Development Level

Tchem 3 | 1,598

IMPC Phenotype

abnormal behavior 1 | 298
abnormal embryo size 1 | 220
abnormal forebrain development 1 | 20
abnormal hindbrain development 1 | 16
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
hydrometra 1 | 53
microphthalmia 1 | 26
preweaning lethality, complete... 1 | 979
small epididymis 1 | 3
small seminal vesicle 1 | 10
small testis 1 | 58

Disease

Porokeratosis of Mibelli 3 | 4
malignant mesothelioma 3 | 3,232
Aplasia/Hypoplasia of the skin 2 | 16
Disseminated superficial actinic porokeratosis 2 | 4
Hyperkeratosis 2 | 50
Keratosis 2 | 37
Photosensitivity of skin 2 | 51
Porokeratosis, Disseminated Superficial Actinic 2 | 4
Pruritus 2 | 58
Abdominal Pain 1 | 98
Aciduria 1 | 1
Aphthous stomatitis 1 | 16
Arthralgia 1 | 90
Atrophy of cerebellum 1 | 103
Autosomal dominant familial periodic fever 1 | 3
Blue sclera 1 | 32
Brucellosis 1 | 24
Carcinoma, Hepatocellular 1 | 228
Cerebellar degeneration 1 | 103
Cerebral atrophy 1 | 178
Chromosome Breakage 1 | 36
Creatine phosphokinase serum increased 1 | 110
Decreased platelet count 1 | 111
Deficiency of mevalonate kinase 1 | 2
Degenerative brain disorder 1 | 100
Diarrhea 1 | 253
Difficulties with night vision 1 | 87
Dizziness 1 | 26
Downward slant of palpebral fissure 1 | 158
ESR raised 1 | 20
Edema 1 | 81
Elevated creatine kinase 1 | 110
Elevated hepatic transaminases 1 | 81
Elevated serum IgA 1 | 5
Exanthem 1 | 37
Exanthema 1 | 43
Familial Mediterranean fever 1 | 13
Familial cold autoinflammatory syndrome 1 | 10
Fever 1 | 138
Fluctuating hepatomegaly 1 | 1
Fluctuating splenomegaly 1 | 1
Gastrointestinal Hemorrhage 1 | 52
Headache 1 | 37
Hepatic enzyme increased 1 | 81
Hyperimmunoglobulin D with periodic fever 1 | 1
Hyperimmunoglobulinemia D 1 | 1
Hyperpigmented macules 1 | 42
Increased chromosomal breakage 1 | 27
Infratentorial atrophy 1 | 103
Intermittent fever 1 | 15
Intermittent migraine headaches 1 | 68
Large bregma sutures 1 | 46
Large fontanelle 1 | 46
Large, late-closing fontanelle 1 | 46
Leukocytosis 1 | 17
Liver Dysfunction 1 | 99
Liver carcinoma 1 | 240
Liver enzymes abnormal 1 | 81
Liver function test increased 1 | 81
Liver function tests abnormal finding 1 | 81
Long narrow head 1 | 75
Lymphadenitis 1 | 15
Lymphadenopathy 1 | 62
Malignant neoplasm of skin 1 | 15
Mevalonic aciduria 1 | 16
Migraine Disorders 1 | 76
Mitral valve insufficiency 1 | 49
Morbilliform rash 1 | 1
Muckle-Wells syndrome 1 | 12
Myalgia 1 | 54
Narrow cranium shape 1 | 75
Narrow head shape 1 | 75
Narrow skull shape 1 | 75
Night Blindness 1 | 101
Normocytic hypoplastic anemia 1 | 1
Onset in middle age 1 | 4
POROK1 1 | 1
POROKERATOSIS 1, MULTIPLE TYPES 1 | 1
POROKERATOSIS 7, MULTIPLE TYPES 1 | 1
POROKERATOSIS, DISSEMINATED SUPERFICIAL ACTINIC, 1 1 | 2
Pallor of optic disc 1 | 39
Papule 1 | 43
Pharyngitis 1 | 17
Porokeratosis, disseminated superficial actinic 1 1 | 2
Progressive cerebellar ataxia 1 | 13
Pyoderma gangrenosum 1 | 9
Recurrent aphthous ulcer 1 | 14
Skin Neoplasms 1 | 69
Subclinical abnormal liver function tests 1 | 81
Supratentorial atrophy 1 | 94
Thrombocytopenia 1 | 197
Transaminases increased 1 | 81
Triangular face 1 | 58
Turridolichocephaly 1 | 75
Vertigo 1 | 29
Vitamin B12 deficiency 1 | 20
Vomiting 1 | 116
Waterhouse-Friderichsen syndrome 1 | 11
Wide bregma sutures 1 | 46
Zellweger syndrome 1 | 37

Tissue

Blood and immune system 3 | 16,909
Cardiovascular System 3 | 15,192
Digestive Tract 3 | 17,369
Endocrine System 3 | 18,159
Female tissues 3 | 17,400
Liver and Pancreas 3 | 16,750
Male tissues 3 | 17,142
Nervous System 3 | 16,725
Respiratory system 3 | 16,393
Skin and soft tissues 3 | 17,230
Urinary Tract 3 | 16,678

Target Family

Enzyme 2 | 4,145
Kinase 1 | 634

GO Process

isopentenyl diphosphate biosyn... 3 | 3
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Diphosphomevalonate decarboxylase MVD Tchem Enzyme -2.09917 118.7 136
Phosphomevalonate kinase PMVK Tchem Enzyme -1.96385 92.3 144
Mevalonate kinase MVK Tchem Kinase -2.25702 177.5 271