Development Level

Tdark 110 | 6,593
Tbio 70 | 11,651
Tchem 2 | 1,388

IMPC Phenotype

preweaning lethality, incomple... 4 | 499
abnormal bone structure 2 | 187
abnormal coat appearance 2 | 31
abnormal kidney morphology 2 | 65
decreased circulating HDL chol... 2 | 68
decreased circulating insulin ... 2 | 76
decreased total body fat amoun... 2 | 207
embryonic lethality prior to t... 2 | 278
increased lean body mass 2 | 172
preweaning lethality, complete... 2 | 979
abnormal behavior 1 | 298
abnormal coat- hair morphology 1 | 19
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal embryo size 1 | 220
abnormal retina morphology 1 | 71
corneal opacity 1 | 32
corneal vascularization 1 | 6
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased cardiac muscle contr... 1 | 11
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating free fat... 1 | 31
decreased circulating serum al... 1 | 82
decreased coping response 1 | 8
decreased fasted circulating g... 1 | 65
decreased lean body mass 1 | 135
decreased spleen weight 1 | 10
decreased vertical activity 1 | 208
dilated heart left ventricle 1 | 11
embryonic lethality prior to o... 1 | 239
enlarged kidney 1 | 14
hypoactivity 1 | 132
impaired righting response 1 | 26
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
increased total body fat amoun... 1 | 134
narrow eye opening 1 | 12
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
short tibia 1 | 97

Disease

psoriasis 120 | 6,694
Carcinoma 88 | 11,493
diabetes mellitus 48 | 1,728
Atopic dermatitis 42 | 952
ovarian cancer 35 | 8,520
Breast cancer 25 | 3,578
non-small cell lung cancer 23 | 2,890
osteosarcoma 21 | 7,950
spina bifida 20 | 1,074
cystic fibrosis 19 | 1,696
Cancer 18 | 2,499
Palmoplantar keratosis 18 | 74
esophageal adenocarcinoma 18 | 737
lung cancer 18 | 4,740
medulloblastoma, large-cell 17 | 6,241
malignant mesothelioma 16 | 3,232
Kidney cancer 14 | 2,613
lung adenocarcinoma 14 | 2,716
Dystrophia unguium 13 | 53
Hypotrichosis 13 | 47
interstitial cystitis 13 | 2,312
Alopecia 12 | 115
adult high grade glioma 12 | 3,801
nasopharyngeal carcinoma 12 | 1,058
pancreatic cancer 12 | 2,398
Monilethrix 11 | 18
Nail Diseases 11 | 24
Nail abnormality 11 | 22
atypical teratoid / rhabdoid tumor 11 | 5,112
Pachyonychia congenita 10 | 10
Autosomal recessive predisposition 9 | 1,442
Hyperhidrosis disorder 9 | 81
Increased sweating 9 | 81
Skin cancer 9 | 469
Sweating 9 | 81
breast carcinoma 9 | 1,638
ductal carcinoma in situ 9 | 1,745
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
Abnormal blistering of the skin 8 | 54
Blister of skin 8 | 54
Melanoma 8 | 711
Skin bulla 8 | 54
cutaneous lupus erythematosus 8 | 1,057
Arrhythmogenic right ventricular cardiomyopathy 7 | 30
Dermatitis 7 | 157
Hereditary mucosal leukokeratosis 7 | 7
Keratosis 7 | 37
Leukokeratosis 7 | 19
Leukoplakia, Oral 7 | 20
Nail dysplasia 7 | 52
Wooly hair 7 | 17
ependymoma 7 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
lung carcinoma 7 | 2,843
periodontitis 7 | 293
ulcerative colitis 7 | 1,819
Cardiomyopathy 6 | 116
Congenital ichthyosiform erythroderma 6 | 28
Dental caries 6 | 164
Epidermolytic hyperkeratosis 6 | 14
Erythema 6 | 58
Flushing 6 | 60
Ichthyoses 6 | 41
Onychogryposis 6 | 13
Rotting teeth 6 | 73
Squamous cell carcinoma 6 | 129
colon cancer 6 | 1,478
glioblastoma 6 | 5,792
group 3 medulloblastoma 6 | 4,104
Abnormality of metabolism/homeostasis 5 | 134
Astrocytoma, Pilocytic 5 | 3,081
Breast Neoplasms 5 | 445
Brittle hair 5 | 25
Carcinoma, Squamous Cell 5 | 110
Cardiomyopathy, right ventricular 5 | 7
Dilated cardiomyopathy 5 | 56
Epidermolysis bullosa simplex 5 | 9
Esophageal Squamous Cell Carcinoma 5 | 77
Fractured hair 5 | 25
Fragile hair 5 | 25
Highly variable severity 5 | 157
Mammary Neoplasms 5 | 425
Papilloma 5 | 44
Reduced tensile strength of hair 5 | 25
Ritter's disease 5 | 10
Squamous cell carcinoma of esophagus 5 | 77
Variable expressivity 5 | 157
primitive neuroectodermal tumor 5 | 3,035
Adenoma 4 | 167
Epidermolysis bullosa 4 | 21
Fine hair 4 | 42
Ichthyosis 4 | 56
Liver disease 4 | 237
Skin disease 4 | 66
Sudden Cardiac Death 4 | 29
active ulcerative colitis 4 | 764
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
oligodendroglioma 4 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
pituitary cancer 4 | 1,972

Tissue

Skin and soft tissues 101 | 17,230
Female tissues 100 | 17,400
Endocrine System 90 | 18,159
Digestive Tract 84 | 17,369
Blood and immune system 76 | 16,909
Male tissues 60 | 17,142
Nervous System 56 | 16,725
Liver and Pancreas 52 | 16,750
Urinary Tract 49 | 16,678
Respiratory system 46 | 16,393
Cardiovascular System 34 | 15,192

Target Family

Non-IDG 178 | 12,091
Enzyme 3 | 4,145
Transporter 1 | 473

GO Process

keratinization 182 | 182
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Desmoglein-3 DSG3 Tbio Non-IDG -2.57795 402.0 381
Desmoglein-1 DSG1 Tbio Non-IDG -2.72159 516.2 406
Desmocollin-2 DSC2 Tbio Non-IDG -1.89689 79.7 173
14-3-3 protein sigma SFN Tbio Non-IDG -2.56638 391.2 550
Protein-glutamine gamma-glutamyltransferase E TGM3 Tchem Enzyme -2.69033 481.2 236
Sharpin SHARPIN Tbio Non-IDG -1.34381 25.4 127
Junction plakoglobin JUP Tbio Non-IDG -2.01808 101.8 719
Keratin, type II cytoskeletal 6C KRT6C Tbio Non-IDG -0.47272 2.11 89
Keratin-associated protein 10-2 KRTAP10-2 Tdark Non-IDG 0.00000 5
Keratin-associated protein 10-3 KRTAP10-3 Tdark Non-IDG 1.08 0.05 0