Development Level

Tbio 58 | 10,625
Tchem 43 | 1,890
Tclin 19 | 602
Tdark 2 | 7,003

Collection

GPCR: IDG Consortium (Targets) 1 | 128

IMPC Phenotype

preweaning lethality, incomple... 5 | 260
decreased circulating creatini... 3 | 31
decreased circulating glucose ... 3 | 121
decreased total body fat amoun... 3 | 186
abnormal femur morphology 2 | 14
decreased circulating insulin ... 2 | 75
decreased circulating triglyce... 2 | 83
increased or absent threshold ... 2 | 128
preweaning lethality, complete... 2 | 633
tremors 2 | 34
abnormal QRS complex 1 | 25
abnormal behavior 1 | 226
abnormal colon morphology 1 | 1
abnormal coping response 1 | 12
abnormal cornea morphology 1 | 24
abnormal eye anterior chamber ... 1 | 3
abnormal gait 1 | 51
abnormal ileum morphology 1 | 2
abnormal iris morphology 1 | 12
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal sleep behavior 1 | 63
abnormal vibrissa morphology 1 | 17
abnormal vitreous body morphol... 1 | 7
abnormal whole-body plethysmog... 1 | 4
convulsive seizures 1 | 11
decreased blood urea nitrogen ... 1 | 31
decreased body weight 1 | 174
decreased circulating alanine ... 1 | 53
decreased circulating magnesiu... 1 | 11
decreased circulating phosphat... 1 | 15
decreased heart weight 1 | 44
decreased hematocrit 1 | 25
decreased lumbar vertebrae num... 1 | 62
decreased prepulse inhibition 1 | 52
decreased pulmonary respirator... 1 | 4
decreased rib number 1 | 59
decreased startle reflex 1 | 48
decreased threshold for audito... 1 | 32
dilated heart left ventricle 1 | 10
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
enlarged heart 1 | 111
enlarged spleen 1 | 26
hydrops fetalis 1 | 22
immune system phenotype 1 | 17
impaired glucose tolerance 1 | 52
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating alkaline... 1 | 119
increased circulating glycerol... 1 | 11
increased circulating potassiu... 1 | 31
increased circulating sodium l... 1 | 71
increased circulating thyroxin... 1 | 7
increased eosinophil cell numb... 1 | 9
increased erythrocyte cell num... 1 | 26
increased exploration in new e... 1 | 56
increased fasted circulating g... 1 | 68
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased leukocyte cell numbe... 1 | 37
increased lymphocyte cell numb... 1 | 9
increased mean corpuscular hem... 1 | 93
increased mean corpuscular hem... 1 | 25
increased rib number 1 | 41
increased spleen weight 1 | 3
increased tidal volume 1 | 1
irregularly shaped pupil 1 | 7
oligodactyly 1 | 14
short tibia 1 | 82

