitis 17 | 1,819
Kidney cancer 16 | 2,613
cystic fibrosis 16 | 1,696
Alzheimer's disease 15 | 658
astrocytic glioma 15 | 2,597
Atopic dermatitis 14 | 952
Lipid metabolism disorder 14 | 114
group 4 medulloblastoma 14 | 1,855
primitive neuroectodermal tumor 14 | 3,035
Coronary artery disease 13 | 268
Pick disease 13 | 1,894
Prostatic Neoplasms 13 | 495
acute quadriplegic myopathy 13 | 1,158
adrenocortical carcinoma 13 | 1,428
astrocytoma 13 | 1,146
cutaneous lupus erythematosus 13 | 1,057
esophageal adenocarcinoma 13 | 737
Fatty liver disease 11 | 103
active ulcerative colitis 11 | 764
aldosterone-producing adenoma 11 | 665
pituitary cancer 11 | 1,972
Down syndrome 10 | 499
Epilepsy 10 | 792
Hepatomegaly 10 | 285
Intellectual disability 10 | 1,016
Liver Cirrhosis, Experimental 10 | 769
Melanoma 10 | 711
Seizures 10 | 596
active Crohn's disease 10 | 922
dermatomyositis 10 | 966
juvenile dermatomyositis 10 | 1,187
nasopharyngeal carcinoma 10 | 1,058
pediatric high grade glioma 10 | 1,064
primary Sjogren syndrome 10 | 735
primary pancreatic ductal adenocarcinoma 10 | 1,109
Cognitive delay 9 | 608
Dull intelligence 9 | 645
Global developmental delay 9 | 608
Low intelligence 9 | 645
Mental Retardation 9 | 645
Mental and motor retardation 9 | 608
Mental deficiency 9 | 645
Muscle hypotonia 9 | 571
Poor school performance 9 | 645
mucosa-associated lymphoid tissue lymphoma 9 | 484
pancreatic carcinoma 9 | 562
spina bifida 9 | 1,074
Hyperinsulinism 8 | 133
Liver disease 8 | 237
Non-alcoholic Fatty Liver Disease 8 | 42
autosomal dominant Emery-Dreifuss muscular dystrophy 8 | 510
Arthritis 7 | 290
Asthma 7 | 385
Carcinoma, Hepatocellular 7 | 228
Hypertension 7 | 396
Hypertensive disease 7 | 292
Hypoglycemia 7 | 152
Kidney disease 7 | 430
Liver carcinoma 7 | 240
Myocardial Infarction 7 | 151
Proteinuria 7 | 144
Rheumatoid arthritis 7 | 1,191
acute myeloid leukemia 7 | 783
fibroadenoma 7 | 559

Tissue

Digestive Tract 122 | 17,369
Endocrine System 122 | 18,159
Female tissues 121 | 17,400
Liver and Pancreas 120 | 16,750
Male tissues 118 | 17,142
Skin and soft tissues 118 | 17,230
Blood and immune system 116 | 16,909
Nervous System 116 | 16,725
Urinary Tract 116 | 16,678
Respiratory system 113 | 16,393
Cardiovascular System 109 | 15,192

Target Family

Enzyme 64 | 4,145
Non-IDG 44 | 12,091
Nuclear Receptor 5 | 48
Transcription Factor 5 | 1,400
Transporter 5 | 473
GPCR 1 | 408
Ion Channel 1 | 344
Kinase 1 | 634

GO Process

lipid metabolic process 126 | 126
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cholesterol 25-hydroxylase CH25H Tbio Enzyme -1.54426 38.2 54
Isobutyryl-CoA dehydrogenase, mitochondrial ACAD8 Tbio Enzyme -1.14784 13.9 150
UDP-glucuronosyltransferase 2B7 UGT2B7 Tchem Enzyme -2.31570 219.0 131
Glycerophosphoinositol inositolphosphodiesterase GDPD2 GDPD2 Tbio Enzyme -0.91821 8.09 101
Copine-1 CPNE1 Tbio Non-IDG -1.04880 11.6 151
Hydroxymethylglutaryl-CoA synthase, cytoplasmic HMGCS1 Tchem Enzyme -1.67608 43.7 137
Mitochondrial uncoupling protein 3 UCP3 Tbio Non-IDG -2.74050 585.4 181
PI-PLC X domain-containing protein 1 PLCXD1 Tdark Non-IDG -0.26745 1.80 108
Cholinephosphotransferase 1 CHPT1 Tbio Enzyme -1.42313 23.5 80
Fatty acid-binding protein, epidermal FABP5 Tchem Non-IDG -1.94229 141.2 226