Disease

osteosarcoma 79 | 7,933
Cancer 69 | 2,346
ovarian cancer 69 | 8,491
glioblastoma 65 | 5,572
lung cancer 65 | 4,473
psoriasis 64 | 6,685
invasive ductal carcinoma 57 | 2,950
medulloblastoma, large-cell 53 | 6,234
interstitial cystitis 52 | 2,299
non-small cell lung cancer 50 | 2,798
ulcerative colitis 47 | 2,087
lung carcinoma 46 | 2,844
lung adenocarcinoma 44 | 2,714
pilocytic astrocytoma 43 | 3,086
Breast cancer 42 | 3,098
malignant mesothelioma 42 | 3,163
atypical teratoid / rhabdoid tumor 37 | 4,369
intraductal papillary-mucinous carcinoma (IPMC) 37 | 2,988
pediatric high grade glioma 37 | 2,712
intraductal papillary-mucinous neoplasm (IPMN) 35 | 3,289
pancreatic cancer 35 | 2,300
intraductal papillary-mucinous adenoma (IPMA) 33 | 2,956
cutaneous lupus erythematosus 31 | 1,056
tuberculosis 29 | 1,563
cystic fibrosis 28 | 1,670
diabetes mellitus 28 | 1,663
ductal carcinoma in situ 28 | 1,745
subependymal giant cell astrocytoma 28 | 2,287
Carcinoma 27 | 2,147
astrocytoma 27 | 1,493
colon cancer 26 | 1,475
oligodendroglioma 24 | 2,849
breast carcinoma 22 | 1,614
juvenile dermatomyositis 22 | 1,189
primary Sjogren syndrome 22 | 788
dermatomyositis 21 | 966
pituitary cancer 20 | 1,972
primary pancreatic ductal adenocarcinoma 20 | 1,271
gastric carcinoma 19 | 832
posterior fossa group A ependymoma 19 | 1,511
IGA Glomerulonephritis 18 | 454
mucosa-associated lymphoid tissue lymphoma 18 | 480
primitive neuroectodermal tumor 18 | 3,031
Down syndrome 17 | 548
adrenocortical carcinoma 17 | 1,427
group 3 medulloblastoma 17 | 2,254
Duchenne muscular dystrophy 16 | 602
Rheumatoid Arthritis 16 | 1,170
Vascular disease 16 | 281
pancreatic carcinoma 16 | 567
Atherosclerosis 15 | 275
Kidney disease 15 | 397
Arthritis 14 | 248
Coronary artery disease 14 | 240
Hypertension 14 | 293
group 4 medulloblastoma 14 | 1,875
Hypersensitivity reaction type II disease 13 | 235
active Crohn's disease 13 | 918
adult high grade glioma 13 | 2,148
astrocytic glioma 13 | 2,241
ependymoma 13 | 2,514
head and neck cancer and chronic obstructive pulmonary disease 13 | 237
nasopharyngeal carcinoma 13 | 1,056
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,795
Asthma 12 | 349
Atopic dermatitis 12 | 944
Cerebrovascular disease 12 | 231
Multiple Sclerosis 12 | 498
Waldenstrons macroglobulinemia 12 | 764
esophageal adenocarcinoma 12 | 737
non-small cell lung carcinoma 12 | 413
Mammary Neoplasms 11 | 410
medulloblastoma 11 | 1,524
periodontitis 11 | 269
Heart disease 10 | 279
Multiple myeloma 10 | 1,327
Peripheral Neuropathy 10 | 303
Pick disease 10 | 1,893
autosomal dominant Emery-Dreifuss muscular dystrophy 10 | 499
nephrosclerosis 10 | 329
Lung disease 9 | 136
Neoplasm Metastasis 9 | 138
Stomach Neoplasms 9 | 282
Thrombocytopenia 9 | 105
Thrombosis 9 | 42
acute quadriplegic myopathy 9 | 1,157
hepatocellular carcinoma 9 | 550
posterior fossa group B ependymoma 9 | 1,530
sonic hedgehog group medulloblastoma 9 | 1,482
Dermatitis 8 | 141
Endometriosis 8 | 535
Inflammatory bowel disease 8 | 142
Neoplasm Invasiveness 8 | 127
Prostatic Neoplasms 8 | 471
acute myeloid leukemia 8 | 785
tuberculosis and treatment for 6 months 8 | 686
Crohn's disease 7 | 304
chronic lymphosyte leukemia 7 | 232
inflammatory breast cancer 7 | 404
urothelial carcinoma 7 | 318

Tissue

Endocrine System 122 | 18,511
Female tissues 122 | 18,646
Nervous System 122 | 18,560
Blood and immune system 121 | 17,994
Cardiovascular System 121 | 17,957
Digestive Tract 121 | 18,472
Liver and Pancreas 121 | 18,135
Male tissues 121 | 17,968
Urinary Tract 121 | 18,443
Respiratory system 120 | 17,483
Skin and soft tissues 119 | 18,114

Target Family

Non-IDG 68 | 11,969
Enzyme 19 | 4,146
Transporter 14 | 473
Kinase 11 | 634
GPCR 8 | 408
Transcription Factor 2 | 1,400

GO Process

leukocyte migration 122 | 122
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 367 | 367
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
chemical synaptic transmission 238 | 238
MAPK cascade 237 | 237
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 199 | 199
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 180 | 180
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 175 | 175
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
protein folding 162 | 162
negative regulation of canonic... 161 | 161
response to lipopolysaccharide 161 | 161
T cell receptor signaling path... 160 | 160
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2-M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
type I interferon signaling pa... 130 | 130
endocytosis 129 | 129

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
E-selectin SELE Tchem Non-IDG -3.43650 2598.8 820
Large neutral amino acids transporter small subunit 1 SLC7A5 Tbio Transporter -1.84839 135.6 220
Monocarboxylate transporter 1 SLC16A1 Tchem Transporter -2.42636 263.7 235
Sodium/potassium-transporting ATPase subunit beta-3 ATP1B3 Tclin Transporter -1.08214 10.9 189
Collagen alpha-1(I) chain COL1A1 Tbio Non-IDG -2.94271 807.7 451
GTPase KRas KRAS Tbio Enzyme -3.77389 5694.2 421
Endothelial protein C receptor PROCR Tbio Non-IDG -2.67797 519.6 324
Macrophage migration inhibitory factor MIF Tchem Non-IDG -3.18923 1481.9 433
L-selectin SELL Tchem Non-IDG -3.45880 2781.0 888
Sodium/potassium-transporting ATPase subunit beta-2 ATP1B2 Tclin Transporter -1.33849 19.3 155